Abrasion Resistance and Mechanism Analysis of Polyethylene Fiber-reinforced Cementitious Composite by ZI Jinjia, LI Weibin, WANG Jihong, WANG Zhiwen, LIU Yunjun, NONG Qingshun, LI Bixiong

“…ObjectiveIn hydraulic structures of the Qinghai–Xizang Plateau region, abrasion damage caused by sediment-laden water flows severely undermines the durability of hydraulic spillways, posing a significant challenge to the long - term stability and functionality of water conservancy infrastructure. …”
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Enzymatically enhanced ultrastructure expansion microscopy unlocks expansion of in vitro Toxoplasma gondii cysts by Kseniia Bondarenko, Floriane Limoge, Kayvon Pedram, Mathieu Gissot, Joanna C. Young

“…The cyst is critical for disease transmission and pathology, yet it is harder to study, with the function of many chronic-stage proteins still unknown. …”
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Enabling next-generation engineered TCR-T therapies based on high-throughput TCR discovery from diagnostic tumor biopsies by Thomas Kuilman, Deborah S. Schrikkema, Jules Gadiot, Raquel Gomez-Eerland, Laura Bies, Julia Walker, Robbert M. Spaapen, Hanna Kok, Demi Houg, Milena Viyacheva, Yvonne B. Claassen, Manuel Saornil, Oscar Krijgsman, Bas Stringer, Huiwen Ding, Anou Geleijnse, Anne C. Meinema, Bianca Weissbrich, Melissa Lancee, Carmen G. Engele, Marianna Sabatino, Pei-Ling Chen, Kenneth Y. Tsai, James J. Mulé, Vernon K. Sondak, Jitske van den Bulk, Noel F. de Miranda, Inge Jedema, John G. Haanen, Jeroen W. J. van Heijst, Ton N. Schumacher, Carsten Linnemann, Gavin M. Bendle

“…Abstract Adoptive cell therapy with tumor-infiltrating lymphocytes (TIL) can mediate tumor regression, including complete and durable responses, in a range of solid cancers, most notably in melanoma. …”
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Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice by Henry A. Paz, Henry A. Paz, C. G. Shashank, C. G. Shashank, Lasya Buddha, Tian Lam, Taylor Zhang, Ying Zhong, James D. Sikes, Craig Porter, Reid D. Landes, Roy Morello, Umesh D. Wankhade, Umesh D. Wankhade

“…Proteomic analysis of iWAT identified 38 differentially expressed proteins, with enrichment of pathways related to mitochondrial function and mTOR signaling.DiscussionShort-term cold exposure induced lasting histological and proteomic changes in iWAT and BAT without sustained effects on energy metabolism, likely due to reversion to RT and limited sample size.ConclusionBrief temperature manipulation around pregnancy can durably alter maternal adipose tissue architecture and molecular signatures, underscoring ambient temperature as an important modulator of maternal metabolic adaptation.…”
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Multiomics identifies tumor-intrinsic SREBP1 driving immune exclusion in hepatocellular carcinoma by Jie Chen, Arjun Singh, Riyue Bao, Jason John Luke, Sarah Newman, Aatur Singhi, Carsten Krieg, Ryan Augustin, Aofei Li, Brian Isett, Rebekah E Dadey, Ruxuan Li, Jake Griner, Joseph A Manning, Satdarshan P Monga, David A A Geller, Ioannis K Zervantonakis

“…Immune checkpoint inhibitors (ICI) have improved patient outcomes in hepatocellular carcinoma (HCC); however, most patients do not experience durable benefit. The non-T cell-inflamed tumor microenvironment, characterized by limited CD8+ T-cell infiltration, reduced dendritic cell function, and low interferon-γ-associated gene expression, is associated with a lower likelihood of response to ICI. …”
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LILRB2 blockade facilitates macrophage repolarization and enhances T cell-mediated antitumor immunity by D Gareth Rees, Robert W Wilkinson, Mark Cobbold, Georgina Bowyer, Kathy Mulgrew, Simon J Dovedi, Fernanda Arnaldez, Des C Jones, Lorraine Irving, Marcin Wolny, Seraina Blümli, Stacy Pryts, Michael Kierny, Sonja Hess, Rebecca Dudley, Elisavet I Chatzopoulou, Shreya Ahuja, Alan M Sandercock, Saravanan Rajan, Reena Varkey, Andrew Kayserian, Saly Songvilay, Kamila Bienkowska, Matthew S Glover

“…Despite these advancements, achieving durable antitumor responses remains challenging, often due to additional immunosuppressive mechanisms within the tumor microenvironment (TME). …”
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JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors by Yang Li, Taeko Hayakawa, Shinsuke Iida, Toshiaki Yoshikawa, Yusuke Ito, Satoshi Inoue, Yuichi Ishikawa, Takahiro Nakashima, Tetsuya Matsukawa, Hitoshi Kiyoi, Yuki Kagoya, Hitomi Kasuya, Haosong Zhang, Tsunenori Ouchida

“…In addition, ectopic expression of G6/7R improved the effector function of TNF-NTF CAR-T cells through constitutive activation of janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling. …”
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A pilot randomized aerobic exercise trial in older HIV-infected men: Insights into strategies for successful aging with HIV. by Krisann K Oursler, John D Sorkin, Alice S Ryan, Leslie I Katzel

“…Future research is needed to determine exercise strategies in older HIV-infected adults that address advanced aging and comorbidity yet are durable and feasible.…”
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Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects by Maria Jure-Kunkel, Christina Yu, Nora Pencheva, Mark Fereshteh, Alexander Muik, Aras Toker, Özlem Türeci, Tahamtan Ahmadi, Ugur Sahin, Brandon W Higgs, Jordan M Blum, Saskia M Burm, Vanessa M Spires, Angelica Sette, Sina Fellermeier-Kopf, Andrea Imle, Michela Capello, Kristin Strumane, Theo Plantinga, Craig J Thalhauser, Kristina B Nürmberger, Patricia Garrido Castro, Carol Costa Sa, Bruna de Andrade Pereira

“…Since 4-1BB is coexpressed with programmed cell death protein-1 (PD-1) on CD8+ T cells, PD-1 blockade and simultaneous costimulation through 4-1BB may synergistically enhance T-cell effector functions. We hypothesized that combining acasunlimab with PD-1 blockade to fully disrupt PD-1 interactions with both PD-L1 and PD-L2 would amplify the depth and duration of antitumor immunity.Methods The effect of acasunlimab and pembrolizumab combination was analyzed in vitro using functional immune cell assays, including mixed-lymphocyte reactions and antigen-specific T-cell proliferation and cytotoxicity assays. …”
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Prace konserwatorskie przy kamiennej rzeźbie Matki Boskiej autorstwa Andrzeja Pruszyńskiego z elewacji kościoła pw. Matki Bożej Pocieszenia w Żyrardowie – wybrane zagadnienia histo... by Piotr Owczarek

“…The aesthetic effect achieved this way brings a new quality to work that can be the object of criticism but by restoring the sculpture’s lost aesthetic values it is possible to continue to function as an object of religious worship. …”
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Comparison of the long‐term outcomes of patients with hepatocellular carcinoma within the Milan criteria treated by ablation, resection, or transplantation by Ning‐Ning Zhang, Jian Zheng, Ying Wu, Jia‐Yu Lv, Shu‐Wen Zhang, Ya‐Min Zhang, Wen‐Tao Jiang, Tian‐Qiang Song, Victoria Kim, Samer Tohme, Tian Liu, Wei Zhang, Jie Gu, Ze‐Yu Wang, Yu‐Hong Suo, Shuai Wang, Wang Li, Li Zhang, Yan Xie, Yong‐He Zhou, Jian‐Yong Liu, Yi‐Bo Qiu, Zhong‐Yang Shen, Ji‐Hui Hao, David Geller, Wei Lu

“…Conclusions Although LT resulted in the best recurrence and survival outcomes, LR and LA also offered durable long‐term alternatives. This prognostic calculator is a useful tool for clinicians to guide an informed and personalized discussion with patients based on their tumor biology and liver function.…”
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Sustained and specific multiplexed immune checkpoint modulation in CAR T cells induced by targeted epigenome editing by Maria Silvia Roman Azcona, Gianni Monaco, Melissa Whitehead, Masako Monika Kaufmann, Jamal Alzubi, Toni Cathomen, Claudio Mussolino

“…Epigenetically modified CAR T cells are indistinguishable from parental cells across a range of functional assays. Although the model does not fully mimic T cell exhaustion, limiting functional assessment, gene silencing remains durable across multiple divisions and repeated CAR stimulations. …”
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Sarcoma of the Lower Limb: Reconstructive Surgeon's Perspective by Zhixue Lim, Sophia A. Strike, Mark E. Puhaindran

“…Management of sarcomas in the lower extremities have evolved from amputations to limb-preserving surgeries with evidence to support that they have equal overall survival, albeit with better functional outcome. The challenge of reconstruction lies in providing a durable, functional, and aesthetically pleasing limb. …”
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L’autorité éducative : bienveillance envers l’autre, vigilance envers soi by Camille Roelens

“…The reflexion, conducted from a philosophical point of view, is articulated around a wide acceptation of the kindness, and in permanent resonance with the double-dealing of individual autonomy and autonomous functioning of collectives, which seems to be the functioning of the individuals’ society. …”
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Adaptabilité de la biodiversité paysagère dans les littoraux humides antillais by Michelle Dahomé Di Ruggiero

“…The obvious fact of their values and functions showed that these areas were important and major. …”
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Preparation and dyeability of lyocell fabric with structural color for apparel application by Rashid Hussain Memon, Zeeshan Khatri, Farooq Ahmed, Ayaz Memon

“…In contrast, bio-inspired structural colors, which arise from nanoscale interaction with light, offer a sustainable and durable alternative for fabric coloration. Thus, nanostructured coloration offers various advantages such as operational stability, eco-friendly dyeing, and multiple functions, including nontoxicity. …”
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The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…In this latter case, the BCI functions ethically by creating the very possibility for ethical engagement where none previously existed. …”
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A longitudinal assessment of the antibody response to SARS-CoV-2 infection in the New Mexican population. by Frances M Twohig, Tonilynn M Baranowski, Chunyan Ye, Michelle Harkins, Steven B Bradfute

“…While many studies have assessed immune responses to SARS-CoV-2 infection, none have studied functional antibody responses before and after vaccination of exposed patients in New Mexico in the United States. …”
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CONCRETE CREEP THEORY MODELS AND THEIR FINITE-ELEMENT IMPLEMENTATION by Petr Pavlovich Gaydzhurov, Elvira Rashidovna Iskhakova

“…Alexandrovsky are used as the hereditary functions of the second kind. The friendly programming expressions for the concrete relaxation kernels are obtained by the symbolic processor. …”
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A thorough assessment of 10-MDP primers in modern dental adhesive systems by Ahmed A Abduljawad, Harraa SM Salih, Omar F Tawfiq

“… Background: Dental primers are pivotal in achieving durable and reliable bonding between dental adhesives and tooth structures. …”
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