Stem Cell Applications and Tenogenic Differentiation Strategies for Tendon Repair by Ziyang Yuan, Haomiao Yu, Huibin Long, Yike Dai, Lin Shi, Jiaming Zhao, Ai Guo, Naicheng Diao, Lifeng Ma, Heyong Yin

“…Nowadays, the application of various stem cell sources, including mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs), for tendon repair has shown great potential, because these cells can differentiate into a tendon lineage and promote functional tendon repair. …”
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The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells by Rafał Bieś, Agnieszka Mikosińska, Jakub Parys, Mateusz Litwin, Patrycja Kałuziak, Marta Jajczak, Maciej Mossakowski, Aleksandra Witek, Martyna Kaźmierczak, Stanisław Jesionek

“…We explore how HGF/c-Met signaling contributes to stem cell function, tissue repair, and cancer biology, as well as the development of targeted therapies aimed at modulating this pathway. …”
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Impacts of Circular RNAs on the Osteogenic Differentiation of Dental Stem Cells by Yang Wang, Meijie Tu, Huihui Gao, Shuli Deng

“…This review provides a comprehensive overview of the functions and mechanisms of circRNAs, with a particular focus on their expression patterns and regulatory roles in osteogenic differentiation of various dental stem cell types. …”
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Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. by Amanda L Evans, Tiago Faial, Michael J Gilchrist, Thomas Down, Ludovic Vallier, Roger A Pedersen, Fiona C Wardle, James C Smith

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Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres by Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

“…The expression of stemness genes <i>SOX2</i>, <i>NES</i>, and <i>PRTG</i> was differentially affected by VPA in MB cells with different <i>TP53</i> status. …”
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Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes by Angela Maria Cozzolino, Valeria Noce, Cecilia Battistelli, Alessandra Marchetti, Germana Grassi, Carla Cicchini, Marco Tripodi, Laura Amicone

“…Furthermore, standard cultivation of liver stem/precursor cells impedes an efficient execution of the epithelial/hepatocyte differentiation program, leading to the expansion of a cell population expressing only partially liver functions and products. …”
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ARAP3 functions in hematopoietic stem cells. by Yiwen Song, Jing Jiang, Sonja Vermeren, Wei Tong

“…Here, we report that hematopoietic stem cells (HSCs) from rare adult Arap3KI/KI bone marrow are compromised in their ability to reconstitute recipient mice and to self-renew. …”
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A perfect islet: reviewing recent protocol developments and proposing strategies for stem cell derived functional pancreatic islets by Sujitha Sali, Leen Azzam, Taraf Jaro, Ahmed Ali Gebril Ali, Ali Mardini, Omar Al-Dajani, Shahryar Khattak, Alexandra E. Butler, Juberiya M. Azeez, Manjula Nandakumar

“…Nevertheless, challenges remain in generating fully functional and mature β cells from hPSCs. This review underscores the significant efforts made by researchers to optimize various differentiation protocols aimed at enhancing the efficiency and quality of hPSC-derived pancreatic islets and proposes methods for their improvement. …”
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Recent advances of SNHG in regulating mesenchymal stem cell osteogenic differentiation by HUANG Jie, WANG Zuolin

“…Herein, this article aims to review the biological functions and emerging mechanisms of SNHG involved in the mesenchymal stem cell osteogenic differentiation.…”
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Epigenetic Regulation of Mesenchymal Stem Cell Differentiation and the role of external response by Zhang Enwei, Xie Jingwen

“…Mesenchymal stem cells (MSCs) possess important physiological characteristics such as self- proliferation and multipotent differentiation potential, making them highly promising for applications in tissue repair and regeneration. …”
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In Vitro Differentiation and Maturation of Human Embryonic Stem Cell into Multipotent Cells by Amer Mahmood, Claudio Napoli, Abdullah Aldahmash

“…Human embryonic stem cells (hESCs), which have the potential to generate virtually any differentiated progeny, are an attractive cell source for transplantation therapy, regenerative medicine, and tissue engineering. …”
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Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering by Hong Cheng, Yan Huang, Hangqi Yue, Yubo Fan

“…Nerve injuries and neurodegenerative disorders remain serious challenges, owing to the poor treatment outcomes of in situ neural stem cell regeneration. The most promising treatment for such injuries and disorders is stem cell-based therapies, but there remain obstacles in controlling the differentiation of stem cells into fully functional neuronal cells. …”
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Differential exosome miRNA expression in oral cancer stem cells by M. Shoff, T. Booker, B. Leavitt, D. Harmon, K. Kingsley, K. M. Howard

“…The corresponding OSCC stem cells that demonstrated phenotypic adhesion independent tumor spheres (AiTS) were manually isolated. …”
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DKK3 promotes adipogenic differentiation of stem cells by inhibiting Wnt/β-catenin signaling pathway related gene expression and mitochondrial autophagy function by Ze Zhang, Haohui Wei, Tao Lin, Changbin Zhao, Yongxiang Song, Yuelin Deng, Yiqing Sun, Yongxia Zhao, Qingbin Luo, Xiquan Zhang, Dexiang Zhang, Hongmei Li

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Gelatin/Cerium-Doped Bioactive Glass Composites for Enhancing Cellular Functions of Human Mesenchymal Stem Cells (hBMSCs) by Andrey Iodchik, Gigliola Lusvardi, Alfonso Zambon, Poh Soo Lee, Hans-Peter Wiesmann, Anne Bernhardt, Vera Hintze

“…Here, novel cerium-doped mesoporous BG microparticles (Ce-MBGs) with different cerium content were included in photocrosslinkable, methacrylated gelatin (GelMA) for promoting cellular functions of human mesenchymal stem cells (hBMSCs). …”
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Gingival Stem Cell‐Conditioned Media and Low‐Level Laser Therapy Enhance Periodontal Ligament Stem Cells Function by Upregulating Wnt and TGF‐β Pathway Components: An In Vitro Stud... by Mohammed Y. Aljabri, Yaser A. Alhazmi, Salah A. Elsayyad, Shehabeldin M. Saber, Mohamed Shamel

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Transcriptomic and Functional Landscape of Adult Human Spinal Cord NSPCs Compared to iPSC-Derived Neural Progenitor Cells by Sasi Kumar Jagadeesan, Ahmad Galuta, Ryan Vimukthi Sandarage, Eve Chung Tsai

“…While induced pluripotent stem cell (iPSC)-derived NSPCs offer significant therapeutic potential, understanding their molecular and functional alignment with bona fide spinal cord NSPCs is crucial for developing autologous cell therapies that enhance spinal cord regeneration and minimize immune rejection. …”
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Modelling Functional Thyroid Follicular Structures Using P19 Embryonal Carcinoma Cells by Fatimah Najjar, Liming Milbauer, Chin-Wen Wei, Thomas Lerdall, Li-Na Wei

“…Thyroid gland diseases remain clinical challenges due to the lack of reliable in vitro models to examine molecular pathways of thyrocytes development, maturation, and functional maintenance. This study aimed to develop in vitro thyrocytes model using a stem cell culture, P19 embryonal carcinoma which requires no feeder layer, differentiation into mature and functional thyrocytes that allow molecular and genetic manipulation for studying thyroid diseases. …”
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Optimizing the Method for Differentiation of Macrophages from Human Induced Pluripotent Stem Cells by Shanshan Li, Lili Song, Yingwen Zhang, Zhiyan Zhan, Yi Yang, Lisha Yu, Hua Zhu, Weihua Huang, Wanqiao Wang, Haizhong Feng, Yanxin Li

“…Macrophage is a very promising cell type for cancer immunotherapy, yet it is difficult to obtain enough functional macrophages for clinical cell therapy. Herein, we descibe a reliable method to produce functional macrophages through the differentiation of human induced pluripotent stem cells (hiPSCs). …”
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Continuous map of early hematopoietic stem cell differentiation across human lifetime by Hana Komic, Tessa Schmachtel, Catia Simoes, Marius Külp, Weijia Yu, Adrien Jolly, Malin S. Nilsson, Carmen Gonzalez, Felipe Prosper, Halvard Bonig, Bruno Paiva, Fredrik B. Thorén, Michael A. Rieger

“…Abstract Uncovering early gene network changes of human hematopoietic stem cells (HSCs) leading to differentiation induction is of utmost importance for therapeutic manipulation. …”
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