Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8⁺ T Cells to Promote an Antitumor Response by Hsin-Fang Tu, Julia Tao, Ming-Hung Hu, Darrell Fan, Ya-Chea Tsai, Tzyy-Choou Wu, Chien-Fu Hung

“…This study investigates the functional impact of Ly6C expression on CD8⁺ T cells and explores albumin-conjugated IFNβ (Alb-IFNβ) as a strategy to modulate Ly6C expression and improve cancer vaccine efficacy. <b>Methods:</b> We analyzed the functional differences between Ly6C high-expressing (Ly6C^hi) and Ly6C low-expressing (Ly6C^lo) naïve CD8⁺ T cells in tumor suppression. …”
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Abnormal metal ion levels following spinal instrumentation surgery by Ping Liu, Guoqiang Wang, Bing Zhou, Yijun Kang

“…Given the high heterogeneity among studies, more robust and standardized research is needed to establish clear clinical thresholds for safe metal ion levels and to assess the long-term implications of these findings. …”
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Association between intake of less-healthy foods defined by the United Kingdom's nutrient profile model and cardiovascular disease: A population-based cohort study. by Oliver T Mytton, Nita G Forouhi, Peter Scarborough, Marleen Lentjes, Robert Luben, Mike Rayner, Kay Tee Khaw, Nicholas J Wareham, Pablo Monsivais

“…Items were classified as less-healthy using Ofcom regulation thresholds. We used Cox proportional hazards regression to test for an association between consumption of less-healthy food and incident CVD. …”
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Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery &amp;ndash; A Secondary Analysis of a Prospective Cohort Study by Mewes C, Wei P, Yang Y, Kainz E, Kahl U, Beck S, Graefen M, Zöllner C, Fischer M

“…The mean duration of intraoperative CVA measurement was 178 min.Conclusion: This study demonstrates a wide range of individual intraoperative MAPopt values and underscores that CVA-based MAPopt during non-cardiac surgery may differ from commonly accepted intraoperative MAP thresholds in clinical practice (ie 65 mmHg).Keywords: cerebral autoregulation, optimal mean arterial pressure, limits of cerebral autoregulation, non-cardiac surgery, personalized arterial pressure management…”
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Analysis of self‐monitoring of blood glucose metrics in gestational diabetes mellitus and their association with infants born large for gestational age: A historical observational... by Nael Shaat, Omar Akel, Karl Kristensen, Anton Nilsson, Kerstin Berntorp, Anastasia Katsarou

“…Receiver operating characteristic (ROC) curves were used to evaluate glucose levels for LGA prediction. Differences in means were tested using analysis of variance. …”
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Breastfeeding, HIV exposure, childhood obesity, and prehypertension: A South African cohort study. by Brian Houle, Tamsen J Rochat, Marie-Louise Newell, Alan Stein, Ruth M Bland

“…We dichotomized 3 outcome measures using pre-established thresholds for clinical interpretability: (1) overfat: ≥85th percentile of body fat; (2) overweight: >1 SD BMI z score; and (3) prehypertension: ≥90th percentile for systolic BP (SBP) or diastolic BP (DBP). …”
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The role of scapular morphological structure in degenerative rotator cuff injury: a digital reconstruction radiograph study by Wen-bin Zhang, Fei-Long Lu, Yu-Lin Ma, Xiao-Ming Du, Hao Song, Zhao-Xi Yang, Yi-Mei Hu

“…Results (1) Inter-observer reliability was excellent for all the parameters (intra-class correlation coefficient (ICC) > 0.8). (2) CSA and AGA were significantly greater in the rotator cuff injury group (P CSA = 0.003;P AGA < 0.001), whereas GIA was significantly lower (P < 0.001); no difference was detected in AT (P > 0.05). (3) Binary logistic regression analysis revealed that GIA, CSA, and AGA were risk factors for rotator cuff injury (P CSA =0.008; P AGA = 0.001; P GIA = 0.001). (4) ROC analysis yielded area under the curve (AUC) values of 0.755 (GIA), 0.700 (CSA), and 0.796 (AGA), with cutoff thresholds of 83.98°, 30.67°, and 42.04°, respectively. (5) Strong correlations were observed between the CSA and AGA (r = 0.939), whereas the GIA was inversely correlated with both the CSA (r = -0.423) and the AGA (r = -0.471). …”
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Improving chest pain risk assessment: validation of HEART, TIMI, GRACE, EDACS-ADP, and HET for MACE prediction in the emergency department by Mehdi Nasr Isfahani, Hamidreza Mohseni, Elahe Nasri Nasrabadi, Nizal Sarrafzadegan

“…Performance variations were attributed to differences in population demographics, and study design. …”
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Analysis of climate variability and its linkage with large-scale climate oscillations: implications to pastoral and agropastoral livelihood resilience in Siti Zone, Somali Region,... by Esayas Nigatu Gebremeskel, Degefa Tolossa, Getachew Gebru

“…Spatiotemporal sea surface temperature was established using the Pearson correlation method. Mann–Kendal and Sen’s slope estimator trend test were also used for trend analysis. …”
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Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). by Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Hywel C Williams, Taraneh Dean, Nigel P Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J Mitchell, Fiona Cowdell, Sara J Brown, Alan A Montgomery, UK Dermatology Clinical Trials Network’s CLOTHES Trial Team

“…This confidence interval is equivalent to a difference of -1.5 to 0.5 in the original EASI units, which is not clinically important. …”
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Gestational weight gain adequacy and intrapartum oxytocin and cesarean section use: Observational population‐based study in France by Melissa Amyx, Jennifer Zeitlin, Béatrice Blondel, Camille Le Ray

“…GWG was calculated as the difference between end of pregnancy and prepregnancy weight (both self‐reported) and categorized as insufficient, adequate (reference group), or excessive by prepregnancy body mass index (BMI; underweight <18.5, normal weight 18.5–24.9, overweight 25–29.9, obese ≥30 kg/m2) using the 2009 Institute of Medicine thresholds. …”
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Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample by Damien Lekkas, Amanda C. Collins, Michael V. Heinz, Tess Z Griffin, Arvind Pillai, Subigya K. Nepal, Daniel M. Mackin, Andrew T. Campbell, Nicholas C. Jacobson

“…Data consisted of thrice-daily SI severity scores measured through self-report responses to item 9 of the Patient Health Questionnaire mobile version (MPHQ-9) as well as free-form diary text. Using difference scores and probability of acute change thresholds, eleven acute SI phase trajectory types were defined to label change in SI over three consecutive EMAs. …”
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Prediction of pathological response to neoadjuvant immunochemotherapy with baseline and post-treatment 18F-FDG PET imaging biomarkers in patients with locally advanced gastric canc... by Mimi Xu, Yafei Zhang, Kui Zhao, Haiping Jiang, Guangfa Wang, Yan Wu, Yu Wang, Nian Liu, Xinhui Su

“…These thresholds demonstrated high sensitivity (80% for bMTV and 100% for others), specificity (83.9%, 71.0%, 67.7%, 83.9%, 61.3%, and 71.0%), and accuracy (86.1%, 66.7%, 72.2%, 86.1%, 66.7%, and 75.0%) in predicting TRG 0 after NICT, with no statistically significant differences between them after the McNemar test (all p > 0.05). …”
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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…OMERACT-OARSI criteria and Patient Acceptable Symptom State outcome score thresholds for the KOOS-12 and Oxford Knee Score will be used in secondary analyses. …”
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Sleep characteristics and hearing loss in middle-aged and older adults: The National Health and Nutrition Examination Survey 2015–2018 by Kening Jiang, Adam P. Spira, Nicholas S. Reed, Frank R. Lin, Jennifer A. Deal

“…Audiometric hearing thresholds at 0.5, 1, 2 and 4 kilohertz were averaged to calculate better-ear pure-tone average (PTA). …”
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Encouraging arm use in stroke survivors: the impact of smart reminders during a home-based intervention by Laura Mayrhuber, Sebastian D. Andres, Mathilde L. Legrand, Andreas R. Luft, Franziska Ryser, Roger Gassert, Janne M. Veerbeek, Jannie van Duinen, Anne Schwarz, Karmen Franinovic, Christoph Rickert, Erik Schkommodau, Jeremia P. O. Held, Chris Awai Easthope, Olivier Lambercy

“…While the results regarding the increased arm use at home are promising, patient-reported outcomes remained below clinically meaningful thresholds and showed no group differences. Further, it is essential to acknowledge feasibility issues such as adherence to wearing the trackers during the intervention and missing sensor data. …”
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Melanocortin-1 receptor expression as a predictive factor for postoperative outcomes in melanoma patients: a retrospective study by Tian Xiang, Tian Xiang, Haiying Li, Xiaowei Wang, Danke Su

“…Background and objectiveThis study aims to explore the relationship between melanocortin-1 receptor (MC1R) expression levels and clinical pathological parameters of melanoma, as well as its potential as a prognostic biomarker.MethodsThis retrospective study included 99 melanoma patients in our hospital from June 2017 to July 2023. …”
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Peripartum fetal Doppler sonography and perinatal outcome: a systematic review and meta-analysis by Bram Packet, Ann-Sophie Page, Jan Bosteels, Jute Richter

“…Summary Odds Ratios (ORs) and Mean Differences (MDs) are reported with 95% confidence intervals. …”
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Patient-Reported Outcomes From LIBRETTO-431: First-Line Selpercatinib Versus Chemotherapy With Pembrolizumab in RET Fusion-Positive NSCLC by Caicun Zhou, MD, PhD, Silvia Novello, MD, PhD, Pilar Garrido, MD, PhD, Christophe Dooms, MD, PhD, Jorge Alatorre-Alexander, MD, Niels Reinmuth, MD, Gill Worthy, PhD, Kim Cocks, PhD, Justin Williams, PhD, Hongmei Han, MS, MApSt, Minji K. Uh, PhD, Nalin Payakachat, PhD, Adrienne M. Gilligan, PhD, Koichi Goto, MD, PhD

“…TTCD was defined as the time from randomization to first deterioration in score that met prespecified thresholds, confirmed at next assessment. Patient-reported tolerability was reported as the proportion of patients with side effect bother over time. …”
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Effects of 8-weeks of supplementation with a plant protein blend + creatine monohydrate on changes in maximal strength in resistance-trained males and females by Anthony M. Hagele, Kevin F. Holley, Alex C. Schrautemeier, James L. Tice, Joshua Iannotti, Joesi M. Krieger, Connor J. Gaige, Wyatt B. McLaughlin, Ralf Jäger, Chad M. Kerksick

“…For entry, participants were required to have 12 months of resistance training experience and achieve relative strength thresholds. Participants were randomly assigned (n = 15 each group) to supplement with either 48 g of a plant protein blend + creatine (PPCr), 48 g of a plant protein blend (PP), 49 g of whey protein (WP), or 48 g of a carbohydrate placebo (CHO) for 8 weeks, while following a 4-day per week structured resistance training program. …”
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