Hematopoietic stem cell size heterogeneity is not linked to changes in stem cell potential of aged HSCs by Mehmet Saçma, Ali Hageb, Alex Zadro, Tanja Schuster, Mona Vogel, Karina Eiwen, Vadim Sakk, Hartmut Geiger, Hartmut Geiger

“…Aging is associated with a decline in the function of hematopoietic stem cells (HSCs). This decline in HSC function results in reduced hematologic regenerative capacity and an increased incidence of hematologic disorders. …”
Get full text

Effects of ECM Components on Periodontal Ligament Stem Cell Differentiation Under Conditions of Disruption of Wnt and TGF-β Signaling Pathways by Alla V. Kuznetsova, Olga P. Popova, Tamara I. Danilova, Andrey V. Latyshev, Oleg O. Yanushevich, Alexey A. Ivanov

Get full text

Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease by Orit Harari‐Steinberg, Sally Metsuyanim, Dorit Omer, Yehudit Gnatek, Rotem Gershon, Sara Pri‐Chen, Derya D. Ozdemir, Yaniv Lerenthal, Tzahi Noiman, Herzel Ben‐Hur, Zvi Vaknin, David F. Schneider, Bruce J. Aronow, Ronald S. Goldstein, Peter Hohenstein, Benjamin Dekel

“…Here we show that growth of human foetal kidneys in serum‐free defined conditions and prospective isolation of NCAM1+ cells selects for nephron lineage that includes the SIX2‐positive cap mesenchyme cells identifying a mitotically active population with in vitro clonogenic and stem/progenitor properties. After transplantation in the chick embryo, these cells—but not differentiated counterparts—efficiently formed various nephron tubule types. hNPCs engrafted and integrated in diseased murine kidneys and treatment of renal failure in the 5/6 nephrectomy kidney injury model had beneficial effects on renal function halting disease progression. …”
Get full text

Effect of Octacalcium Phosphate on Osteogenic Differentiation of Induced Pluripotent Stem Cells in a 3D Hybrid Spheroid Culture by Yuki Sugai, Ryo Hamai, Yukari Shiwaku, Takahisa Anada, Kaori Tsuchiya, Tai Kimura, Manami Tadano, Kensuke Yamauchi, Tetsu Takahashi, Hiroshi Egusa, Osamu Suzuki

Get full text

Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors. by Myrto Bami, Vasso Episkopou, Anthony Gavalas, Mina Gouti

Get full text

A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells by Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia‐Ojalvo, Alfonso Martinez Arias

“…Abstract Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control the expression of ‘self‐renewal’ and ‘differentiation’ genes. …”
Get full text

Targeted Knockdown of RNA-Binding Protein TIAR for Promoting Self-Renewal and Attenuating Differentiation of Mouse Embryonic Stem Cells by Zhe Geng, Ping Li, Li Tan, Houyan Song

Get full text

Antibiotics Disturb Dentin Formation and Differentiation of Dental Pulp Stem Cells: The Role of Microbiota in Cellular Turnover of Mouse Incisor by Shenping Su, Yi Ren, Yi Zhang, Yuming Zhao, E. Xiao

“…Dentin formation was dependent on osteo-/odontogenic differentiation of dental pulp stem cells (DPSCs). It was observed in previous studies that antibiotic treatment in a clinical and animal model resulted in impaired mineralization of dental tissues. …”
Get full text

Current Progress and Challenges for Skeletal Muscle Differentiation from Human Pluripotent Stem Cells Using Transgene-Free Approaches by Nunnapas Jiwlawat, Eileen Lynch, Jeremy Jeffrey, Jonathan M. Van Dyke, Masatoshi Suzuki

“…We then summarize current methods to differentiate human pluripotent stem cells toward the myogenic lineage, specifically focusing on transgene-free approaches. …”
Get full text

Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats by Wen Li, Zhiyuan Shi, Huaqing Jing, Yunsheng Dou, Xinyi Liu, Mengyao Zhang, Zitong Qiu, Zbynek Heger, Nan Li

Get full text

Transglutaminase 2 Prevents Premature Senescence and Promotes Osteoblastic Differentiation of Mesenchymal Stem Cells through NRF2 Activation by Soo-Jin Lee, Ji-Woong Shin, Mee-Ae Kwon, Ki Baek Lee, Hyo-Jun Kim, Jin-Haeng Lee, Heun-Soo Kang, Jong Kwan Jun, Sung-Yup Cho, In-Gyu Kim

“…Of these, transamidase-mediated modification of proteins regulates apoptosis, differentiation, inflammation, and fibrosis. TG2 is highly expressed in mesenchymal stem cells (MSCs) compared with differentiated cells, suggesting a role of TG2 specific for MSC characteristics. …”
Get full text

Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging by Jingyu Zhao, Ao Chen, Rong Wang, Dong Qiu, Haiyun Chen, Jiyu Li, Jin'ge Zhang, Tianxiao Wang, Yue Wang, Yujie Lin, Jiawen Zhou, Yifei Du, Hua Yuan, Yongjie Zhang, Dengshun Miao, Yuli Wang, Jianliang Jin

“…Prx1‐driven Bmi‐1 knockout in bone‐marrow mesenchymal stem cells (BMSCs) reduced bone mass and increased bone marrow adiposity by inhibiting osteoblastic bone formation, promoting osteoclastic bone resorption, downregulating the proliferation and osteogenic differentiation of BMSCs, and upregulating the adipogenic differentiation of BMSCs. …”
Get full text

Maintenance of pluripotency and osteogenic differentiation of human mesenchymal stem cells on acrylate-based substrates exhibiting gelatin or heparin grafting by María Noel Tamaño-Machiavello, Juan Carlos Marín Payá, Silvia Flores, Lourdes Cordón, Amparo Sempere, Roser Sabater i Serra, José Luis Gómez Ribelles

Get full text

Signals from the niche promote distinct modes of translation initiation to control stem cell differentiation and renewal in the Drosophila testis. by Ruoxu Wang, Mykola Roiuk, Freya Storer, Aurelio A Teleman, Marc Amoyel

“…Stem cells have the unique ability among adult cells to give rise to cells of different identities. …”
Get full text

Bioinformatic Analysis of Transcriptomic Data Reveals Novel Key Genes Regulating Osteogenic Differentiation of Human Adipose Stem Cells by Jinluo Cheng, Xinyuan Zhao, Juan Liu, Li Cui, Yanfeng Zhu, Xiaoqing Yuan, Jianbo Gao, Yunfeng Du, Xinmin Yan, Shen Hu

“…A total of 1521 upregulated and 3020 downregulated genes were identified between the ASCs with osteogenic induction and controls. Functional gene ontology analysis revealed that these significantly differentially expressed genes (DEGs) were associated with cell cycle, protein binding, and nucleotide binding. …”
Get full text

NAT10 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Mediating N4-Acetylcytidine Modification of Gremlin 1 by Zhenbiao Zhu, Xiaowei Xing, Shisi Huang, Yuanyuan Tu

“…Objective. To investigate the function of NAT10 in mesenchymal stem cell (MSC) osteogenic differentiation and study the mechanism by which NAT10 affects MSC osteogenesis by mediating Gremlin 1 N4-acetylcytidine (ac4C) modification. …”
Get full text

A roadmap towards targeted differentiation of mouse trophoblast stem cells into cell types of the feto-maternal exchange surface by Noura Ballasy, Bethany N. Radford, Shuhiba Mohammad, Wendy Dean, Myriam Hemberger

“…Abstract Background The characteristic constituents of the mature placenta are made up of highly specialised trophoblast cell types. Trophoblast stem cells (TSCs) possess the developmental plasticity to differentiate into all these mature placental cell types. …”
Get full text

FOXL2 drives the differentiation of supporting gonadal cells in early ovarian development by Laura Danti, Karolina Lundin, Petra Nedeczey-Ruzsák, Timo Tuuri, Juha S. Tapanainen

Get full text

Effects of nanosilicate functionalized polycaprolactone membrane on bone mesenchymal stem cells-induced bone repairing by XIAO Long, HU Weiqiang, LIN Xuxin, HE Mengjiao, LUO Kai, XU Xiongcheng

“…Objective To fabricate nanosilicate functionalized polycaprolactone (PCL/LAP) electrospun membrane and evaluate its role in bone marrow mesenchymal stem cells (BMSCs)-induced bone repairing. …”
Get full text

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. by Maurice A Canham, Alexei A Sharov, Minoru S H Ko, Joshua M Brickman

Get full text