Stem cell-derived exosomes: a potential therapeutic strategy for enhancing tendon stem/progenitor cells function in tendon-bone healing by Junjie Tang, Peng Shen, Xinyuan Wu, Minhao Chen, Hua Xu

“…This review provides an overview of the mechanisms and functions of stem cell-derived exosomes in altering the properties of TSPCs and facilitating tendon-bone healing. …”
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DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells by Jiayu Yu, Nannan Zhao, Yuying Wang, Nan Ding, Zhenchang Guo, Zichan He, Qingye Zhang, Jingai Zhang, Xiaoqiong Yang, Ming Zhang, Xiaoling Du, Kai Zhang, Lingyi Chen

“…In summary, our study identified 66 MEK substrates supporting the extracellular signal-regulated kinase (ERK)-independent function of MEK and revealed that DCP1A, phosphorylated by MEK, regulates ESC self-renewal and differentiation through modulating P body formation.…”
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Proteomics and lipidomics of human umbilical cord mesenchymal stem cells exposed to ionizing radiation by Dongmei Han, Li Ding, Xiaoli Zheng, Sheng Li, Hongmin Yan, Jing Liu, Hengxiang Wang

“…However, whether ionizing radiation affects the functions of human umbilical cord mesenchymal stem cells (hucMSCs) remains unclear. …”
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Generation of vascularized pancreatic progenitors through co-differentiation of endoderm and mesoderm from human pluripotent stem cells by Xiaopu Sang, Junming Xu, Yihang Wang, Jingyi Li, Jiasen Xu, Xiaoni Chen, Xianjie Shi, Fenfang Wu

“…Abstract Background The simultaneous differentiation of human pluripotent stem cells (hPSCs) into both endodermal and mesodermal lineages is crucial for developing complex, vascularized tissues, yet poses significant challenges. …”
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The subventricular zone neurogenic niche provides adult born functional neurons to repair cortical brain injuries in response to diterpenoid therapy by Ricardo Pardillo-Díaz, Patricia Pérez-García, María Ortego-Domínguez, Ricardo Gómez-Oliva, Nora Martínez-Gómez, Samuel Domínguez-García, Francisco García-Cózar, Juan Pedro Muñoz-Miranda, Rosario Hernández-Galán, Livia Carrascal, Carmen Castro, Pedro Nunez-Abades

“…In addition, using electrophysiological recordings we have studied the differentiation of these neuroblasts into mature neurons and their functional integration into the cortical circuitry. …”
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Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions by Jun Song, Meiqi Li, Yuan Tao, Yumeng Li, Canrong Mai, Jingting Zhang, Lan Yao, Shaoquan Shi, Jianyong Xu

“…Among proposed hypotheses on IUA development, the reduced endometrial regeneration resulting from loss of functional stem cells has been proposed as the key factor affecting the IUA prognosis. …”
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Blood vessels bioengineered from induced pluripotent stem cell derived mesenchymal stem cells and porous silk fibroin coated functional scaffolds by Luis Larrea Murillo, Zhongda Chen, Jun Song, Adam Mitchel, Steven Woods, Susan J. Kimber, Jiashen Li, Yi Li, Tao Wang

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Distal electrical stimulation enhances neuromuscular reinnervation and satellite cell differentiation for functional recovery by Chun-Wei Lin, Szu-Han Chen, Siao Muk Cheng, Tzu-Chun Chung, Wentai Liu, Daw-Yang Hwang, Song Li, Sheng-Che Lin, Yuan-Yu Hsueh

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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…The effects of these exosomes on HSCs were analyzed using the same methods as those used to assess MSCs function. Results Our findings demonstrated that MDS-MSCs exhibited significant functional impairments, including reduced proliferation, impaired differentiation, diminished support for hematopoiesis, and increased apoptosis. …”
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Alternative splicing in stem cells and development: research progress and emerging technologies by Yan Jin, XiaoLin Liang, Xiangting Wang

“…Recent studies have highlighted how alternative splicing contributes to stem cells self-renewal and differentiation, as well as how dysregulation of splicing factors can impact stem cells behavior and lead to developmental abnormalities or diseases. …”
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CXCR4+ Sorted Adipose-Derived Stem Cells Enhance Their Functional Benefits and Improve Cardiac Function after Myocardial Infarction by Zihui Yuan, Chuanqi Cai, You Qin, Kai Yan, Jian Wang

“…The homing of adipose-derived stem cells (ASCs) to infarcted myocardium, which is important for improved cardiac function, has been investigated previously, but with poor efficiency. …”
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Constraint-induced movement therapy combined with mesenchymal stem cell transplantation promotes myelination and functional recovery by inhibiting PRKCD/MEK/ERK pathway in hemipleg... by Xiaolin Guo, Liru Liu, Jie Luo, Tingting Peng Jr., You Wang, Shiya Huang, Xiaoli Zeng, Tingting Peng Sr., Aihua Chen, Mengru Zhong, Yage Zhang, Kaishou Xu, Lu He

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Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…The GO analysis of differentially methylated region- (DMR-) associated genes (DMGs) showed that GO terms, including cytoskeletal protein binding (included in Molecular Function GO terms), skeletal development (included in Biological Process GO terms), mesenchymal cell differentiation (included in Biological Process GO terms), and stem cell differentiation (included in Biological Process), were enriched in the hypermethylated DMGs. …”
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Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering by Davide Adamo, Vincenzo Giuseppe Genna, Giulia Galaverni, Chiara Chiavelli, Alessia Merra, Fabio Lepore, Federica Boraldi, Daniela Quaglino, Jessica Evangelista, Filippo Lococo, Graziella Pellegrini

“…A major challenge is the inability to regenerate a functional airway epithelium containing the appropriate amount of stem cells required for long-term tissue renewal following transplantation of the bioengineered graft. …”
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Effect of lncRNA RMRP on proliferation, apoptosis, osteoblast differentiation and mineralization of bone marrow mesenchymal stem cells by Jingyuan Guo, Yiwang Man, Shuai Xiang, Xiaomei Zhong, Genyun Tang, Jiefu Tang

“…Results of a previous study have identified a potential role of RMRP in chondrogenic differentiation in mouse cell lines. However, the specific functions of RMRP in osteogenic processes remain unclear. …”
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Deciphering transcriptome patterns in porcine mesenchymal stem cells promoting phenotypic maintenance and differentiation by key driver genes by Nadia Khaveh, Nadia Khaveh, René Buschow, Julia Metzger, Julia Metzger

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KLF6-mediated glutamine metabolism governs odontogenic differentiation and matrix mineralization of dental pulp stem cells by Wenzhi Wu, Zekai Xu, Yulian Zhang, Xiatong Zhang, Xiaoyuan Huang, Zhijian Xie, Zhuo Chen

“…However, the mechanisms by which KLF6 regulates the function of odontoblast-like cells differentiated from human dental pulp stem cells (hDPSCs) remain unknown. …”
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Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival by Xinran Huang, Xiaoting Liang, Qian Han, Ying Shen, Jiaqi Chen, Ziqi Li, Jie Qiu, Xiaoyan Gao, Yimei Hong, Fang Lin, Weifeng Li, Xin Li, Yuelin Zhang

“…Abstract Background The clinical application of mesenchymal stem cells (MSCs) in myocardial infarction (MI) is severely hampered by their poor survival. …”
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Protocol for differentiating hematopoietic progenitor cells from human pluripotent stem cells in chemically defined monolayer culture by Shaokang Mo, Kengyuan Qu, Jun Shen, Kuangyu Yen

“…We outline steps for evaluating the efficiency of HPC generation and assessing their potential to differentiate into various hematopoietic lineages. This protocol serves as a framework for exploring human hematopoiesis and generating various functional blood cells.For complete details on the use and execution of this protocol, please refer to Shen et al.1 and Qu et al.2 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.…”
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The relationship between MAPK signaling pathways and osteogenic differentiation of periodontal ligament stem cells: a literature review by Xuanning Liu, Wanqing Zhao, Yanhui Peng, Na Liu, Qing Liu

“…These pathways are closely related to the osteogenic differentiation of PDLSCs, and this paper provides an overview of the research on the MAPK signaling pathways and the osteogenic differentiation of PDLSCs.…”
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