PROBLEM AND PERSPECTIVE TO IMPROVE MOLECULAR TESTING TO CHOOSE APPROPRIATE TARGET THERAPY by P. A. Gervas, N. V. Litviakov, N. O. Popova, A. Yu. Dobrodeev, A. S. Tarasova, E. L. Yumov, F. G. Ivanova, O. V. Cheremisina, S. G. Afanasyev, V. E. Goldberg, N. V. Cherdyntseva

“…In addition, it is important to use molecular testing to monitor the treatment efficacy, because therapy can drive the tumor clonal evolution, leading to the emergence of resistant cell clones.…”
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The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue by Angelica Johansson, Eirini Kalliara, Emma Belfrage, Teodor Alling, Paul Theodor Pyl, Anna Sandström Gerdtsson, Urban Gullberg, Anna Porwit, Kristina Drott, Sara Ek

“…<b>Background/objectives:</b> Mycosis fungoides (MF) is a rare malignancy, with an indolent course in the early stages of the disease. However, due to major molecular and clinical heterogeneity, patients at an advanced stage of the disease have variable responses to treatment and considerably reduced life expectancy. …”
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Modern Problems of Pedagogical Education by A. V. Lubkov

“…The author’s understanding of innovation, where a person is a carrier of value, purpose, volitional and intellectual principles, allows the straightforward and mechanistic understanding of laws of social development in general and the laws of education and pedagogy to be overcome and the reduction of norms and values due to overloads of information flows and many other factors to be counteracted. …”
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Assessing Safety and Sustainability of a Monitoring System for Nuclear Waste Management by Michele Di Giovanni, Laura Verde, Lelio Campanile, Mauro Romoli, Carlo Sabbarese, Stefano Marrone

“…One of the most critical phases is the pre-disposal, due to the uncertainty related to the evolution of the materials and their potential impact on environmental protection. …”
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Water system sustainability of China’s Yellow River Basin: A Refactoring and integrated evaluation based on the sustainable development Goal 6 by Xiujing Guan, Zihua Liu, Yang Guan, Wenhao Wu, Rongguang Shi, Bing Rong

“…Upstream areas demonstrate improved coordination due to enhanced ecological restoration and governance, whereas downstream regions experience greater pressures from industrial growth and population expansion. …”
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Experimental study on I/II/III mixed mode fracture characteristics of a combined rock mass under creep loading by Shuai Li, Chao Zheng, Peng Li, Shuo Zhang

“…The axial strain increases sharply due to the sharp increase in the number of AE events in the third creep stage. …”
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Forecasting the eddying ocean with a deep neural network by Yingzhe Cui, Ruohan Wu, Xiang Zhang, Ziqi Zhu, Bo Liu, Jun Shi, Junshi Chen, Hailong Liu, Shenghui Zhou, Liang Su, Zhao Jing, Hong An, Lixin Wu

“…Yet, their application to ocean forecasts remains challenging due to the different dynamic characteristics of the atmosphere and the ocean. …”
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Digital biomarkers: Redefining clinical outcomes and the concept of meaningful change by Maria Florencia Iulita, Emmanuel Streel, John Harrison

“…Highlights Minimal clinically important difference (MCID) represents the smallest change in a patient's condition that would be considered meaningful, but defining this for Alzheimer's disease is challenging due to its heterogeneity. The perception of what is clinically meaningful may differ at the individual level, at different disease stages within the same individual, and between patient and caregiver. …”
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Role of plate convergence rate in shaping earthquake recurrence in subduction zones by Sayak Ray, Bhaskar Kundu, Batakrushna Senapati, Abhijit Ghosh, Arun K. Singh

“…Megathrust earthquakes, though extensively investigated and their quasi-repetitive nature well recognised, remain challenging to assess globally due to their long recurrence intervals and limited historical data. …”
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A Survey on Adversarial Attacks for Malware Analysis by Kshitiz Aryal, Maanak Gupta, Mahmoud Abdelsalam, Pradip Kunwar, Bhavani Thuraisingham

“…While significant strides have been made in adversarial research in other fields, the specific challenges of adversarial malware remain under-explored due to the intricate nature and constraints of the malware domain. …”
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Knowledge, attitudes, and representations of caregivers of individuals with major neurocognitive disorders regarding palliative and end-of-life care: a narrative literature review by Roxane Pellerin, Diane Tapp, Catherine Filion, Sophie Castonguay-Paradis, Gina Bravo, Guillaume Robert

“…Abstract Background Caregivers of individuals with major neurocognitive disorders often bear the responsibility of participating in decisions related to the provision of palliative care for their loved ones due to the loss of capacity to consent as the disease progresses. …”
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Dynamic Response Analysis of Roadway Surrounding Rock Induced by Dynamic Load under the Action of Hard and Thick Rock Stratum by Kaihua Liang, Quansen Wu, Quanlin Wu, Xiang Shi, Hong Zhao, Fuwu Ma, Zhaomin Zhang

“…In the process of coal seam mining, there are often hard thick key layers in the overlying strata. Due to the high strength and good integrity of the hard thick key layer, after the hard thick key layer is broken, the overlying strata will collapse and lose stability in a large area, which is very easy to induce dynamic disasters such as rock burst, mine earthquake, coal wall caving, and roof slab caving. …”
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Study on the Interactions Process of Coupled Model of Furrow Opener–Soil–Pot Seedling Based on Discrete Approach by Bin Jiang, Jinping Cai, Xiongfei Chen, Junan Liu, Liping Xiao, Jinlong Lin, Yuqiang Chen

“…The upright state of pot seedlings in the process of rice mechanized throwing operations has an important influence on the growth rate and yield of rice, and pot seedling uprightness is affected by the influence of soil backfilling during trenching. Due to the complexity of the furrow opener–soil–pot seedling interaction mechanism in the rice pot seedling planting process, the soil backfilling process is difficult to observe. …”
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Multimodal Ensemble Fusion Deep Learning Using Histopathological Images and Clinical Data for Glioma Subtype Classification by Satoshi Shirae, Shyam Sundar Debsarkar, Hiroharu Kawanaka, Bruce Aronow, V. B. Surya Prasath

“…On the other hand, due to the disease complexities of Glioma patients, multimodal analysis using various types of data rather than a single data set has been attracting attention. …”
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Spatiotemporal changes and interconnections between meteorological and hydrological droughts in China over past 34 years by Ke Zhang, Zhi-lin Li, Wu-zhi Shi, Ran Tao, Xu Yang, Yi-ming Huang

“…Understanding the evolution and lag effects of droughts is critical to effective drought warning and water resources management. …”
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Ultrafast Decay of Interlayer Exciton in WS2/MoSe2 Heterostructure Under Pressure by Zhiying Bai, He Zhang, Jiaqi He, Dawei He, Jiarong Wang, Wenwen Wu, Yinglin Zhang, Wenjie Wang, Yongsheng Wang, Xiaohui Yu, Xiaoxian Zhang

“…For comparison, the intralayer exciton lifetime of monolayer MoSe2 is increased due to the transition of direct to indirect bandgap under pressure. …”
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Phase separation behavior of polymer modified asphalt by molecular dynamics and phase field method: A review by Lin Chen, Ming Liang, Xin Wang, Xue Xin, Zhenchao Chen, Yuepeng Jiao, Jianjiang Wang, Yunfeng Zhang, Linping Su, Zhanyong Yao

“…In-depth exploration and understanding in this area is highly challenged due to the current lack of sophistication in research tools and the lack of precision in research results. …”
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Evolving infectious disease dynamics shape school-based intervention effectiveness by Javier Perez-Saez, Mathilde Bellon, Justin Lessler, Julie Berthelot, Emma B. Hodcroft, Grégoire Michielin, Francesco Pennacchio, Julien Lamour, Florian Laubscher, Arnaud G. L’Huillier, Klara M. Posfay-Barbe, Sebastian J. Maerkl, Idris Guessous, Andrew S. Azman, Isabella Eckerle, Silvia Stringhini, Elsa Lorthe, On behalf of the SEROCoV-Schools study group

“…With pandemic preparedness in mind, this study advocates for a dynamic perspective on the role and importance of schools in infectious disease control, one that adapts to the evolving epidemiological landscape shaped by pathogen characteristics and evolution, shifting public health policies, and changes in human behavior.…”
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Bifurcation Instability Modulated by a Connecting Channel Leads to Periodic Water Partitioning in a Simple Channel Network by Weilun Gao, Zheng Bing Wang, Maarten G. Kleinhans, Dongdong Shao, Zhenchang Zhu, Zhifeng Yang

“…Our results improve the understanding on the evolution and restoration of channel networks under increasing human interventions in global deltas.…”
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Analysis of spatial-temporal variations in landslide susceptibility assessment considering surface deformation and land use dynamics by Jinrui ZHANG, Yang WANG, Xiao FENG, Yuanyao LI, Bijing JIN, Chao ZHOU, Xin ZHANG, Yang DENG

“…Objective To investigate the spatial-temporal variations in landslide susceptibility due to human engineering activities in resettled urban areas. …”
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