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Analyzing collaboration dynamics in new drug R&D: A case study of two lipid-lowering drugs
Published 2025-05-01“…However, there remains a limited understanding of how scientific and technological advancements are influencing these research collaborations.MethodsIn this study, the development of two types of lipid-lowering drugs served as case studies. …”
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ADVANTAGES OF PRODUCT QUALITY MANAGEMENT BASED ON CORPORATE INFORMATION SYSTEMS FOR THE GROWTH OF THE AI ECONOMY
Published 2025-03-01“…The methodological basis of the research is formed by the multidisciplinary and system approaches, which allow combining theoretical and conceptual views of the research problem, which are realised in different scientific spheres: information theory, digital transformation, quality management, theory of organisation, and economic theory. …”
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A comparative study of four deep learning algorithms for predicting tree stem radius measured by dendrometer: A case study
Published 2025-05-01“…However, when these machine learning methods are applied without careful consideration of data quality, model biases, and other critical factors, their potential is often compromised. …”
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YES‐associated protein‐regulated Smad7 worsen epithelial barrier injury of chronic sinusitis with nasal polyps
Published 2023-06-01“…Methods Patients were divided into CRSwNP group (n = 12) and control group (n = 9). …”
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Assessing the temporal transferability of machine learning models for predicting processing pea yield and quality using Sentinel-2 and ERA5-land data
Published 2025-12-01“…Machine learning (ML) models offer potential, but their real-world utility depends on their performance stability across different years. This ability, known as temporal transferability, is often overestimated by standard validation methods, creating a gap between theoretical performance and operational reliability. …”
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BIOMARKERS ROLE IN THE DEVELOPMENT OF SINUS NODE DYSFUNCTION
Published 2012-04-01“…Material and methods. The study included 83 individuals: 63 patients with SND (the main group) and 20 controls. …”
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Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis
Published 2025-04-01“…Methods We hypothesized that saturated palmitic acid and mono-unsaturated oleic acid (OA and PA) could play diverse roles in the activation of pancreatic stellate cells (PSCs) during the genesis of pancreatic fibrosis and the promotion of precancerous lesions. …”
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Deep Learning Forecast of Semidiurnal Internal Tides From the Mariana Arc
Published 2025-03-01“…Abstract The semidiurnal internal tides radiated from the Mariana Arc converge in a focal region of the West Mariana Basin, featuring rich variations under the modulation of complex topographies and background circulations. Traditional methods, including harmonic analysis and numerical simulations, are difficult to reliably characterize and forecast such multimodal and incoherent internal tide field. …”
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Highly Efficient Catalytic Oxidation of Glucose to Formic Acid over Mn-Mo Doped Carbon Nanotube
Published 2025-04-01“…Glyoxylic acid and arabinose were identified as two main intermediates, suggesting that the transformation of glucose into FA over Mn<sub>9</sub>Mo<sub>1</sub>O<sub>X</sub>@MWCNT involved two different paths. …”
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Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol
Published 2023-11-01“…Considering the continuous rise in the number of patients dealing with neurological, oncological, and other conditions accompanied by chronic pain, there is a growing demand for innovative methods of treatment and pain management. The combination of two different heterocyclic fragments within one molecule makes it possible to use the possibilities of influencing such a molecule on various mechanisms of occurrence and development of various pathological conditions, including those accompanied by pain. …”
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Accuracy and cost comparison of 3D-printed guides in complex spinal deformity correction: direct vs indirect design
Published 2025-05-01“…Among these techniques, patient-specific guides, which feature pre-defined and pre-validated trajectories, present an attractive solution for achieving precision in screw placement and osteotomies.MethodsCT scan data (DICOM format) from 10 patients with complex and severe spinal deformities were selected. …”
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Topical Adipose Mesenchymal Stem cell metabolites regulate the expression of MMP-1, MMP-9, EGF, TGF-β in oral mucosa ulcer rat model
Published 2024-06-01“…Objective: Matrix metalloproteinase (MMP-1 and −9), Epidermal Growth Factor (EGF), and Transforming Growth factor (TGF)-β are expressed in the oral ulcer wound-healing process. …”
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The Relationship of Youth Family Values with Hedonism and Eudemonia
Published 2019-10-01“…A notable trend in modern society is the transformation of family institution, which has long been considered the most important social and personal value. …”
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Professional Features of IT Specialists’ Activities as Burnout Risk Factors
Published 2024-11-01“…Finally, conclusions are made that the digital environment significantly influences the information environment around an IT specialist, transforms the perception of time, space, information, methods of communication and self-presentation, and changes the motivational sensory-cognitive involvement in work.…”
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Longitudinal Trend Monitoring of Multiple Sclerosis Ambulation Using Smartphones
Published 2022-01-01“…This work, therefore, explores how smartphones can administer daily two-minute walking assessments to monitor PwMS physical function at home. <italic>Methods:</italic> Remotely collected smartphone inertial sensor data was transformed through state-of-the-art Deep Convolutional Neural Networks, to estimate a participant's daily ambulatory-related disease severity, longitudinally over a 24-week study. …”
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The effects of compost application on soil properties: Agricultural and environmental benefits
Published 2025-06-01“…Composting offers a valuable alternative, transforming waste into organic fertilizers that can improve soil health. …”
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Type II collagen peptide is able to accelerate embryonic chondrocyte differentiation: an association with articular cartilage matrix resorption in osteoarthrosis
Published 2010-12-01“…Objective: To study the effect of type II collagen peptide (CP) on the decomposition of type II collagen and the differentiation of embryonic chondrocytes of various morphotypes, isolated from the bovine growth plate. Material and methods. Bovine growth plate chondrocytes were separated into morphotypes on a Percoll gradient in accordance with different differentiation stages and then cultured in the presence or absence of 10 ßM of CP. …”
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Association of body roundness index with circadian syndrome: a cross-sectional study using NHANES data from 2009 to 2018
Published 2025-07-01“…However, it remains unclear whether BRI is linked to the risk of CircS. Methods In this population-based cross-sectional study, data from adults aged ≥ 20 years from the 2009–2018 National Health and Nutrition Examination Survey (NHANES) database were analyzed. …”
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