PINK1 suppresses malignant phenotypes in esophageal squamous cell carcinoma by Xiangyun Lu, Yuhui Pei, Hao Peng, Man Li, Jing Li, Yongkun Yao, Lianghai Wang

“…Methods The expression levels of PINK1 in tumor samples and corresponding normal tissues were evaluated using RNA-sequencing and gene expression array datasets. Pathway enrichment and immune infiltration analyses were performed to explore the role of PINK1 in ESCC development. …”
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Baricitinib-associated changes in global gene expression during a 24-week phase II clinical systemic lupus erythematosus trial implicates a mechanism of action through multiple imm... by Daniel J Wallace, Thomas Dörner, Stephanie de Bono, Robert J Benschop, Ernst R Dow, Damiano Fantini, Richard E Higgs, Guilherme Rocha, Brenda Crowe, Nicole L Byers, Maria E Silk, Robert W Hoffman

“…Objective To characterise the molecular pathways impacted by the pharmacologic effects of the Janus kinase (JAK) 1 and JAK2 inhibitor baricitinib in SLE.Methods In a phase II, 24-week, randomised, placebo-controlled, double-blind study (JAHH), RNA was isolated from whole blood in 274 patients and analysed using Affymetrix HTA2.0 array. …”
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Genetic composition of Kazakh horses of Zhabe type evaluated by SNP genotyping by Alexandr Pozharskiy, Indira Beishova, Askar Nametov, Alzhan Shamshidin, Tatyana Ulyanova, Alexandr Kovalchuk, Vadim Ulyanov, Malika Shamekova, Gulmira Bekova, Dilyara Gritsenko

“…In contrast, the ‘Zhetysu Asyly’ horse breed derived from Kazakh horses demonstrate the effect of intense breeding process on the same landrace. …”
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Spatiotemporally weighted regression (STWR) for assessing Lyme disease and landscape fragmentation dynamics in Connecticut towns by Zhe Wang, Xiang Que, Meifang Li, Zhuoming Liu, Xun Shi, Xiaogang Ma, Chao Fan, Yan Lin

“…This research introduces a novel data-driven framework to identify potential indicators from an extensive array of potential variables. We then deployed an advanced spatiotemporal weighted regression (STWR) model to investigate how landscape fragmentation metrics correlate with the spatiotemporal variability of LD incidence rate in Connecticut towns. …”
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Environmental change between 1980 and 2020 followed by societal change in the Gulf of Gdańsk, Southern Baltic, a review by Jan Marcin Węsławski, Jacek Urbański, Joanna Piwowarczyk, Lech Kotwicki, Jacek Piskozub, Karol Kuliński, Ksenia Pazdro, Józef Wiktor, Sławomir Sagan, Iwona Psuty, Waldemar Walczowski, Aleksandra Koroza

“…The Gulf of Gdańsk belongs to the best-known marine areas in the Baltic, with regular environmental observations since mid-20th century. It covers the widest array of marine habitats in Polish Maritime areas (from large river mouth to Gdańsk Deep), shallow vegetated lagoon and stony reefs and the highest resources of species diversity (about 400 Metazoa and over 300 Protista species). …”
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Energy and Exergy Analysis of a Hybrid Photovoltaic–Thermoelectric System with Passive Thermal Management by Francisco J. Montero, Paco Jovanni Vásquez Carrera, William Armando Hidalgo Osorio, Aleph Salvador Acebo Arcentales, Héctor Calvopiña, Yousra Filali Baba

“…This study also analyzed the inclusion of two TEG arrays on both sides of the HP condenser section. …”
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Shotgun Metagenomic Sequencing Analysis as a Diagnostic Strategy for Patients with Lower Respiratory Tract Infections by Ha-eun Cho, Min Jin Kim, Jongmun Choi, Yong-Hak Sohn, Jae Joon Lee, Kyung Sun Park, Sun Young Cho, Ki-Ho Park, Young Jin Kim

“…SMS shows promise as a supplementary diagnostic method, with further research needed to optimize its performance and cost-effectiveness.…”
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Geometrical constraints dictate assembly and phenotype of human iPSC-derived motoneuronal spheroids by Eleonora Mello, Stefano Sorrentino, Alessio Bucciarelli, Ermanno Cordelli, Elisa De Luca, Haakon Nygaard, Stefan Wendt, Alberto Rainer, Giuseppe Gigli, Lorenzo Moroni, Alessandro Polini, Pamela Mozetic

“…We generated nine different pyramidal microwell array geometries for culturing size-controlled spheroids in the 40–140 μm diameter range. …”
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Genomic Insights and Comparative Analysis of Novel <i>Rhodopseudomonas</i> Species: A Purple Non-Sulfur Bacterium Isolated from Latex Rubber Sheet Wastewater by Chollachai Klaysubun, Nattarika Chaichana, Sirikan Suwannasin, Kamonnut Singkhamanan, Thunchanok Yaikhan, Duangporn Kantachote, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Komwit Surachat

“…<i>Rhodopseudomonas</i> is recognized for its versatile metabolic capabilities that enable it to effectively degrade pollutants and survive various environmental stresses. …”
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Taurine stimulation of planarian motility: a role for the dopamine receptor pathway by Elisa J. Livengood, Robyn A. M. V. Fong, Angela M. Pratt, Veronika O. Alinskas, Grace Van Gorder, Michael Mezzio, Margaret E. Mulligan, Evelyn B. Voura

“…Due to its possible benefits to health and development, taurine is added as a supplement to a wide array of products, including infant formula and energy drinks. …”
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Occurrence and ecological risk assessment of commonly used pharmaceuticals in water and soil of Sefwi Wiawso, Ghana by Seidu Atta Ishmael, Rita Opoku, Michael Konney Laryea, Edward Ebo Kwaansa-Ansah, Godfred Darko, Lawrence Sheringham Borquaye

“…Abstract Over the past two decades, pharmaceutical pollutants have emerged as a significant global concern due to their harmful effects on water quality, human health, and aquatic ecosystems. …”
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Systematic Investigation of Phosphate Decomposition and Soil Fertility Modulation by the Filamentous Fungus <i>Talaromyces nanjingensis</i> by Xiao-Rui Sun, Pu-Sheng Li, Huan Qiao, Wei-Liang Kong, Ya-Hui Wang, Xiao-Qin Wu

“…This paper systematically presents a comprehensive array of qualitative and quantitative techniques to assess the phosphate-decomposing capabilities of microbes. …”
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Individual Compounds of <i>Rhodoila quadrifida</i> Rhizomes and Roots: Isolating and Establishing Structure by A. V. Lezina, A. K. Whaley, A. O. Whaley, I. I. Terninko

“…The ethanol extract fractions (ethanol, hexane, butanol, and water) obtained during sequential liquid-liquid extraction were examined on a LC-20 Prominence instrument (Shimadzu, Japan) with an SPD-M20A diode array detector to determine the chromatographic profile. …”
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Exposure to a Titanium Dioxide Product Alters DNA Methylation in Human Cells by Carlos Wells, Marta Pogribna, Arjun Sharmah, Angel Paredes, Beverly Word, Anil K. Patri, Beverly Lyn-Cook, George Hammons

“…Gene promoter methylation was evaluated using EpiTect Methyl II Signature PCR System Array technology. Expression of DNA methyltransferases, <i>MBD2</i>, and <i>URHF1</i> was quantified by qRT-PCR. …”
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Targeting microRNA methylation: Innovative approaches to diagnosing and treating hepatocellular carcinoma by Albert Sufianov, Murad Agaverdiev, Andrey Mashkin, Tatiana Ilyasova

“…These factors contribute to the limited effectiveness of current treatment modalities and result in poor patient prognosis. …”
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Epidemiological and genetic factors affecting severe epizootic hemorrhagic disease in Spanish Holstein cattle during the Southern Europe outbreak of 2023 by O. González-Recio, A. Fernández, J.A. Jiménez Montero

“…All animals were genotyped using the Illumina EuroG MD SNP array, and imputation to whole-genome sequencing was carried out using the 1,000 bull genomes dataset as a reference. …”
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Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization by Maya Bolger-Chen, Manuela Lopera Higuita, Casie A. Pendexter, Mohammadreza Mojoudi, Korkut Uygun, Shannon N. Tessier

“…This manuscript leverages the wide array of perfusion parameters (i.e. perfusate, flow rate, coronary pressures), to demonstrate the capability of ex vivo heart perfusion protocols to accommodate a large range of experimental needs. …”
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Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis by Jiangqin He, Cao Zhang, Lili Yang

“…IntroductionOsteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. …”
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Genomic analyses in Cavalier King Charles spaniels identify loci associated with clinical signs of Chiari-like malformation and Syringomyelia by Courtney R. Sparks, Jonah N. Cullen, Michael W. Vandewege, Meghan Leber, Katie M. Minor, Steven G. Friedenberg, Natasha J. Olby

“…Dogs were genotyped using the Axiom K9 HD (710,000 snps) array. GWAS analyses were performed using GEMMA and categorical and quantitative approaches were used to define clinical phenotypes. …”
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Promoting Physical Activity Among Adolescents: Recommendations From Correlation Research (La promoción de la actividad físicas entre los adolescentes: recomendaciones a partir de l... by Paula Louise Bush, Cathy MacDonald

“…Adolescents are not meeting physical activity (PA) guidelines for health and, although there has been much PA intervention research for this age group, most studies have had only a small effect on teens’ PA. Many have observed that teenagers’ PA is determined by a complex array of intrapersonal, interpersonal, and family, school, and community environmental factors. …”
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