Exploring potential therapeutic targets for colorectal tumors based on whole genome sequencing of colorectal tumors and paracancerous tissues by Yufan Sheng, Sen Niu, Da Li, Chunyuan Meng, Tong Wang

“…This suggests that SH3BP1 may promote tumor proliferation and migration in colorectal cancer and offers the opportunity to be used as a therapeutic target.ConclusionThe large differences between single nucleotide mutations and insertion-deletion mutations in somatic cells and germ line cells indicate the large changes in the genome, especially in the non-coding region genome, during the transformation of normal tissue adjacent to cancer into cancerous tissue. …”
Get full text

Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Work package 2: optimising care for patients with dementia and hip fracture We used an action research approach, with a mixed-methods case study design to study implementation on an orthopaedic ward in each of three hospitals, using a series of plan, do, study, act (PDSA) cycles. …”
Get full text

Effect of tool angle in nanocutting of single crystal GaN using diamond cutter by Yongqiang WANG, Hao XIA, Zhihang HU, Shuaiyang ZHANG, Shaohui YIN

“…MethodsTo achieve these objectives, a rigorous multi-scale investigation is conducted, combining molecular dynamics simulation with experimental verification. …”
Get full text

Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Analysis showed the differences detected occurred in entities known to produce differences in interpretation between pathologists. …”
Get full text

Rural Landscape Characters and Spatial Correlation Mechanism in the Tiaoxi River – Canal Basin in Zhejiang Province by Lin ZHANG, You ZUO, Binyi LIU

“…And significant region − basin differences are explored from the perspectives of spatial proportion, layout pattern, and coupling relationship. …”
Get full text

Adjuvant rituximab and elevated intratumoural CD8 expression are associated with sustained disease control after radiotherapy in a randomised trial of systemic therapy in early-sta... by Michael P. MacManus, John F. Seymour, Hennes Tsang, Richard Fisher, Colm Keane, Muhammed B. Sabdia, Soi C. Law, Jay Gunawardana, Karthik Nath, Stephen H. Kazakoff, Mario L. Marques-Piubelli, Daniela E. Duenas, Michael R. Green, Daniel Roos, Peter O'Brien, Andrew McCann, Richard Tsang, Sidney Davis, David Christie, Chan Cheah, Benhur Amanuel, Tara Cochrane, Jason Butler, Anna Johnston, Mohamed Shanavas, Li Li, Claire Vajdic, Robert Kridel, Victoria Shelton, Samantha Hershenfield, Tara Baetz, David Lebrun, Nathalie Johnson, Marianne Brodtkorb, Maja Ludvigsen, Francesco d’Amore, Ella R. Thompson, Piers Blombery, Maher K. Gandhi, Joshua W.D. Tobin

“…Although no significant difference in overall survival was observed (HR = 0.44, 95% CI = 0.16–1.18, p = 0.11, 10-year OS 95% vs. 84%), patients receiving IFRT+(R)CVP experienced fewer composite (histological transformation and death) events (p = 0.045). …”
Get full text

Efficacy and Safety of Afatinib Plus Bevacizumab as First‐Line Treatment for Advanced NSCLC Patients With Epidermal Growth Factor Receptor (EGFR) Mutations: A Multicenter, Phase II... by Huiyang Shi, Miaohan Wang, Junling Li, Shi Jin, Minglei Zhuo, Jun Zhao, Hongxia Zhang, Meng Yang, Qingfang Shi, Haifeng Qin, Guilan Dong, Dongmei Lan, Zhong Dai, Yu Feng, Haohua Zhu, Jingyu Lu, Kai Zhu, Yuankai Shi, Xingsheng Hu

Get full text

Unpacking the behavioural components and delivery features of early childhood obesity prevention interventions in the TOPCHILD Collaboration: a systematic review and intervention c... by Finn Rasmussen, Hein Raat, Cristina Palacios, Barry J Taylor, Lisa Askie, Alison Hayes, Karen Campbell, Wendy Smith, Luke Wolfenden, Sharleen O’Reilly, Eva Corpeleijn, Maria Bryant, Chris Rissel, Denise O’Connor, Paul Chadwick, Jessica Thomson, Anna Lene Seidler, Kylie E Hunter, Ian Paul, Rachael W Taylor, Angie Barba, Kristy Robledo, Ken Ong, Carolina González Acero, Kylie D Hesketh, Rebecca K Golley, Denise A O'Connor, David Espinoza, Sarah Taki, Rachael Taylor, Louise A Baur, Li Ming Wen, Seema Mihrshahi, Emily Oken, Barry Taylor, Ian Marschner, Junilla K Larsen, Kylie Hesketh, Rajalakshmi Lakshman, Amanda L Thompson, Sharleen L O'Reilly, Charles Wood, Alison J Hayes, Kaumudi Joshipura, Lynne Daniels, Alison Karasz, Rebecca Golley, Kaumudi J Joshipura, Nina Cecilie Øverby, Brittany J Johnson, Mason Aberoumand, Sol Libesman, Kristy P Robledo, Charles T Wood, Lukas P Staub, Michelle Sue-See, Ian C Marschner, Jessica L Thomson, Vera Verbestel, Cathleen Odar Stough, Sarah-Jeanne Salvy, Levie T Karssen, Finn E Rasmussen, Mary Jo Messito, Rachel S Gross, Ian M Paul, Ana M Linares, Heather M Wasser, Claudio Maffeis, Ata Ghaderi, Jinan C Banna, Maribel Campos Rivera, Ana B Pérez-Expósito, Jennifer S Savage, Margrethe Røed, Michael Goran, Kayla de la Haye, Stephanie Anzman-Frasca, Kylie Hunter, Brittany Johnson, Louise Baur, Lukas Staub, Shonna Yin, Lee Sanders, Amanda Thompson, Ana Maria Linares, Ana Perez Exposito, Carolina González Acero, Cathleen Odar Stough, Christine Helle, Eliana Perrin, Heather Wasser, Jennifer Savage, Jinan Banna, Junilla Larsen, Kayla dela Haye, Levie Karssen, Maribel Campos Rivera, Nina Øverby, Rachel Gross, Russell Rothman

“…This study aims to (1) characterise early obesity prevention interventions in terms of target behaviours, delivery features and behaviour change techniques (BCTs), (2) explore similarities and differences in BCTs used to target behaviours and (3) explore effectiveness of intervention components in preventing childhood obesity.Methods and analysis Annual comprehensive systematic searches will be performed in Epub Ahead of Print/MEDLINE, Embase, Cochrane (CENTRAL), CINAHL, PsycINFO, as well as clinical trial registries. …”
Get full text

Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review by Brittany J. Johnson, Paul M. Chadwick, Samantha Pryde, Anna Lene Seidler, Kylie E. Hunter, Mason Aberoumand, Jonathan G. Williams, Hei In Lau, Sol Libesman, Jannik Aagerup, Angie Barba, Louise A. Baur, Samantha Morgillo, Lee Sanders, Sarah Taki, Kylie D. Hesketh, Karen Campbell, Alexandra Manson, Alison Hayes, Angela Webster, Charles Wood, Denise A. O’Connor, Karen Matvienko-Sikar, Kristy Robledo, Lisa Askie, Luke Wolfenden, Rachael Taylor, H. Shonna Yin, Vicki Brown, Alexander Fiks, Alison Ventura, Ata Ghaderi, Barry J. Taylor, Cathleen Stough, Christine Helle, Cristina Palacios, Eliana M. Perrin, Elizabeth Reifsnider, Finn Rasmussen, Ian M. Paul, Jennifer S. Savage, Jessica Thomson, Jinan Banna, Junilla Larsen, Kaumudi Joshipura, Ken K. Ong, Levie Karssen, Li Ming Wen, Márcia Vitolo, Margrethe Røed, Maria Bryant, Maribel Campos Rivera, Mary Jo Messito, Natalia Golova, Nina Cecilie Øverby, Rachel Gross, Rajalakshmi Lakshman, Rebecca Byrne, Russell L. Rothman, Sharleen O’Reilly, Stephanie Anzman-Frasca, Vera Verbestel, Claudio Maffeis, Kayla de la Haye, Sarah-Jeanne Salvy, Seema Mihrshahi, Janani Ramachandran, Paola Seffrin Baratto, Rebecca K. Golley, on behalf of the TOPCHILD Collaboration

“…We aimed to 1) systematically characterise the target behaviours, delivery features, and Behaviour Change Techniques (BCTs) used in interventions in the international Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration, and 2) explore similarities and differences in BCTs used in interventions by target behaviour domains. …”
Get full text

Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context by Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala

“…Summary: Background: Although terminal complement inhibitors transformed the prognosis of atypical haemolytic uraemic syndrome (aHUS) from dismal to favourable, treatment approaches vary due to the intermittent disease nature and high costs. …”
Get full text

The Effectiveness of Psychological Well-Being Training based on the PERMA Model for 14 to 16-Year-Old Girls with Anxiety Symptoms Zahra Daneshian: M.A. Student of Child and Adoles... by zahra danesian, Shahriar Shahidi, Saeed Ghanbari

“…Each pillar contributes to overall happiness and fulfillment, emphasizing the importance of personal strengths and resilience (Seligman, 2011). MethodsThe study employed a quasi-experimental design with pre-test, post-test, and follow-up phases, targeting 9th and 10th-grade female students in Tehran. …”
Get full text

Analyse multidimensionnelle de contenus des réseaux sociaux : stratégies, calcul et visualisation d’indicateurs pour le tourisme by Maxime Masson, Rodrigo Agerri, Christian Sallaberry, Marie-Noelle Bessagnet, Philippe Roose, Annig Le Parc Lacayrelle

“…Les expérimentations menées sur ce jeu de données suggèrent la possibilité d’appliquer les méthodes de TALN à base d’apprentissage à divers domaines, tout en réduisant le besoin d’annotations manuelles et évitant les complexités des méthodes basées sur des règles. …”
Get full text

Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…Contextual vulnerability is an important consideration in reviewing proposed subject selection methods. Some recipients are uniquely prone to receiving an unfair offer to enroll in an experimental clinical trial when excluded from allograft waitlists due to psychosocial or compliance evaluations. …”
Get full text

Forecasting and Evaluation of Ecosystem Services Supply-Demand Under SSP-RCP Scenarios in the Henan Segment of the Yellow River Basin, China by Chaokun Wang, Yujie Chang, Benxin Guo, Pengfei Liu

“…As a result, there is an imperative necessity to methodically evaluate and predict these alterations by including both social and environmental elements. …”
Get full text

Caractérisation d'une modification éventuelle de la relation pluie-débit en Afrique de l'Ouest : cas du bassin versant du N'zi (Bandama) en Côte d'Ivoire, Thèse de Doctorat, Univer... by Amani Michel Kouassi

“…L'objectif de ce travail est d'identifier des tendances au sein de la relation pluie-débit et d'étudier ses impacts sur les ressources en eau du bassin versant du N'zi (Bandama) dans un contexte de variabilité hydroclimatique et de modification de l'occupation du sol. Les résultats des différentes méthodes statistiques appliquées aux séries chronologiques de variables caractéristiques du régime pluviométrique et hydrométrique montrent que globalement sur le bassin versant du N'zi (Bandama), ces variables sont en baisse depuis les années 1970. …”
Get full text