The subventricular zone structure, function and implications for neurological disease by Kaishu Li, Yin Zheng, Shubing Cai, Zhiming Fan, Junyi Yang, Yuanrun Liu, Shengqi Liang, Meihui Song, Siyuan Du, Ling Qi

“…The subventricular zone (SVZ) is a region surrounding the lateral ventricles that contains neural stem cells and neural progenitor cells, which can proliferate and differentiate into various neural and glial cells. …”
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Acceleration of Functional Maturation and Differentiation of Neonatal Porcine Islet Cell Monolayers Shortly In Vitro Cocultured with Microencapsulated Sertoli Cells by Francesca Mancuso, Mario Calvitti, Giovanni Luca, Claudio Nastruzzi, Tiziano Baroni, Stefania Mazzitelli, Ennio Becchetti, Iva Arato, Carlo Boselli, Monique D. Ngo Nselel, Riccardo Calafiore

“…To assess the development of the cocultured cell monolayers, we have studied either endocrine cell phenotype differentiation markers or c-kit, a hematopoietic stem cell marker, has recently been involved with growth and differentiation of β-cell subpopulations in human as well as rodent animal models. …”
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ATM knock out alters calcium signalling and augments contraction in skeletal muscle cells differentiated from human urine-derived stem cells by Giulia Dematteis, Giulia Lecchi, Giulia Boni, Diana Pendin, Carla Distasi, Mariagrazia Grilli, Dmitry Lim, Luigia Grazia Fresu, Maria Talmon

“…To this aim, by using CRISPR/Cas9 technology, we knocked out the ATM protein in urine-derived stem cells (USCs) from healthy donors. The resulting USCs-ATM-KO maintained stemness but showed G2/S cell cycle progression and an inability to repair DNA after UV damage. …”
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LINC01089 governs the miR-1287-5p/HSPA4 axis to negatively regulate osteogenic differentiation of mesenchymal stem cells by Hao Zou, Fei Hu, Xin Wu, Bin Xu, Guifeng Shang, Dong An, Dehao Qin, Xiaolei Zhang, Aofei Yang

“…In this study, we aimed to disclose how LINC01089 functions in human mesenchymal stem cell (hMSC) osteogenic differentiation, and to study the mechanism by which LINC01089 regulates MSC osteogenesis. …”
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Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis by Ying Wang, Yang Cui, Xiaoyu Liu, Shengxian Liang, Li Zhong, Rui Guo

“…Abstract Background and aim Generation of functional cardiomyocytes from human pluripotent stem cells (hPSCs) offers promising applications for cardiac regenerative medicine. …”
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POU3F4 up-regulates Gli1 expression and promotes neuronal differentiation and synaptic development of hippocampal neural stem cells by Lei Zhang, Jue Wang, Naijuan Xu, Jingjing Guo, Yujian Lin, Xunrui Zhang, Ruijie Ji, Yaya Ji, Haoming Li, Xiao Han, Wen Li, Xiang Cheng, Jianbing Qin, Meiling Tian, Min Xu, Xinhua Zhang

“…RNA sequencing and ChIP assays confirmed that Gli1 was downstream of POU3F4. Loss and gain function experiments indicated that Gli1 mediated POU3F4 promoting neuronal differentiation and synapse development. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Dalia Ali, Radhakrishnan Vishnubalaji, Muthurangan Manikandan, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…Methods. Stem cell signaling small molecule library functional screen was performed employing human bone marrow skeletal (mesenchymal) stem cells (hBMSCs). …”
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Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi, Nuha Almasoud, Sarah Binhamdan, Ghaydaa Younis, Dalia Ali, Muthurangan Manikandan, Radhakrishnan Vishnubalaji, Muhammad Atteya, Abdulaziz Siyal, Musaad Alfayez, Abdullah Aldahmash, Moustapha Kassem, Nehad M. Alajez

“…A Smoothened (SMO) antagonist/Hedgehog inhibitor, BMS-833923, identified during a functional screening of a stem cell signaling small molecule library, was investigated for its effects on the osteoblast differentiation of human skeletal (mesenchymal) stem cells (hMSC). …”
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A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation. by Shen-Hsi Yang, Tuzer Kalkan, Claire Morrisroe, Austin Smith, Andrew D Sharrocks

“…Complex interlinked transcriptional and signaling networks control the fate of these cells towards maintenance of pluripotency or differentiation. In this study we have focused on how mouse embryonic stem cells begin to differentiate and lose pluripotency and, in particular, the role that the ERK MAP kinase and GSK3 signaling pathways play in this process. …”
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Effects of magnetic fields-stimulated 3D-Schwann cell-secreted extracellular vesicles regulate differentiation of neural stem cells and nerve regeneration by Yueh-Sheng Chen, Jian-Jr Lee, Yen-Hong Lin, Yun-Jhen Lin, Min-Hua Yu, Cheng-Yu Chen, Der-Yang Cho, Ming-You Shie

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MGP regulates the adipogenic differentiation of mesenchymal stem cells in osteoporosis via the Ca2+/CaMKII/RIP140/FABP3 axis by Xinglang Wang, Yunhui Zhang, Chenhao Xu, Quanfeng Li, Pengfei Ji, Huatao Liu, Yibin Zhang, Jiahao Jin, Zihao Yuan, Miao Yuan, Pei Feng, Yanfeng Wu, Wenjie Liu, Huiyong Shen, Peng Wang

“…Abstract The dysregulation of bone marrow mesenchymal stem cells (BM-MSCs) is crucial in the pathogenesis of osteoporosis, and adipogenic differentiation of BM-MSCs is considered an essential factor in this process. …”
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Genomic locus of lncRNA-Gm26793 forms an inter-chromosomal interaction with Cubn to ensure proper stem cell differentiation in vitro and in vivo by Zhiwen Liu, Xin Wan, Jiehui Chen, Yongjian Ma, Yonggao Fu, Yingying Chen, Mingzhu Wen, Yun Yang, Yun Qian, Yong Zhang, Dahai Zhu, Jinsong Li, Naihe Jing, Xianfa Yang

“…Overall, our study provides a clear paradigm that inter-chromosomal interaction collaborates with architectural factors to stabilize nuclear conformation and guarantee faithful gene expression during stem cell differentiation and mammalian embryogenesis.…”
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Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis by Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeong

“…Human bone marrow-derived stem cells (hBMSC) displayed neuronal functional characteristics after differentiation by basic fibroblast growth factor (bFGF) and forskolin. …”
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Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells improves cardiac function through extracellular vesicle-mediated tissue repair in a rat mode... by Ryo Kawasumi, Takuji Kawamura, Kizuku Yamashita, Yuji Tominaga, Akima Harada, Emiko Ito, Maki Takeda, Shunbun Kita, Iichiro Shimomura, Shigeru Miyagawa

“…Introduction: Systemic administration of induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSCs) has a therapeutic effect on myocardial ischemia. …”
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Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision by Ji Liu, Zhihui Jiang, Juanmin Zha, Qiong Lin, Weiqi He

“…In summary, this review offers valuable insights into the regulatory mechanisms that control stem cell behavior and epithelial cell differentiation, suggesting promising directions for future research in intestinal biology and tissue homeostasis.…”
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Could CH₃-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration? by Fidan Huseynova, Cătălina Ionescu, Frederic Cuisinier, Irada Huseynova, Alamdar Mammadov, Véronique Barragan-Montero

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Histone variants: key regulators of inflammation in cell dedifferentiation and transdifferentiation by Manlio Vinciguerra, Desislava K. Tsoneva

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The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses by Issam Tout, Salim Bougarn, Mohammed Toufiq, Neha Gopinath, Ola Hussein, Abbirami Sathappan, Evonne Chin-Smith, Fazulur Rehaman, Rebecca Mathew, Lisa Mathew, Kun Wang, Li Liu, Abdulrahman Salhab, Oleksandr Soloviov, Sara Tomei, Waseem Hasan, Sahar Da’as, Yosra Bejaoui, Nady El Hajj, Karama Makni Maalej, Said Dermime, Kakil Rasul, Paolo Dellabona, Giulia Casorati, Alice Turdo, Matilde Todaro, Giorgio Stassi, Soldano Ferrone, Xinhui Wang, Cristina Maccalli

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A single-cell transcriptomic atlas of human lens epithelium: identification and functional insights into lens stem/progenitor cells by Yuzhou Gu, Lu Chen, Shuying Chen, Yuhao Wu, Shengjie Hao, Feiyin Sheng, Jiali Yuan, Zhenwei Qin, Di Wu, Yu Han, Zengying Yao, Zhijian Chen, I. Michael Wormstone, Yibo Yu, Junbin Qian, Qiuli Fu, Ke Yao

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Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cells by Maissa Ben Mahmoud, Anikó Rátkai, Krisztina Bauer, Norbert Bencsik, Attila Szücs, Katalin Schlett, Krisztián Tárnok

“…Abstract Neurons derived from induced pluripotent stem cells (h-iPSC-Ns) provide an invaluable model for studying the physiological aspects of human neuronal development under healthy and pathological conditions. …”
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