Type-1 (CB1) cannabinoid receptor promotes neuronal differentiation and maturation of neural stem cells. by Claudia Compagnucci, Sara Di Siena, Maria Blaire Bustamante, Daniele Di Giacomo, Monia Di Tommaso, Mauro Maccarrone, Paola Grimaldi, Claudio Sette

“…Lastly, gene array profiling showed that CB(1) activation augmented the expression of genes involved in neuronal differentiation while decreasing that of stemness genes. …”
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THE CHEMISTRY OF NUTRACEUTICALS: DRIVING HEALTH INNOVATIONS AND SHAPING NEW PARADIGMS

“…Recent evidence demonstrates the ability of several secondary metabolites, such as polyphenols, to inhibit molecular processes underlying aging events, acting on a wild array of biological targets belonging to several molecular networks. …”
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Designing precise dynamical steady states in disordered networks by Marc Berneman, Daniel Hexner

“…Our work demonstrates that within physical bounds, a broad array of exotic behaviors in the dynamic regime can be obtained, allowing for a richer range of possible applications.…”
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The Integration of Geospatial Data for the BIM-Based Inventory of a Skatepark—A Case Study by Przemysław Klapa, Maciej Małek

“…Skateparks, renowned for their avant-garde designs, are meticulously crafted to exude distinctiveness, featuring an array of constructions, surfaces, and intricate shapes. …”
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Searching for fat tails in CRISPR-Cas systems: Data analysis and mathematical modeling. by Yekaterina S Pavlova, David Paez-Espino, Andrew Yu Morozov, Ilya S Belalov

“…The resulting library of spacers collected in CRISPR arrays is then compared with the DNA of potential invaders. …”
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Multi-Index Quantitative Analysis of Pharyngiyan Tablet Characteristics by Screening Different Quality Control Components by Huan Cao, Liang Zhang, Xiaoning Zhan, Nan Hu, Xueyan Bi, Yanhong Wang

“…These indexes were selected based on their effectiveness in demonstrating differences, stability after processing, specificity, and cost-effectiveness in measurement. …”
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miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons. by Manavendra Pathania, Juan Torres-Reveron, Lily Yan, Tomoki Kimura, Tiffany V Lin, Valerie Gordon, Zhao-Qian Teng, Xinyu Zhao, Tudor A Fulga, David Van Vactor, Angélique Bordey

“…An array of signals regulating the early stages of postnatal subventricular zone (SVZ) neurogenesis has been identified, but much less is known regarding the molecules controlling late stages. …”
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Monopole Acoustic Logging While Drilling Acoustic Insulator Based on Labyrinthine Grooved Structure by DOU Yifan, ZHANG Chao, GUAN Wei

“…The results show that, within the sound source's central frequency range of 10~16 kHz, the structure presented in this paper has a good suppression effect on drill collar waves. Moreover, by using the proposed structure, formation P-wave and S-wave velocities can be derived by analyzing the array-received waveform data. …”
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A Prospective Study of Adverse Childhood Experiences and Illicit Drug Use in Adulthood by Angela M. Kaufman-Parks, Monica A. Longmore, Wendy D. Manning, Peggy C. Giordano

“…Yet, much of this research relies on retrospective ACE reports and does not consider the wide array of more proximal life experiences that may impact adults' substance use. …”
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Impact of Target Surface Building Direction on the Heat Transfer Characteristics of Additive Manufactured Impingement Systems by Tommaso Bacci, Alessio Picchi, Luca Innocenti, Francesco Morante, Bruno Facchini

“…A lumped approach was used to test additive manufactured coupons reproducing an impingement array in 1:1 scale and retrieve an average heat transfer assessment. …”
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Decoding Cytokine Dynamics: Wharton’s Jelly Stromal Cells and Chondro-Differentiates in PHA-Stimulated Co-Culture by Raja Sundari Meenakshi Sundaram, Secunda Rupert, Prasanna Srinivasan, Jeswanth Sathyanesan, Kavitha Govarthanan, Naveen Jeyaraman, Swaminathan Ramasubramanian, Madhan Jeyaraman, Ho Yun Chung, Prakash Gangadaran, Byeong-Cheol Ahn

“…Cytokine expression profiles were analyzed using the RT² Customized Gene Array to evaluate pro- and anti-inflammatory markers. …”
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Evaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot–Marie Tooth patients by Dace Pretkalnina, Dace Pretkalnina, Dace Pretkalnina, Elizabete Kenina, Elizabete Kenina, Linda Gailite, Dmitrijs Rots, Dmitrijs Rots, Kaj Blennow, Kaj Blennow, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Viktorija Kenina, Viktorija Kenina, Viktorija Kenina

“…BackgroundCharcot–Marie–Tooth disease (CMT), a slowly advancing hereditary nerve disorder, presents a significant challenge in the medical field. Effective drugs for treatment are lacking, and we struggle to find sensitive markers to track the disease’s severity and progression. …”
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New pneumococcal serotype 20C is a WciG O-acetyltransferase deficient variant of canonical serotype 20B by Jigui Yu, Neil Ravenscroft, Peter Davey, Roshan Liyanage, Oliver Lorenz, Michelle M. Kuttel, Stephanie W. Lo, Feroze A. Ganaie, Moon H. Nahm

“…Consequently, genome-based serotyping/bioinformatic tools must scrutinize all cps genes for mutations that might inactivate/modify cps-encoded enzymes, ensuring effective tracking of emerging capsule variants in response to ongoing vaccination efforts.IMPORTANCEStreptococcus pneumoniae (pneumococcus) is a significant human pathogen known for producing a wide array of antigenically and structurally diverse capsule types, a fact that poses a serious challenge to the effectiveness of vaccines targeting pneumococcal capsule polysaccharide (PS). …”
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Optimization of antibacterial and antifungal activities in Moroccan saffron by-products using mixture design and simplex centroid methodology by Abdellah Baraich, Amine Elbouzidi, Naoufal El Hachlafi, Mohamed Taibi, Mounir Haddou, Sanae Baddaoui, Reda Bellaouchi, Mohamed Addi, Redouane Benabbes, Abdeslam Asehraou, Bassem Jaouadi, Ammar AL-Farga, Saleh M. Al-Maaqar, Ennouamane Saalaoui

“…Phytochemical analysis using high-performance liquid chromatography with diode-array detection (HPLC–DAD) identified key antimicrobial compounds, including ellagic acid (68.43% in leaves, 50.31% in tepals) and crocin (9.59% in stigmas). …”
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Microbiome-based surveillance of zoonotic tick-borne pathogens from urban wild boars in Barcelona, 2022–2023 by Laura Carrera-Faja, Elmira Ghadamnan, Iris Sarmiento, Jordi Manuel Cabrera-Gumbau, Mariette Viladomat Jasso, Josep Estruch, Daniel Borràs, Jaime Martínez-Urtaza, Johan Espunyes, Oscar Cabezón

“…Monitoring the presence of pathogens in these animals is crucial for assessing zoonotic risks but remains challenging due to the vast array of known and unknown pathogens harboured by animals. …”
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Combining chromosome conformation capture and exome sequencing for simultaneous detection of structural and single-nucleotide variants by Maria Gridina, Timofey Lagunov, Polina Belokopytova, Nikita Torgunakov, Miroslav Nuriddinov, Artem Nurislamov, Lyudmila P. Nazarenko, Anna A. Kashevarova, Maria E. Lopatkina, Stanislav Vasilyev, Andrey Zuev, Elena O. Belyaeva, Olga A. Salyukova, Aleksandr D. Cheremnykh, Natalia N. Sukhanova, Marina E. Minzhenkova, Zhanna G. Markova, Nina A. Demina, Yana Stepanchuk, Anna Khabarova, Alexandra Yan, Emil Valeev, Galina Koksharova, Elena V. Grigor’eva, Natalia Kokh, Tatiana Lukjanova, Yulia Maximova, Elizaveta Musatova, Elena Shabanova, Andrey Kechin, Evgeniy Khrapov, Uliana Boyarskih, Oxana Ryzhkova, Maria Suntsova, Alina Matrosova, Mikhail Karoli, Andrey Manakhov, Maxim Filipenko, Evgeny Rogaev, Nadezhda V. Shilova, Igor N. Lebedev, Veniamin Fishman

“…Abstract Background Effective molecular diagnosis of congenital diseases hinges on comprehensive genomic analysis, traditionally reliant on various methodologies specific to each variant type—whole exome or genome sequencing for single nucleotide variants (SNVs), array CGH for copy-number variants (CNVs), and microscopy for structural variants (SVs). …”
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Experimental and computational evaluation of capacitive hyperthermia by Marcus Beck, Peter Wust, Eva Oberacker, Alexander Rattunde, Tom Päßler, Benjamin Chrzon, Paraskevi Danai Veltsista, Jacek Nadobny, Ruben Pellicer, Enrico Herz, Lukas Winter, Volker Budach, Sebastian Zschaeck, Pirus Ghadjar

“…We implemented models for electrodes and phantom setups for simulation studies using Sim4Life.Results For a standard total power of 200 W, we measured effective SAR until depths of 6–8 cm in a homogeneous phantom, which indicates fair heating conditions for tumor diseases in superficial and intermediate depths. …”
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Investigation of internal action to enhance structural stability and electrochemical performance of K+/Mg2+ co-doped cathodes in high voltage environments utilizing dual coordinati... by Xuantian Feng, Minjie Hou, Bowen Xu, Yiyong Zhang, Da Zhang, Yun Zeng, Yong Lei, Feng Liang

“…Sodium-ion batteries (SIBs) are emerging as a promising alternative for large-scale energy storage, particularly in grid applications. Within the array of potential cathode materials, Fe/Mn-based layered oxides are notable for their advantageous theoretical specific capacity, economic viability, and environmental sustainability. …”
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On the Feasibility of Adapting the LiVec Tactile Sensing Principle to Non-Planar Surfaces: A Thin, Flexible Tactile Sensor by Olivia Leslie, David Córdova Bulens, Stephen J. Redmond

“…This proof-of-concept design eliminates rigid circuit boards, creating a sensor capable of providing localized 3D force and 3D displacement measurements across an array of sensing units in a small-thickness, non-camera-based optical tactile sensor skin covering a curved surface. …”
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Facile preparation of alkalized MXene with a larger interlayer for efficient removal of methylene blue by Ying Shi, Xiuying Fang, Yao Zhang, Mingrong Lu, Junxiu Ye, Min Yang, Hongbin Wang, Jiaxiong Li, Guizhen Li

“…It can be fabricated and processed in a variety of scalable and cost-effective way. A novel adsorbent Ti3C2-NaOH was prepared by using NaOH as an intercalating agent to remove dyes in wastewater. …”
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