Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis by Song Fu, Renhua Lv, Longqiang Wang, Zhenyu Wang, Fengming Wang, Hao Gao, Wei Zhao, Xiaoling Huang, Xiaojun Li, Yanan Wang

“…The activation of STAT3 (colivelin, a specific agonist for STAT3) reversed the effects on the ferroptosis of BMSCs. Additionally, BMSCs alleviated IVDD progression based on matrix hydrogels, while colivelin abolished the protective effects of BMSCs-encapsulated hydrogels on IVDD. …”
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Analysis of the Surface Quality Characteristics in Hard Turning Under a Minimal Cutting Fluid Environment by Sandip Mane, Rajkumar Bhimgonda Patil, Anindita Roy, Pritesh Shah, Ravi Sekhar

“…Taguchi’s L27 orthogonal array was used to conduct the experiments. The findings showed that surface roughness increases with feed rate, identified as the most influential parameter, while the depth of cut shows a negligible effect. …”
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Editorial by Aniss MOUMEN

“… The Moroccan Journal of Quantitative and Qualitative Research (MJQR), in its Volume 6, Issue 4 (2024), presents a rich array of research addressing key challenges and opportunities in governance, education, migration, and organizational dynamics. …”
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Development and identification of wheat–Psathyrostachys huashanica 7NsS small segment translocation lines with early heading date gene Ehd-7Ns by Binwen Tan, Jing Gao, Zhijun Yao, Wei Zhu, Lili Xu, Yiran Cheng, Yi Wang, Jian Zeng, Xing Fan, Lina Sha, Haiqin Zhang, Peng Qin, Yinghui Li, Yonghong Zhou, Dandan Wu, Houyang Kang

“…Furthermore, 21 specific Kompetitive Allele Specific PCR (KASP) markers were developed based on transcriptome data, enabling effective tracing of alien chromosomal segments carrying this source of Ehd-7Ns in marker-assisted breeding. …”
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Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission-Longitudinal (UNIVERSAL) study: a prospective observational cohort study protocol by Nicola White, James D Chalmers, Salman Siddiqui, Paul H Lee, Cyrus Daneshvar, James Raftery, Charles Roberts, Philip Mitchelmore, Kerensa Thorne, Stefan J Marciniak, Tom Wilkinson, Angelica Cazaly, Gareth Griffiths, Neil J Greening, Anna Freeman, Alexander Allen, Andrew Cook, Karl J Staples, Tommaso Morelli, Jacqueline Nuttall, James Myerson, Olivia Cox, Emma Chamberlain, Tristan William Clark, Martha Purcell, Pedro Rodrigues, Matthew Pavitt, Michael G Crooks, Emma Tilt, Emma Knox, Monica Gil, Max Ellis, Ingrid Seath, Sandy Aitken, Barbara Costa, Sarah Dudley

“…Adults admitted with respiratory symptoms who test positive for RVIs via the BioFire® FilmArray® System or other validated diagnostic PCR tests will be enrolled. …”
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Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis by Rui Chai, Xiaomin Li, Wei Shen, Wei Shen, Ziyi Jin, Ziyi Jin, Genhong Yao, Genhong Yao, Xiaojun Tang, Xiaojun Tang, Linyu Geng, Linyu Geng, Lingyun Sun, Lingyun Sun

“…ObjectiveThere is a growing array of options for the treatment of immune-mediated inflammatory diseases (IMIDs). …”
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Hepatic stellate cell-specific Kcnma1 deletion mitigates metabolic dysfunction-associated steatotic liver disease progression via upregulating Amphiregulin secretion by Yunhan Zou, Jiaoxiang Wu, Sheng Cheng, Daqing Cheng, Taoying Chen, Xirong Guo, Li Tang, Xianbin Su, Man Zhang, Xin Zhang, Ying Liu, Jin Zhang, Qun Bao, Shangwei Hou, Peng Sun, Yong Li, Bo Han

“…CM transfer experiment and 3D spheroid studies show Kcnma1 deletion effectively prevents lipid accumulation in hepatocytes. …”
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Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma by Minglu Zhang, Minglu Zhang, Minglu Zhang, Minglu Zhang, Jianbo He, Jianbo He, Jianbo He, Jianbo He, Rao Fu, Rao Fu, Rao Fu, Rao Fu, Guojian Bao, Guojian Bao, Guojian Bao, Yijun Lu, Yijun Lu, Yijun Lu, Zechuan Zhang, Zechuan Zhang, Zechuan Zhang, Jiawu Yan, Jiawu Yan, Jiawu Yan, Jialu Ding, Jialu Ding, Jialu Ding, Fei Yang, Fei Yang, Fei Yang, Fei Yang, Beicheng Sun, Beicheng Sun, Beicheng Sun, Beicheng Sun

“…However, the role of snoRNA in the epigenetics of tumors remains poorly understood due to the lack of sufficiently effective experimental methods to identify snoRNA targets. …”
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Predicting Insemination Outcome in Holstein Dairy Cattle using Deep Learning by Mohammad Alishahi, Mahdi Ravakhah

“…The dataset encompasses a diverse array of tables containing entries spanning various aspects such as reproduction, milking, health profiles, genetic insights, and broader characteristic attributes. …”
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Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses by Shi-Ze Leng, Mei-Jia Fang, Yi-Min Wang, Zhen-Jia Lin, Qian-Yi Li, Ya-Nan Xu, Chun-Lin Mai, Jun-Ya Wan, Yangyinhui Yu, Ming Wei, Ying Li, Yu-Fan Zheng, Kai-Lang Zhang, Ya-Juan Wang, Li-jun Zhou, Zhi Tan, Hui Zhang

“…ELISA, immunofluorescence staining, Western blot, quantitative Real Time-PCR and Cytokine array were applied to detect the expressions of different molecules. …”
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Bridging cell morphological behaviors and molecular dynamics in multi-modal spatial omics with MorphLink by Jing Huang, Chenyang Yuan, Jiahui Jiang, Jianfeng Chen, Sunil S. Badve, Yesim Gokmen-Polar, Rossana L. Segura, Xinmiao Yan, Alexander Lazar, Jianjun Gao, Bing Yao, Michael Epstein, Linghua Wang, Jian Hu

“…MorphLink has been evaluated across a wide array of datasets, showcasing its effectiveness in extracting and linking interpretable morphological features with various molecular measurements in spatial omics analyses. …”
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Electrically programmable pixelated coherent mid-infrared thermal emission by Xiu Liu, Yibai Zhong, Zexiao Wang, Tianyi Huang, Sen Lin, Jingyi Zou, Haozhe Wang, Zhien Wang, Zhuo Li, Xiao Luo, Rui Cheng, Jiayu Li, Hyeong Seok Yun, Han Wang, Jing Kong, Xu Zhang, Sheng Shen

“…This integrated temperature-emissivity modulation of metasurfaces is systematically extended to form a pixelated 2D array with low crosstalk, envisioning advanced approaches toward scalable 2D electrical wiring for densely packed, independently addressable pixels.…”
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In vitro and in vivo anti-cancer activity of silymarin on oral cancer by Dong-Hoon Won, Lee-Han Kim, Boonsil Jang, In-Hyoung Yang, Hye-Jeong Kwon, Bohwan Jin, Seung Hyun Oh, Ju-Hee Kang, Seong-Doo Hong, Ji-Ae Shin, Sung-Dae Cho

“…Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vitro and in vivo. …”
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Inhibition of Rho Kinase Induces Antioxidative Molecules and Suppresses Reactive Oxidative Species in Trabecular Meshwork Cells by Tomokazu Fujimoto, Toshihiro Inoue, Saori Ohira, Nanako Awai-Kasaoka, Takanori Kameda, Miyuki Inoue-Mochita, Hidenobu Tanihara

“…Purpose. To investigate the effect of rho kinase inhibitors on oxidative stress in trabecular meshwork (TM) cells. …”
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Large-scale biosynthetic analysis of human microbiomes reveals diverse protective ribosomal peptides by Jian Zhang, Dengwei Zhang, Yi Xu, Junliang Zhang, Runze Liu, Ying Gao, Yuqi Shi, Peiyan Cai, Zheng Zhong, Beibei He, Xuechen Li, Hongwei Zhou, Muxuan Chen, Yong-Xin Li

“…Our findings reveal that five AIPs effectively inhibit the biofilm formation of disease-associated pathogens. …”
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Emerging roles of exosomes in the diagnosis and treatment of kidney diseases by Huanhuan Cao, Zixi Li, Jiajia Ye, Yi Lv, Chun Zhang, Tao Liang, Yumei Wang

“…Exosomes are nano-sized extracellular vesicles that transport a diverse array of bioactive substances, which can influence various pathological processes associated with kidney diseases and exhibit detrimental or beneficial effects. …”
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House dust microbiome differentiation and phage-mediated antibiotic resistance and virulence dissemination in the presence of endocrine-disrupting chemicals and pharmaceuticals by Shicong Du, Huiju Lin, Qiong Luo, Chung Ling Man, Sze Han Lai, Kin Fai Ho, Kenneth M. Y. Leung, Patrick K. H. Lee

“…However, the effects of anthropogenic chemicals on dust microbiomes remain poorly understood. …”
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Phenolic Extract from Moringa oleifera Leaves Inhibits Key Enzymes Linked to Erectile Dysfunction and Oxidative Stress in Rats’ Penile Tissues by Ganiyu Oboh, Adedayo O. Ademiluyi, Ayokunle O. Ademosun, Tosin A. Olasehinde, Sunday I. Oyeleye, Aline A. Boligon, Margareth L. Athayde

“…Characterization of the phenolic constituents was done via high performance liquid chromatography-diode array detection (HPLC-DAD) analysis. Furthermore, the effects of the extract on Fe2+-induced MDA production in rats’ penile tissue homogenate as well as its action on ACE and arginase activities were also determined. …”
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Electronic Nose System Based on Metal Oxide Semiconductor Sensors for the Analysis of Volatile Organic Compounds in Exhaled Breath for the Discrimination of Liver Cirrhosis Patient... by Makhtar War, Benachir Bouchikhi, Omar Zaim, Naoual Lagdali, Fatima Zohra Ajana, Nezha El Bari

“…This paper focuses on the emerging role of sensor array-based volatile organic compounds (VOCs) analysis of exhaled breath, particularly using electronic nose (e-nose) technology to differentiate LC patients from healthy controls (HCs). …”
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Systematic review and network meta-analysis on the efficacy and safety of parmacotherapy for hand osteoarthritis. by Ruiqi Wu, Qinglin Peng, Weiwei Wang, Jixian Zheng, Yi Zhou, Qipei Yang, Xuan Zhang, Hongyu Li, Lin Meng

“…This study seeks to conduct a network meta-analysis to assess the effectiveness and safety of various drug intervention measures in the treatment of hand osteoarthritis. …”
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