Temporal optimization of CD25-biased IL-2 agonists and immune checkpoint blockade leads to synergistic anticancer activity despite robust regulatory T cell expansion by Blanka Rihova, Kathy Liu, Katerina Behalova, Vladyslav Mazhara, Milada Sirova, Marek Kovar, Irfan Baki Kilic, Petra Weberova, Derek VanDyke, Katerina Kubesova, Charina S Fabilane, Bohumil Ptacek, Jamie B Spangler

“…Background Interleukin-2 (IL-2) immunotherapy can induce durable tumor remissions, but its clinical performance has been limited by significant drawbacks such as short serum half-life and high toxicity. …”
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Efficacy and Safety of Transcatheter Mitral Valve Edge-to-Edge Repair with a MitraClip Device in Real-World Canadian Practice by Shamir R. Mehta, MD, MSc, Anita Asgar, MD, Robert Boone, MD, Josep Rodes-Cabau, MD, PhD, Eric A. Cohen, MD, Andrew Czarnecki, MD, Marino Labinaz, MD, Shahar Lavi, MD, Nicolo Piazza, MD, Kevin R. Bainey, MD, Akshay Bagai, MD, Jean-Michel Paradis, MD, J.D. Schwalm, MD, Douglas Wright, MD, Helen Nguyen, BSc, Tara McCready, PhD, Rajibul Mian, PhD, John Webb, MD, Neil Fam, MD

“…Secondary outcomes included hospitalizations for heart failure (HF) and New York Heart Association (NYHA) functional class. Results: MR etiology was degenerative in 41%, and functional in 59%. …”
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Uncovering the role of Gpr45 in obesity regulation by Eva O. Karolczak, Chia Li, Ivan C. Alcantara, Isabel M. Cohen, Claire Gao, Cuiying Xiao, Abigail I. Goldschmidt, Cynthia A. Pinkus, Junjie Li, Monica M. Li, Ryan M. Esquejo, Jean-Philippe Fortin, Kendra K. Bence, Marc L. Reitman, Michael J. Krashes

“…Methods: Three novel transgenic mouse models were engineered to investigate the functional contribution of Gpr45 to body weight and appetite regulation: 1) a global Gpr45 knockout, 2) a conditional floxed Gpr45 allele, and 3) a Gpr45-CreERT2 knock-in. …”
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Serum FGF21 as a predictor of response to atezolizumab and bevacizumab in HCC by Risako Kohya, Goki Suda, Masatsugu Ohara, Shunichi Hosoda, Takuya Sho, Makoto Chuma, Atsumasa Komori, Yuki Kugiyama, Yutaka Yasui, Kaoru Tsuchiya, Masayuki Kurosaki, Joji Tani, Shun Kaneko, Mina Nakagawa, Yasuhiro Asahina, Shinya Maekawa, Nobuyuki Enomoto, Yoshiya Yamamoto, Masaru Baba, Ren Yamada, Takashi Sasaki, Tomoka Yoda, Sonoe Yoshida, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Yoshimasa Tokuchi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Mitsuteru Natsuizaka, Koji Ogawa, Naoya Sakamoto

“…Tumour-secreted FGF21 has shown immune-checkpoint factor functions, and high FGF21 levels are associated with a poor prognosis for patients. …”
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COMPARATIVE CHARACTERISTICS OF THE EFFECTIVENESS OF DIRECT AND INDIRECT RESTORATIONS ON TEETH WITH DISCOLORATION by I.V. Zhyvotovskyi, Yu.I. Sylenko, M.V. Khrebor

“… The rapid development of dental industry and constant improvement of technologies in production of basic dental materials contribute to the increase of the quality of rendering dental care with the obligatory consideration not only of functional but also aesthetic parameters during a patient's rehabilitation. …”
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