Diagnostic value of serum TGF-β1 and CysC in type 2 diabetic kidney disease: a cross-sectional study by Yi Kang, Yi Kang, Yi Kang, Qian Jin, Mengqi Zhou, Huijuan Zheng, Huijuan Zheng, Xiaobin Li, Aoshuang Li, Aoshuang Li, Jing Wei Zhou, Jing Wei Zhou, Jie Lv, Jie Lv, Yaoxian Wang, Yaoxian Wang

“…This study aims to investigate the diagnostic value of transforming growth factor-β1 (TGF-β1) and cystatin C (CysC) in DKD patients.MethodsA total of 126 patients with type 2 diabetes mellitus (T2DM) diagnosed at Dongzhimen Hospital, Beijing University of Chinese Medicine, between May 2021 and March 2023 were enrolled. …”
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EDA1 variants inhibit the odontogenic differentiation and proliferation of human dental pulp stem cells by Yulin Ding, Genqi Lu, Ya Zhao, Yi Zhang, Jing Zhang, Jingle Ma, Yunyun Yuan, Boyu Liu, Wei Liu, Wenjing Shen

“…Further study of these variants could reveal the mechanism by which EDA1 induces tooth development. Methods The following groups of hDPSCs were studied: those expressing wild-type (Wt) EDA1, those expressing EDA1 non-syndromic tooth agenesis (NSTA) variants (NSTA-A259E, NSTA-S374R), those expressing a syndrome type (STA) variant of EDA1 (STA-H252L), and those transformed with the empty vector (NC, negative control). hDPSCs proliferation was assessed using Cell Counting kit 8 assays. …”
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Piloting a team-based telemedicine care for hypertension focused on Black patients by Srista Manandhar, Sunit Chhetri, Danielle Sutton, Animita C. Saha, Suneet Kaur, Josh Brown, Jeff Williamson, Kathryn E. Callahan, Justin B. Moore, Yhenneko J. Taylor, Hayden B. Bosworth, Yashashwi Pokharel

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Cerebral microvascular density, blood-brain barrier permeability, and support for neuroinflammation indicate early aging in a Marfan syndrome mouse model by Tala Curry-Koski, Tala Curry-Koski, Liam P. Curtin, Mitra Esfandiarei, Mitra Esfandiarei, Mitra Esfandiarei, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas, Theresa Currier Thomas

“…Despite these significant clinical observations, investigation into cerebrovascular dysfunction and neuropathology in MFS remains limited.MethodsUsing 6M-control (C57BL/6) and 6M-MFS (Fbn1C1041G/+) and healthy 12M-control male and female mice, we test the hypothesis that abnormal Fbn1 protein expression is associated with altered cerebral microvascular density, BBB permeability, and neuroinflammation in the PCA-perfused hippocampus, all indicative of a pre-mature aging brain phenotype. …”
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Impact of Helicobacter pylori infection on iron deficiency anemia in children: a systematic review and meta-analysis with early intervention implications by Ziteng Wang, Wentao Tan, Huanhuan Xiong, Jiali Huang, Herui Wei, Mengqi Li, Jing Luo, Wen An, Lingling He, Jiali Ma, Fan Xiao, Fan Xiao, Fan Xiao, Fan Xiao, Hongshan Wei

“…BackgroundThis study investigates the association between Helicobacter pylori (H. pylori) infection and iron deficiency (ID) as well as its potential link to iron deficiency anemia (IDA) in children.MethodsAs of August 2024, we conducted a comprehensive literature review using the Embase, PubMed, Web of Science, Ovid Medline, and Cochrane databases to compare the risk of IDA in patients with and without H. pylori infection. …”
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Risk factors for new-onset diabetes after transplantation in kidney transplant recipients: own data and meta-analysis by Maria S. Novikova, Larisa O. Minushkina, Oleg N. Kotenko, Dmitry A. Zateyshchikov, Olga I. Boeva, Sona S. Allazova, Eugene M. Shilov, Olga M. Koteshkova, Mikhail B. Antsiferov

“…To compare risk factors for new-onset diabetes after transplantation (NODAT) among renal transplant recipients (RTRs) from 1989 to 2018 in the City Clinical Hospital №52, with a systematic analysis of published studies on this topic. Materials and methods. In a 30-year (1989–2018) retrospective study, we found statistically significant differences in age, gender, polycystic kidney disease, cadaveric kidney, cyclosporine, i-mTOR, and steroids between two groups of recipients with and without NODAT. …”
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Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection by Juanjuan Jiang, Tao Kang, Ronghua Ling, Yingqian Liu, Jiuai Sun, Yiming Li, Xiaoou Li, Hui Yang, Bingcang Huang, the Alzheimer’s Disease Neuroimaging Initiative

“…DFC metrics (standard deviation of Fisher z-transformed correlations) were used to identify group differences and classify AD spectrum stages. …”
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Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study by Jianqing Qiu, Cheng Yu, Yalan Kuang, Yao Hu, Ting Zhu, Ting Zhu, Ke Qin, Wei Zhang, Wei Zhang, Wei Zhang, Wei Zhang

“…In this study, we investigated the associations between peripheral blood test indexes with various symptom levels of major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) to explore the availability of peripheral blood test indexes.MethodsWe extracted cases diagnosed with MDD, BD, and SCZ at West China Hospital from 2009 to 2021, translated their main complaints into Research Domain Criteria (RDoC) symptom severity scores using nature language processing (NLP), and collected their detailed psychiatric symptoms and peripheral blood test results. …”
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Efficacy of traditional Chinese medicine injections for treating idiopathic pulmonary fibrosis: A systematic review and network meta-analysis. by Shuai-Yang Huang, Hong-Sheng Cui, Ming-Sheng Lyu, Gui-Rui Huang, Dan Hou, Ming-Xia Yu

“…However, there were limitations to the conclusions of this study due to quality control differences in the included trials.…”
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Performance of popular large language models in glaucoma patient education: A randomized controlled study by Yuyu Cao, Wei Lu, Runhan Shi, Fuying Liu, Steven Liu, Xinwei Xu, Jin Yang, Guangyu Rong, Changchang Xin, Xujiao Zhou, Xinghuai Sun, Jiaxu Hong

“…Purpose: The advent of chatbots based on large language models (LLMs), such as ChatGPT, has significantly transformed knowledge acquisition. However, the application of LLMs in glaucoma patient education remains elusive. …”
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Clinical application value of intracavitary PRP infusion combined with IVF-FET in patients with chronic endometritis by ZHANG Xiaotong, HAO Xiaoyuan, FANG Rui, HU Shuyao, MA Linkun, ZHAO Yaqi, HAN Wei

“…[Results] No significant differences in endometrial thickness were observed among the three groups during the transformation phase (P>0.05). …”
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Nucleus accumbens functional connectivity changes underlying alcohol expectancies in bipolar disorder and prospective alcohol outcomes: a within-subject randomized placebo-controll... by Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Elizabeth T. C. Lippard, Dylan E. Kirsch, Dylan E. Kirsch, Dylan E. Kirsch, Dylan E. Kirsch, Vanessa Le, Vanessa Le, Skyler Lee, Nadia Bibb, Kaitlyn Meek, Raquel Kosted, Ansley Huffman, J. R. C. Almeida, Kim Fromme, Kim Fromme, Stephen M. Strakowski, Stephen M. Strakowski, Stephen M. Strakowski

“…Fisher-transformed correlation coefficients between ROIs and seed-to-clusters showing a significant group-by-condition (placebo, pre-beverage rsfMRI) interaction were calculated. …”
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Theranostic Potential of the iPSMA-Bombesin Radioligand in Patients with Metastatic Prostate Cancer: A Pilot Study by Sofía González-Rueda, Osvaldo García-Pérez, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Gerardo Ramírez-Nava, Joel Vargas-Ahumada, Erika Azorín-Vega, Guillermina Ferro-Flores, Laura Meléndez-Alafort

“…[^99mTc]Tc-iPSMA-BN appears to have better lesion detection in patients with aggressive histologic transformation. Two-way ANOVA analysis revealed a significant difference in TBR values between patients with mCRPC and mCSPC (<i>p</i> < 0.05) but no difference between [¹⁸F]-PSMA-1007 and [^99mTc]Tc-iPSMA-BN (<i>p</i> > 0.05). …”
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Assessment of antibiotic utilization patterns in an Indian Level-1 Trauma Center: a pilot study exploring days of antibiotic spectrum coverage and defined daily doses using WHO AWa... by M Nizam Ahmed, Arpan Kumar Thakur, Smriti Srivastava, Aparna Ningombam, Madhavi Kirti, Sushma Sagar, Keshav Goyal, Subodh Kumar, Ashish Bindra, Gyaninder Pal Singh, Navdeep Sokhal, Richa Aggarwal, Vijay Sharma, Samarth Mittal, Kamran Farooque, Purva Mathur

“…This study evaluated antibiotic use in an Indian trauma center using DASC, defined daily doses (DDD), and the World Health Organization (WHO) Access, Watch, Reserve (AWaRe) classification.MethodsThis retrospective cohort study analyzed data from 1,812 adult inpatients (mean age: 35 years; 70% male; 80% with polytrauma) admitted to a 250-bed Level-1 Trauma Center at the All India Institute of Medical Sciences (AIIMS), India, from August to October 2022. …”
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Modeling and finite element simulation of temperature field in rail abrasive belt grinding by Haipeng WANG, Jianyong LI, Chaoyue ZHAO, Yueming LIU

“…Therefore, it is necessary to accurately control the grinding temperature during rail grinding, and accurately grasp the influence law of rail grinding parameters on the grinding temperature, so as to further improve the grinding quality of rails and extend their service life.MethodsBased on elastic contact theory and the grinding process of an abrasive belt rail driven by a concave contact wheel, a contact pressure distribution region model of the rail surface is established. …”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. …”
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Gas exchange efficiency slopes to assess exercise tolerance in chronic obstructive pulmonary disease by Hiromi Yanagi, Keisuke Miki, Kazumi Koyama, Satoshi Miyamoto, Yasuhiro Mihashi, Yuka Nagata, Kazuki Hashimoto, Hisako Hashimoto, Mari Fukai, Tomonori Maekura, Rika Yonezawa, Shizuka Sakaguchi, Takuro Nii, Takanori Matsuki, Kazuyuki Tsujino, Hiroshi Kida

“…Methods We hypothesized that the $$\rm{\dot V}$$ E- $$\rm{\dot V}$$ CO2 slope is more useful than OUES in clinical use for the pathophysiological evaluation of COPD. …”
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Structural and functional changes of the heart in patients with chronic ischemic heart failure, associated with renal dysfunction by D. A. Lashkul

“…The aim of the study was to examine the structural and functional changes, geometric remodeling of the heart in patients with ischemic chronic heart failure, being hospitalized, according to the presence of renal dysfunction. Materials and methods. The study involved 333 patients with ischemic CHF (277 men and 56 women, mean age 59,3±9,4 years). …”
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Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation by Litteral CA, Martel MM, Mattingly DT, Moore JX

“…Substance preference concordance and sex-specific links between affected family members and participants were also assessed.Methods: A cross-sectional analysis of the National Epidemiological Survey on Alcohol and Related Conditions III (NESARC-III) included 36,309 adults. …”
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Depletion of regulatory T cells enhances the T cell response induced by the neoantigen vaccine with weak immunogenicity by Ruichen Huang, Qiao Zhou, Jiajun Liu, Yang Xia, Yang Jiao, Bi Zhao, Tangtao Feng, Haosu Zhou, Xiuyan Song, Hao Qin, Jun Wang, Lan Cheng, Yunye Ning, Qinying Sun, Yanfang Liu, Xiaoping Su, Yuchao Dong, Wei Zhang

“…Eliminating immunosuppressive cells will improve the priming and expansion of anti-tumor immune cells induced by the vaccine. Methods: In this study, a Treg-depleting regimen (consisting of CD25mAb and low-dose cyclophosphamide (LD-CTX)) was used in conjunction with a neoantigen vaccine for treating mice with solid tumors. …”
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