A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
Get full text

Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes by Kazuhiro Kakimi, Hirokazu Matsushita, Masaaki Komatsu, Eiryo Kawakami, Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Katsuyuki Shiroguchi, Heiichiro Udono

“…In addition, conditional knockout mice for Nrf2 and p62 were used to detect these markers, together with the monitoring of in vivo tumor growth. RNA sequencing was performed for CD8TILs and tumor cells. …”
Get full text

The initial results of using brolucizumab (Beovu®), an angiogenesis inhibitor, for choroidal neovascularization in patients with age-related macular degeneration by N.S. Zhayvoronok, O.V. Kolenko, L.P. Danilova, E.L. Sorokin

“…</p> <p> <b>Patients and Methods:</b> clinical assessment of the efficacy of brolucizumab was performed in 25 patients (25 eyes) with neovascular AMD. The dynamic monitoring included optical coherence tomography to assess the localization and area of the neovascular complex, as well as the density and thickness of the new blood vessels (OCT-angiography). …”
Get full text

Identification and Classification of Factors Influencing the Regulation of Priority Goods Markets Based on Network Governance with an Interpretive Structural Modeling Approach by sadegh Dadashi, Fattah Sharifzadeh, Reza Vaezi, Hossein Aslipour

“…Policy cycles within the market regulation network should facilitate a clear division of labor, implementation, and rigorous monitoring at both national and provincial levels. Lastly, network management should focus on transparency and accountability among all actors. …”
Get full text

BCL-2 overexpression exosomes promote the proliferation and migration of mesenchymal stem cells in hypoxic environment for skin injury in rats by Ying Wang, Guang Li, Guofeng Li, Yutao Pan, Zhongmin Liu

“…Cell proliferation ability was monitored by cell proliferation test. Cell migration test was used to check the migration capacity of MSCs. …”
Get full text

Determining nutritional indices of Dori bleak, Alburnus doriae and Brond Snout, Chondrostoma regium in Zayandehroud River, Central Iran by Omidvar Farhadian, JAVAD BAGHERI, Nasrollah Mahboobi Soofiani, Safiollah Heidari, Eisa Ebrahimi

“…Conclusion: The results demonstrated that A. doriae and C. regium are carnivorous and omnivorous, respectively. A. doriae prefers insects, but C. regium consumes mostly insects and filamentous algae as the preferred food. …”
Get full text

Phenotypes of primary sclerosing cholangitis in children by M.B. Dyba, V.S. Berezenko

“…Active diagnostic search for biliary and intestinal lesions in children with PSC will facilitate the development of effective personalized approaches to treatment and monitoring, thereby improving disease prognosis.…”
Get full text

Impact of Wheat Harvest on Levels and Sources of PM2.5-associated PAHs in an Urban Area Located at the Center of Beijing-Tianjin-Hebei Region by Zhiyong Li, Zhenxin Li, Ziyuan Yue, Dingyuan Yang, Yutong Wang, Lan Chen, Songtao Guo, Jinsong Yao, Lei Wang, Xiao Lou, Xiaolin Xu, Jinye Wei, Baole Deng, Hong Wu

Get full text

On-demand and efficient scheduling scheme for cryptographic service resource by Wenlong KOU, Yuyang ZHANG, Fenghua LI, Xiaogang CAO, Jiamin LI, Zhu WANG, Kui GENG

“…The description and dynamic monitoring of cryptographic service capability are realized by using the normalized evaluation model of cryptographic devices based on optimized entropy method. …”
Get full text

Prediksi Kelulusan Tepat Waktu Berdasarkan Riwayat Akademik Menggunakan Metode K-Nearest Neighbor by Imam Riadi, Rusydi Umar, Rio Anggara

“…It is expected that graduating students meet the graduation standard requirements within a maximum of 4 years of study period. Evaluation and monitoring of graduation is very important to do, one of which is by studying the history data of students who have graduated as an effort for students to graduate not to exceed the standard time that has been set. …”
Get full text

Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma by Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian

“…We purified the scFvs and measured the affinity. We monitored CAR-T cell phenotype and scFv binding stability to CEA antigen through flow cytometry. …”
Get full text

The effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial by Gansheng Tan, Anna L Huguenard, Kara M Donovan, Phillip Demarest, Xiaoxuan Liu, Ziwei Li, Markus Adamek, Kory Lavine, Ananthv K Vellimana, Terrance T Kummer, Joshua W Osbun, Gregory J Zipfel, Peter Brunner, Eric C Leuthardt

“…During their stay in the intensive care unit, we monitored patient electrocardiogram readings and vital signs. …”
Get full text

Hurricane Effects on a Shallow Lake Ecosystem and Its Response to a Controlled Manipulation of Water Level by Karl E. Havens, Kang-Ren Jin, Andrew J. Rodusky, Bruce Sharfstein, Mark A. Brady, Therese L. East, Nenad Iricanin, R. Thomas James, Matthew C. Harwell, Alan D. Steinman

“…We treated this operation as a whole ecosystem experiment, and assessed ecological responses using data from an existing network of water quality and submerged plant monitoring sites. As a result of large-scale discharges of water from the lake, coupled with losses to evaporation and to water supply deliveries to agriculture and other regional users, the lake surface elevation receded by approximately 1 m between April and June. …”
Get full text

Efficacy and Safety of High-dose versus Standard-dose Prazosin in Paediatric Scorpion Envenomation: A Single-blinded Randomised Controlled Study by Apoorva Gayatri Abbadi, Hidaytullah R Bijapure, Chandrika R Doddihal, Bhavana B Lakhkar, Y Rohith, VJ Prakash, Kumar BM Prasanna, Mallanagouda Patil

“…Children were randomised into three groups: Group A: 30 μg/kg every three hours; Group B: 60 μg/kg initially, followed by 30 μg/kg every three hours; and Group C: 90 μg/kg initially, followed by 30 μg/kg every three hours. They were monitored for sweating, cold or warm extremities, the appearance and disappearance of pain, vital parameters and priapism (in male children) hourly until stabilised, then every third hourly for 24 hours and then sixth hourly til discharged from the PICU. …”
Get full text

Circulating Soluble ST2 Predicts All-Cause Mortality in Severe Heart Failure Patients with an Implantable Cardioverter Defibrillator by Zhi-wei Hou, Hai-bo Yu, Yan-chun Liang, Yang Gao, Guo-qing Xu, Min Wu, Zhu Mei, Zu-lu Wang, Zhi-guo Li, Yu-ying Li, Hai-xu Song, Jia-yin Li, Ya-ling Han

“…Patients with sST2 levels more than 43.42671 ng/ml even after ICD implantation should therefore be monitored carefully.…”
Get full text

Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study by Xiang Si, Hao Yuan, Rui Shi, Wenliang Song, Jiayan Guo, Jinlong Jiang, Tao Yang, Xiaoxun Ma, Huiming Wang, Minying Chen, Jianfeng Wu, Xiangdong Guan, Xavier Monnet

“…Further studies, incorporating comprehensive hemodynamic monitoring, are warranted to clarify the clinical implications of heart rate control with β-blockers in ICU patients with tachycardia.…”
Get full text

Mixture density networks for re-constructing historical ocean-color products over inland and coastal waters: demonstration and validation by Sundarabalan V. Balasubramanian, Ryan E. O’Shea, Ryan E. O’Shea, Arun M. Saranathan, Arun M. Saranathan, Christopher C. Begeman, Christopher C. Begeman, Daniela Gurlin, Caren Binding, Claudia Giardino, Michelle C. Tomlinson, Krista Alikas, Kersti Kangro, Moritz K. Lehmann, Moritz K. Lehmann, Lisa Reed

“…The developed MDN is shown to be capable of robustly retrieving 10 water quality variables for monitoring coastal and inland waters from multiple multispectral satellite sensors (MODIS, MERIS, and VIIRS).…”
Get full text

Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa by Longjie Zhou, Jiayao Yao, Ying Zhang, Xiaofan Zhang, Yueyue Hu, Haiyang Liu, Jintao He, Yunsong Yu, Minhua Chen, Yuexing Tu, Xi Li

“…Close attention to the development of resistance to CZA during clinical treatment of CRPA infection and monitoring CZA-resistant strains is necessary to prevent further spread.…”
Get full text

Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Autologous transduced cells were infused after conditioning with a nonmyeloablative, reduced dose, melphalan regimen. Safety monitoring was performed. α‐Gal A activity was measured in plasma and peripheral blood (PB) leucocytes. …”
Get full text

Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…Primary outcomes include adolescents’ physical activity and sedentary time (assessed with accelerometry), and secondary outcomes include health (sleep and well-being), class and school engagement (on-task behaviour assessed via classroom observation and school attendance) and sitting time (assessed with posture monitors). Descriptive analyses will summarise students’ demographics, physical activity, sedentary behaviour and engagement, while mixed models will evaluate intervention effects on these outcomes, adjusted for confounders. …”
Get full text