Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism by Ielizaveta Gorodetska, Vasyl Lukiyanchuk, Marta Gawin, Myroslava Sliusar, Annett Linge, Fabian Lohaus, Tobias Hölscher, Kati Erdmann, Susanne Fuessel, Angelika Borkowetz, Anna Wojakowska, Daniel Fochtman, Mark Reardon, Ananya Choudhury, Yasmin Antonelli, Aldo Leal-Egaña, Ayse Sedef Köseer, Uğur Kahya, Jakob Püschel, Andrea Petzold, Daria Klusa, Claudia Peitzsch, Romy Kronstein-Wiedemann, Torsten Tonn, Lukasz Marczak, Christian Thomas, Piotr Widłak, Monika Pietrowska, Mechthild Krause, Anna Dubrovska

“…Still, the exact mechanisms mediating the role of these proteins in PCa metastatic dissemination remain not fully understood, and plasma-based biomarkers of these metastatic mechanisms are not available. Methods Genetic silencing, gene overexpression, or treatment with different concentrations of the retinoic acid (RA) isomers, which are the products of ALDH catalytic activity, were used to modulate the interplay between retinoic acid receptors (RARs) and androgen receptor (AR). …”
Get full text

Basic research on CVD single crystal diamond processing by UV nanosecond laser by Huabin ZHAN, Kaixuan FENG, Yupeng CHEN, Jing LI, Jiawei WEI, Jianhui CHEN, Qi HAO, Changwei WAN, Ni CHEN

“…Changes in the model are observed by varying different combinations of parameters, and the processing law is predicted and verified by combining with the actual line etching test. …”
Get full text

Political Order and Nomadic Life in Iran: From the Afsharid Period to the End of the Qajar Dynasty by Shahram Gholami, Siavash Gholipour

“…The resulting insecurity prompted a transformation in village morphology, evolving into more complex structures resembling castles. …”
Get full text

Identifying Factors Affecting Self-Development of Iranian TV School Teachers: Report of A Qualitative Study by abbas mohammadi, maede arshadrad

“…The validity of the research findings was confirmed through three methods: member checking, triangulation of data sources, and analysis of negative/deviant cases. …”
Get full text

Global, regional and national burden of bladder cancer and its attributable risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of... by Jasvinder A Singh, Vesna Zadnik, Mohammad Ali Mansournia, Alessandra Lugo, Silvano Gallus, Amir Almasi-Hashiani, Saeid Safiri, Mahdi Sepidarkish, Mohsen Naghavi, Fares Alahdab, Félix Carvalho, Lalit Dandona, Rakhi Dandona, Farshad Farzadfar, Eduarda Fernandes, Irina Filip, Samer Hamidi, Simon I Hay, Reza Malekzadeh, Tomislav Mestrovic, Shafiu Mohammed, Ali H Mokdad, Lorenzo Monasta, Huong Lan Thi Nguyen, Amir Radfar, Alireza Rafiei, Gholamreza Roshandel, Khanh Bao Tran, Ahmad Ghashghaee, Giuseppe Gorini, Mariam Molokhia, Ahad Ashrafi-Asgarabad, Salman Rawaf, Dejana Braithwaite, Nicholas L S Roberts, Vahid Alipour, Jalal Arabloo, Ali Bijani, Mowafa Househ, Olayinka Stephen Ilesanmi, Bartosz Miazgowski, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Cuong Tat Nguyen, Navid Rabiee, David Laith Rawaf, Abdallah M Samy, Sadaf G Sepanlou, Bach Xuan Tran, Zhi-Jiang Zhang, Giulia Carreras, Masood Ali Shaikh, Hai Quang Pham, Faris Hasan Lami, Stanislav S Otstavnov, Rajan Nikbakhsh, Roman Topor-Madry, G Anil Kumar, Tone Bjørge, Nima Hafezi-Nejad, Dinh-Toi Chu, Farahnaz Joukar, Mukhammad David Naimzada, Ali-Asghar Kolahi, Amir Abdoli, Atif Amin Baig, Mansour Ghafourifard, Soheil Hassanipour, Segun Emmanuel Ibitoye, Milena D Ilic, Carlo La Vecchia, Masoud Moghadaszadeh, Priya Rathi, Feng Sha, Maryam Zamanian, Mahaveer Golechha, Shailesh M Advani, Akshaya Srikanth Bhagavathula, Artem Alekseevich Fomenkov, Rahmatollah Moradzadeh, Mariya Vladimirovna Titova, Yohannes Tekalegn, Xiaochen Dai, Yonas Getaye Tefera, Bingyu Li, Iman El Sayed, Seyed Aria Nejadghaderi, Mark J M Sullman, Eman Abu-Gharbieh, Erfan Amini, Etsay Woldu Anbesu, Jason A Anderson, Atalel Fentahun Awedew, Antonio Biondi, Florentino Luciano Caetano dos Santos, Kelly Compton, Vera Marisa Costa, Meseret Derbew Molla, Abebaw Alemayehu Desta, Mostafa Dianatinasab, Hedyeh Ebrahimi, Sahar Eftekharzadeh, Babak Eshrati, Berhanu Elfu Feleke, Kebebe Bekele Gonfa, James D Harvey, Hannah Jacqueline Henrikson, Irena M Ilic, Seyedeh-Sanam Ladi-Seyedian, Iván Landires, Irmina Maria Michalek, Osama Mohamad, Behnam Nabavizadeh, Mohammad Reza Nowroozi, Virginia Nuñez-Samudio, Majid Pirestani, Faheem Hyder Pottoo, Nima Rezaei, Sara Sheikhbahaei, Sudeep K Siddappa Malleshappa, Emma Elizabeth Spurlock, Eyayou Girma Tadesse, Eugenio Traini, Ravensara S Travillian, Marco Vacante, Rixing Xu, Yordanos Gizachew Yeshitila

“…Introduction The current study determined the level and trends associated with the incidence, death and disability rates for bladder cancer and its attributable risk factors in 204 countries and territories, from 1990 to 2019, by age, sex and sociodemographic index (SDI; a composite measure of sociodemographic factors).Methods Various data sources from different countries, including vital registration and cancer registries were used to generate estimates. …”
Get full text

Unlocking ecological insights from sub‐seasonal visible‐to‐shortwave infrared imaging spectroscopy: The SHIFT campaign by K. Dana Chadwick, Frank Davis, Kimberley R. Miner, Ryan Pavlick, Mark Reynolds, Philip A. Townsend, Philip G. Brodrick, Christiana Ade, Jean Allen, Leander Anderegg, Yoseline Angel, Indra Boving, Kristin B. Byrd, Petya Campbell, Luke Carberry, Katherine C. Cavanaugh, Kyle C. Cavanaugh, Kelly Easterday, Regina Eckert, Michelle Gierach, Kaitlin Gold, Erin Hestir, Fred Huemmrich, Maggie Klope, Raymond F Kokaly, Piper Lovegreen, Kelly Luis, Conor McMahon, Nicholas Nidzieko, Francisco Ochoa, Anna Jiselle Ongjoco, Elsa Ordway, Madeleine Pascolini‐Campbell, Natalie Queally, Dar A. Roberts, Clare M. Saiki, Fabian D. Schneider, Alexey N. Shiklomanov, Germán D. Silva, Jordan Snyder, Michele Thornton, Anna T. Trugman, Nidhi Vinod, Ting Zheng, Dulcinea M. Avouris, Brianna Baker, Latha Baskaran, Tom Bell, Megan Berg, Michael Bernas, Niklas Bohn, Renato K. Braghiere, Zach Breuer, Andrew J. Brooks, Nolan Burkard, Julia Burmistrova, Kerry Cawse‐Nicholson, John Chapman, Johana Chazaro‐Haraksin, Joel Cryer, K. C. Cushman, Kyla Dahlin, Phuong D. Dao, Athena DiBartolo, Michael Eastwood, Clayton D. Elder, Angela Giordani, Kathleen Grant, Robert O. Green, Alexa Hanson, Brendan Heberlein, Mark Helmlinger, Simon Hook, Daniel Jensen, Emma Johnson, Marie Johnson, Michael Kiper, Christopher Kibler, Jennifer Y. King, Kyle R. Kovach, Aaron Kreisberg, Daniel Lacey, Evan Lang, Christine Lee, Amanda M. Lopez, Brittany Lopez Barreto, Andrew Maguire, Elliott Marsh, Charles Miller, Dieu My T. Nguyen, Cassandra Nickles, Jonathan P. Ocón, Elijah P. Papen, Maria Park, Benjamin Poulter, Ann Raiho, Porter Reim, Timothy H. Robinson, Fernando E. Romero Galvan, Ethan Shafron, Brenen R. Skalitzky, Sydney Stroschein, Niky C. Taylor, David R. Thompson, Kate Thompson, Cecily Tye, Joelie Van Beek, Cecilia Vanden Heuvel, Jonathan Vellanoweth, Evert Vermeer, Claire Villanueva‐Weeks, Kristen Zumdahl, David Schimel

“…Abstract We stand at the threshold of a transformative era in Earth observation, marked by space‐borne visible‐to‐shortwave infrared (VSWIR) imaging spectrometers that promise consistent global observations of ecosystem function, phenology, and inter‐ and intra‐annual change. …”
Get full text

Professionalisation and governance in sports organisations: towards an integrated understanding by Raphael Stieger, Siegfried Nagel, Grazia Lang

“…Fifth, the analysis showed different forms of professionalising governance structures and processes. …”
Get full text

Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Analysis showed the differences detected occurred in entities known to produce differences in interpretation between pathologists. …”
Get full text

How does reorganisation in child and adolescent mental health services affect access to services? An observational study of two services in England. by Mina Fazel, Stephen Rocks, Margaret Glogowska, Melissa Stepney, Apostolos Tsiachristas

“…<h4>Methods</h4>A mixed-methods observational study was conducted to explore the process and impact of transformation over four years in two services. …”
Get full text

A study on land use change simulation based on PLUS model and the U-net structure: A case study of Jilin Province by Jiafu Liu, Xiangli Kong, Yue Zhu, Baihao Zhang

“…By comparing the performance of the two methods in land use change prediction, this study reveals the divergent characteristics of the two approaches in capturing complex transformation patterns. …”
Get full text

A telehealth-delivered intervention to extend the veteran HIV treatment cascade for cardiovascular disease prevention: V-EXTRA-CVD study protocol for a randomized controlled trial by Lewis Musoke, Hayden B. Bosworth, Christina Dickson, Pamela Gentry, Elizabeth Strawbridge, Soumya Subramaniam, Jennifer Gierisch, Valerie Smith, Sandra Woolson, John Pura, Willington Amutuhaire, Susanna Naggie, Julie Schexnayder, Karen Hall, Chris T. Longenecker, Nadine M. Harris, Chantrice Rogers, Puja Van Epps, for V-EXTRA-CVD Group

Get full text

Analysis of Cluster Co3MoS Isomerization Conversion by WANG Zhi-yao, FANG Zhi-gang, QIN Yu, WU Ting-hui, Lv Meng-na, ZHENG Xin-xi

“…And the clusters was analyzed by applying thermodynamic and chemical kinetic methods. The results show that each isomerization reaction of cluster Co3MoS is mainly in the forward reaction direction, and TS3(2)→1(4)isomerization reaction is the easiest to be transformed, TS2(4)→1(2) reaction is the most difficult to be transformed, and the configurations 1(4), 1(2), 2(4), 2(2), 3(4), 3(2) can be steadily existed; the 3(2)→1(4) isomerization reaction is the most radically transformed, which limit is the largest than the other isomerization processes, the 2(4)→1(2) reaction consumes the most activation energy in the process of transformation, which is the least radical transformation; we find a link between equilibrium constants and thermodynamic stability of reactants and products; the isomerization reaction of the cluster Co3MoS can be predicted by the functional equation of energy difference and equilibrium constant, the integral form of the van't Hoff equation, and the Gibbs function.…”
Get full text

ROBO-ADVISORS AND AI-DRIVEN FUNDS: CATALYSTS IN THE DYNAMIC EVOLUTION OF ASSET MANAGEMENT by Amirul Ammar Anuar, Mohammad Taqiuddin Mohamad, Ahmad Azam Sulaiman @ Mohamad

“…AI adoption varies among asset management companies (AMCs), with differing levels of integration. This transformation has supplanted traditional unit trust consultants (UTCs) with robo-advisors and human fund managers with AI-driven funds. …”
Get full text

AN ANALYSIS OF INFLUENCE OF ECONOMIC MENTALITY IS ON ECONOMIC DEVELOPMENT OF COUNTRY: CROSS-CORRELATION REGRESSIVE APPROACH by Z. Halushka, O. Luste

“…The article defines the role of economic mentality as an important factor of social and economic transformation, analyses methods for analyzing mental differences, carried correlation-regression analysis based on mental characteristics and indicators of social economic development, outlines the prospects for further research this issue.…”
Get full text

AN ANALYSIS OF INFLUENCE OF ECONOMIC MENTALITY IS ON ECONOMIC DEVELOPMENT OF COUNTRY: CROSS-CORRELATION REGRESSIVE APPROACH by Z. Halushka, O. Luste

“…The article defines the role of economic mentality as an important factor of social and economic transformation, analyses methods for analyzing mental differences, carried correlation-regression analysis based on mental characteristics and indicators of social economic development, outlines the prospects for further research this issue.…”
Get full text

Statistical analysis plan for the 24-week randomised trial of hypoglycaemia prevention, awareness of symptoms, and treatment: HypoPAST by Sharmala Thuraisingam, Jennifer A. Halliday, Uffe Søholm, Elizabeth Holmes-Truscott, Christel Hendrieckx, Timothy C. Skinner, Vincent L. Versace, Jane Speight

Get full text

Dynamic evolution of innovation efficiency of China’s new energy enterprises by Tian Zhao, Meilu Sun, Jiangxiang Zhang

“…This study examines spatiotemporal patterns and drivers from 2015–2023.MethodsInnovation efficiency was measured via SFA model, differentiating R&amp;D and transformation phases. σ- and β-convergence tracked disparities and catch-up dynamics. …”
Get full text

DiffMamba: semantic diffusion guided feature modeling network for semantic segmentation of remote sensing images by Zhen Wang, Nan Xu, Zhuhong You, Shanwen Zhang

“…SDAM utilizes the diffusion propagation process to fuse local and global information, alleviating the feature redundancy caused by semantic information differences. CAMamba employs state space transformation to construct the correlation of enhanced local features, and guides the model to achieve feature decoding to obtain refined semantic segmentation results. …”
Get full text

Machine learning models in evaluating the malignancy risk of ovarian tumors: a comparative study by Xin He, Xiang-Hui Bai, Hui Chen, Wei-Wei Feng

“…There was a statistically significant difference between the Vision Transformer and SA, and between the Vision Transformer and Swin Transformer models (AUC: 0.87 vs. 0.97, P = 0.01; AUC: 0.87 vs. 0.92, P = 0.04). …”
Get full text

Restoring Authenticity: Literary, Linguistic, and Computational Study of the Manuscripts of Tchaikovsky’s <i>Children’s Album</i> by Evgeny Pyshkin, John Blake

“…This research contributes to the studies on the origins and transformations of Tchaikovsky’s <i>Children’s Album,</i> Op. 39 using the linguistic methods of discourse, metaphor, and comparative analysis to explore a number of connected questions and their impact on how the audiences and scholars perceive and understand the compositions. …”
Get full text