Greenness and averted mortality in 390 cities in China (2000–2020)Research in context by John S. Ji, Zheng Tao, Hui Miao, Tom Cole-Hunter, Xuecao Li, David Rojas-Rueda, Wenjia Cai

“…Our study aims to track greenness trends in urban areas in China and quantify the health impact of greenness on adult mortality. Methods: In China, we mapped the urban human population distribution aged 20 and above with a 1 km grid (30 arc-second) and used satellite-based remote sensing to measure green space over time to create population-weighted normalized difference vegetation index (NDVI). …”
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Proximal row carpectomy versus four-corner arthrodesis: a retrospective comparative study by Richard Chan, Justine Goursat, Mathilde Payen, Matthieu Lalevée, Kamel Guelmi

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Re-Infection Outcomes Following One- And Two-Stage Surgical Revision of Infected Knee Prosthesis: A Systematic Review and Meta-Analysis. by Setor K Kunutsor, Michael R Whitehouse, Erik Lenguerrand, Ashley W Blom, Andrew D Beswick, INFORM Team

“…No clinical trials comparing both revision strategies were identified.<h4>Review methods</h4>Two independent investigators extracted data and discrepancies were resolved by consensus with a third investigator. …”
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Effects of Yunnan Baiyao retention enema combined with mesalazine enteric-coated tablets and bifidobacterium triple viable capsules for treating ulcerative colitis by Liu Junjie, Gao Jian, Li Shuling

“…[Objectives] To determine the effects of Yunnan Baiyao retention enema combined with mesalazine enteric-coated tablets and bifidobacterium triple viable capsules for treating ulcerative colitis (UC). [Methods] Sixty patients with UC treated at our hospital between January 2020 and June 2021 were randomly divided into the treatment group (n=30) and the control group (n=30). …”
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Ex vivo biotransformation of lady’s mantle extracts via the human gut microbiota: the formation of phenolic metabolites and their impact on human normal and colon cancer cell lines... by Katarzyna Jakimiuk, Aleksandra Kruk, Marta Kinga Lemieszek, Jakub W. Strawa, Sebastian Granica, Adrian Wiater, Michał Tomczyk

“…(Rosaceae) stands out as a promising herbal drug candidate due to its phytochemicals displaying anti-inflammatory and antioxidant properties.MethodsIn our study, we investigated the interaction between the human gut microbiota and lady’s mantle herb extract (AV) following the biotransformation of the extract’s constituents and their impact on colorectal cancer cells (HT-29) and normal CCD 841 CoN epithelial cells. …”
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Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxel-mirrored homotopic connectivity: a resting state fMRI study by Xue-Lin Wang, Yu Chen, Jin-Yu Hu, Hong Wei, Qian Ling, Liang-Qi He, Cheng Chen, Yi-Xin Wang, Yan-Mei Zeng, Xiao-Yu Wang, Qian-Min Ge, Xu Chen, Yi Shao

“…AIM: To analyze whether alterations of voxel mirror homology connectivity (VMHC) values, as determined by resting-state functional magnetic resonance imaging (rs-fMRI), occur in cerebral regions of patients with hypertensive retinopathy (HR) and to determine the relationship between VMHC values and clinical characteristics in patients with HR. METHODS: Twenty-one patients with HR and 21 age-matched healthy controls (HCs) were assessed by rs-fMRI scanning. …”
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Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched a... by Federico De Santis, Raffaele Ornello, Eleonora De Matteis, Lucio D’Anna, Michele Romoli, Tiziana Tassinari, Valentina Saia, Silvia Cenciarelli, Chiara Bedetti, Chiara Padiglioni, Bruno Censori, Valentina Puglisi, Luisa Vinciguerra, Maria Guarino, Valentina Barone, Marialuisa Zedde, Ilaria Grisendi, Marina Diomedi, Maria Rosaria Bagnato, Marco Petruzzellis, Domenico Maria Mezzapesa, Vincenzo Inchingolo, Manuel Cappellari, Cecilia Zivelonghi, Paolo Candelaresi, Vincenzo Andreone, Giuseppe Rinaldi, Alessandra Bavaro, Anna Cavallini, Maria Grazia Piscaglia, Valeria Terruso, Marina Mannino, Alessandro Pezzini, Giovanni Frisullo, Francesco Muscia, Maurizio Paciaroni, Maria Giulia Mosconi, Andrea Zini, Ruggiero Leone, Carmela Palmieri, Letizia Maria Cupini, Michela Marcon, Rossana Tassi, Enzo Sanzaro, Giuli Papiri, Giovanna Viticchi, Daniele Orsucci, Anne Falcou, Simone Beretta, Roberto Tarletti, Patrizia Nencini, Eugenia Rota, Federica Nicoletta Sepe, Delfina Ferrandi, Luigi Caputi, Gino Volpi, Salvatore La Spada, Mario Beccia, Claudia Rinaldi, Vincenzo Mastrangelo, Francesco Di Blasio, Paolo Invernizzi, Giuseppe Pelliccioni, Maria Vittoria De Angelis, Laura Bonanni, Giampietro Ruzza, Emanuele Alessandro Caggia, Monia Russo, Agnese Tonon, Maria Cristina Acciarri, Sabrina Anticoli, Cinzia Roberti, Gaspare Scaglione, Francesca Pistoia, Alberto Fortini, Antonella De Boni, Alessandra Sanna, Alberto Chiti, Leonardo Barbarini, Marcella Caggiula, Maela Masato, Massimo Del Sette, Francesco Passarelli, Maria Roberta Bongioanni, Manuela De Michele, Stefano Ricci, Simona Sacco, Matteo Foschi

“…Patients with PCI had worse 90-day mRS ordinal distribution compared to those with ACI (odds ratio 1.18 (95% CI 1.01–1.39); p  = 0.046). There were no differences in other secondary outcomes. Safety outcomes had low incidence and did not differ between groups (any bleedings: 3.2% vs 2.6%; 24-h hemorrhagic transformation: 1.8% vs 1.2%). …”
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Time trends in the clinical management of cervical intraepithelial neoplasia grade 2: A Danish register‐based study by Dina Overgaard Eriksen, Tina Hovgaard Randrup, Kathrine Dyhr Lycke, Rikke Kamp Damgaard, Johnny Kahlert, Eva Bjerre Ostenfeld, Pernille Tine Jensen, Nicolas Wentzensen, Megan A. Clarke, Anne Hammer

“…Material and Methods We conducted a Danish nationwide study using data from healthcare registries. …”
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Antifungal effect of Quillaja saponaria plant extract on biofilms of five Candida species of dental interest by Ellen Roberta Lima Bessa, Ana Bessa Muniz, Lucas de Paula Ramos, Luciane Dias de Oliveira

“…To analyze cell viability, the MTT test was used, and the optical densities were transformed into a percentage of metabolic activity. …”
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ETAPAS DO ENVELHECIMENTO REPRODUTIVO: EFEITOS NOS NÍVEIS DE ADIPOSIDADE, ATIVIDADE FÍSICA E VISITA À NATUREZA by Helena Moreira, Mário Santos, Graça Pinto, José Martinho, Ronaldo Gabriel, Andreia Teixeira

“…Purpose: This study analyzed the variation of adiposity levels, PA and nature visits according to the stages of reproductive aging in women. Methods In this cross-sectional study, women aged 18 to 75 were categorized in the reproductive age (G1, n=94), menopausal transition (G2, n=12) and postmenopause (G3, n=36), considering the reproductive aging stages described in STRAW +10. …”
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High incidence of rare TGFB1 haplotypes in children with biliary atresia by R. M. Kurabekova, O. E. Gichkun, O. M. Tsirulnikova, I. E. Pashkova, E. A. Vakurova, O. P. Shevchenko, S. V. Gautier

“…Objective: to evaluate the occurrence of single nucleotide polymorphisms (SNPs) in transforming growth factor beta 1 (TGFB1) – rs1800469, rs1800470, rs1800471 – and their haplotypes in children with biliary atresia (BA).Materials and methods. …”
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Where you live shapes who you are: morphological changes in urban Triatoma infestans by Romina V. Piccinali, Romina V. Piccinali, Julieta Nattero, Julieta Nattero, Florencia Cano, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Ana L. Carbajal-de-la-Fuente, Ana L. Carbajal-de-la-Fuente

“…IntroductionUrbanization has transformed landscapes, driving ecological and morphological changes in insects. …”
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Llegir críticament textos d'història Critical Literacy in History Texts Leer críticamente textos de historia by Francesc-Xavier Hernàndez Cardona, Cèlia Romea Castro

“…A text is of interest insofar as it supplies information and the historian's method is what serves to unearth this information. …”
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Dual-stage Acting Dendrimeric Nanoparticle for Deepened Chemotherapeutic Drug Delivery to Tumor Cells by Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Hossein Mahmudi, Saeedeh Ghiasvand, Hamed Dadashi, Aysan Salemi, Sajjad Alimohammadvand, Leila Roshangar, Abolfazl Barzegari, Mehdi Jaymand, Rana Jahanban-Esfahlan

“…Purpose: We report on the design of hypoxia-induced dual-stage acting dendrimeric nanoparticles (NPs) for selective delivery of two chemotherapeutic model drugs doxorubicin (DOX) and tirapazamin (TPZ) for deepened drug delivery into hypoxic tumors in vitro. Methods: PAMAM G5 dendrimers were crosslinked with a hypoxic azo linker, attached to a mPEG to form a detachable corona on the dendrimer surface (PAP NPs). …”
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Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health by Iván Artemio Corral-Guerrero, Angela Elena Martínez-Medina, Litzy Yazmin Alvarado-Mata, Ana Cristina Figueroa Chávez, Roberto Muñoz-García, Miriam Paulina Luévanos-Escareño, Jazel Doménica Sosa-Martínez, María José Castro-Alonso, Padma Nimmakayala, Umesh K. Reddy, Nagamani Balagurusamy

“…This review aims to provide an integrative synthesis of capsaicin’s metabolism, its interaction with the gut microbiome, and its physiological implications across organ systems. <b>Methods:</b> We conducted a critical literature review of recent in vivo and in vitro studies exploring capsaicin’s metabolic fate, biotransformation by host enzymes and gut microbes, tissue distribution, and molecular pathways. …”
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Automatic segmentation and volume measurement of anterior visual pathway in brain 3D-T1WI using deep learning by Yongliang Han, Haixiang Wang, Qi Luo, Jingjie Wang, Chun Zeng, Qiao Zheng, Linquan Dai, Yiqiu Wei, Qiyuan Zhu, Wenlong Lin, Shaoguo Cui, Yongmei Li

“…The 3D UX-Net’s performance was compared against 3D U-Net, Swin UNEt TRansformers (UNETR), UNETR++, and Swin Soft Mixture Transformer (Swin SMT). …”
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Predicting the risk of left ventricular diastolic dysfunction in obesity by G. A. Chumakova, O. V. Gritsenko, O. V. Gruzdeva, A. V. Zateev

“…To assess the prognostic value of key and additional metabolic risk factors (RFs), neurohumoral and profibrotic factors in the development of LV DD in obese patients.Material and methods. The study included 149 men with general obesity. …”
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Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes by Kaiyu Jiang, Yao Fu, Jennifer A. Kelly, Patrick M. Gaffney, Lucy C. Holmes, James N. Jarvis

“…We undertook a systematic analysis of B cells and B cell lines to compare 3D genomic features encompassing risk loci for juvenile idiopathic arthritis (JIA), systemic lupus (SLE), and type 1 diabetes (T1D). Methods We isolated B cells from four healthy individuals, ages 9–17. …”
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Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia by Elena Timokhina, Alexander Strizhakov, Sapiyat Ibragimova, Evgeny Gitel, Irina Ignatko, Vera Belousova, Nikoleta Zafiridi

“…The object of the present study was to reveal the role of MMP-2 and MMP-9 in the development of severe preeclampsia. Materials and Methods. We conducted a retrospective study that included 92 pregnant women at a gestational age of 26-38 weeks, of which the principal group consisted of 61 patients with severe PE. …”
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Socioeconomic inequalities in patient-reported outcome measures among total hip and knee arthroplasty patients: a comprehensive analysis of instruments and domains by Joshua M. Bonsel, Max Reijman, Erin M. Macri, Jan A. N. Verhaar, Liza N. van Steenbergen, Gouke J. Bonsel

“…This study explores which self-reported PROMs and their specific domains are most involved. Methods We obtained data from the Dutch Arthroplasty Registry (2014–2022), including over 100,000 THA/TKA patients with complete preoperative and 12-month follow-up PROMs. …”
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