Universal fibroblasts across tissues can differentiate into niche cells for hematopoietic stem cells by Kei Higaki, Shota Aiba, Takashi Shimoyama, Yoshiki Omatsu, Takashi Nagasawa

“…Summary: Hematopoietic stem cells (HSCs) generating all blood cells are maintained by their niche cells, termed CXCL12-abundant reticular (CAR) cells, which strongly overlap with leptin-receptor-expressing (LepR+) cells in the bone marrow. …”
Get full text

Graphene nanoplatelets enhance neuronal differentiation of human bone marrow mesenchymal stem cells by Gulsah Sevimli, Eda Kus, Gulin Baran, Mahya Marashian, Nasrollah Tabatabaei, Nur Mustafaoglu

“…Differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into neurons shows promise for treating neurodegenerative diseases. …”
Get full text

Isolation of Female Germline Stem Cells from Mouse and Human Ovaries by Differential Adhesion by Maryam Saber, Pouya Tavakol, Fereshteh Esfandiari

“…Spermatogonial stem cell (SSC) counterparts known as female germline stem cells (fGSCs) were found in the mammalian ovary in 2004. …”
Get full text

Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation by Andrea C. Romero, Eugenio Vilanova, Miguel A. Sogorb

“…The embryonic Stem cell Test (EST) is a validated assay for testing embryotoxicity in vitro. …”
Get full text

The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells by Sakhavat Abolhasani, Yasin Ahmadi, Yavar Rostami, Davood Fattahi

“…Abstract MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth muscle cells (VSMCs). …”
Get full text

5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells by XiaoLin Sun, HongXiao Li, Ye Zhu, Pei Xu, QiSheng Zuo, BiChun Li, Xiang Gu

“…Very small embryonic-like stem cells (VSELs) are a unique and rare adult stem cell population, which have the same structural, genetic, biochemical, and functional characteristics as embryonic stem cells without the ethical controversy. …”
Get full text

The Role of Protein Kinase C During the Differentiation of Stem and Precursor Cells into Tissue Cells by Oliver Pieles, Christian Morsczeck

“…Furthermore, PKC is capable of directly phosphorylating transcription factors with pivotal function for a certain developmental process. Ultimately, profound knowledge about the role of distinct PKC isoforms and the involved signaling pathways during differentiation constitutes a promising tool to improve the use of stem cells in regenerative therapies by precisely manipulating the activity of PKC or downstream effectors.…”
Get full text

APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells by Man Wang, Fitriana Nur Rahmawati, Wenting Li, Zeynep Bal, Faya Nuralda Sitompul, Fumitaka Muramatsu, Weizhen Jia, Nobuyuki Takakura

“…Methods APJ knockout (KO) mice were utilized to explore the role of apelin/APJ signaling in VESC functionality. Flow cytometry, colony-forming unit assays, and in vitro differentiation experiments were conducted to characterize VESC populations. …”
Get full text

LL-37 regulates odontogenic differentiation of dental pulp stem cells in an inflammatory microenvironment by Yunfeng Ma, Xinyuan Liu, Ruoxi Dai, Quanli Li, Chris Ying Cao

“…However, the presence of proinflammatory factors can affect DPSCs proliferation, differentiation, migration, and other functions. LL-37 is a natural cationic polypeptide that inhibits lipopolysaccharide (LPS) activity, enhances cytokine production, and promotes the migration of stem cells. …”
Get full text

Functions and mechanisms of UC-MSC-derived exosomal miR-486-5p in pulmonary fibrosis by Xue-feng Shi, Ya-jun Tuo, Zhen-yun Liao, Jie Duo, Hao Yang

“…However, neither of these medications effectively halts the progression of PF or preserves lung function. As a result, lung transplantation remains the sole viable treatment option for patients in the advanced stages of the disease. …”
Get full text

Microvesicles and exosomes isolated from murine bone marrow-derived mesenchymal stromal cells primed with p38MAPK inhibitor differentially regulate hematopoietic stem cell function by Pallavi Budgude, Vaijayanti Kale, Anuradha Vaidya

“…These findings provide insights into the molecular mechanisms underlying the differential regulation of HSC function by pMVs and pExos. …”
Get full text

Dishevelled localization and function are differentially regulated by structurally distinct sterols by Sonali Sengupta, Jazmine D.W. Yaeger, Maycie M. Schultz, Danielle G. May, Kyle J. Roux, Kevin R. Francis

Get full text

Viscoelastic properties of differentiating blood cells are fate- and function-dependent. by Andrew E Ekpenyong, Graeme Whyte, Kevin Chalut, Stefano Pagliara, Franziska Lautenschläger, Christine Fiddler, Stephan Paschke, Ulrich F Keyser, Edwin R Chilvers, Jochen Guck

“…Although cellular mechanical properties are known to alter during stem cell differentiation, understanding of the functional relevance of such alterations is incomplete. …”
Get full text

HUMAN AMNIOTIC EPITHELIAL CELLS FOR RETINAL REGENERATION: INVESTIGATING THEIR DIFFERENTIATIVE POTENTIAL IN VITRO

Get full text

Functional mechanism on stem cells by tea (Camellia sinensis) bioactive compounds by Yao Cheng, Jiachen Sun, Hui Zhao, Hongxing Guo, Jianying Li

“…The main active ingredients of tea include polyphenols, alkaloids, polysaccharides, amino acids, aroma and volatile constitutes, all of which are potentially responsible for the activities of tea. Stem cells (SCs) are the immature and undifferentiated cells by a varying capacity for proliferation, self-renewal and the capability to differentiate into one or more different derivatives with specialized function or maintain their stem cell phenotype. …”
Get full text

Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction by Zhi Chen, Long Chen, Chunyu Zeng, Wei Eric Wang

“…Myocardial infarction (MI) is one of the leading causes of death worldwide. Mesenchymal stem cell (MSC) transplantation is considered a promising approach and has made significant progress in preclinical studies and clinical trials for treating MI. …”
Get full text

The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells by Jianghong Xiang, Yihan Lai, Zuping He

“…Variants in the subunit components of the cohesin complex and proteins’ modifications further confer functional plasticity, and its mutations can lead to abnormal stem cell functions and are correlated with diseases including cancers. …”
Get full text

The Role of Long Non-Coding RNAs in Human Endoderm Differentiation by Annanda Lyra Ribeiro, Bruno Dallagiovanna

“…Only recently has the involvement of lncRNAs in human endoderm differentiation of pluripotent stem cells begun to be addressed, creating an opportunity to explore the mechanisms by which lncRNAs exert their functions in germ layer formation, lineage specification, and commitment. …”
Get full text

Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation by Hans Felix Staehle, Christoph Koellerer, Anne Marie Staehle, Jana Schulze, Philipp Eble, Anja Müller, Franziska Zell, Judith M. Müller, Florian Perner, Aya Attia, Jan-Philipp Mallm, Olga Pozdnyakova, Karsten Rippe, Benedikt Brors, Lars Feuerbach, Charles D. Imbusch, Eric Metzger, Roland Schüle, Heike L. Pahl, Jonas S. Jutzi

“…Abstract The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. …”
Get full text

Meioc-Piwil1 complexes regulate rRNA transcription for differentiation of spermatogonial stem cells by Toshihiro Kawasaki, Toshiya Nishimura, Naoki Tani, Carina Ramos, Emil Karaulanov, Minori Shinya, Kenji Saito, Emily Taylor, René F Ketting, Kei-ichiro Ishiguro, Minoru Tanaka, Kellee R Siegfried, Noriyoshi Sakai

“…Herein, we show unique properties of zebrafish meioc mutants in which spermatogonial stem cells (SSCs) do not differentiate or upregulate rRNAs. …”
Get full text