The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. by Herbert Schulz, Raivo Kolde, Priit Adler, Irène Aksoy, Konstantinos Anastassiadis, Michael Bader, Nathalie Billon, Hélène Boeuf, Pierre-Yves Bourillot, Frank Buchholz, Christian Dani, Michael Xavier Doss, Lesley Forrester, Murielle Gitton, Domingos Henrique, Jürgen Hescheler, Heinz Himmelbauer, Norbert Hübner, Efthimia Karantzali, Androniki Kretsovali, Sandra Lubitz, Laurent Pradier, Meena Rai, Jüri Reimand, Alexandra Rolletschek, Agapios Sachinidis, Pierre Savatier, Francis Stewart, Mike P Storm, Marina Trouillas, Jaak Vilo, Melanie J Welham, Johannes Winkler, Anna M Wobus, Antonis K Hatzopoulos, Functional Genomics in Embryonic Stem Cells Consortium

“…Embryonic stem (ES) cells have high self-renewal capacity and the potential to differentiate into a large variety of cell types. …”
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The Role of CDR1as in Proliferation and Differentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells by Lunyu Yang, Zhang Bin, Shi Hui, Li Rong, Benshuai You, Peipei Wu, Xinye Han, Hui Qian, Wenrong Xu

“…However, little has been known about the function of circRNAs in the proliferation and differentiation of hucMSCs. …”
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Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation by Takashi Hoshiba, Guoping Chen, Chiho Endo, Hiroka Maruyama, Miyuki Wakui, Eri Nemoto, Naoki Kawazoe, Masaru Tanaka

“…Therefore, it is important to understand the comprehensive role of the ECM in stem cell differentiation as well as the functions of the individual ECM molecules. …”
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Alveolar Differentiation Potency of Human Distal Airway Stem Cells Is Associated with Pulmonary Pathological Conditions by Yujia Wang, Yi Lu, Yingchuan Wu, Yufen Sun, Yueqing Zhou, Qiwang Ma, Yawen Zheng, Qianwen Yu, Yujie Cao, Guangdong Chen, Ting Zhang, Xiaotian Dai, Tao Ren, Yu Ma, Wei Zuo

“…DASCs were isolated from healthy subjects or patients diagnosed with bronchiectasis, chronic obstructive pulmonary diseases (COPD), or interstitial lung disease (ILD). Differentiation capacity, a key property of the stem cells, was studied using a novel monolayer differentiation system. …”
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Osteoblast‐Derived Mitochondria Formulated with Cationic Liposome Guide Mesenchymal Stem Cells into Osteogenic Differentiation by Hye‐Ryoung Kim, Seonjeong Woo, Hui Bang Cho, Sujeong Lee, Chae Won Cho, Ji‐In Park, Seulki Youn, Gyuwon So, Sumin Kang, Sohyun Hwang, Hye Jin Kim, Keun‐Hong Park

“…This study aims to evaluate whether mitochondria isolated from osteoblasts can promote osteogenic differentiation in mesenchymal stem cells (MSCs). Mitochondria from MSCs, which primarily utilize glycolysis, are compared with those from MG63 cells, which depend on oxidative phosphorylation. …”
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Static Magnetic Field Induced Neural Stem/Progenitor Cell Early Differentiation and Promotes Maturation by Shih-Yin Ho, I-Chun Chen, Yi-Jyun Chen, Chien-Hsing Lee, Chao-Ming Fu, Fei-Chih Liu, Horng-Huei Liou

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Transcript-activated collagen matrix for enhanced bone marrow stem cell differentiation and osteochondral repair by Gang Zhong, Yixuan Luo, Meng Wang, Zhengran Yu, Xuenong Zou, Gang Wang, Fei Chen, Yin Yu

“…Moreover, TAM therapy maintained subchondral bone integrity This work highlights the transformative potential of mRNA-activated matrices as a platform technology that not only addresses key limitations of existing cartilage repair strategies but also provides a biomimetic microenvironment that guides stem cell differentiation and tissue regeneration.…”
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Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair by Tianwei Wang, Tianwei Wang, Qing Han, Qing Han, Shi Lv, Shi Lv, Li-ping Zhang, Li-ping Zhang, Hengrui Li, Hengrui Li, Jian Liu, Jian Liu, Jinyi Kuang, Jinyi Kuang, Bao-liang Sun, Bao-liang Sun, Jing-yi Sun

“…However, after SCI, eNSCs predominantly differentiate into astrocytes, with minimal neuronal differentiation, thereby hindering effective neural regeneration. …”
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miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells by Xuanran Feng, Xue Du, Xiaoyu Yang, Changqi Chen, Zhanping Liang, Xiaonan Xu, Yi Wang, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Jialin C. Zheng, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Xiaohuan Xia, Jianhui Liu, Jianhui Liu

“…Perturbation of miR-185-5p’s function showed that miR-185-5p inhibited NPCs’ proliferation and promoted embryonic NPCs to differentiate more favorably to the glial lineage. …”
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GSDME knockout alleviates hematopoietic stem cell irradiation injury and aggravates myeloid-biased differentiation by Lulu Su, Lulu Su, Yinping Dong, Bowen Guan, Yuquan Wang, Yanhua Lu, Xinyue Wang, Wenxuan Li, Qidong Huo, Aimin Meng, Deguan Li

“…The colony-forming unit-granulocyte and macrophage assays and competitive repopulation assays were measured to evaluate the function of hematopoietic cells.ResultsWe demonstrated that GSDME regulates the survival and differentiation of hematopoietic stem cells (HSCs). …”
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Cooperative role of LSD1 and CHD7 in regulating differentiation of mouse embryonic stem cells by Sandhya Malla, Carlos Martinez-Gamero, Kanchan Kumari, Cyrinne Achour, Georgios Mermelekas, David Martinez-Delgado, Alba Coego, Diana Guallar, Angel-Carlos Roman, Francesca Aguilo

“…Recently, catalytically independent functions of LSD1, serving as a scaffold for assembling chromatin-regulator and transcription factor complexes, have been identified. …”
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Stepwise differentiation of airway epithelial cells from human tonsil-derived mesenchymal stem cells by Ha Yeong Kim, Jiin Yang, Han Su Kim, Soo Yeon Jung

“…Although autologous epithelial or progenitor cells are used to reconstruct the epithelium, they are not ideal for regeneration because of difficulties in expansion and differentiation in vitro. In this study, we developed an alternative approach to respiratory epithelial regeneration using human tonsil-derived mesenchymal stem cells (TMSCs) to induce epithelial cell differentiation through a stepwise process. …”
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Piezo1 Promotes Odontogenic Differentiation of Dental Pulp Stem Cells Under Stress Conditions by Xiaxia Wang, Shaojie Dong, Qianqian Dong, Xuefei Sun

“…Objectives: Mechanical stimuli signals regulate the odontogenic differentiation of dental pulp stem cells (DPSCs), but they are difficult to apply in clinical treatment. …”
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Machine Learning and Metabolomics Predict Mesenchymal Stem Cell Osteogenic Differentiation in 2D and 3D Cultures by Michail E. Klontzas, Spyros I. Vernardis, Aristea Batsali, Fotios Papadogiannis, Nicki Panoskaltsis, Athanasios Mantalaris

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Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells by Patrik Milić, Mojca Justin Kjuder, Katerina Jazbec Gradišar, Urban Švajger, Primož Rožman

“…Therefore, we created in vitro models of young and old HSC niches and examined how these microenvironments affect the differentiation and maturation and functionality of BM-derived DCs (BMDCs). …”
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Intermediate cell states in spermatogonial stem cell differentiation: enhancing neurogenesis and angiogenesis in spinal cord injury by Xinyu Guo, Hao Yang, Haihong Zhang

“…Abstract Background Spermatogonial stem cells (SSCs) can differentiate into various cell types, including neurons. …”
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An optimized method for directed differentiation of hypothalamic neural stem cells in a 3D culture system by Jiao Luo, Qiaoyan Tang, Tanjing Lin, Jiabang Liu, Zhiheng Wu, Xintao Zhang, Xiaohua Zhang, Junhai Jiang, Yulong Wang

“…These differentiated neurons exhibit typical neuronal morphology and functional characteristics. …”
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High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells by Supawadee Duangprom, Pakpoom Kheolamai, Chairat Tantrawatpan, Sirikul Manochantr

“…This study investigates the effects of elevated glucose levels on human placenta-derived mesenchymal stem cells (hP-MSCs), especially since these cells hold a promise for tissue engineering and regenerative medicine due to their multipotency and self-renewal capabilities. hP-MSCs were treated with 10–40 mM D-glucose to study the effects of high glucose on hP-MSCs functions. hP-MSCs viability and proliferation were determined by using thiazolyl blue tetrazolium bromide (MTT), cell cycle analysis, and senescence assays. …”
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Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses. by Kiana Toufighi, Jae-Seong Yang, Nuno Miguel Luis, Salvador Aznar Benitah, Ben Lehner, Luis Serrano, Christina Kiel

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Dual Inhibition of BMP and WNT Signals Promotes Pancreatic Differentiation from Human Pluripotent Stem Cells by Mengtian Tan, Lai Jiang, Yinglei Li, Wei Jiang

“…Signaling pathway analysis indicated potent BMP inhibitor resulted in the decrease of WNT signal activity and inhibition of WNT could contribute to the improved pancreatic differentiation. Herein, we combined the dual inhibition of BMP and WNT signaling and greatly enhanced human pancreatic progenitor differentiation as well as beta cell generation from both embryonic stem cells and induced pluripotent stem cells. …”
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