Co-Delivery of Dacarbazine and miRNA 34a Combinations to Synergistically Improve Malignant Melanoma Treatments by Ding B, Li M, Zhang J, Zhang X, Gao H, Gao J, Shen C, Zhou Y, Li F, Liu A

“…Baoyue Ding,1,2,* Mingjuan Li,2,* Jie Zhang,2,* Xiaojuan Zhang,2 Huan Gao,2 Jianqing Gao,3 Chunyan Shen,4 Yan Zhou,4 Fanzhu Li,5 Ailin Liu1 1Department of Pharmaceutical Analysis, Higher Educational Key Laboratory for Nano Biomedical Technology of Fujian Province, The School of Pharmacy, Fujian Medical University, Fuzhou, 350122, People’s Republic of China; 2Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, Jiaxing University College of Medicine, Jiaxing, Zhejiang, People’s Republic of China; 3Institute of Pharmaceutics, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 People’s Republic of China; 4Jiaxing Institute for Food, Drug and Product Quality Control, Jiaxing, Zhejiang, People’s Republic of China; 5Zhejiang Chinese Medical University, School of Pharmaceutical Science, Hangzhou, 310053, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fanzhu Li; Ailin Liu, Email lifanzhu@zcmu.edu.cn; ailinliu@mail.fjmu.edu.cnPurpose: The incidence of malignant melanoma (MM) has risen over the past three decades, and despite advancements in treatment, there is still a need to improve treatment modalities. …”
Get full text

Interleukin-1 Receptor-Associated Kinase-3 Aggravates Neuroinflammatory Injury After Intracerebral Hemorrhage via Activation NF-κB/IL-17A Pathway in Mice by Wang J, Li Y, Tan C, Shao J, Tang W, Kong Q, Sheng W, Ding Z, Li F, Piao J, Lv D, Hu L, Wang Q, Jiang X

“…Jun Wang,1,* Yulong Li,1,* Chunyu Tan,1,* Jinlian Shao,1 Weitai Tang,2 Quan Kong,3 Wenqianjun Sheng,1 Zhiquan Ding,1 Feng Li,1 Jifeng Piao,1 Dingyi Lv,1 Libin Hu,1 Qinghua Wang,1 Xiaodan Jiang1 1Neuromedicine Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People’s Republic of China; 2Department of Neurosurgery, The People’s Hospital of Luoding & Affiliated Luoding Hospital of Guangdong Medical University, Luoding, 527200, People’s Republic of China; 3Neurosurgery Department of Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qinghua Wang; Xiaodan Jiang, Email wqh1123@126.com; jiangxiao_dan@163.comBackground: Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). …”
Get full text

Non-Luminal Disease Score for Everolimus in Patients with Hormone Receptor‑positive and Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: A Mult... by Tan Y, Jiang H, Tian X, Ma F, Wang J, Zhang P, Xu B, Fan Y, Zhao W

“…Yujing Tan,1,* Hanfang Jiang,2,* Xinzhu Tian,1,* Fei Ma,1 Jiayu Wang,1 Pin Zhang,1 Binghe Xu,1 Ying Fan,1 Weihong Zhao3 1Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, People’s Republic of China; 2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing, 100142, People’s Republic of China; 3Department of Medical Oncology, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Fan; Weihong Zhao, Email fanying@cicams.ac.cn; zhaowh0818@163.comPurpose: This study aims to explore the role of the non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC).Methods: NOLUS has previously been established as an algorithm: NOLUS (0– 100) = − 0.45 × ER(%) − 0.28 × PR(%) + 0.27 × Ki67(%) + 73. …”
Get full text

Fear of Missing out and Online Social Anxiety in University Students: Mediation by Irrational Procrastination and Media Multitasking by Weimiao Wu, Jie Zhang, Namjeong Jo

Get full text

Interface effects in the phase determination of Hf0.5Zr0.5O2 epitaxial thin films by Jesse Schimpf, Wang Zhang, Mahir Manna, Sandhya Susarla, Xue-Zeng Lu, James M. Rondinelli, Lane W. Martin

Get full text

Transcriptomic and metabolomic analyses reveal the mechanism of color difference between two kinds of Cistanche deserticola before and after drying by Tiantian Zhu, Tiantian Zhu, Tiantian Zhu, Jing Zhang, Tianle Liu, Shuai Zhang, Baimei Yang, Li Xu, Lei Zhao, Lei Zhao, Mengfei Li, Ling Jin, Ling Jin, Ling Jin

Get full text

Assessment of Knowledge Gaps in Cervical Cancer Screening and HPV Vaccination Among Chinese Women: A Comprehensive Population-Based Study by Huang X, Ruan G, Sun P

“…Xinxin Huang,1 Guanyu Ruan,2 Pengming Sun2 1The Ministry of Health, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of China; 2Laboratory of Gynecologic Oncology, Fujian Clinical Research Center for Gynecologic Oncology, Fujian Matermity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian Province, People’s Republic of ChinaCorrespondence: Guanyu Ruan; Pengming Sun, Email ruangy_fjsfy@163.com; sunfemy@hotmail.comBackground: While studies on cervical cancer screening (CCS) and human papillomavirus (HPV) vaccine uptake exist in China, few have examined both within populations participating in CCS programs.Methods: This cross-sectional, population-based survey included 37,797 women aged 18– 64 years attending gynecological outpatient clinics. …”
Get full text

Fabrication of Nano-Silver Composite Using Amomum longiligulare Fruit Polysaccharides and Their Biological Activities by Lian Y, Ma N, Cheng Q, Luo M, Xu Z, He F, Zhou X, Zhang Y, Jin D, Kong Y, Wang Y, Wei N

“…Yong Lian,1,* Ning Ma,2,* Qianying Cheng,1,* Mingquan Luo,1 Zhen Xu,1 Fei He,1 Xiaomei Zhou,1 Ying Zhang,1 Dejun Jin,1 Yidan Kong,1 Yong Wang,1 Na Wei1 1Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education, International Joint Research Center of Human-Machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China; 2Reproductive Medical Center, Hainan Women and Children’s Medical Center, Haikou, Hainan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Na Wei; Yong Wang, Hainan Provincial Key Laboratory of R&D on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China, Email weina-0613@163.com; wangyong1982_2004@163.comPurpose: Study aims to optimize the synthesis conditions for silver nanoparticle composites [ALP(D)-AgNPs] using a rapid and environmentally friendly method and investigate the antioxidant, antibacterial, and anticancer activities of the fabricated composite.Methods: The polysaccharide component ALP-D was extracted and purified from the fruits of Amomum longiligulare and subsequently used for further experiments. …”
Get full text

Multilayer Shielding Design for Intermediate Radioactive Waste Storage Drums: A Comparative Study between FLUKA and QAD-CGA by Wenqian Li, Xuegang Liu, Ming Li, Yilin Huang, Sheng Fang

Get full text

The System of Sociocultural Adaptation of Foreign Students at Leading Russian Universities (On the Example of Azerbaijani and Chinese Students) by V. Yu. Ledеneva, R. Abdullaev, L. Guseynova

“…To achieve an accurate result, we conducted a survey of international students from the Republic of Azerbaijan and the People’s Republic of China studying at Russian universities. 107 students in total (45% Azerbaijani students and 55% Chinese students) from leading Moscow universities participated in the questionnaire-based survey, the age cohort of respondents ranged from 21 to 35 years. …”
Get full text

A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

Get full text

Simultaneous determination of 74 pesticide residues in Panax notoginseng by QuEChERS coupled with gas chromatography tandem mass spectrometry by Huijun Li, Jieshan Wu, Chao Chen, Wenfeng Xin, Wensheng Zhang

Get full text

Corticosteroid Phobia: A Key Barrier to Treatment in Young Women with Idiopathic Granulomatous Mastitis by Lin W, Wang Q, Liu J, Tan Q

“…Weiyi Lin,1,2,* Qiuzhou Wang,2,* Jia Liu,1,2 Qiuwen Tan1,2 1Division of Breast Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, People’s Republic of China; 2Breast Center, West China Hospital, Sichuan University, Chengdu City, Sichuan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiuwen Tan, Division of Breast Surgery, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu City, Sichuan Province, 610041, People’s Republic of China, Email hxtanqiuwen@163.comPurpose: Corticosteroids are recommended as a first-line treatment for idiopathic granulomatous mastitis (IGM), a disease that usually occurs in young women. …”
Get full text

Dynamic Impact of the Sleep Disorder, Depression and Anxiety on the Cognitive Function in the First-Episode Depressive Patients by Zhang W, Zhou N, Li J

“…Wenqiong Zhang,1,* Nan Zhou,1,* Jie Li2 1Department of Mood Disorders, Tianjin Anding Hospital, Tianjin City, 300222, People’s Republic of China; 2The Dean’s Office, Tianjin Anding Hospital, Tianjin City, 300222, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Li, The Dean’s Office, Tianjin Anding Hospital, No. 13, Liulin Road, Hexi District, Tianjin City, 300222, People’s Republic of China, Tel +86-022-88188326, Email jielimd859@163.comBackground: Sleep disorder is closely related to depressive and anxious status as well as cognitive symptoms.Materials and Methods: A total of 173 cases with the first-episode major depressive disorder (MDD) were involved in this study. …”
Get full text

Nurses’ Knowledge in the Prevention and Management of Nasointestinal Tube Obstruction: A Cross Sectional Study by Wang L, Hou W, Liu Z, Chen L, Lin R, Huang Y

“…Lun Wang,1,2 Wanling Hou,1 Zhong Liu,2 Li Chen,2 Ruidua Lin,2 Yinying Huang1 1Department of Nursing, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province, People’s Republic of China; 2Neurosurgery Department, Zhong Shan Hospital, Xiamen University, Xiamen, Fujian Province, People’s Republic of ChinaCorrespondence: Wanling Hou, Department of Nursing, Women and Children’s Hospital, School of Medicine, Xiamen University, 10 Zhen Hai Road, Si Ming District, Xiamen, Fujian Province, People’s Republic of China, Tel +8613705033186, Email hwldyx2007@126.comBackground: The nasointestinal tube is a route of nutritional support for patients and maintaining patency is essential. …”
Get full text

Improving Patient Outcomes in mTBI: The Role of Integrated Nursing Interventions in the Emergency Department by Feng T, Zhao P, Wang J, Du X, Ai M, Yang J, Li J

“…Ting Feng, Peng Zhao, Jiao Wang, Xiaoye Du, Meimei Ai, Jing Yang, Junjie Li Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of ChinaCorrespondence: Ting Feng, Department of Emergency, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, 710032, People’s Republic of China, Email fengtingff24@163.comBackground: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, often requiring emergency department (ED) management. …”
Get full text

The relationships of metals exposure and disturbance of the vaginal microbiota with the risk of PROM: Results from a birth cohort study by Dongyang Zhang, Rui Dong, Tingting Jiang, Shiwei Ren, Xinyu Yue, Muxin Zhai, Siyu Jiang, Bingxia He, Ran Tang, Yujie Deng, Wenjie Lyu, Baojing Zhao, Fangbiao Tao, Yuanyuan Yang, Zongzhi Yin, Zhen Yu, Dongmei Ji, Chunmei Liang

Get full text

INFRASTRUCTURE APPROACH AS INNOVATION METHOD OF TERRITORY DEVELOPMENT OF RUSSIA FEDERATION by F. Sharipov, O. Timofeev

“…It is particularly important that the crucial today’s perspectives of the Russian Federation and the People’s Republic of China cooperation in the Chinese project of the Silk way Economic belt with the Russian Eurasian initiatives integration have been reviewed in the article. …”
Get full text

Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

Get full text

Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey by Chen Zhao, Liang Tang, Ting Chen, Hui Yang, Xiong Chen, Xiaobo Cui, Li Shi, Xiangping Li, Jian He, Xiaoxia Peng, Shuifang Xiao, Jinrang Li, Hongliang Zheng, Junbo Zhang, Shuihong Zhou, Donghui Chen, Xuping Xiao, Hui Huangfu, Zhenfeng Tao, Yehai Liu, Shenhong Qu, Guangke Wang, Linli Tian, Wensheng Zhou, Hongyan Fang, Yongwang Huang, Guodong Yu, Zhenqun Lin, Ruixia Ma, Zhaoyan Yu

Get full text