Exploring the Effects of Electroacupuncture on Bone Metabolism in Ovariectomized Rats via the Gut Microbiota-Th17/Treg Axis by WANG Zhiqiang, WEI Zhengpu, CHEN Xuzheng, CHEN Sainan, HUANG Yunmei, LIN Yanping

“…The gut microbiota of fecal samples from both groups was analyzed using 16S rDNA technology, followed by microbial profiling analysis, intergroup difference analysis, and LEfSe Multi-Level Species Difference Discriminant Analysis. …”
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In Vitro Anthelmintic Activities of Khaya anthotheca and Faidherbia albida Extracts Used in Chad by Traditional Healers for the Treatment of Helminthiasis and In Silico Study of Ph... by Baigomen Christalin, Masoud Besati, Noumedem Anangmo Christelle Nadia, Mahdi Yaghoobi, Yamssi Cédric, Claire Ciancia, Mounvera Abdel Azizi, Gamago Nkadeu Guy-Armand, Vincent Khan Payne, Haibo Hu

“…Examining the ADME properties of these compounds also supports the potential of these ligands to be transformed into pharmaceutical forms.…”
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Cyclic activity of signal transduction pathways in fimbrial epithelium of the human fallopian tube by Phyllis van derPloeg, Aniek Uittenboogaard, Karlijn M. M. Bucks, Marjolein H. F. M. Lentjes‐Beer, Steven L. Bosch, Minouche M. E. vanRumste, M. Caroline Vos, Paul J. vanDiest, Sandrina Lambrechts, Anja van deStolpe, Ruud L. M. Bekkers, Jurgen M. J. Piek

“…Wnt pathway activity in postmenopausal patients was comparable to the late follicular and early luteal phase. We observed no differences in HH and TGF‐β pathway activity between pre‐ and postmenopausal samples. …”
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Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF by E. Riveland, A. Ushakova, T. Valborgland, T. Karlsen, H. Dalen, E. Prescott, T. Omland, A. Linke, M. Halle, M. Marber, Ø. Ellingsen, A.I. Larsen, the SMARTEX‐HF Study Group

“…Due to non‐normal distribution, cMyC and hs‐cTnI measurements were log‐transformed. A Bland–Altman plot was employed to evaluate the agreement of cMyC with hs‐cTnI measurements. …”
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Prognostic Role of Tumour Stroma Ratio in Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis: A Retrospective Study by Pradeep Veerappan, Reshma Poothakulath Krishnan, Deepak Pandiar, Pratibha Ramani, Selvaraj Jayaraman

“…Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder with an increased risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) arising in the background of OSMF shows distinct clinical presentation and behaviour. …”
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Urinary Metabolic Profiling During Epileptogenesis in Rat Model of Lithium–Pilocarpine-Induced Temporal Lobe Epilepsy by Fatma Merve Antmen, Emir Matpan, Ekin Dongel Dayanc, Eylem Ozge Savas, Yunus Eken, Dilan Acar, Alara Ak, Begum Ozefe, Damla Sakar, Ufuk Canozer, Sehla Nurefsan Sancak, Ozkan Ozdemir, Osman Ugur Sezerman, Ahmet Tarık Baykal, Mustafa Serteser, Guldal Suyen

“…<b>Background/Objectives</b>: Temporal lobe epilepsy (TLE) often develops following an initial brain injury, where specific triggers lead to epileptogenesis—a process transforming a healthy brain into one prone to spontaneous, recurrent seizures. …”
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Interventions designed to promote the consumption of locally produced foods: a scoping review by Emily Haynes, Catherine R. Brown, Cassandra Halliday, Lutgardo Alcantara, Cristobal Cayetano, Lota Creencia, Lea Janine Gajardo, Amanda Goodwin, Cornelia Guell, Christina Howitt, Viliamu Iese, Alison Karley, John Roderick Madarcos, Karen Madarcos, Karyn Morrissey, Khadija Patel, Natasha Sobers, Filipe Veisa, Madhuvanti M. Murphy, Nigel Unwin, Nigel Unwin

“…IntroductionFood system transformation is required for planetary health. Localizing food systems and applying agroecological principles to food production and supply have been suggested to support a resilient and sustainable food system. …”
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An open-label phase I comparator-controlled clinical trial to assess tolerability and pharmacokinetics of IHL-675 A a fixed dose combination of cannabidiol plus hydroxychloroquine... by George Williams Mbogo, Pia Kroner, Rosemarie Walsh, Jonathan Newchurch, Mark Robert Bleackley

“…Plasma concentrations of CBD, HCQ and their major metabolites, 7-OH-CBD, and 7-COOH-CBD, and desethylhydroxychloroquine (DHCQ), desethylchloroquine (DCQ), and bisdesethylhydroxy-chloroquine (BDCQ) were assessed at predefined timepoints across the monitoring period and PK parameters were determined and compared between treatments using noncompartmental methods and analysis of variance (ANOVA) of log-transformed values exposure PK parameters. …”
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Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: A secondary, pooled analysis of Phase II and III trial data from 33 countries. by Julia M Baker, Jacqueline E Tate, Juan Leon, Michael J Haber, Benjamin A Lopman

“…Mixed-effect logistic regression and mixed-effect linear regression of log-transformed data were used to identify individual- and country-level predictors of seroconversion (dichotomous) and antibody titer (continuous), respectively. …”
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Identifying Adverse Events in Outpatients With Prostate Cancer Using Pharmaceutical Care Records in Community Pharmacies: Application of Named Entity Recognition by Yuki Yanagisawa, Satoshi Watabe, Sakura Yokoyama, Kyoko Sayama, Hayato Kizaki, Masami Tsuchiya, Shungo Imai, Mitsuhiro Someya, Ryoo Taniguchi, Shuntaro Yada, Eiji Aramaki, Satoko Hori

“…Additionally, the study sought to determine whether outpatient pharmacotherapy monitoring can be enhanced by using NER to systematically collect AEs from pharmaceutical care records. MethodsWe used an NER system based on the widely used Japanese medical term extraction system MedNER-CR-JA, which uses Bidirectional Encoder Representations from Transformers (BERT). …”
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Challenges to creating primary care teams in a public sector health centre: a co-operative inquiry by Bob Mash, Pat Mayers, Hoffie Conradie, Abraham Orayn, Marjan Kuiper, Joey Marais, Bennie Cornelissen, Shaamelah Titus

“…Conclusion Key lessons learnt included the need to engage with a transformational leadership style, to foster dialogical openness in the planning process and to address differences in understanding of roles and responsibilities between the doctors and the CNPs. …”
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Association Between Vitamin D Status and Insulin Resistance in Adolescents: A Cross-sectional Observational Study by GUO Xiaoyuan, WANG Yutong, ZHOU Zhibo, CHEN Shi, ZHANG Mei, BAN Bo, LI Ping, ZHANG Xinran, ZHANG Qiuping, YANG Kai, YANG Hongbo, DU Hanze, PAN Hui

“…ObjectiveTo investigate the correlation between vitamin D nutritional status and insulin resistance in pubertal adolescents.MethodsThis cross-sectional observational study employed convenience sampling to recruit 2021-grade(8th grade) students from Jining No.7 Middle School in Shandong Province on June 5, 2023. …”
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PD-1/PD-L1 inhibitors monotherapy vs. combination therapy in elderly advanced NSCLC: a real-world study and nomogram for survival prognosis by Yunye Mao, An Wang, Xiangwei Ge, Jinzhao Zhai, Yi Hu, Jinliang Wang

“…Abstract Background Immunotherapy with PD-1/PD-L1 inhibitors has transformed advanced non-small cell lung cancer (NSCLC) treatment, yet optimal strategies for elderly patients remain uncertain. …”
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Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study by Jiaxin Zhang, Jiaxin Zhang, Jiaxin Zhang, Jiaxin Zhang, Jiaxin Zhang, Ju Tian, Jiuju Wang, Huiting Qiao, Huiting Qiao, Huiting Qiao, Huiting Qiao, Wenxiang Quan, Yanping Song, Daifa Wang, Daifa Wang, Daifa Wang, Daifa Wang, Wentian Dong

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Future Proofing Study: a cluster randomised controlled trial evaluating the effectiveness of a universal school-based cognitive–behavioural programme for adolescent depression by Maree Teesson, Helen Christensen, Svetha Venkatesh, Aliza Werner-Seidler, Lara Johnston, Bridianne O’Dea, Michelle Torok, Katharine Steinbeck, Raghu Lingam, Andrew Mackinnon, Yael Perry, Kit Huckvale, Joanne R Beames, Alison L Calear, Kate Maston, Philip J Batterham, Ju Lee Oei, Mark E Larsen, Jennifer L Hudson, Lyndsay Brown, Hiroko Fujimoto, Alexandra Batholomew, Debopriyo Bal, Susan Rachel Skinner, Katherine M Boydell, Susanne Schweizer

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Impact of all-oral bedaquiline-based shorter regimens in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis by Ming Liu, Lianping Yang, Shanquan Chen, Yan He, Nathorn Chaiyakunapruk, Wai-kit Ming, Jing Yu, Tesfaye Regassa Feyissa, Xiaohan Chen, Getahun Fetensa, Ebisa Turi, Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xinyao Yi, Dinka Dugassa

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Historical overview, advancements, and future prospects of coalfield structure research in China by Daiyong CAO, Yiwen JU, Yucheng XIA, Bo JIANG, Shuzheng NING, Yingchun WEI, Anmin WANG, Xiaoming LI, Wenfeng ZHAN, Huantong LI, Lu WANG, Zhuocheng CAI

“…Amidst the ongoing energy structure optimization and the transformation and upgrading of coalfield geology in China, it is both practically and historically significant to review the history of coalfield structure research, summarize relevant experience, and contemplate future directions of the research under emerging circumstances.Methods Based on literature analysis, as well as the long-term research practices of the authors’ team, this study discusses the disciplinary attribute of coalfield structure research, reviews the history of this field both at home and abroad, and summarizes major achievements in China. …”
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INTERNATIONAL FORUM “OLD AND NEW MEDIA: ALONG THE PATH TOWARDS A NEW AESTHETICS” / МЕЖДУНАРОДНЫЙ ФОРУМ «СТАРЫЕ И НОВЫЕ МЕДИА: ПУТИ К НОВОЙ ЭСТЕТИКЕ»... by BOGATYRYOVA ELENA A.

“…Notice was made of alarming tendencies of transforming consciousness into that of “gamers,” reacting in correlations with certain algorithms, and a transference from discourse and substantiations towards reactions and evaluations. …”
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Key events in the process of sex determination and differentiation in early chicken embryos by Xiaoqian Lv, Changhua Sun, Xin Liu, Guanzheng Liu, Wei Gong, Hongwu Qian, Zeyu Li, Jun Wu, Xilin Zhu, Jiuzhou Song, Yingjie Niu, Hongyan Sun, Wei Han, Guo hong Chen, Kai Jin, Bichun Li, Qisheng Zuo

“…To address this, we applied RNA sequencing to identify male-female expression differences at critical developmental stages (E0 blastocysts, E3.5-E6.5 genital ridges, E18.5 gonads), focusing on glycolysis, histone acetylation, and DNA methylation. …”
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Diagnostic value of serum TGF-β1 and CysC in type 2 diabetic kidney disease: a cross-sectional study by Yi Kang, Yi Kang, Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Huijuan Zheng, Xiaobin Li, Aoshuang Li, Aoshuang Li, Jing Wei Zhou, Jing Wei Zhou, Jie Lv, Jie Lv, Yaoxian Wang, Yaoxian Wang

“…This study aims to investigate the diagnostic value of transforming growth factor-β1 (TGF-β1) and cystatin C (CysC) in DKD patients.MethodsA total of 126 patients with type 2 diabetes mellitus (T2DM) diagnosed at Dongzhimen Hospital, Beijing University of Chinese Medicine, between May 2021 and March 2023 were enrolled. …”
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