Abstract 078: Managing Clopidogrel Resistance in Neurointervention: Surveying Current Approaches by Hyun Woo Kim, Ivo Bach, Juan Carlos Martinez‐Gutierrez, Adam Dmytriw, Hussein Zeineddine, Salvatore D'Amato, Sunil Sheth

“…Respondents reported 25 different therapeutic thresholds, with the P2Y12 Reaction Units range between 60 and 180 most commonly used (16.4%). 61% reported they would switch to ticagrelor in the case of persistent resistance. …”
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Performance with an additional load: formula-based predictions for controlling the load intensity when carrying backpacks by Saskia Klughardt, Bettina Schaar

“…Conclusion The formulas can predict the adaptation of running speeds and heart rates at the ventilatory thresholds with different additional loads. This is useful for controlling optimal load intensities in endurance performance with additional loads, to prevent overstraining. …”
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Automated note annotation after bioacoustic classification: Unsupervised clustering of extracted acoustic features improves detection of a cryptic owl by Callan Alexander, Robert Clemens, Paul Roe, Susan Fuller

“…The pipeline helps to address two key challenges in bioacoustic monitoring: the need for manual validation of automated detections and the difficulty of obtaining accurate note-level annotations in noisy field recordings. Adaptation of these methods to other species and vocalisations may facilitate improved detection and investigation of vocal characteristics across different populations or regions.…”
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The Influence of Insertion Torque on Stress Distribution in Peri-Implant Bones Around Ultra-Short Implants: An FEA Study by Mario Ceddia, Lorenzo Montesani, Luca Comuzzi, Alessandro Cipollina, Douglas A. Deporter, Natalia Di Pietro, Bartolomeo Trentadue

“…However, the amount of insertion torque (IT) applied during implant placement significantly influences stress distribution in the peri-implant bone, which affects implant stability and long-term success. Materials and Methods: This study used finite element analysis (FEA) to examine how different insertion torques (35 N·cm and 75 N·cm) affect stress distribution in cortical and trabecular bone types D2 and D4 surrounding ultra-short implants. …”
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De novo genome hybrid assembly and annotation of the endangered and euryhaline fish Aphanius iberus (Valenciennes, 1846) with identification of genes potentially involved in salini... by Alfonso López-Solano, Ignacio Doadrio, Tessa Lynn Nester, Silvia Perea

“…In addition to the assembly, an extensive functional annotation of the genome is provided by using AUGUSTUS, and two different approaches (InterProScan and Sma3s). The genome size (1.15 Gb) is consistent with that of the most closely related species, and its quality and completeness, as assessed with various methods, exceeded the suggested minimum thresholds, thus confirming the robustness of the assembly. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…A cost-effectiveness curve was generated to depict the probability of each intervention being cost-effective at different willingness-to-pay thresholds. Results We identified and screened 4708 publications from the search and retrieved 508 full-text articles for eligibility assessment. …”
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Hazard Assessment of Extreme Compound Flood Hazards in Coastal Cities under Climate Change: A Case Study of Haikou City by Liu Qing, Wu Guofeng, Yao Qian, Xu Hanqing, Niu Yiying, Wei Xuchen, Wang Jun, Li Mengya

“…Using rainfall data from the climate model, we applied the peak-over-threshold method and extreme value analysis to systematically assess changes in storm tides, rainfall, and upstream discharge under climate change. …”
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Economic evaluation in collaborative hospital drug evaluation reports by Ana Ortega, María Dolores Fraga, Roberto Marín-Gil, Eduardo Lopez-Briz, Francesc Puigventós, George Dranitsaris

“…Main difficulties: low quality evidence in the target population, no comparative studies with a relevant comparator, non-final outcomes evaluated, no quality of life data, no fixed drug price available, dosing uncertainty, and different prices for the same drug. Conclusions: proposed improvements: incorporating different forms of aid for non-drug costs, survival estimation and adapting published economic evaluations; establishing criteria for drug price selection, decision-making in conditions of uncertainty and poor quality evidence, dose calculation and cost-effectiveness thresholds depending on different situations.…”
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A simple and efficient algorithm for genome‐wide homozygosity analysis in disease by Wei Liu, Jinhui Ding, Jesse Raphael Gibbs, Sue Jane Wang, John Hardy, Andrew Singleton

“…This algorithm identifies loci by defining homozygous segments of the genome present at significantly different frequencies between cases and controls. We found that false positive loci could be effectively removed from the output of this procedure by applying different physical size thresholds for the homozygous segments. …”
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Research on Plant Disease and Pest Diagnosis Model Based on Generalized Stochastic Petri Net by Wenxue Ran, Qilian Tang

“…By comprehensively analyzing the interaction between mild, moderate, and severe infection rates, the critical zone surface under different disease and pest warning thresholds was obtained. …”
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China Aerosol Raman Lidar Network (CARLNET)—Part I: Water Vapor Raman Channel Calibration and Quality Control by Nan Shao, Qin Wang, Zhichao Bu, Zhenping Yin, Yaru Dai, Yubao Chen, Xuan Wang

“…Based on the distribution of lidar in regions with different humidity conditions, the method of real-time calibration and quality control based on radiosonde data is established for the first time. …”
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Exploring voluntary sector specialist services for victim-survivors of sexual violence in England: the PROSPER co-production study by Caroline Bradbury-Jones, Sarah Damery, Kirsten Fruin, Clare Gunby, Jenny Harlock, Lucy Hebberts, Louise Isham, Anne-Marie Jones, Fay Maxted, Amelia Mighty, Priti Parmar, Laura Patterson, Jason Schaub, Fee Scott, Harriet Smailes, Debs Smith, Julie Taylor

“…Explore the usefulness of different approaches to service delivery and different therapy models. …”
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Validation of genetic risk scores for hypertension in the Central Russian population by A. S. Limonova, A. I. Ershova, A. V. Kiseleva, V. A. Kutsenko, V. E. Ramensky, Yu. V. Vyatkin, E. A. Sotnikova, A. A. Zharikova, M. Zaichenoka, M. S. Pokrovskaya, S. А. Shalnova, A. N. Meshkov, O. M. Drapkina

“…A combined GRS was compiled based on coefficients from individual GRSs using the clumping + thresholding (C+T) method.Results. The study demonstrated that the predictive value of previously developed GRSs when used for Central Russian population is lower than in the original studies. …”
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Integrative radiomics of intra- and peri-tumoral features for enhanced risk prediction in thymic tumors: a multimodal analysis of tumor microenvironment contributions by Liang zhu, Jiamin Li, Xuefeng Wang, Yan He, Siyuan Li, Shuyan He, Biao Deng

“…To further evaluate the effectiveness of these models, various statistical methods were applied, including DeLong’s test, NRI, and IDI, to compare predictive differences among models. …”
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Validating the pathogenic mechanism of chronic obstructive pulmonary disease induced by negative emotions via Mendelian randomization and traditional Chinese medicine theory of emo... by Zhiying Wang, Yun Li, Zhixian Zhong, Ling Xu, Yi Zhong, Jian Chen

“…Weak instrument bias was mitigated via F-statistic thresholds (> 10). All analyses were conducted in RStudio. …”
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Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT by Lucy Thompson, Jessica Tanner, Matthew Breckons, Naomi Young, Laura Ternent, Thenmalar Vadiveloo, Philip Wilson, Danny Wight, Louise Marryat, Iain McGowan, Graeme MacLennan, Angus MacBeth, James McTaggart, Tim Allison, John Norrie

“…Participants recruited before the pandemic were no different from those recruited afterwards. What did this mean? …”
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Imaging modalities for characterising T1 renal tumours: A systematic review and meta‐analysis of diagnostic accuracy by Hannah Warren, Jack B. Fanshawe, Valerie Mok, Priyanka Iyer, Vinson Wai‐Shun Chan, Richard Hesketh, Eleanor Zimmermann, Veeru Kasivisvanathan, Mark Emberton, Maxine G. B. Tran, Kurinchi Gurusamy

“…Meta‐analysis was not performed for other imaging due to different thresholds for test positivity. Conclusion The optimal imaging strategy for T1 renal masses is not clear. [99mTc]Tc‐sestamibi SPECT/CT is an emerging tool, but further studies are required to inform its role in clinical practice. …”
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Customised and Noncustomised Birth Weight Centiles and Prediction of Stillbirth and Infant Mortality and Morbidity: A Cohort Study of 979,912 Term Singleton Pregnancies in Scotland... by Stamatina Iliodromiti, Daniel F Mackay, Gordon C S Smith, Jill P Pell, Naveed Sattar, Debbie A Lawlor, Scott M Nelson

“…<h4>Methods</h4>This is a population-based linkage study of 979,912 term singleton pregnancies in Scotland, United Kingdom, between 1992 and 2010. …”
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Impact of the COVID-19 pandemic on continuity of medical treatment for patients with chronic diseases in Japan: a retrospective cohort analysis by Tomoki Ishikawa, Akihito Kako, Jumpei Sato, Junko Hattori, Hiromasa Yoshimoto, Masaru Kitsuregawa, Kazuo Goda, Yoshimitsu Takahashi, Takeo Nakayama, Naohiro Mitsutake

“…Sensitivity analyses showed consistent findings, despite slight variations in hazard ratios for different gap thresholds. Conclusions The COVID-19 pandemic was associated with an increased risk of treatment interruption in patients with chronic diseases, underscoring the need for targeted strategies to maintain care continuity during public health emergencies. …”
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Evaluation of intestinal tissue safety during the compression process of circular end-to-end anastomosis stapler based on finite element simulation by Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Yuanda Zhou, Zhen Tan, Peishi Jiang, Yi Sun, Yi Sun, Yi Sun, Yi Sun, Dewang Wu

“…ObjectiveCurrently, there is no standardized finite element analysis method for investigating the safe compression range of circular end-to-end anastomosis stapler. …”
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