Understanding the interests of academics from diverse disciplines to identify the prospective focus for a UK-based transdisciplinary network involving farm-to-fork stakeholders on... by K. Marie McIntyre, Maha Khan, Martha Betson, Lucy Brunton, Hernan Botero Degiovanni, Andrew P. Desbois, Mahmoud Eltholth, Paul Hurley, Lisa Morgans, John E. Pearl, Ruben Sakrabani, Orla Shortall, Katharina Watson, Jennifer Cole

“…An online survey determined prospective network focus, structure and priorities, with responses analysed using mixed methods.Survey results suggested respondents have interests in synthesising data using systems-approaches and using certain disciplines such as ‘social sciences’ within network activities. …”
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Historical overview, advancements, and future prospects of coalfield structure research in China by Daiyong CAO, Yiwen JU, Yucheng XIA, Bo JIANG, Shuzheng NING, Yingchun WEI, Anmin WANG, Xiaoming LI, Wenfeng ZHAN, Huantong LI, Lu WANG, Zhuocheng CAI

“…Amidst the ongoing energy structure optimization and the transformation and upgrading of coalfield geology in China, it is both practically and historically significant to review the history of coalfield structure research, summarize relevant experience, and contemplate future directions of the research under emerging circumstances.Methods Based on literature analysis, as well as the long-term research practices of the authors’ team, this study discusses the disciplinary attribute of coalfield structure research, reviews the history of this field both at home and abroad, and summarizes major achievements in China. …”
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An Overview of Patient-reported Outcomes for Men with Prostate Cancer: Results from the PIONEER Consortium by Sebastiaan Remmers, Katharina Beyer, Tariq A. Lalmahomed, Peter Prinsen, Nicole J.E. Horevoorts, Nora Tabea Sibert, Christoph Kowalski, Francesco Barletta, Oliver Brunckhorst, Giorgio Gandaglia, Jochem R.N. van der Voort van Zyp, Emma J. Smith, Andre Deschamps, Laurence Collette, Philip Cornford, Susan Evans-Axelsson, James N’Dow, Mieke Van Hemelrijck, Monique J. Roobol, Lionne D.F. Venderbos

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Cyclic activity of signal transduction pathways in fimbrial epithelium of the human fallopian tube by Phyllis van derPloeg, Aniek Uittenboogaard, Karlijn M. M. Bucks, Marjolein H. F. M. Lentjes‐Beer, Steven L. Bosch, Minouche M. E. vanRumste, M. Caroline Vos, Paul J. vanDiest, Sandrina Lambrechts, Anja van deStolpe, Ruud L. M. Bekkers, Jurgen M. J. Piek

“…Wnt pathway activity in postmenopausal patients was comparable to the late follicular and early luteal phase. We observed no differences in HH and TGF‐β pathway activity between pre‐ and postmenopausal samples. …”
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Cardiac myosin binding protein C correlate with cardiac troponin I during an exercise training program in patients with HFrEF by E. Riveland, A. Ushakova, T. Valborgland, T. Karlsen, H. Dalen, E. Prescott, T. Omland, A. Linke, M. Halle, M. Marber, Ø. Ellingsen, A.I. Larsen, the SMARTEX‐HF Study Group

“…Due to non‐normal distribution, cMyC and hs‐cTnI measurements were log‐transformed. A Bland–Altman plot was employed to evaluate the agreement of cMyC with hs‐cTnI measurements. …”
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Prognostic Role of Tumour Stroma Ratio in Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis: A Retrospective Study by Pradeep Veerappan, Reshma Poothakulath Krishnan, Deepak Pandiar, Pratibha Ramani, Selvaraj Jayaraman

“…Introduction: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder with an increased risk of malignant transformation. Oral Squamous Cell Carcinoma (OSCC) arising in the background of OSMF shows distinct clinical presentation and behaviour. …”
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Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…Although no significant difference in overall survival was observed (HR = 0.44, 95% CI = 0.16–1.18, p = 0.11, 10-year OS 95% vs. 84%), patients receiving IFRT+(R)CVP experienced fewer composite (histological transformation and death) events (p = 0.045). …”
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An open-label phase I comparator-controlled clinical trial to assess tolerability and pharmacokinetics of IHL-675 A a fixed dose combination of cannabidiol plus hydroxychloroquine... by George Williams Mbogo, Pia Kroner, Rosemarie Walsh, Jonathan Newchurch, Mark Robert Bleackley

“…Plasma concentrations of CBD, HCQ and their major metabolites, 7-OH-CBD, and 7-COOH-CBD, and desethylhydroxychloroquine (DHCQ), desethylchloroquine (DCQ), and bisdesethylhydroxy-chloroquine (BDCQ) were assessed at predefined timepoints across the monitoring period and PK parameters were determined and compared between treatments using noncompartmental methods and analysis of variance (ANOVA) of log-transformed values exposure PK parameters. …”
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Antirotavirus IgA seroconversion rates in children who receive concomitant oral poliovirus vaccine: A secondary, pooled analysis of Phase II and III trial data from 33 countries. by Julia M Baker, Jacqueline E Tate, Juan Leon, Michael J Haber, Benjamin A Lopman

“…Mixed-effect logistic regression and mixed-effect linear regression of log-transformed data were used to identify individual- and country-level predictors of seroconversion (dichotomous) and antibody titer (continuous), respectively. …”
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Identifying Adverse Events in Outpatients With Prostate Cancer Using Pharmaceutical Care Records in Community Pharmacies: Application of Named Entity Recognition by Yuki Yanagisawa, Satoshi Watabe, Sakura Yokoyama, Kyoko Sayama, Hayato Kizaki, Masami Tsuchiya, Shungo Imai, Mitsuhiro Someya, Ryoo Taniguchi, Shuntaro Yada, Eiji Aramaki, Satoko Hori

“…Additionally, the study sought to determine whether outpatient pharmacotherapy monitoring can be enhanced by using NER to systematically collect AEs from pharmaceutical care records. MethodsWe used an NER system based on the widely used Japanese medical term extraction system MedNER-CR-JA, which uses Bidirectional Encoder Representations from Transformers (BERT). …”
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Challenges to creating primary care teams in a public sector health centre: a co-operative inquiry by Bob Mash, Pat Mayers, Hoffie Conradie, Abraham Orayn, Marjan Kuiper, Joey Marais, Bennie Cornelissen, Shaamelah Titus

“…Conclusion Key lessons learnt included the need to engage with a transformational leadership style, to foster dialogical openness in the planning process and to address differences in understanding of roles and responsibilities between the doctors and the CNPs. …”
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Association Between Vitamin D Status and Insulin Resistance in Adolescents: A Cross-sectional Observational Study by GUO Xiaoyuan, WANG Yutong, ZHOU Zhibo, CHEN Shi, ZHANG Mei, BAN Bo, LI Ping, ZHANG Xinran, ZHANG Qiuping, YANG Kai, YANG Hongbo, DU Hanze, PAN Hui

“…ObjectiveTo investigate the correlation between vitamin D nutritional status and insulin resistance in pubertal adolescents.MethodsThis cross-sectional observational study employed convenience sampling to recruit 2021-grade(8th grade) students from Jining No.7 Middle School in Shandong Province on June 5, 2023. …”
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PD-1/PD-L1 inhibitors monotherapy vs. combination therapy in elderly advanced NSCLC: a real-world study and nomogram for survival prognosis by Yunye Mao, An Wang, Xiangwei Ge, Jinzhao Zhai, Yi Hu, Jinliang Wang

“…Abstract Background Immunotherapy with PD-1/PD-L1 inhibitors has transformed advanced non-small cell lung cancer (NSCLC) treatment, yet optimal strategies for elderly patients remain uncertain. …”
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Content of Some Endothotelium-Dependent Vasoactive Substances in the Blood of Patients, Depending on the Liver Cirrhosis Severity and the Organism’s Redox System State by Abrahamovych M., Abrahamovych O., Fayura O., Tolopko S., Ferko M.

“…It is known that liver cirrhosis (LC) is a chronic diffuse liver disease, the severity of which is manifested by the restructuring of its parenchyma in the form of nodular transformation and fibrosis due to necrosis of hepatocytes, the appearance of shunts between the portal and central veins and liver failure. …”
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Diagnostic value of serum TGF-β1 and CysC in type 2 diabetic kidney disease: a cross-sectional study by Yi Kang, Yi Kang, Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Huijuan Zheng, Xiaobin Li, Aoshuang Li, Aoshuang Li, Jing Wei Zhou, Jing Wei Zhou, Jie Lv, Jie Lv, Yaoxian Wang, Yaoxian Wang

“…This study aims to investigate the diagnostic value of transforming growth factor-β1 (TGF-β1) and cystatin C (CysC) in DKD patients.MethodsA total of 126 patients with type 2 diabetes mellitus (T2DM) diagnosed at Dongzhimen Hospital, Beijing University of Chinese Medicine, between May 2021 and March 2023 were enrolled. …”
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EDA1 variants inhibit the odontogenic differentiation and proliferation of human dental pulp stem cells by Yulin Ding, Genqi Lu, Ya Zhao, Yi Zhang, Jing Zhang, Jingle Ma, Yunyun Yuan, Boyu Liu, Wei Liu, Wenjing Shen

“…Further study of these variants could reveal the mechanism by which EDA1 induces tooth development. Methods The following groups of hDPSCs were studied: those expressing wild-type (Wt) EDA1, those expressing EDA1 non-syndromic tooth agenesis (NSTA) variants (NSTA-A259E, NSTA-S374R), those expressing a syndrome type (STA) variant of EDA1 (STA-H252L), and those transformed with the empty vector (NC, negative control). hDPSCs proliferation was assessed using Cell Counting kit 8 assays. …”
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Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…However, DASC’s novel, spectrum-focused approach offers a transformative tool for antibiotic stewardship, supporting targeted de-escalation and improved benchmarking. …”
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Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…This suggests that SH3BP1 may promote tumor proliferation and migration in colorectal cancer and offers the opportunity to be used as a therapeutic target.ConclusionThe large differences between single nucleotide mutations and insertion-deletion mutations in somatic cells and germ line cells indicate the large changes in the genome, especially in the non-coding region genome, during the transformation of normal tissue adjacent to cancer into cancerous tissue. …”
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Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review by Brittany J. Johnson, Paul M. Chadwick, Samantha Pryde, Anna Lene Seidler, Kylie E. Hunter, Mason Aberoumand, Jonathan G. Williams, Hei In Lau, Sol Libesman, Jannik Aagerup, Angie Barba, Louise A. Baur, Samantha Morgillo, Lee Sanders, Sarah Taki, Kylie D. Hesketh, Karen Campbell, Alexandra Manson, Alison Hayes, Angela Webster, Charles Wood, Denise A. O’Connor, Karen Matvienko-Sikar, Kristy Robledo, Lisa Askie, Luke Wolfenden, Rachael Taylor, H. Shonna Yin, Vicki Brown, Alexander Fiks, Alison Ventura, Ata Ghaderi, Barry J. Taylor, Cathleen Stough, Christine Helle, Cristina Palacios, Eliana M. Perrin, Elizabeth Reifsnider, Finn Rasmussen, Ian M. Paul, Jennifer S. Savage, Jessica Thomson, Jinan Banna, Junilla Larsen, Kaumudi Joshipura, Ken K. Ong, Levie Karssen, Li Ming Wen, Márcia Vitolo, Margrethe Røed, Maria Bryant, Maribel Campos Rivera, Mary Jo Messito, Natalia Golova, Nina Cecilie Øverby, Rachel Gross, Rajalakshmi Lakshman, Rebecca Byrne, Russell L. Rothman, Sharleen O’Reilly, Stephanie Anzman-Frasca, Vera Verbestel, Claudio Maffeis, Kayla de la Haye, Sarah-Jeanne Salvy, Seema Mihrshahi, Janani Ramachandran, Paola Seffrin Baratto, Rebecca K. Golley, on behalf of the TOPCHILD Collaboration

“…We aimed to 1) systematically characterise the target behaviours, delivery features, and Behaviour Change Techniques (BCTs) used in interventions in the international Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration, and 2) explore similarities and differences in BCTs used in interventions by target behaviour domains. …”
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Piloting a team-based telemedicine care for hypertension focused on Black patients by Srista Manandhar, Sunit Chhetri, Danielle Sutton, Animita C. Saha, Suneet Kaur, Josh Brown, Jeff Williamson, Kathryn E. Callahan, Justin B. Moore, Yhenneko J. Taylor, Hayden B. Bosworth, Yashashwi Pokharel

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