Cost‐effectiveness of Resonance® metallic ureteral stent compared with standard polyurethane ureteral stents in malignant ureteric obstruction: A cost‐utility analysis by Dawn M. Cooper, Rachel Lines, Iqbal Shergill

“…More durable metallic stents are available, although these incur an increased initial purchase price. …”
Get full text

Computational studies reveal structural characterization and novel families of Puccinia striiformis f. sp. tritici effectors. by Raheel Asghar, Nan Wu, Noman Ali, Yulei Wang, Mahinur Akkaya

“…Understanding the biological functions of Puccinia striiformis f. sp. tritici (Pst) effectors is fundamental for uncovering the mechanisms of pathogenicity and variability, thereby paving the way for developing durable and effective control strategies for stripe rust. …”
Get full text

Demographic Transition in Sub-Saharan Africa by IVANOV Sergey Felixovich

“…Instead, there are always universal socioeconomic mechanisms that translate improvements in child survival into fertility reduction and these mechanisms function in tend in culture- or country-specific ways. …”
Get full text

Safety and efficacy of sintilimab versus pembrolizumab in the treatment of advanced or recurrent pediatric malignancies: a real-world study in China by Lei Mao, Mengzhen Li, Linnan Wu, Juan Wang, Yi Que, Feifei Sun, Junting Huang, Suying Lu, Zijun Zhen, Jia Zhu, Mengjia Song, Yizhuo Zhang

“…BackgroundProgrammed death receptor 1 (PD-1) inhibitors have shown durable response and mild adverse events in adult malignancies. …”
Get full text

In vivo base editing of Angptl3 via lipid nanoparticles to treat cardiovascular disease by Jennifer Khirallah, Hanan Bloomer, Douglas Wich, Changfeng Huang, J. Noah Workman, Yamin Li, Gregory A. Newby, David R. Liu, Qiaobing Xu

“…Gene therapy represents a promising ''one and done'' strategy to durably reduce blood lipid levels. ANGPTL3 has emerged as a potential target for gene therapy, as naturally occurring loss-of-function variants are cardioprotective. …”
Get full text

Temporary dietary fiber depletion prompts rapid and lasting gut microbiota restructuring in mice by Colombe Rous, Julie Cadiou, Hiba Yazbek, Elena Monzel, Mahesh S. Desai, Joel Doré, Maarten van de Guchte, Stanislas Mondot

“…On the host side, we report transiently higher quantities of host DNA in feces during the RFD suggesting an impaired gut barrier function. Six weeks after the return to the chow diet, lasting changes in microbiota composition were observed, as exemplified by the replacement of durably depleted amplicon sequence variants close to Duncaniella dubosii by other members of the Muribaculaceae family. …”
Get full text

Integrating in situ vaccination with checkpoint blockade therapy: a novel approach to enhance anti-tumour immunity in colorectal cancer by Tolulope A. Owolabi, Samson A. Adeyemi, Lindokuhle M. Ngema, Clement Penny, Yahya E. Choonara

“…This review discusses the prospects of combining ISV with checkpoint inhibitors, which can enhance immune cell function. This dual approach may lead to a more potent and durable anti-tumour effect with minimal adverse events, ultimately contributing to significant improvements in tumour regression, overall survival, and the overall well-being of individuals diagnosed with CRC.…”
Get full text

Next-generation immunotherapeutic approaches for blood cancers: Exploring the efficacy of CAR-T and cancer vaccines by Kiavash Hushmandi, Abbas Ali Imani Fooladi, Russel J. Reiter, Najma Farahani, Liping Liang, Amir Reza Aref, Noushin Nabavi, Mina Alimohammadi, Le Liu, Gautam Sethi

“…This integrative approach promises to pave the way for more effective and durable treatment strategies in the oncology field. …”
Get full text

Multimodal spatial proteomic profiling in acute myeloid leukemia by Christopher P. Ly, Ivo Veletic, Christopher D. Pacheco, Enes Dasdemir, Fatima Z. Jelloul, Sammy Ferri-Borgogno, Akshay V. Basi, Javier A. Gomez, Jessica L. Root, Patrick K. Reville, Sonali Jindal, Sreyashi Basu, Padmanee Sharma, Andres E. Quesada, Carlos Bueso-Ramos, Taghi Manshouri, Branko Cuglievan, Miriam Garcia, Jared K. Burks, Hussein A. Abbas

“…Using unbiased clustering on the spatial K function, we unveiled the presence of tertiary lymphoid-like aggregates in bone marrow, which we validated using spatial transcriptomics and an independent proteomics approach. …”
Get full text

Terahertz photoneuromodulation of lateral orbitofrontal cortex neurons ameliorates stress-induced depression and cognitive impairment by Yuanyuan He, Jing Ma, Yun Yu, Junkai Yin, Ge Gao, Yifang Yuan, Hao Ruan, Xueqing Yan, Zihua Song, Chao Chang

“…This led to marked improvements in depressive-like behaviors and cognitive function. Furthermore, THz modulation of OFC activity recapitulated the effects of chemogenetic inhibition, underscoring the OFC's pivotal role in regulating depressive states. …”
Get full text

Immunotherapy with IL12 and PD1/CTLA4 inhibition is effective in advanced ovarian cancer and associates with reversal of myeloid cell-induced immunosuppression by Paul G. Pavicic, Patricia A. Rayman, Shadi Swaidani, Amit Rupani, Vladimir Makarov, Charles S. Tannenbaum, Robert P. Edwards, Anda M. Vlad, C. Marcela Diaz-Montero, Haider Mahdi

“…Detailed immunophenotyping of peripheral blood, ascites, and tumors revealed that durable treatment responses were associated with reversal of myeloid cell-induced immune suppression, which resulted in enhanced anti-tumor activity by T cells. …”
Get full text

Innovative approach to IOL-bag complex fixation with Siepser’s scleral sliding knots in pseudoexfoliation syndrome by Dario Furgiuele, Piera Giunta, Michele Rinaldi, Luca D’Andrea, Ciro Costagliola

“…This novel surgical technique may represent a viable, economic, and durable solution to restore dislocations of IOLs accessible from the anterior chamber that respect the cornea and restores visual function without damaging ocular structures.…”
Get full text

An updated narrative review on revolutionizing erectile dysfunction treatment: the crucial role of trophic factors in Adipose-Derived stem cell therapy by Armaghan Ghavam, Farhad Sheikhnia, Mohammad Mahdi Heidari, Mohammad Valilo, Zanyar Mahmoudnejad, Serap Gur

“…Collectively, these effects culminate in enhanced erectile function…”
Get full text

The bispecific innate cell engager AFM28 eliminates CD123+ leukemic stem and progenitor cells in AML and MDS by Nanni Schmitt, Jana-Julia Siegler, Alexandra Beck, Thomas Müller, Izabela Kozlowska, Séverine Sarlang, Uwe Reusch, Stefan Knackmuss, José Medina-Echeverz, Joachim Koch, Thorsten Ross, Ali Darwich, Lea Hoppe, Mohammed Abba, Alexander Streuer, Stefan Klein, Wolf-Karsten Hofmann, Anna Lisa Gündner, Christian Merz, Jan Endell, Jens Pahl, Daniel Nowak

“…Abstract Strategies targeting leukemic stem and progenitor cells (LSPCs) are needed for durable remissions in acute myeloid leukemia (AML) and high-risk myelodysplastic neoplasms (MDS). …”
Get full text

Dynamic Properties and Vibration Control of Additively Manufactured Carbon and Glass Fiber Reinforced Polymer Composites Using MFC: A Numerical Study with Experimental Validation by Ali Raza, Magdalena Mieloszyk, Rūta Rimašauskienė, Vytautas Jūrėnas, Nabeel Maqsood, Marius Rimašauskas, Tomas Kuncius

“…With the growing need for lightweight, durable, and high-performance structures, additively manufactured (AM) polymer composite structures have captured significant attention in the engineering community. …”
Get full text

Growth and yield models for Centrolobium ochroxylum Rose ex Rudd in silvopastoral systems of Ecuadorian western lowlands by Álvaro Cañadas-López, Paul Gamboa-Trujillo, Christian Wehenkel

“…AG has heavy (0.78 g/cm3) and durable wood, with whitish sapwood and orange-yellow heartwood, making it ideal for carpentry and construction. …”
Get full text

Evaluation of 3D printed nano-modified resin shear bond strength on titanium surfaces (an in-vitro study) by Noha Sabry ElMalah, Yomna Ibrahim, Dawlat Mostafa

“…Abstract Background Interim restorations are crucial in dental implant procedures as they ensure patient’s comfort, maintain esthetic appearance, and restore function during the healing process. Optimizing retention of these restorations ensures their long-term success. …”
Get full text

Is Stretching exercises Superior to Steroids for Sustained Relief in Plantar Fasciitis? Evidence from a Prospective Study by Divya Nand Pandey, Harsh Pratap Singh, Chetan Singh, Shrikant Raj, Harshit Tripathi, Ayush Prakash

“…Results: While the steroid group showed superior pain relief and functional improvement at 2 and 6 weeks, the stretching group demonstrated significantly better outcomes at 12 and 16 weeks. …”
Get full text

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis by Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst

“…We used mice expressing knock-in/knockout reporter alleles of Ccr2 and Cx3cr1 to interrogate their expression and function in monocyte-derived populations of the lungs and draining mediastinal lymph nodes during Mtb infection. …”
Get full text

Rehabilitation treatment of coxo-femoral osteo-arthritis - a usefull alternative by Sterian Apostol, Liliana-Elena Stanciu, Corneliu-Dan Blendea, Andreea-Dalila Nedelcu, Elena Apostol, Dimitri Apostol, Petru Bordei

“…Augmenting balneotherapy with structured kinetotherapy further enhances functional recovery and should be routinely incorpo-rated into balnear rehabilitation protocols.…”
Get full text