Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. by Michal Yalon, Liron Tuval-Kochen, David Castel, Itai Moshe, Inbal Mazal, Osher Cohen, Camila Avivi, Kineret Rosenblatt, Sarit Aviel-Ronen, Ginette Schiby, Joachim Yahalom, Ninette Amariglio, Raphael Pfeffer, Yaacov Lawrence, Amos Toren, Gideon Rechavi, Shoshana Paglin

“…However, new therapeutic strategies are required in order to overcome innate and acquired resistance to these drugs and thus expand the array of cancers that could benefit from them. We show that human cancer cell lines which respond poorly to ABT-888 (a PARPi), become sensitive to it when co-treated with vorinostat (a histone deacetylase inhibitor (HDACi)). …”
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Neuronal ion channel modulation by Drimys winteri compounds: Opening a new chemical space to neuropharmacology by Macarena E. Meza, Oscar Ramirez-Molina, Oscar Flores, Katherine Fariña-Oliva, Pamela A. Godoy, Jorge Fuentealba, Gonzalo E. Yévenes

“…Further studies at the molecular level may aid in developing multi-targeted drugs with enhanced therapeutic effects.…”
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A Standalone and Quantitative Point‐of‐Need Testing Platform with Manual Readout Capability Based on Smart Hydrogel Strands by Saeed Boroomand, Navid Farhoudi, Christopher F. Reiche, Jules J. Magda, Florian Solzbacher, Lars B. Laurentius

“…Abstract Smart hydrogels hold great promise as sensing elements that can be tailored to respond to a wide array of biomarkers and can be integrated with different readout modalities. …”
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Bacteria in the adventitia of cardiovascular disease patients with and without rheumatoid arthritis. by Samuel A Curran, Ivana Hollan, Clett Erridge, David F Lappin, Colin A Murray, Gunnar Sturfelt, Knut Mikkelsen, Oystein T Førre, Sven M Almdahl, Magne K Fagerhol, Carl S Goodyear, Marcello P Riggio

“…Human primary macrophages were infected with M. oryzae, and a TLDA qPCR array targeting 90 genes involved in inflammation and immune regulation was used to profile the transcriptional response. …”
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Artesunate regulates malignant progression of breast cancer cells via lncRNA TUG1/miR-145-5p/HOXA5 axis. by Chao Yang, Yunjiang Liu, Lingyun Gai, Ziteng Zhang, Yanshou Zhang, Geng Zhang, Kaiye Du, Chao Gao

“…<h4>Methods</h4>A comprehensive array of in vitro assays was employed to investigate the proposed molecular pathway, including CCK-8 proliferation assay, EdU incorporation assay, Transwell invasion assay, scratch wound healing assay, TUNEL apoptosis assay, and dual-luciferase reporter assay. …”
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Integral Imaging-Based Light Field Display System With Optimum Voxel Space by Ze-Sheng Liu, Da-Hai Li, Huan Deng

“…Secondly, it proposes a method to generate an elemental image array (EIA) from a pair of RGB and depth (RGBD) images based on the optimally selected voxel space. …”
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Nuclear receptors CAR and PXR as cardiometabolic regulators by Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä

“…Together, they regulate a wide array of target genes, whose functions range from elimination of xenobiotics to energy metabolism. …”
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Possibilities of Using of Surface and Subsurface Waves’ Amplitude-Angle Characteristics for Control of Materials with Surface-Hardened Inhomogeneous Layer by A. R. Baev, M. V. Asadchaya, A. L. Mayorov, O. S. Sergeeva, N. V. Delenkovsky

“…As a result of this research, the possibility of using a phased array transducers to solve the above problems.The effect of the hardened layer depth varying from zero to five in the working frequency range of 1.8– 10 MHz on the peculiarities of the refraction effect (including interference) and dependence of the subsurface wave amplitude on the acoustic base has been studied, making it possible to establish conditions that provide for the determination of the hardened layer depth.Circuit solutions have been offered in order to increase the efficiency of control of properties of the surface layers of metal articles on the basis of utilization of small-aperture transducers and ultrasonic reflectors making it possible to form fields of surface waves of different directional pattern.…”
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Computational prediction of the pathogenic variants of arachidonate 5-lipoxygenase activating protein using Molecular Dynamics simulation. by Mohamed E Elnageeb, Imadeldin Elfaki, Gad Allah Modawe, Abdelrahman Osman Elfaki, Othman R Alzahrani, Hytham A Abuagla, Hayam A Alwabsi, Adel I Alalawy, Mohammad Rehan Ajmal, Elsiddig Idriss Mohamed, Hussein Eledum, Syed Khalid Mustafa, Elham M Alhathli

“…We employed an array of bioinformatics techniques, including SIFT, PolyPhen-2, PANTHER, SNPs&GO, PhD-SNP, i-Mutant, MuPro, MutPred, ConSurf, and GROMACS. …”
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Patient Preferences with Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Multinational Discrete Cho... by Alfredo García-Layana, Gloria C. Chi, Laurent Kodjikian, Mariacristina Parravano, David Chow, Timothy L. Jackson, Carl Danzig, Liliana P. Paris, Mirela Mirt, Mickael Henry-Szatkowski, Hannah B. Lewis, Brittany Gentile

“…Individual treatment preferences should be identified and given key consideration when helping patients select from an expanding array of treatment options. …”
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Sustainable Cooling Strategies in End Milling of AISI H11 Steel Based on ANFIS Model by Arumugam Balasuadhakar, Sundaresan Thirumalai Kumaran, Saood Ali

“…The experimental framework is based on a Taguchi L36 orthogonal array, with key parameters including feed rate, cutting speed, cooling condition, and air pressure. …”
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Integrated optimization and prediction of mechanical properties in FDM printed polyamide/carbon fiber composites using PSI–VIKOR and ANN by Kavimani Vijayananth, Gopal Pudhupalayam Muthukutti, Arulmurugan Raju, Imad Barsoum

“…Results indicated that infill percentage has the maximum effect on the assessed properties and the same is confirmed by analysis of variance (ANOVA). …”
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Compositional Influence on Martensitic Transformations in Ni-Ti Alloys by Molecular Dynamics by Luis César Rodríguez Aliaga, Pedro Henrique Pinheiro de Souza, Ivan Napoleão Bastos, Alexandre Melhorance Barboza

“…Over the last decades, high-entropy refractory alloys with shape memory (SM) effect have been increasingly studied. However, identifying the optimal composition among the vast array of potential systems remains a significant challenge for the scientific community. …”
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Assessing the Use of Electrical Resistivity for Monitoring Crude Oil Contaminant Distribution in Unsaturated Coastal Sands Under Varying Salinity by Margaret A. Adeniran, Michael A. Oladunjoye, Kennedy O. Doro

“…This study assessed the effectiveness of ERI for monitoring crude oil spills in sandy soil using a 200 × 60 × 60 cm 3D sandbox filled with medium-fine-grained sand under unsaturated conditions. …”
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African strains of Zika virus resist ISG-mediated restriction. by Inès Bribes, Jim Zoladek, Marion Cannac, Sara Salinas, Sam J Wilson, Sébastien Nisole

“…In particular, SHFL, RTP4 and IFI6, which were the three most active ISGs against Asian viruses, had little or no effect on the replication of African ZIKV strains. …”
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An open source code for modeling radio wave propagation in earth’s ionosphere by Alexander Green, William J. Longley, Meers M. Oppenheim, Matthew A. Young

“…We present FARR (Finite-difference time-domain ARRay), an open source, high-performance, finite-difference time-domain (FDTD) code. …”
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Downregulation of STAT3 transcription factor reverses synaptotoxic phenotype of reactive astrocytes associated with prion diseases by Rajesh Kushwaha, Kara Molesworth, Natallia Makarava, Ilia V. Baskakov

“…The current study addresses this gap by investigating the effects of Stat3 deletion in reactive astrocytes isolated from prion-infected mice. …”
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CA3 bridges dietary restriction to glioblastoma suppression and tumor progression as a key downstream effector by Junxiang Mao, Zhibiao Cai, Dong Xie, Man Guo, Yu Gao, Guohui Zhao, Jie Zhou

“…Abstract Dietary restriction (DR) is recognized as a health-promoting, non-pharmacological intervention with demonstrated inhibitory effects on the initiation and progression of cancer. …”
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Improving tumor microenvironment assessment in chip systems through next-generation technology integration by Daniela Gaebler, Stephanie J. Hachey, Christopher C. W. Hughes, Christopher C. W. Hughes

“…The tumor microenvironment (TME) comprises a diverse array of cells, both cancerous and non-cancerous, including stromal cells and immune cells. …”
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Green Synthesis of Iron Oxide Nanoparticles and Their Antibacterial Efficacy against Carbapenem-resistant Klebsiella pneumoniae in Bloodstream Infections by Rahul Harikumar Lathakumari, Leela Kakithakara Vajravelu, Jayaprakash Thulukanam, Vishnupriya Panneerselvam, Poornima Baskar Vimala, Dakshina Manoj Nair, Sujith Sri Surya Ravi

“…Genotypic analysis revealed the presence of blaOXA-48 in 100% of isolates, blaVIM in 93%, and blaNDM in 70%, indicating a diverse array of carbapenemase genes. The green-synthesized IONPs demonstrated potent antibacterial activity against CRKP, with a MIC of 0.15 mg/mL, effectively reducing genomic resistance in the tested isolates. …”
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