Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose. by Peitao Wu, Denis Rybin, Lawrence F Bielak, Mary F Feitosa, Nora Franceschini, Yize Li, Yingchang Lu, Jonathan Marten, Solomon K Musani, Raymond Noordam, Sridharan Raghavan, Lynda M Rose, Karen Schwander, Albert V Smith, Salman M Tajuddin, Dina Vojinovic, Najaf Amin, Donna K Arnett, Erwin P Bottinger, Ayse Demirkan, Jose C Florez, Mohsen Ghanbari, Tamara B Harris, Lenore J Launer, Jingmin Liu, Jun Liu, Dennis O Mook-Kanamori, Alison D Murray, Mike A Nalls, Patricia A Peyser, André G Uitterlinden, Trudy Voortman, Claude Bouchard, Daniel Chasman, Adolfo Correa, Renée de Mutsert, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Linda Kao, Sharon L R Kardia, Charles Kooperberg, Ruth J F Loos, Michael M Province, Tuomo Rankinen, Susan Redline, Paul M Ridker, Jerome I Rotter, David Siscovick, Blair H Smith, Cornelia van Duijn, Alan B Zonderman, D C Rao, James G Wilson, Josée Dupuis, James B Meigs, Ching-Ti Liu, Jason L Vassy

“…In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p<1x10-7 (adjusted for multiple hypothesis-testing with the IBC array). Two SNPs had significant joint effects in the overall model and significant main effects only in one smoking stratum: rs140637 (FBN1) in AA individuals had a significant main effect only among smokers, and rs1444261 (closest gene C2orf63) in EA individuals had a significant main effect only among nonsmokers. …”
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Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis by Zhen Guan, Yingchao Liang, Zhiqiang Zhu, Aiyun Yang, Shen Li, Xiuwei Wang, Jianhua Wang

“…We also evaluated the effects of inositol supplementation on cilia during Li2CO3 exposure. …”
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Plant diversity on high elevation islands – drivers of species richness and endemism by Severin D.H. Irl

“…<p>High elevation islands elicit fascination because of their large array of endemic species and strong environmental gradients. …”
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Gene-centric meta-analysis of lipid traits in African, East Asian and Hispanic populations. by Clara C Elbers, Yiran Guo, Vinicius Tragante, Erik P A van Iperen, Matthew B Lanktree, Berta Almoguera Castillo, Fang Chen, Lisa R Yanek, Mary K Wojczynski, Yun R Li, Bart Ferwerda, Christie M Ballantyne, Sarah G Buxbaum, Yii-Der Ida Chen, Wei-Min Chen, L Adrienne Cupples, Mary Cushman, Yanan Duan, David Duggan, Michele K Evans, Jyotika K Fernandes, Myriam Fornage, Melissa Garcia, W Timothy Garvey, Nicole Glazer, Felicia Gomez, Tamara B Harris, Indrani Halder, Virginia J Howard, Margaux F Keller, M Ilyas Kamboh, Charles Kooperberg, Stephen B Kritchevsky, Andrea LaCroix, Kiang Liu, Yongmei Liu, Kiran Musunuru, Anne B Newman, N Charlotte Onland-Moret, Jose Ordovas, Inga Peter, Wendy Post, Susan Redline, Steven E Reis, Richa Saxena, Pamela J Schreiner, Kelly A Volcik, Xingbin Wang, Salim Yusuf, Alan B Zonderland, Sonia S Anand, Diane M Becker, Bruce Psaty, Daniel J Rader, Alex P Reiner, Stephen S Rich, Jerome I Rotter, Michèle M Sale, Michael Y Tsai, Ingrid B Borecki, Robert A Hegele, Sekar Kathiresan, Michael A Nalls, Herman A Taylor, Hakon Hakonarson, Suthesh Sivapalaratnam, Folkert W Asselbergs, Fotios Drenos, James G Wilson, Brendan J Keating

“…To address this, we performed dense genotyping of ∼2,000 candidate genes in 7,657 African Americans, 1,315 Hispanics and 841 East Asians, using the IBC array, a custom ∼50,000 SNP genotyping array. Meta-analyses confirmed 16 lipid loci previously established in European populations at genome-wide significance level, and found multiple independent association signals within these lipid loci. …”
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Multi-bioinspired electronic skins with on-demand adhesion and opto-electronic synergistic display capabilities by Wenzhao Li, Jinbo Li, Xiaoya Ding, Qitao Tan, Weijian Sun, Puxiang Lai, Yuanjin Zhao

“…Additionally, the integration of the photothermal effect of CNTs and the temperature-sensitive octopus-inspired PNIPAm adhesive array enables on-demand adhesion. …”
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Genomic regions of Solanum tuberosum L. associated with the tuber eye depth by I. V. Totsky, I. V. Rozanova, A. D. Safonova, A. S. Batov, Yu. A. Gureeva, A. V. Kochetov, E. K. Khlestkina

“…The aim of this study is to search for loci associated with the eye depth by analyzing Solanum tuberosum varieties from the GenAgro collection of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, genotyped using the Illumina 22K SNP potato array DNA chip. The 24 significant markers associated with the “eye depth” trait were identified using 15,214 SNP markers genotyped with the Illumina 22K SNP potato array chip and the general linear model (GLM) taking into account the population structure. …”
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LDOC1 regulates Wnt5a expression and osteosarcoma cell metastasis and is correlated with the survival of osteosarcoma patients by Bi-Cheng Yong, Jin-Chang Lu, Xian-Biao Xie, Qiao Su, Ping-Xian Tan, Qing-Lian Tang, Jing Wang, Gang Huang, Ju Han, Hong-Wen Xu, Jing-Nan Shen

“…LDOC1-associated changes in expression of metastasis-promoting genes were analyzed with a quantitative real-time polymerase chain reaction primer array. A xenograft tumor model (n = 7 mice/group) was used to assess the effect of LDOC1 on osteosarcoma metastasis in vivo. …”
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OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution by J. Macuada, I. Molina-Riquelme, G. Vidal, N. Pérez-Bravo, C. Vásquez-Trincado, G. Aedo, D. Lagos, P. Yu-Wai-Man, R. Horvath, T. J. Rudge, B. Cartes-Saavedra, V. Eisner

“…We applied a novel model incorporating the mitochondrial context, separating nucleoid distribution into the array in the mitochondrial population and intramitochondrial longitudinal distribution. …”
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The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape by Jani Nöthling, Jacqueline Samantha Womersley, Shibe Mhlongo, Carl Lombard, Naeemah Abrahams, Soraya Seedat, Sian Megan Joanne Hemmings

“…Methylation levels at five FKBP5 intron 7 CpG sites were determined using EpiTYPER Sequenom MassArray technology. Genotyping of rs1360980 was completed using the Agena MassArray genotyping system. …”
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High-throughput mesoscopic optical imaging data processing and parsing using differential-guided filtered neural networks by Hong Zhang, Zhikang Lu, Peicong Gong, Shilong Zhang, Xiaoquan Yang, Xiangning Li, Zhao Feng, Anan Li, Chi Xiao

“…However, obtaining a batch of raw array mouse brain data at a resolution of $$0.65 \times 0.65 \times 3 \,\upmu \hbox {m}^{3}$$ 0.65 × 0.65 × 3 μ m 3 can reach 220TB, and the cropping of the outer contour areas in the disjointed processing still relies on manual visual observation, which consumes substantial computational resources and labor costs. …”
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Energy costs for cutting soil with disks analysis by V. A. Nikolaev

“…From another scheme of forces, the normal reaction of the lateral surface of the disc to the effects of the soil was revealed. The total volumetric energy costs for cutting soil with disks are obtained by adding the identified partial energy costs.Conclusion. …”
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The biological agent rituximab ameliorates DNA damage and repair efficiency in the somatic cells of arthritic mice by Mohammed A. Al-Hamamah, Mohamed A. Mahmoud, Moureq R. Alotaibi, Ahmed Nadeem, Mushtaq A. Ansari, Sheikh F. Ahmad, Saleh A. Bakheet, Gamaleldin I. Harisa, Sabry M. Attia

“…Additionally, the ameliorative effect of rituximab has also been shown by its ability to reduce the severity of joint inflammation and histopathological alterations induced by arthritis. …”
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The intersection between circulatory microRNAs and biomarkers of neurodegeneration by Amber Yaqub, Rima Mustafa, M. Arfan Ikram, Mohsen Ghanbari

“…Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs with a vast array of biological functions, including the regulation of gene expression. …”
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Freeze-Drying for the Reduction of Fruit and Vegetable Chain Losses: A Sustainable Solution to Produce Potential Health-Promoting Food Applications by Dario Donno, Giovanna Neirotti, Annachiara Fioccardi, Zoarilala Rinah Razafindrakoto, Nantenaina Tombozara, Maria Gabriella Mellano, Gabriele Loris Beccaro, Giovanni Gamba

“…The proposed approach may be an effective tool for quality control and valorization of these products. …”
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Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer by Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti

“…Targeting the heterodimer MDM2/MDM4 is a novel and effective route for the reactivation of wild‐type p53 in human tumors with reduced toxicity in nontransformed cells. …”
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Polarization-independent high-sensitive metamaterial sensor for chemical sensing and EMI shielding application by Md Kutub Uddin, Shawon Hossen, Touhidul Alam, Mohammad Tariqul Islam, Saleh Albadran, Haitham Alsaif, Ahmed S. Alshammari, Ahmed Alzamil, Mohammad Lutful Hakim

“…This study proposes a polarization-independent high-sensitive quadrant-shaped metamaterial (QM) sensor for chemical sensing and effective electromagnetic interference (EMI) shielding applications. …”
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Dual Role of Host Toll-Like Receptor 3 in Parasitic Diseases by Yixin Yang, Qilong Li, Yiwei Zhang, Ning Jiang, Qijun Chen

“…Parasitic diseases, caused by a diverse array of parasites, remain a substantial threat to global health. …”
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Deep Search for a Scattered Light Dust Halo Around Vega with the Hubble Space Telescope by Schuyler G. Wolff, András Gáspár, George H. Rieke, Jarron M. Leisenring, Kate Su, David J. Wilner, Luca Matrà, Marie Ygouf, Nicholas P. Ballering

“…We detect a halo extending from the inner edge of our effective inner working angle at 10.″5 out to the photon noise floor at 30″ (80–230 au). …”
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CD16 and Siglec expression refine the phenotypic heterogeneity of steady-state myeloid-derived suppressor cells by Chris D. St. Laurent, Zeinab Jame-Chenarboo, Alyssa E. Beck, Stacey Stubblefield, Shiteng Duan, Darren Sigal, Matthew S. Macauley

“…BackgroundPolymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) mediate cancer immune suppression by promoting an immunosuppressive microenvironment that inhibits effective anti-tumor immunity. However, they are still a poorly understood, heterogeneous mix of neutrophil subsets. …”
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The insulator EACBE regulates V(D)J recombination of Tcrd gene by modulating chromatin organization by Yongchang Zhu, Yongchang Zhu, Ranran Dai, Ranran Dai, Hao Zhao, Junwei Luo, Keyi Li, Wei Xue, Litao Qin, Hongyuan Pan, Shixiu Liao, Bingtao Hao, Bingtao Hao

“…T cell receptor (TCR) diversity, essential for the recognition of a wide array of antigens, is generated through V(D)J recombination. …”
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