Bridging Data Silos in Oncology with Modular Software for Federated Analysis on Fast Healthcare Interoperability Resources: Multisite Implementation Study by Jasmin Ziegler, Marcel Pascal Erpenbeck, Timo Fuchs, Anna Saibold, Paul-Christian Volkmer, Guenter Schmidt, Johanna Eicher, Peter Pallaoro, Renata De Souza Falguera, Fabio Aubele, Marlien Hagedorn, Ekaterina Vansovich, Johannes Raffler, Stephan Ringshandl, Alexander Kerscher, Julia Karolin Maurer, Brigitte Kühnel, Gerhard Schenkirsch, Marvin Kampf, Lorenz A Kapsner, Hadieh Ghanbarian, Helmut Spengler, Iñaki Soto-Rey, Fady Albashiti, Dirk Hellwig, Maximilian Ertl, Georg Fette, Detlef Kraska, Martin Boeker, Hans-Ulrich Prokosch, Christian Gulden

“…ObjectiveThis study aimed to outline the design, implementation, and deployment of a modular data transformation pipeline that transforms oncological RWD into a Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) format and then into a tabular format in preparation for a federated analysis (FA) across the 6 Bavarian Cancer Research Center university hospitals. …”
Get full text

Placental transfer of SARS-CoV-2 antibodies in mother-neonate pairs: a prospective nested cohort study by Alex G. Mugo, Angela Koech, Liberty Cantrell, Moses Mukhanya, Isaac Mwaniki, Joseph Mutunga, Merryn Voysey, Rachel Craik, Peter von Dadelszen, Kirsty Le Doare, Marleen Temmerman, Geoffrey Omuse, periCOVID-Africa, The PRECISE Network

“…The log-transformed maternal and cord blood anti-spike IgG concentrations showed a weak positive correlation (r = 0.364, n = 496, p < 0.001). …”
Get full text

Association of self-efficacy, risk attitudes, and time preferences with health-related quality of life and functioning after total hip or knee replacement – Results of the MobilE-T... by Sebastian Fuchs, Lars Schwettmann, Benedict Katzenberger, Alexander Paulus, Boris Michael Holzapfel, Johanna Theresia Biebl, Martin Weigl

“…All WOMAC scores were transformed into scales with 0 = worst health and 100 = best health. …”
Get full text

Asprosin Levels in Adults with Type 2 Diabetes Mellitus and Diabetic Kidney Disease: A Systematic Review and Meta-Analysis by Ristic J, Kodalak S, Peralta-Jiménez GA, Moura de Lima MF, Kovacevic M, Masic S, Nikolic T

“…Standard mean differences (SMD) with 95% confidence intervals (CI) and Fisher’s Z transformation were used to examine the relationship between asprosin and DKD. …”
Get full text

INTERNATIONAL TECHNICAL AID IN POST-CONFLICT RECOVERY: LESSONS FROM GLOBAL PRACTICES FOR DE-OCCUPIED AREAS by Viktoriia Zalizniuk, Anton Plaksun

“…Key criteria for evaluating the effectiveness of ITA are outlined, along with methods of monitoring, auditing, and risk management. …”
Get full text

Association of maternal SARS‐CoV‐2 infection at the time of admission for delivery with labor process and outcomes of vaginal birth: A cohort study by An Chen, Ganesh Acharya, Min Hu, Xin Gao, Guizhi Cheng, Lai Jiang, Qianqian Ni

“…Women in the positive group had an increased likelihood of having longer labor (median 9.3 vs 8.3 hours; sB [log‐transformed] 0.19; 95% confidence interval [CI] 0.09–0.28), episiotomy (39.1% vs 23.8%; adjusted odds ratio [aOR] 2.31; 95% CI 1.27–4.21), grade III meconium‐stained amniotic fluid (19.5% vs 7.0%; aOR 2.52; 95% CI 1.15–5.54) and postpartum hospital stay exceeding 37 hours (58.6% vs 46.5%; aOR 1.71; 95% CI 1.00–2.91). …”
Get full text

Multiomic characterization, immunological and prognostic potential of SMAD3 in pan-cancer and validation in LIHC by Tao Zhou, Dan Dan Zhang, Jiejing jin, Jinyang Xie, Jianhua Yu, Chao Zhu, Rong Wan

“…Abstract SMAD3, a protein-coding gene, assumes a pivotal role within the transforming growth factor-beta (TGF-β) signaling pathway. …”
Get full text

Diagnostically significant changes in subsets CD11b⁺CD64^-CD32⁺CD16⁺, CD11b⁺CD64⁺CD32⁺CD16⁺ n... by S. V. Kovaleva, I. V. Nesterova, S. N. Pikturno, E. I. Dydyshko, N. S. Prosolypova, А. M. Chulkova

“…It was found that in PID during the period of exacerbation, diagnostically significant differences in the subset composition of NG were revealed. …”
Get full text

Students’ experiences of placements in urban Indigenous health contexts: developing a culturally responsive workforce by Kate Odgers-Jewell, Alison Nelson, Renee Brown, Nicole Hunter, Tiffany Atkins, Kelly Menzel

“…Conclusions Indigenous-led, regionally coordinated placements in urban Indigenous health contexts can support transformative learning and the development of a culturally responsive workforce. …”
Get full text

Assessment of Water Resources Carrying Capacity and Analysis of Its Coupling Coordination in the Yangtze River Economic Belt by XIONG Ying, JIANG Yi-xin, CHEN Si-xuan

“…The aim is to reveal the current status and future development trend of water resources carrying capacity in the Yangtze River Economic Belt, and to provide a scientific basis and decision-making reference for the rational planning and utilization of water resources, the adjustment and optimization of industrial structure, and ecological environment protection within the region. [Methods] The spatiotemporal evolution characteristics of water resources carrying capacity in the Yangtze River Economic Belt from 2012 to 2021 were analyzed using the TOPSIS method and the standard deviation ellipse method. …”
Get full text

Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cells by Amélie Nadeau, Thupten Tsering, Mohamed Abdouh, Laura Kienzle, Jenna Cleyle, Lorne Taylor, Noélie Douanne, Kyle Dickinson, Peter M. Siegel, Julia V. Burnier

“…We found enrichment of specific integrin receptors in metastatic cancer EVs compared to EVs secreted from non-transformed epithelial cells and matched tumorigenic non-metastatic cells. …”
Get full text

RETRACTED ARTICLE: Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Sna... by Yaodong Zhu, Yanqing Liu, Yayun Qian, Xiaojun Dai, Ling Yang, Jue Chen, Shiyu Guo, Tadashi Hisamitsu

“…In vitro, a well-established experimental EMT model involving transforming growth factor β1 (TGF-β1) was applied. Viability, invasion and migration, protein and mRNA expression of tumor cells were analyzed by MTT assay, transwell assay, western blot and real-time PCR, respectively. …”
Get full text

The Century of Authoritarianism (Analysis of the Characteristics and Forms of Authoritarianism in the 21st Century by Moslem Karamzadi

“…Research Method This research employs a mixed-methods approach (quantitative-qualitative) with a descriptive-analytical framework to investigate the dimensions and characteristics of the expansion of authoritarianism in governance. …”
Get full text

Results of a three-year observation of the course of non-radiological axial spondyloarthritis by Yu. Yu. Grabovetskaya, A. V. Smirnov, M. V. Cherkasova, A. A. Rudneva, A. M. Lila

“…After 3 years of follow-up, the diagnosis still met the criteria for nr-axSpA in 30 (44.1%) of the 68 patients, in 16 (23.5%) it transformed into radiographic axSpA (r-axSpA), in 7 (10.3%) – to axial psoriatic arthritis, in 13 (19.1%) the clinical picture no longer met the criteria for nr-axSpA, 2 (3%) patients dropped out of the study. …”
Get full text

Dynamics of resistant hypertension in the postoperative period of carotid endarterectomy with and without carotid body saving by A. N. Kazantsev, R. A. Vinogradov, M. A. Chernyavsky, V. N. Kravchuk, D. V. Shmatov, A. A. Sorokin, A. A. Erofeev, V. A. Lutsenko, R. V. Sultanov, A. R. Shabaev, I. M. Radzhabov, G. Sh. Bagdavadze, N. E. Zarkua, V. V. Matusevich, E. F. Vaiman, A. I. Solobuev, R. Yu. Leader, V. A. Porkhanov, G. G. Khubulava

“…The incidence of hemorrhagic transformation (group 1: 0%; group 2: 0,6%; p=0,04; OR=0,06; 95% CI, 0,003-1,25) and composite endpoint (death+MI+ischemic stroke+hemorrhagic transformation) (group 1: 1,06%; group 2: 3,0%; p=0,004; odds ratio (OR)=0,34; 95% CI, 0,16-0,69) significantly differs between groups. …”
Get full text

Novel potential biomarkers for predicting childhood caries via metagenomic analysis by Hui Zhang, Hui Zhang, Xiao Zheng, Xiao Zheng, Xiao Zheng, Yongmao Huang, Yongmao Huang, Yuanqiang Zou, Tao Zhang, Maria Alice Repo, Maria Alice Repo, Meixiang Yin, Yang You, Zhuye Jie, Wen-an Xu, Wen-an Xu

“…The predictive capacity of the identified biomarkers warrants further investigation for early caries detection and intervention.Clinical SignificanceThe identification of novel biomarkers through metagenomic analysis enables early detection and targeted intervention for childhood caries, potentially transforming children dental care and significantly improving long-term oral health outcomes.…”
Get full text

Exploring the predictive “psycho-biomarkers” for checkpoint immunotherapy in cancer by Qian Zuo, Jieting Chen, Jieting Chen, Xi Xiao, Yan Dai, Liushan Chen, Liushan Chen, Yuqi Liang, Yingchao Wu, Junfeng Huang, Rutao Cui, Rui Xu, Qianjun Chen, Qianjun Chen, Qianjun Chen, Qianjun Chen

“…BackgroundIn recent decades, cancer immunotherapy has transformed the treatment landscape, offering significant advantages over traditional therapies by improving progression-free survival (PFS) and overall survival (OS). …”
Get full text

High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation by Jing Chen, Rui Feng, Bin-Bin Gong, Wei-Kang Wu, Bang-Shun Dai, Rui Tan, Wen-Long Xu, Tong Meng, Xiao-Bin Wang, Yun-Zheng Xiao, Cheng Yang, Li Zhang, Chao-Zhao Liang

Get full text

Independent and joint associations of neighbourhood greenness and walkability with transportational and recreational physical activity among youth and adults in Canada by Natalie Doan, Sebastian A. Srugo, Stephanie A. Prince, Rachel C. Colley, Daniel G. Rainham, Taru Manyanga, Gregory P. Butler, Richard Larouche, Sarah E. Turner, Justin J. Lang

“…To derive an indicator of neighbourhood greenness, for each survey year, we aggregated mean Normalized Difference Vegetation Index (NDVI) values within 2016 dissemination areas. …”
Get full text

Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
Get full text