Immunohistochemical features of gastrointestinal stromal tumors and the role of expression of p16ink4A, Ki-67, VEGF and MMP-9 in their behavior by I. I. Yakovtsova, Ya. M. Miroshnichenko, T. M. Chertenko

“…Aim: to clarify the prognostic value of cytoplasmic p16ink4A, VEGF, MMP-9 and Ki-67 expressions in gastrointestinal stromal tumors (GISTs) and connection of different levels of these markers expression with aggressive transformation of GISTs. …”
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Research Progress on Aflatoxin Inhibitors and Their Mechanisms of Action by Shaowen WU, Weijie ZHOU, Siyuan YANG, Shijuan YAN

“…Further analysis reveals that inhibitors function through five major mechanisms: (1) Disrupting cell membrane structural integrity and mitochondrial respiratory chain function in A. flavus, destroying fundamental cellular physiological structures. (2) Regulating the expression of key genes in the aflatoxin biosynthesis gene cluster and inhibiting activities of key enzymes such as polyketide synthase and monooxygenases, directly blocking aflatoxin biosynthetic pathway. (3) Modulating intracellular reactive oxygen species levels and antioxidant enzyme systems to maintain redox balance. (4) Inhibiting fungal development and differentiation processes, including key stages such as sclerotia formation, asexual reproduction, and spore germination. (5) Promoting detoxification of produced aflatoxins through physical adsorption, biodegradation, and chemical transformation. Based on mechanistic analysis, the review further explores potential targets for aflatoxin biosynthesis inhibition and provides perspectives on future directions for aflatoxin control strategies, aiming to provide theoretical guidance and a practical basis for developing effective control methods.…”
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RISKS AND VULNERABILITIES IN EDUCATION AS PRIORITY AREAS OF EDUCATIONAL POLICY by G. V. Stankevich

“…Innovative pedagogical methods in higher education should be author's, professionally oriented, allowing to implement a competence model. …”
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Cloud-Based Solutions for Scalable Enterprise Resource Planning Systems Benefits and Implementation Strategies by Kumar Gooda Satheesh, P Mohanraj, J Veni, Ashish, S Kannadhasan, B Thamizhkani

“…Focusing on gaining the competitive advantage, the study concluded that adapting the traditional ERP model gives organizations the capacity to face transforming circumstances, as the progressed ERP systems are different of the old model, based on systematic management based on historical results, of governance.…”
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Proportions of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in patients with surgical site infections in mainland China: a systematic review and meta-analy... by Zhirong Yang, Jing Wang, Weiwei Wang, Yuelun Zhang, Lizhong Han, Yuan Zhang, Xiaolu Nie, Siyan Zhan

“…This systematic review aimed to estimate proportions of S. aureus and MRSA in SSIs through available published studies.<h4>Methods</h4>PubMed, Embase and four Chinese electronic databases were searched to identify relevant primary studies published between 2007 and 2012. …”
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ANTHROPOGENIC APPELLATIVE DERIVED ORONYMS OF HISTORICAL UMAN REGION by Oksana B. Kolesnyk, Svitlana P. Karychkovska

“…The study of onym material involves the use of scientific cognition methods, including descriptive one for sorting out oronyms taken from written texts of the seventeenth and nineteenth centuries and documents from Ukrainian archival institutions, comparative-historical – to establish the reasons for the nomination of land forms recorded in Uman region in the seventeenth century, diachronic – as a means of studying names in historical development. …”
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A scoping review of national policies for hierarchical medical system in China since the 2009 health reform by Tingting Cai, Yuting Hua, Leyi Fang, Yunhui Xia, Jiantong Shen, Jiantong Shen, Jianlin Lou

“…We aim to summarize and review the evolution of China’s hierarchical medical system policy.MethodsEligible policies were identified between March 7, 2009 and December 31, 2022, by searching the official websites of the PKULAW Database, the Chinese State Council, and related ministries. …”
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Spatial-Spectral Linear Extrapolation for Cross-Scene Hyperspectral Image Classification by Lianlei Lin, Hanqing Zhao, Sheng Gao, Junkai Wang, Zongwei Zhang

“…In particular, on the Houston18/Shanghai datasets, its overall accuracy was 0.51%/0.83% higher than the best results of the other methods, and its Kappa coefficient was 0.78%/2.07% higher, respectively.…”
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Brain Functional Connectome Gradients Analysis Study of Chronic Back Pain by YANG Junchao, YIN Xiaolong, HUANG Li, JIANG Feng, LI Zuanfang, LIANG Shengxiang

“…ObjectiveThe aim of this study was to investigate the relationship between changes in functional network hierarchy and pain in patients with chronic back pain (CBP) by analyzing the differences in functional network connectivity gradients between the CBP group and the healthy control group.MethodsData (including basic clinical information such as VAS scores, years of pain, and resting functional MRI images) from the patients with CBP and healthy controls (HC) were obtained from the OpenPain database. …”
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The Epidemiology of Injuries and Illnesses During SailGP Season 4: A Prospective Cohort Study by Thomas Fallon, Hélène Rousselon, Neil Heron

“…Sail Grand Prix (SailGP), inaugurated in 2019, epitomises a transformative approach to professional sailing. This study aims to provide a comprehensive analysis of injury and illness epidemiology among SailGP elite sailors, comparing injury and illness types and locations across different sailing activities. …”
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Association between CRP-Albumin-Lymphocyte (CALLY) index and Asthma-COPD overlap: analysis of NHANES 2015–2018 data by Shasha Fu, Zongcun Chen, Hongchuan Wu

“…This study aimed to investigate the association between CALLY index and Asthma-COPD Overlap (ACO) in the general US population. Methods We analyzed data from 6,797 participants aged ≥ 40 years from the 2015–2018 National Health and Nutrition Examination Survey (NHANES). …”
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Remote sensing monitoring of vegetation and analysis of carbon storage changes in Fengshan Park, Jiaozuo by Erwen ZHENG, Zhe LI, Ping WANG, Zhonghao JIN, Libo NING

“…Global climate change has attracted much attention to the study of ecosystem carbon storage, with vegetation carbon estimation after mine restoration emerging as a critical component for evaluating ecological restoration effectiveness and supporting the development of a “dual-carbon society”. Traditional methods for estimating vegetation carbon storage have limitations, while advances in remote sensing technology offer promising alternatives. …”
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Assessing the impact of a potential canine vaccine for the control of Chagas disease: a mathematical modeling study by Edem Fiatsonu, Aniruddha Deka, Martial L. Ndeffo-Mbah, Martial L. Ndeffo-Mbah

“…As dogs are important reservoirs in the disease’s spread, developing a canine vaccine could be transformative for controlling disease transmission to dogs and humans.MethodsWe developed a compartmental Susceptible-Infected model to simulate the transmission dynamics of Trypanosoma cruzi, considering interactions among dogs, humans, cats, rodents, and triatomine vectors. …”
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CHRONIC ENDOMETRITIS: CURRENT ASPECTS by V. E. RADZINSKY, Yu. A. PETROV, M. L. PОLINA

“…To broaden the understanding of chronic endometritis (CE) pathogenesis on the basis of the reception study of steroid hormones and markers of cell proliferation/apoptosis in its different types depending on the nature of microbial colonization of the uterine mucosa.Materials and methods. …”
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Determinants of growth differentiation factor 15 plasma levels in outpatients with peripheral arterial disease by Emma Skau, Philippe Wagner, Jerzy Leppert, Johan Ärnlöv, Pär Hedberg

“…The relations between GDF-15 concentrations (transformed with the natural logarithm) and the different determinants were evaluated using uni- and multivariable linear regression models. …”
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From Fact Drafts to Operational Systems: Semantic Search in Legal Decisions Using Fact Drafts by Gergely Márk Csányi, Dorina Lakatos, István Üveges, Andrea Megyeri , János Pál Vadász, Dániel Nagy, Renátó Vági

“…To address this, the study employs manually created fact drafts for legal cases, enabling reliable ranking of original cases within retrieved documents and quantitative comparison of various vectorization methods. The study compares twelve different text embedding solutions (the most recent became available just a few weeks before the manuscript was written) identifying Cohere’s embed-multilingual-v3.0, Beijing Academy of Artificial Intelligence’s bge-m3, Jina AI’s jina-embeddings-v3, OpenAI’s text-embedding-3-large, and Microsoft’s multilingual-e5-large models as top performers. …”
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Examiner workload comparison: three structured oral examination formats for the European diploma in anaesthesiology and intensive care by Mikhail Dziadzko, Andrey Varvinskiy, Rodolphe Di Loreto, Hugues Scipioni, Bazil Ateleanu, Markus Klimek, Joana Berger-Estilita

“…The COVID-19 pandemic triggered transformations in academic medicine, rapidly adopting remote teaching and online assessments. …”
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Breast cancer diagnosis using radiomics-guided DL/ML model-systematic review and meta-analysis by Nazmul Ahasan Maruf, Abdullah Basuhail

“…The QUADAS-2 instrument is employed to evaluate the articles to ensure their quality and eligibility. Feature extraction methods that employ radiomics and deep learning are extracted from each study. …”
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DEVELOPMENT OF ENTREPRENEURIAL COMPETENCE IN DESIGN EDUCATION by L. Bazyl, V. Orlov, O. Fursa, L. Оruzha

“…It ts characterized the features of entrepreneurial activity in the field of design as a process of development of innovative ideas and projects of young people — authors of extraordinary methods and technologies, inventors of new ways of society development. …”
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The CASPAR study protocol. Can cervical stiffness predict successful vaginal delivery after induction of labour? a feasibility, cohort study. by Elizabeth Medford, Steven Lane, Abi Merriel, Andrew Sharp, Angharad Care

“…This study will explore its' potential for pre-induction cervical assessment and indication of delivery outcome following IOL.<h4>Methods</h4>CASPAR is a feasibility study of term, primiparous women with singleton pregnancies undergoing IOL. …”
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