Realistic electric field characterization of clinically used deformable large TMS coils in a large cohort by Torge Worbs, Bianka Rumi, Kristoffer H. Madsen, Axel Thielscher

“…This also affected the electric field calculated in the cortex, with a median peak difference of ∼16 %. In addition, the new method outperformed grid search-based optimization for maximizing the electric field of a standard Fig. 8 coil in a ROI with a comparable computational complexity. …”
Get full text

Dual-stage Acting Dendrimeric Nanoparticle for Deepened Chemotherapeutic Drug Delivery to Tumor Cells by Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Hossein Mahmudi, Saeedeh Ghiasvand, Hamed Dadashi, Aysan Salemi, Sajjad Alimohammadvand, Leila Roshangar, Abolfazl Barzegari, Mehdi Jaymand, Rana Jahanban-Esfahlan

“…NPs were characterized by Zeta sizer, transmission electron microscope (TEM), Fourier transforms infrared (FTIR) and drug release kinetics. …”
Get full text

Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health by Iván Artemio Corral-Guerrero, Angela Elena Martínez-Medina, Litzy Yazmin Alvarado-Mata, Ana Cristina Figueroa Chávez, Roberto Muñoz-García, Miriam Paulina Luévanos-Escareño, Jazel Doménica Sosa-Martínez, María José Castro-Alonso, Padma Nimmakayala, Umesh K. Reddy, Nagamani Balagurusamy

“…In addition to its systemic effects, capsaicin appears to undergo microbial transformation and influences gut microbial composition, favoring short-chain fatty acid producers and suppressing pro-inflammatory taxa. …”
Get full text

Predicting the risk of left ventricular diastolic dysfunction in obesity by G. A. Chumakova, O. V. Gritsenko, O. V. Gruzdeva, A. V. Zateev

“…There was a significant difference in left atrial volume index (p=0,0003). LV DD was detected in 20 patients. …”
Get full text

Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes by Kaiyu Jiang, Yao Fu, Jennifer A. Kelly, Patrick M. Gaffney, Lucy C. Holmes, James N. Jarvis

“…The differences were even less apparent when comparing loops called with the pediatric vs ENCODE adult primary B cell peak datasets. …”
Get full text

Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia by Elena Timokhina, Alexander Strizhakov, Sapiyat Ibragimova, Evgeny Gitel, Irina Ignatko, Vera Belousova, Nikoleta Zafiridi

“…A diminution in MMP-9 in the EO-PE group confirmed the participation of MMP-9 in the process of spiral artery transformation.…”
Get full text

Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…At 12-month follow-up, the difference was smaller: EQ-5D-3L 1.3 [-1.9, -0.7], p < 0.001. …”
Get full text

Decoding Digital Discourse Through Multimodal Text and Image Machine Learning Models to Classify Sentiment and Detect Hate Speech in Race- and Lesbian, Gay, Bisexual, Transgender,... by Thu T Nguyen, Xiaohe Yue, Heran Mane, Kyle Seelman, Penchala Sai Priya Mullaputi, Elizabeth Dennard, Amrutha S Alibilli, Junaid S Merchant, Shaniece Criss, Yulin Hswen, Quynh C Nguyen

“…ResultsOur findings highlighted key differences in model performance. Among unimodal models, Bidirectional Encoder Representations from Transformer outperformed Visual Geometry Group 16, achieving higher accuracy and macro–F1-scores across all tasks. …”
Get full text

Impact of a multi-component implementation strategy to increase outdoor free play opportunities in early childhood education and care (ECEC) services: the get outside get active (G... by Sze Lin Yoong, Nicole Pearson, Luke Giles, Hannah Lamont, Luke Wolfenden, Jannah Jones, Christophe Lecathelinais, Patti-Jean Naylor, Anthony Okely, Nicole Nathan, Kathryn Reilly, Rebecca Lorch, John Wiggers, Jacklyn Jackson, Melanie Lum, Karen Gillham, Alice Grady

Get full text

Prenatal exposure to phthalates and preschool children’s intellectual scores: Effect modification by child sex by Carly V. Goodman, Christine Till, Sietske Berghuis, Joseph M. Braun, Gina Muckle, Aimin Chen, Youssef Oulhote, Bruce Lanphear, Jillian Ashley-Martin, Tye E. Arbuckle

“…Associations between ΣDiDPm and VIQ and MMP and PIQ differed by child sex (negative for boys and positive for girls, respectively). …”
Get full text

Role of CDH1 gene variants and E-cadherin localization in gastric mucosal cancerization by Yunbo Wu, Yunzhan Zhang, Yunkai Dai, Qi Luo, Shaoyang Lan, Xu Chen, Weijing Chen, Ruliu Li, Ling Hu

“…The loss and ectopic expression of E-cadherin may be significant risk factors for malignant transformation in the gastric mucosa.…”
Get full text

Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…For the health economic analysis, health utility scores for patients only were measured using the EuroQol-5 Domains, three-level version instrument at baseline and 12 months. These were transformed into quality-adjusted life-years (QALYs) using published UK population tariffs calculated using the time trade-off method. …”
Get full text

Development of Aeromonas salmonicida Vaccine Carrier Expressing G Protein of Infectious Hematopoietic Necrosis Virus by Yatong GAO, Zhipeng WANG, Ye GAO, Ming ZHU, Jie LI

“…The recombinant plasmid pGEX-4T-1-G was transformed into A. salmonicida subsp. salmonicida SC18032201 by electronic transformation, to obtain the A. salmonicida vaccine carrier SC18032201-G, which expressed the G protein of IHNV as a polyvalent vaccine. …”
Get full text

Guidelines and variations in patterns of GnRH analogue use in castration-resistant prostate cancer across six countries by G. George, D. Enting, H. Garmo, P. Stattin, I.F. Lissbrant, M. Monroy-Iglesias, L.-M. Scailteux, F. Balusson, C. Van Praet, N. Lumen, G. Marvaso, G. Corrao, B.A. Jereczek-Fossa, L. Chehade, A. Shamseddine, M. Charafeddine, M. Van Hemelrijck

Get full text

Reflections and implementation strategies for constructing a standard system for deep coalbed methane exploration and exploitation by Xinjun CHEN, Zengqin LIU, Baojian SHEN, Shihu ZHAO, Jiaqi ZHANG, Jincheng YE

“…This leads to insufficient technical adaptability and pronounced risks of safety and environmental protection in the exploration and exploitation of deep CBM. MethodsThrough a systematic analysis of differences in geological and engineering characteristics between shallow and deep CBM, this study proposed a standard system framework following three dimensions (i.e., geological complexity, technical adaptability, and industrial and ecological collaboration) and four principles (scientific, systematic, practical, and dynamic natures). …”
Get full text

Meta-analyses of the effects of high-intensity interval training in elite athletes — part II: relationships between the mean effects on various performance measures by Hans-Peter Wiesinger, Hans-Peter Wiesinger, Hans-Peter Wiesinger, Will G. Hopkins, Nils Haller, Nils Haller, Julia Blumkaitis, Tilmann Strepp, Thomas Leonhard Stöggl, Thomas Leonhard Stöggl

“…There were substantial differences in time-trial speed/power between studies not explained by each predictor. …”
Get full text

Identification of patient endotypes and adalimumab treatment responders in axial spondyloarthritis using blood-derived extracellular matrix biomarkers by Anne Gitte Loft, Inge Juul Sørensen, Mikkel Østergaard, Susanne J Pedersen, Morten Asser Karsdal, Ole Rintek Madsen, Anne-C Bay-Jensen, Peder Frederiksen, Signe Holm Nielsen, Helena Port, Frederik Christiansen, Sengul Seven

“…Objective To explore the potential of a panel of ECM remodelling markers as endotyping tools for axial spondyloarthritis (axSpA) by separating patients into subtypes and investigate how they differ among each other in disease activity scores and response to treatment with adalimumab.Methods In three axSpA studies, a panel of 14 blood-based ECM biomarkers related to formation of collagen (PRO-C2, PRO-C3, PRO-C6), degradation of collagen by metalloproteinases (C1M, C2M, T2CM, C3M, C4M, C6M, C10C), matrix metalloproteinase (MMP)-degraded prolargin (PROM), MMP-degraded and citrullinated vimentin (VICM), basement membrane turnover (PRO-C4) and neutrophil activity (CPa9-HNE) were assessed to enable patient clustering (endotyping). …”
Get full text

Beliefs and perceptions of genetic testing by clinical, demographic, and health characteristics: A U.S.-based study utilizing the health information national trends (HINTS) survey by Pranali G. Patel, Marvin E. Langston, Justin X. Moore, Yunan Han, Marquita W. Lewis-Thames, Lindsay Fuzzell, Saira Khan

Get full text

Accuracy of a novel calibratable real-time continuous glucose monitoring device based on FreeStyle libre in- and out-of-hospital by Zhenghao Wu, Zhenghao Wu, Zhaoxiang Liu, Wenhui Zhao, Shaocheng Wang, Liangbiao Gu, Jianzhong Xiao

“…This study aim to validate the consistency and clinical accuracy of the product by comparing the capillary blood glucose (CBG) with CGM data in both in-hospital and outpatient scenarios.MethodsResults of CGM devices were compared with random capillary glucose values from users in both in-hospital and outpatient settings. …”
Get full text

Study of myelodysplastic features in patients with myelodysplastic syndromes by multicolor flow cytometry by O. Yu. Davydova, I. V. Galtseva, E. N. Parovichnikova, A. V. Kokhno, N. M. Kapranov, V. V. Troitskaya, E. A. Mikhailova, Z. T. Fidarova, T. N. Moiseeva, L. A. Kuzmina, E. A. Lukina, T. N. Obukhova, L. A. Grebenyuk, A. M. Kovrigina, V. N. Dvirnyk, V. G. Savchenko

“…Thus, cytometric abnormalities in MDS are common, even in patients without excess of blasts. The MFC method can be used as an additional diagnostic method in the initial diagnosis of MDS.…”
Get full text