Investigating a new generation of ribozymes in order to target HCV. by Michel V Lévesque, Dominique Lévesque, Francis P Brière, Jean-Pierre Perreault

“…The former switches cleavage activity "on" solely in the presence of the desired RNA substrate, while the latter was the first catalytic RNA reported to function naturally in human cells, specifically in hepatocytes. …”
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Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer's disease. by Bradford M Elmer, Kurt A Swanson, Dinesh S Bangari, Peter A Piepenhagen, Errin Roberts, Tatyana Taksir, Lei Guo, Maria-Carmen Obinu, Pascal Barneoud, Susan Ryan, Bailin Zhang, Laurent Pradier, Zhi-Yong Yang, Gary J Nabel

“…These findings suggest that CNS gene delivery of a silent anti-Aβ scFv-IgG was well-tolerated, durably expressed and functional in a relevant disease model, demonstrating the potential of this modality for the treatment of Alzheimer's disease.…”
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Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM by Danielle R. Cook, Alina C. Boesteanu, Yibo Yin, Yibo Yin, Reiss Reid, Laura Roccograndi, Nadia Dahmane, Maria Martinez-Lage, Donald M. O’Rourke, Carl H. June, Carl H. June, Laura A. Johnson, Laura A. Johnson

“…However, the CAR T cells rapidly became exhausted, losing anti-tumor function, with no durable objective tumor responses.MethodsHere, we evaluated the GBM immune environment in a syngeneic implantable GL261 murine model. …”
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iPSC-Derived Biological Pacemaker—From Bench to Bedside by Quan Duy Vo, Kazufumi Nakamura, Yukihiro Saito, Toshihiro Iida, Masashi Yoshida, Naofumi Amioka, Satoshi Akagi, Toru Miyoshi, Shinsuke Yuasa

“…However, challenges such as achieving cellular maturity, long-term functionality, and immune response remain significant barriers to clinical translation. …”
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The Elevation and Impact of Peripheral Bile Acids in Chronic Lymphocytic Leukemia by Audrey L. Smith, Abigail Ridout, Sydney A. Skupa, Rolando Martinez-Rico, Erin M. Drengler, Eslam Mohamed, Christopher R. D’Angelo, Dalia El-Gamal

“…Elevated BAs demonstrated minimal impact on CLL cell proliferation or CLL-associated T-cell function. <b>Conclusions</b>: Future studies are needed to determine the mechanistic influence of BAs on CLL pathogenesis.…”
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Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy by Quan H. Phung, Alexander K. Tsai, Byoung U. Park, Robben Schat, Richard Spong, L. Jill Tsai, Amit A. Kulkarni, Emmanuel S. Antonarakis, Emmanuel S. Antonarakis, Arjun Gupta

“…Transplant-related immunosuppression was adjusted, and pancreas and kidney transplant function were monitored closely. Potential organ rejection was monitored using donor-derived cell-free DNA. …”
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Influence of the Skid Resistance of Ultrathin Wearing Course with Various Types of Asphalt Binders by Hongfu Liu, Teng Guo, Chenxi Yang, Yunyong Huang, Xuelian Li

“…Ultrathin wearing course (UTWC) has been widely applied in both asphalt pavements preventive maintenance and functional overlay. This study’s objective is to evaluate the influence of different modified asphalt binders with warm mix additives on the skid resistance of UTWC and to reveal the attenuation law of skid resistance of UTWC. …”
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Ultrasonic emulsification and aspiration for coral reef atherosclerosis as a novel alternative to transaortic endarterectomy and thoracic aorta-based bypass grafting by Yamini Vyas, MD, Joshua K. Burk, MD, MBA, Jane M. Chung, MD, Benjamin D. Colvard, MD, Yakov L. Elgudin, MD, PhD, Jae S. Cho, MD

“…Transaortic endarterectomy (TE) is an effective and durable method of restoring patency in the aorta afflicted with atherosclerotic disease, which most commonly affects the infrarenal aorta and common iliac artery. …”
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Beyond insulin: advancing frontiers in cell-based and genetic therapies for type 1 diabetes management by Tamer A. Addissouky

“…Combination immunotherapies and the advent of Teplizumab have demonstrated potential for delaying disease progression and preserving beta cell function. Gene therapy and genome editing (CRISPR/Cas9) are being refined for beta cell regeneration, protection, and immune tolerance induction, though challenges of safety, immunogenicity, and off-target effects persist. …”
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Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits by Erik H. Douma, Jesse Stoop, Matthijs V. R. Lingl, Marten P. Smidt, Lars P. van der Heide

“…Conclusions This study underscores the therapeutic potential of enhancing tyrosine hydroxylase Ser40 phosphorylation to improve motor function in Parkinson’s disease. Both PDE inhibition and GUCY2C activation represent promising non-invasive strategies to modulate endogenous dopamine biosynthesis and address motor deficits. …”
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Identification of Technical Characteristics of Ergonomic Baby Dining Chair Products by Prima Fithri, Ahmad Syafruddin Indrapriyatna, Farrell Syaddad Hamdan, Yuni Handayani Gusmira

“…These needs are then translated into technical specifications using the Quality Function Deployment (QFD) methodology. Data were gathered through questionnaires distributed to families with toddlers and toddler chair providers. …”
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Efficacy and Safety of Simultaneous Integrated Boost Followed by Selective Sequential Boost Radiotherapy for Spinal Metastases: A Single-Arm Retrospective Study by Hui Xiao BS, Fuxin Guo MD, Ang Qu MD, Nan Zhang BS, Shuhua Wei PhD, Qiman Han MS, Xiuwen Deng MD, Chunxiao Li PhD, Junjie Wang MD, PhD, Ping Jiang MD

“…Results The median follow-up was 9.9 months (range: 3.4-44.3 months), and 26 of 34 patients reported pain before treatment; of these, 84.6% (22/26) experienced pain relief (30.8% complete, 53.8% partial). Neurological function improved in 72.7% (16/22) of affected patients, with complete improvement in 27.3% and partial improvement in 45.5%. …”
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Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine. by Jacques C Mbongue, Dequina A Nicholas, Kangling Zhang, Nan-Sun Kim, Brittany N Hamilton, Marco Larios, Guangyu Zhang, Kazuo Umezawa, Anthony F Firek, William H R Langridge

“…Heat map analysis of the proteomic data revealed an overall down-regulation of vaccinated DC functions, suggesting vaccine suppression of DC maturation. …”
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The Challenges of Safety Culture: No more risk! by Julija Melnikova

“…So, the proper life durability could be considered as an indicator of a human beings’ safety according to biogenetic theory. …”
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IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer by Carmen S.M. Yong, Irma Telarovic, Lisa Gregor, Miro E. Raeber, Martin Pruschy, Onur Boyman

“…Summary: Radiotherapy (RT) can stimulate anti-cancer T cell responses, and cytokines, notably interleukin-2 (IL-2), are necessary for optimal T cell function and memory. However, timing and IL-2 receptor (IL-2R) bias of IL-2 signals are ill-defined. …”
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Role of high-dose interleukin-2 for melanoma in the age of cellular therapy by Mario Sznol, Elizabeth Buchbinder, Rodabe Amaria, Amod Sarnaik, David F McDermott, Michael B Atkins, Ann W Silk, Kim A Margolin, Michael T Lotze, Zeynep Eroglu, Virginia Seery, Allison Betof Warner, Harriet M Kluger, Karam Khaddour

“…High-dose bolus IL-2 (HD IL-2) can induce durable complete or partial tumor regression in a small proportion of advanced melanoma and renal cell carcinoma patients. …”
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The Impact of Transurethral Enucleation Therapeutic Approach in All-Size Benign Prostatic Obstruction Pathology: From Contemporary Technological Advances to Evidence-Based Clinical... by Catalin-Andrei Bulai, Razvan-Dragos Multescu, Petrisor-Aurelian Geavlete, Ana Maria Andreea Punga, Adrian Militaru, Bogdan-Gabriel Buzescu, Cosmin-Victor Ene, Cristian Mares, Bogdan-Florin Geavlete

“…Compared to traditional approaches such as transurethral resection of the prostate (TURP) and open prostatectomy, TUE has been associated with reduced complication rates, shorter recovery times, and durable symptom relief. The manuscript also examines patient-centered considerations, such as quality of life improvements and preservation of sexual function, which contribute to high patient satisfaction. …”
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More Choosy for Minor Foods: Diet, Seasonality and Food Selection in Sympatric Frugivorous and Folivorous Lemurs by Mitchell T. Irwin, Vololonirina Rahalinarivo, Bruno Ramorasata, Jean‐Luc Raharison, Jean‐Freddy Ranaivoarisoa, Chloé N. M. Gherardi, Jessica M. Rothman

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Advancing the Engineering Approach to Improving the Quality Cracking Efficiency of Palm Nut Crackiing Machine by Okunola Oluwatobi Israel, Olukunle Olawale John, Adetola Oluwafemi Adeyemi, Akinfiresoye Waleola

“…The design of the cracking drum and beater configuration was based on the impact force required to crack the Palm Nut which is a function of Palm Nut shear strength. A 5 hp electric motor was selected based on the power required to effectively operate the machine. …”
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Management of severe tricuspid valve regurgitation due to ruptured papillary muscle in a patient with mediastinitis early after heart transplantCentral MessagePerspective by Erin M. Schumer, MD, MPH, Kunal D. Kotkar, MD, M. Faraz Masood, MD, Tsuyoshi Kaneko, MD, Ralph J. Damiano, MD, Amit Pawale, MD

“…Results: The patient is doing well, 6 months after discharge to home, asymptomatic, without re-admissions, on renal recovery path, with no tricuspid regurgitation and good biventricular function. Conclusions: Replacing the tricuspid valve in presence of hemodialysis catheter, immunosuppression and mediastinitis could be high risk for endocarditis. …”
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