Neutrophil Percentage-to-Albumin Ratio and Neutrophil-to-Albumin Ratio as novel biomarkers for non-alcoholic fatty liver disease: a systematic review and meta-analysis by Amr Ali Mohamed Abdelgawwad El-Sehrawy, Maryam Jafari, Ahmed Hussein Zwamel, Pegah Rashidian, Suhas Ballal, Rishiv Kalia, Anima Nanda, Laxmidhar Maharana, Sepide Javankiani, Mohammad Hashemi, Ehsan Amini-Salehi

“…NPAR showed a standardized mean difference (SMD) of 0.28 (95% CI: 0.22–0.35, P < 0.01), while NAR had a higher effect size with an SMD of 0.69 (95% CI: 0.44–0.93, P < 0.01). …”
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Bimekizumab Impact on Patient-Reported Outcomes in Patients with Moderate to Severe Hidradenitis Suppurativa: Pooled 48-Week Results from BE HEARD I&II by Vivian Y. Shi, John R. Ingram, Hadar Lev-Tov, Sylke Schneider-Burrus, Seth Forman, Martina L. Porter, Koremasa Hayama, Linnea Thorlacius, Jérémy Lambert, Tom Vaux, Bartosz Lukowski, Robert L. Rolleri, Jacek C. Szepietowski

“…Change from baseline (CfB) and proportions of patients achieving clinically meaningful improvement thresholds or low disease impact are reported to Week 48 (observed case). …”
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The burden of rare cancers among adults in the Canton of Geneva, Switzerland, from 2011 to 2020 by Nathalie Bot, Evelyne Fournier, Marie-Laure Amram, Laura Botta, Alice Bernasconi, Elisabetta Rapiti

“…Five-year survival rates were estimated using the Kaplan–Meier method. Survival differences between rare and common cancers were assessed using log-rank tests and Cox proportional hazards models adjusted for age and gender. …”
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Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial. by Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium

“…<h4>Background</h4>Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. …”
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Predicting injury risk in young female volleyball players through movement and jump assessments by Mustafa Erol, Fatma Gozlukaya Girginer, Sinan Seyhan, Gorkem Acar, Gunay Cerit, Meliha Uzun, Caglar Soylu

“…High-risk athletes (n = 18) were taller (M = 174.2 ± 5.8 cm, p = 0.0013) and showed a 4.2-fold increased risk with FMS ≤ 14 and CMJ &lt; 30 cm (OR = 4.20, p = 0.0158), with combined FMS/SEBT predicting risk with 89% accuracy (AUC = 0.89, p &lt; 0.0001).ConclusionFMS scores, SEBT asymmetry, and CMJ heights effectively predict injury risk in young female volleyball players, with thresholds (FMS ≤ 14, SEBT ≥4 cm, CMJ &lt; 30 cm) guiding targeted interventions. …”
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Diagnostic value of the saliva immunoglobulin free light chains concentrations measured in primary Sjцgren's syndrome by E. S. Kuvardin, I. V. Kholopova, E. A. Belyakova, I. N. Grigoryeva, A. V. Masing, O. Yu. Tkachenko, I. A. Bekhtereva, A. L. Maslyansky, Yu. A. Krivolapov, S. V. Lapin

“…Identification of diagnostic thresholds for the concentration of FLC in saliva for the diagnosis of pSS was carried out using the ROC analysis method. …”
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Comparative genome analysis investigation of nosocomial and community-acquired cases of Legionnaires’ disease caused by ST2858 and ST378 by Maria Najeeb, Gillian Cameron, Marianne Grimard-Conea, Sara Matthews, Julie Brodeur, Geneviève Cadieux, Pierre A. Pilon, Xavier Marchand-Senécal, Cindy Lalancette, Martin Smith, Michèle Prévost, Sebastien P. Faucher

“…Furthermore, Legionella isolates may differ in their ability to resist disinfection methods and potentially acquire novel genetic determinants, and water system characteristics may select for specific Legionella strains.…”
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ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI by Jiayi Peng, Huili Bai, Ying Li, Huating Luo, Jiajun Li, Haifeng Dai, Hongmei Wang, Tao Meng, Jia Zhang, Zhijian Wang, Xuanxin Chen, Wei Cheng, Yan Peng, Wenxiang Huang

“…Droplet digital polymerase chain reaction (ddPCR), a novel pathogen detection method with superior sensitivity and rapid results, demonstrates significant diagnostic and prognostic for BSI. …”
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Physical activity relates to carotid plaque vulnerability in older persons with subclinical carotid atherosclerosisResearch in context by Luoshiyuan Zuo, Maryam Kavousi, Julie A.E. Van Oortmerssen, Trudy Voortman, M Kamran Ikram, Daniel Bos

“…This study aimed to evaluate the association between physical activity and changes in carotid atherosclerotic plaque vulnerability, and the interaction between these two variables with the risk of first-ever stroke. Methods: This prospective study included 1330 stroke-free persons (mean age: 71.5 years) from the population-based Rotterdam Study with carotid atherosclerosis. …”
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Behavioral and biochemical changes associated with the analgesic effects of (2R,6R)-hydroxynorketamine alone and in combination with meloxicam following disk puncture in mice by Vaskar Das, Isabella Milejczyk, Michael B. Basovich, Mario Moric, Jay Kaila, Craig J. Thomas, Asokumar Buvanendran, Robert J. McCarthy

“…Brain, spinal cord, and dorsal root ganglion tissues were obtained for immunohistochemistry and western blot analysis.ResultsPrior to disk puncture paw withdrawal thresholds were 3.44 ± 0.51 g before surgery and were reduced to 0.54 ± 0.38 g at day 7 without a difference by sex; however, sex-specific responses were evident in other behavioral outcomes. …”
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The effect of expanded access to mental health care on economic status of households with a person with a mental disorder in rural Ethiopia: a controlled before-after study by Yohannes Hailemichael, Damen Hailemariam, Kebede Tirfessa, Sumaiyah Docrat, Atalay Alem, Girmay Medhin, Abebaw Fekadu, Crick Lund, Dan Chisholm, Charlotte Hanlon

“…However, there was no significant difference in the proportion of households experiencing catastrophic OOP health care expenditure in the SMD, depression and the comparison groups (p = 0.808 and p = 0.779 ). …”
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Evaluation of the Wondfo G6PD/Hb Test for glucose-6-phosphate dehydrogenase deficiency: preliminary performance, matrix equivalence, and usability by Rebecca K. Green, Stephanie Zobrist, Gornpan Gornsawun, Paw Khu Moo, Laypaw Archasuksan, Huyen Nguyen, Huong Nguyen, Cindy S. Chu, Emily Gerth-Guyette, Podjanee Jittamala, François Nosten, Sampa Pal, Germana Bancone, Gonzalo J. Domingo

“…McNemar’s test showed no significant differences in classification between venous and capillary specimens. …”
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Correlation and predictive value of oxygenation and oxygen saturation indices in extremely preterm infants: a prospective study by Ibrahim Alanazi, Saleh S. Algarni, Saleh S. Algarni, Saad Alshreedah, Naif Alotaibi, Mohammed Sufyani, Sami S. Alanazi, Abeer H. Alharthi, Abadi Ghazwani, Omar M. Almutairi, Maryam Alkaabi, Abdulaziz Homedi, Ibrahim Ali, Mohammed Khawaji, Saif Alsaif, Kamal Ali, Kamal Ali, Kamal Ali

“…Further research is needed to refine these diagnostic thresholds to enhance neonatal care outcomes.…”
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Intracameral prostaglandin implant vs Timolol in open-angle glaucoma or ocular hypertension: a systematic review and meta-analysis by Nikhil Sharma, MahalaquaNazli Khatib, AshokKumar Balaraman, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G․V․Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, MahendraPratap Singh, Ganesh Bushi, Nagavalli Chilakam, Sakshi Pandey, Manvinder Brar, Rachana Mehta, Sanjit Sah, AbhayM Gaidhane, Muhammed Shabil, Abdullah Ahmed, Hashem Abu Serhan

“…Primary outcomes were mean difference (MD) in IOP reduction and adverse events. …”
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Prediction of litchi flower induction in South China region based on the CMIP6 climate model by HOU Wei, ZHANG Liuhong, ZHANG Lei, LUAN Lan, ZHANG Mingjie, WANG Xiuzhen, ZHANG Hui

“…To identify the key climatic factors affecting litchi flower formation, we calculated chilling accumulation for low temperature thresholds of 10 ℃, 12 ℃, 15 ℃, 18 ℃, and 20 ℃, as well as heat accumulation for high temperature thresholds of 25 ℃, 28 ℃, and 30 ℃. …”
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The Association of the Long Prostate Cancer Expressed PDE4D Transcripts to Poor Patient Outcome Depends on the Tumour’s TMPRSS2-ERG Fusion Status by Dianne van Strijp, Christiane de Witz, Birthe Heitkötter, Sebastian Huss, Martin Bögemann, George S. Baillie, Miles D. Houslay, Chris Bangma, Axel Semjonow, Ralf Hoffmann

“…For the DB cohort, this demonstrated significant differences in the AUC between the CAPRA and the PDE4D5/7/9 regression model vs. the CAPRA and PDE4D7 risk model (AUC 0.87 vs. 0.82; p=0.049) vs. the CAPRA score alone (AUC 0.87 vs. 0.77; p=0.005). …”
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Evaluating the impact of the ‘Blow, Breathe, Cough’ health promotion intervention in resolving otitis media with effusion in children: An adaptive randomized-controlled trial proto... by Jaimee R. Rich, Michael Dymock, Elke J. Seppanen, Elena Montgomery, Tanisha Cayley, Tamara Veselinović, Greta Bernabei, Anri Lester, Amy Hannigan, Nicole Irvine, Kerryn Gidgup, Edna Ninyette, Steph Bray, Tu Trang Tran, Valerie M. Swift, Melinda Edmunds, Natalie Strobel, Daniel McAullay, Julie Marsh, Evelyn Tay, Lea-Ann S. Kirkham, Ruth B. Thornton, Robyn S.M. Choi, Lydia Timms, Emily Jackson, Jafri Kuthubutheen, Peter C. Richmond, Christopher G. Brennan-Jones

“…The primary outcome is the difference in OME resolution rates between trial arms, assessed using tympanometry (type B to A or C1 transition) and otoscopy. …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…The interventions appear highly cost-effective at thresholds for societal willingness to pay used by the National Institute for Health and Care Excellence. …”
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BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial by Simon J Davies, David Coyle, Elizabeth Lindley, David Keane, John Belcher, Fergus Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie MacDonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim

“…Probability of the intervention being cost-effective was 76% and 83% at the willingness-to-pay thresholds of £20,000 and £30,000 per quality-adjusted life-year gained, respectively. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…What is the cost-effectiveness of HCL for managing glucose in people who have type 1 diabetes and are having difficulty managing their condition despite prior use of at least one of the following technologies: CSII, rt-CGM, isCGM? Methods Systematic review methods followed the principles outlined in the Cochrane Handbook. …”
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