Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study by Gabriela Fonseca-Souza, Lhorrany Alves-Souza, Maria Angélica Hueb de Menezes-Oliveira, Nikolaos Daratsianos, Svenja Beisel-Memmert, Christian Kirschneck, Rafaela Scariot, Juliana Feltrin-Souza, Erika Calvano Küchler

“…DA was evaluated by calibrated examiners (kappa > 0.80) using the method proposed by Demirjian et al. (1973). Genomic DNA was extracted from buccal cells, and SNPs in Epidermal Growth Factor (EGF) – rs4444903 and rs2237051, Epidermal Growth Factor Receptor (EGFR) – rs2227983 –, Transforming Growth Factor Beta 1 (TGFB1) – rs1800470 and rs4803455 –, and Transforming Growth Factor Beta Receptor 2 (TGFBR2) – rs3087465 – were genotyped by real-time polymerase chain reactions using the TaqMan assay. …”
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Towards the Performance Characterization of a Robotic Multimodal Diagnostic Imaging System by George Papaioannou, Christos Mitrogiannis, Mark Schweitzer, Nikolaos Michailidis, Maria Pappa, Pegah Khosravi, Apostolos Karantanas, Sean Starling, Christian Ruberg

“…This study presents several performance characterization experiments from a new robotic multimodal imaging system using specially designed calibration methods at different system configurations. Additional musculoskeletal imaging and imaging from a pediatric brain stroke patient without anesthesia are presented for comparisons. …”
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Advancing Pediatric Surgery with Indocyanine Green (ICG) Fluorescence Imaging: A Comprehensive Review by Marco Di Mitri, Annalisa Di Carmine, Benedetta Zen, Edoardo Collautti, Cristian Bisanti, Simone D’Antonio, Michele Libri, Tommaso Gargano, Mario Lima

“…In recent years, its use has spread through the framework of pediatric surgery, where its ability to illuminate anatomical structures and pathological conditions has improved surgical outcomes. Methods: We conducted a systematic literature review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. …”
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Tongue-LiteSAM: A Lightweight Model for Tongue Image Segmentation With Zero-Shot by Daiqing Tan, Hao Zang, Xinyue Zhang, Han Gao, Ji Wang, Zaijian Wang, Xing Zhai, Huixia Li, Yan Tang, Aiqing Han

“…Additionally, data perturbation techniques were employed to enhance the zero-shot segmentation capability of the model and ensure robust performance across different data sources. Results: Experiments conducted on six distinct tongue image datasets demonstrated that the Tongue-LiteSAM model outperformed traditional convolutional neural network-based models and transformers, the original SAM model, and other related improved models in tongue image segmentation tasks. …”
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Analysis and identification of sulfate sources in groundwater of a typical profile in the Yinchuan Plain by Ning Liu, Wenke Wang, Deshuai Ji, Zongyu Chen, Yazhen Du

“…By using hydrochemical, multi-isotope, statistical, and microbiological methods on borehole samples of various landforms and depths, sulfate geochemical processes in groundwater were revealed and source contributions quantified. …”
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Optimal information dissemination strategy to promote preventivebehaviors in multilayer epidemic networks by Heman Shakeri, Faryad Darabi Sahneh, Caterina Scoglio, Pietro Poggi-Corradini, Victor M. Preciado

“…Various numerical simulations with network models and a real-world social network validate our method.…”
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Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4 by Stephanie E. Areloegbe, Chukwubueze L. Atuma, Ayodeji Aturamu, Isaac O. Ajadi, Oluseyi E. Adelekan, Mary B. Ajadi, Christopher O. Akintayo, Gloria O. Omoruyi, Samuel O. Onyekweli, Omosola F. Anifowose, Oluwatobi A. Amusa, Kayode Ajayi, Paul A. Oyewole, Tolulope E. Adegoke, Kehinde S. Olaniyi

“…The study in addition elucidates the probable involvement of PDK4 in PCOS-associated renometabolic disorders. Methods Eight-week-old nulliparous female Wistar rats were randomly allotted into four groups (n = 5). …”
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MARC, a novel modular chimeric antigen receptor, improves T cell-based cancer immunotherapies by preventing early T cell exhaustion and enhancing persistence by Jean-Sebastien Delisle, Susan Moore, Etienne Gagnon, Margaux Tual, Angélique Bellemare-Pelletier, Delphine Guipouy, Negar Farzam-Kia, Leila Jafarzadeh, Jordan Quenneville, Benoit Barrette, Marc K Saba-El-Leil

“…In a clinically relevant mouse leukemia model, MARC-T cells exhibited remarkable long-term persistence and a less exhausted phenotype compared with conventional CAR-T cells.Conclusions With its modular architecture, the MARC offers unparalleled opportunities for optimization and broad applicability across different cell types, paving the way for transformative advancements in cell-based therapies. …”
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Lentivirus-Mediated Missense Mutation in HtrA1 Leads to Activation of the TGF-β/Smads Pathway and Increased Apoptosis of Mouse Brain Microvascular Endothelial Cells via the Oxidati... by Shi-na Song, Hui-juan Li, Jian-lin Liang, Qian-qian Ren, Chang-xin Li, Sui-yi Xu

“…Stable strain models were constructed using wild-type and mutant HtrA1 overexpression lentiviral vectors to infect mouse brain microvascular endothelial cells (bEnd.3 cells). Methods: HtrA1 mRNA and protein expression were analyzed by Western blot and quantitative real-time polymerase chain reaction. …”
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Olive stone-derived biochar as a sustainable catalyst support for CO2 methanation by A. Villardon, A. Alcazar-Ruiz, J. Cencerrero, A. Romero, L. Sanchez- Silva, F. Dorado

“…This study explores the potential of biochar derived from agro-industrial waste, specifically olive stones, as an innovative and eco-friendly support for Ni-based catalysts in CO2 methanation. Three different chemical activation methods (KOH, ZnCl2, and H3PO4) were applied to enhance the textural and structural properties of the biochar, significantly influencing its catalytic performance. …”
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Impacts of oxytactic microorganisms and viscous dissipation in Carreau nanoliquid featuring ferromagnetic nanoparticles by Muhammad Tabrez, I. Hussain, W.A. Khan, S.U. Khan, M. Waqas, Rzgar Farooq Rashid, M.I. Anwar, Mohamed Ben Ammar, Nurnadiah Zamri, Ruzimurod Abiyev, Hakim AL Garalleh

“…The numerical computation is also made by using of well-known numerical method termed as bvp4c. Influences of various non dimensional fluid parameters like Brownian motion, viscous dissipation, Curie temperature, Weissenberg number, motile difference parameter and bioconvection Paclet number are examined and expressed graphically. …”
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The pathogenesis of CD4~+ T lymphocytes in IgA nephropathy by 唐余燕, 贺海东, 孙蔚倩, 张栋梁, 胡屏, 徐旭东

“…The peripheral blood samples of the patients in the two groups before and after treatment were collected, to isolate peripheral blood lymphocytes, monocytes and serum.ELISA method was adopted to detect CD4~+ T lymphocyte factor including interferon-γ(IFN-γ), interleukin 4(IL-4), IL-17, IL-21 and transforming growth factor-β1(TGF-β1).The distribution proportion of CD4~+ T cells was detected by flow cytometry.Meanwhile, the expression level of JAK/STAT signal pathway was detected by RT-qPCR and Western blot. …”
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Respiratory Rate Estimation from Thermal Video Data Using Spatio-Temporal Deep Learning by Mohsen Mozafari, Andrew J. Law, Rafik A. Goubran, James R. Green

“…The proposed method sets a new State-of-the-Art for RR estimation accuracy, while still permitting real-time RR estimation.…”
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Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 by Fei Zhang, Fei Zhang, Fei Zhang, Andong Zhang, Andong Zhang, Andong Zhang, Junyue Tao, Junyue Tao, Junyue Tao, Meng Zhang, Meng Zhang, Meng Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

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Older patients affected by COVID-19: investigating the existence of biological phenotypes by Alberto Zucchelli, Marta Parigi, Silvia Giliani, Davide Liborio Vetrano, Daniela Lucente, Emanuele Marzetti, Riccardo Calvani, Giuseppe Bellelli, Alessandra Marengoni

“…The aim our study was to investigate biological phenotypes in older patients hospitalized for COVID-19, exploiting a panel of aging biomarkers. Methods Data were gathered from the FRACOVID Project, an observational multicenter study, aimed to evaluate the impact of frailty on health-related outcomes in patients 60 + with COVID-19 in Northern Italy. …”
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Exploring the feasibility of integrating ultra‐high field magnetic resonance imaging neuroimaging with multimodal artificial intelligence for clinical diagnostics by Yifan Yuan, Kaitao Chen, Youjia Zhu, Yang Yu, Mintao Hu, Ying‐Hua Chu, Yi‐Cheng Hsu, Jie Hu, Qi Yue, Mianxin Liu

“…Concurrently, the application of multimodal AI to medical images enables interactive imaging‐based diagnostic conversation. Methods In this paper, we systematically investigate the capacity and feasibility of applying the existing advanced multimodal AI model ChatGPT‐4V to 7T MRI under the context of brain tumors. …”
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ANALYSIS OF THE FAULT-BLOCK STRUCTURE AND STRESS STATE OF THE SEDIMENTARY COVER IN GAS-CONDENSATE DEPOSITS: BASICS OF THE TECTONOPHYSICAL APPROACH by K. Zh. Seminsky, Yu. P. Burzunova, S. A. Bornyakov, A. I. Miroshnichenko, A. S. Cheremnykh, A. K. Seminsky, I. V. Buddo, A. S. Smirnov, I. V. Gorlov

“…Consideration is being given to the tectonophysical approach to the reconstruction of structure formation mechanisms and stress-strain state of rocks in hydrocarbon deposits localized in the platform cover, which has a complex structure in terms of rheological layering and disturbance by different-rank fractures. With the Kovykta gas condensate field, largest in Eastern Siberia, there were shown the main methods and ways of using modern achievements in tectonophysics for interpreting geological and geophysical information on the upper and lower parts of the sedimentary cover, unique in terms of volume and significance, that was obtained during geological exploration therein. …”
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Acupuncture Alleviates Blood–Brain Barrier Damage After Delayed rtPA Thrombolysis for Acute Ischemic Stroke by Regulating Ferroptosis by Zheng Huang, Tianliang Lu, Xinyu Liu, Zhihui Zhang, Yangyang Song, Yiyang Li, Wentao Xu, Xinchang Zhang, Guangxia Ni

“…This study aims to investigate the protective effects of acupuncture on rats subjected to delayed rtPA thrombolysis in cerebral infarction and its relationship with ferroptosis. Methods Adult male Sprague‐Dawley rats were used to establish a thromboembolic stroke model and were randomly assigned to different treatment groups. …”
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Mamba-YOLO-ML: A State-Space Model-Based Approach for Mulberry Leaf Disease Detection by Chang Yuan, Shicheng Li, Ke Wang, Qinghua Liu, Wentao Li, Weiguo Zhao, Guangyou Guo, Lai Wei

“…Visualization analysis of the detection performance on the test set using GradCAM revealed that the enhanced Mamba-YOLO-ML model demonstrates earlier and more effective focus on characteristic regions of different diseases compared with its predecessor. The improved model achieved superior detection accuracy with 78.2% mAP50 and 59.9% mAP50:95, outperforming YOLO variants and comparable Transformer-based models, establishing new state-of-the-art performance. …”
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Methylation Profile of DAPK-1 Between Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma by Petros Papadopoulos, Vasileios Zisis, Dimitrios Andreadis, Dimitrios Parlitsis, Eirini Louizou, Aikaterini Tsirtsaki, Stamatia Maria Rapti, Stathis Tsitsopoulos, Konstantinos Vahtsevanos, Athanasios Poulopoulos

“…Methods: The paraffin embedded tissue samples were retrieved from the archives of the Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki, Greece and St Lukas Hospital of Thessaloniki, Greece during the period of 2014–2019. …”
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