Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…At 12 months, there were no significant differences between groups with respect to EQ-5D-5L utility, EQ-5D-5L visual analogue scale or CAT scores. …”
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Effects of Apnea-Induced Hypoxia on Hypoalgesia in Healthy Subjects by Cristian Mendoza-Arranz, Omar López-Rebenaque, Carlos Donato Cabrera-López, Alejandro López-Mejías, José Fierro-Marrero, Francisco DeAsís-Fernández

“…Hypoalgesia was tested with pressure pain thresholds (PPTs) and CPM. Oxygen saturation (SpO₂) and HR were also tested. …”
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Cost-Effectiveness of Introducing Nuvaxovid to COVID-19 Vaccination in the United Kingdom: A Dynamic Transmission Model by Clive Pritchard, Lucie Kutikova, Richard Pitman, Kira Zhi Hua Lai, Hadi Beyhaghi, IIana Gibbons, Amanda Erbe, Marija Živković-Gojović, Catherine Cosgrove, Mark Sculpher, David Salisbury

“…Cost savings were driven by reduced cold chain-related operational costs and vaccine wastage, while QALY gains were driven by potential differences in vaccine tolerability. Probabilistic sensitivity analysis indicated an approximately 70% probability of cost-effectiveness with Nuvaxovid-only versus mRNA-only vaccination across most cost-effectiveness thresholds (up to GBP 300,000/QALY gained). …”
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The EAT-Lancet diet in relation nutrient intake among older adults: insights from the Gothenburg H70 birth cohort study by Anna Stubbendorff, Silke Kern, Lina Rydén, Ingmar Skoog, Jessica Samuelsson

“…Similar results were observed using average requirement (AR) thresholds in sensitivity analyses. Conclusions Adherence to the EAT-Lancet diet was associated with a more favourable nutrient profile in this cohort of older adults, without evidence of widespread micronutrient inadequacy. …”
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Appropriate cardiopulmonary resuscitation duration and predictors of return of spontaneous circulation in traumatic cardiac arrest by Dongmin Seo, Inhae Heo, Kyoungwon Jung, Hohyung Jung

“…This study aimed to establish evidence-based CPR duration thresholds and identify factors associated with return of spontaneous circulation (ROSC) in TCA patients. …”
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FWFA: Fairness-Weighted Federated Aggregation for Privacy-Aware Decision Intelligence by Rahul Haripriya, Nilay Khare, Manish Pandey, Shrijal Patel, Jaytrilok Choudhary, Dhirendra Pratap Singh, Surendra Solanki, Duansh Sharma

“…Additionally, a dynamic weighting mechanism was simulated by varying fairness thresholds to explore adaptive aggregation behavior, revealing a controllable trade-off between fairness and model performance. …”
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Parent–Child Agreement on Fatigue in Pediatric Otolaryngology Patients by Amy E. Ensing, Amy L. Zhang, Rebecca Z. Lin, Emma K. Landes, Henok Getahun, Judith E. C. Lieu

“…Only the median child–parent score differences for general domain score in the SDB group (12.5; 95% CI 2.08 to 22.9), and total score (7.41; 95% CI −0.69 to 25.7) and general domain score (11.5; 95% CI 2.08 to 27.1) in the developmental delay group met clinical significance thresholds. …”
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“VisualFields Easy”: an iPad Application as a Simple Tool for Detecting Visual Field Defects by Angelane S. Santos, MD, Evelyn S. Morabe, MD

“…Each subject was tested using the standard automated Humphrey Field Analyzer (Carl Zeiss Meditec, Inc., Germany) with the 30-2 Swedish Interactive Thresholding Algorithm (SITA) and the “VisualFields Easy” application (background = 10 cd/m2 ; size V target; 16-dB stimulus) loaded in an iPad 2 ver. 8.3. …”
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Comparative analysis of differentially expressed genes in breast cancer across Asian and European populations: insights into molecular pathways and biomarkers by Prabhu Meganathan, Sharvari Sawant, Shreshta Reddy

“…This study investigates differences in BC gene expression between European and Asian populations by analysing differentially expressed genes (DEGs) and identifying potential biomarkers for diagnosis and treatment. …”
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Is Age-adjusted Sagittal Parameter Important for Patients Receiving Short Anterior and Oblique Anterolateral Lumbar Surgery? by Kuan-Kai Tung, Wei-Cheng Tseng, Yun-Che Wu, Kun-Hui Chen, Chien-Chou Pan, Cheng-Min Shih, Cheng-Hung Lee

“…Conclusions: Both ALIF and OLIF could achieve satisfactory clinical results targeting age-adjusted thresholds for patients with symptomatic degenerative lumbar disorders, including SVA, PT, and PI-LL. …”
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Value of a BRAFV600E and lymphocyte subset-based nomogram for discriminating benign lesions from papillary thyroid carcinoma in C-TIRADS 3 and higher nodules by Wenran Zhang, Simei Zeng, Jiaqing Dou, Chenfan Yu

“…Decision curve analysis confirmed its clinical utility across relevant probability thresholds. Finally, the comparative analysis demonstrated superior diagnostic performance of the novel nomogram relative to the C-TIRADS system (AUC: 0.862 vs. 0.752; P<0.01).ConclusionThe BRAFV600E-lymphocyte subset nomogram demonstrates robust clinical utility for discriminating benign lesions from PTC in C-TIRADS 3+ thyroid nodules, offering superior diagnostic performance to conventional risk stratification systems.…”
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An echo state network based on enhanced intersecting cortical model for discrete chaotic system prediction by Xubin Wang, Pei Ma, Jing Lian, Jizhao Liu, Yide Ma

“…The model incorporates a neuron model with internal dynamics, including adaptive thresholds and inter-neuron feedback, into the reservoir structure. …”
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Exploring the link between BMI and physical fitness in Sichuan’s ethnic minority primary school students: insights from quantile regression analysis by Jingtao Wu, Yanhong Shao, Jun Hu, Xinjuan Zhao

“…This study aims to delineate the association between BMI and physical fitness among primary school students in Sichuan’s ethnic minority regions, offering insights to inform health policy tailored to these communities. Methods Utilizing a randomized cluster sampling approach, the study was conducted across ethnic minority regions in Sichuan Province from September to October 2023, encompassing a cohort of 10,800 students from Grade 3 to Grade 6. …”
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The prognostic impact of net ultrafiltration intensity in critically ill patients receiving continuous renal replacement therapy: a multivariable and propensity-matched analysis by Lu Jin, Peiyun Li, Youli Tang, Wanhong Yin, Fang Wang, Ling Zhang

“…However, future studies are needed to better define optimal UFnet thresholds in multicenter ICU cohorts.…”
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Low-moderate alcohol use effects on glycemic control of patients presenting in the ED by Dominick DeMasi, Laura Harrison, Fredrick A. Davis, Adam Berman, Sandeep Kapoor, Nancy Kwon

“…These findings suggest the need for substance use interventions at lower AUDIT-C thresholds and further considerations to mitigate future risk in this population.…”
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Combined predictive value of uric acid and serum lipid for stroke events in non-valvular atrial fibrillation patients by Yuqi Tang, Baiqing Song, Tesfaldet H. Hidru, Yiheng Yang, Fei Liu, Jiatian Li, Chenglin Li, Yuhang Wen, Zhongzheng Yang, Ying Chen, Xiaolei Yang, Yunlong Xia

“…We analyzed SUA concentration and lipid profile, along with relevant clinical data, to assess their impact on the occurrence of ischemic stroke (IS) in NAF patients. Due to gender differences in TG (1.39 mmol/L vs. 1.28 mmol/L for males, P = 0.031;1.57 mmol/L vs. 1.28 mmol/L for females, P = 0.001) and SUA levels (424 µmol/L vs. 397 µmol/L for males, P = 0.008; 361 µmol/L vs. 328 µmol/L for females, P = 0.004), we determined the thresholds for SUA (400 µmol/L in males and 330 µmol/L in females) and TG (1.28 mmol/L in males and 1.29 mmol/L in females) that predict stroke events in NAF patients by restricted cubic spline curves. …”
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Application of the American Heart Association/American College of Cardiology/Heart Failure Society of America Heart Failure Staging Guidelines in Adults With Chronic Kidney Disease by Anna M. Zemke, Leila R. Zelnick, Joachim H. Ix, Alan S. Go, Edward D. Siew, Nisha Bansal

“…The applicability of this staging system in chronic kidney disease is not well established. Methods This is a prospective cohort study of 2415 participants from CRIC (Chronic Renal Insufficiency Cohort). …”
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Extreme heat and pediatric health in a warming world: a space-time stratified case-crossover investigation in Ontario, Canada by Hallah Kassem, Eric Lavigne, Kate Weinberger, Michael Brauer

“…This study evaluated pediatric emergency healthcare utilizations associated with EHEs in Ontario. Methods Applying a space-time stratified case-crossover design, associations between EHEs (same-day or lagged exposure to 2 consecutive days of daily maximum temperatures above percentile thresholds) and 15 causes of pediatric emergency healthcare use in Ontario, Canada from 2005 to 2015 were analysed using conditional quasi-Poisson regression. …”
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Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cognitive impairment in patients with acute mild ischemic... by Huiting Wang, Jingru Wang, Depeng Feng, Lin Wang, Jingjing Zhang

“…By collecting data from patients with acute minor ischemic stroke in hospital, we will analyze the relationship between NHHR and cognitive function in these patients. Methods This study enrolled 817 acute ischemic stroke (AIS) patients (NIHSS ≤ 5), Cognitive function was assessed using Mini-Mental State Examination (MMSE) within 2 weeks, with cognitive impairment defined by education-stratified thresholds. …”
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The role of adenosine monophosphate-activated protein kinase and serum amyloid A proteins in the early diagnosis of neonatal sepsis by P.A. Orujova, N.H. Sultanova

“…The ROC analysis indicated that AMPK and SAA levels below specific thresholds were significant for excluding sepsis. …”
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