Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…We projected long-term TB incidence, mortality and costs to 2035 and conducted a threshold analysis to identify the maximum possible epidemiological impact of a DAT intervention by assuming 100% treatment completion for patients on DAT.Findings We estimated small and uncertain epidemiological benefits of the pillbox intervention compared with the standard of care in Ethiopia, with a difference of −0.4% (95% uncertainty interval (UI) −1.1%; +2.0%) incident TB episodes and −0.7% (95% UI −2.2%; +3.6%) TB deaths. …”
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ASSESSMENT OF ADHESION BETWEEN BITUMINOUS BINDER AND MINERAL AGGREGATE USING DIGITAL IMAGE ANALYSIS by Jan Trejbal, Tereza Valentová, Tereza Horová

“…The first is based on a gray level thresholding, while the second one on an entropy-based image segmentation. …”
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Theoretical models for longitudinal coupled-bunch instabilities driven by harmonic cavities in electron storage rings by Murilo B. Alves

“…Notably, for the first time, theoretical predictions of the mode-1 thresholds show excellent agreement with experimental data. …”
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Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial by Jordan M. Cloyd, MD, Rakhsha Khatri, BA, Angela Sarna, BS, Lena Stevens, PhD, Victor Heh, PhD, Mary Dillhoff, MD, Alex Kim, MD, Timothy M. Pawlik, MD, PhD, MPH, Aslam Ejaz, MD, Sharla Wells-Di Gregorio, PhD, Erin Scott, MD, Sachin S. Kale, MD

“…Only 13 of 25 (52%) met the primary endpoint of ambulatory PC within 30 days, less than the prespecified threshold of 70%. Overall, 16 (64%) patients completed ambulatory PC consultation a mean of 29.2 ± 15.8 days after enrollment. …”
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Cost‐effectiveness analysis of a community‐based model for delivery of antiretroviral therapy to people with clinically stable HIV in Cambodia by Lo Yan Esabelle Yam, Pheak Chhoun, Ziya Tian, Michiko Nagashima‐Hayashi, Marina Zahari, Sovannary Tuot, Sovannarith Samreth, Bora Ngauv, Vichea Ouk, Kiesha Prem, Siyan Yi

“…Cost‐effectiveness thresholds (CETs) were one‐time gross domestic product (GDP) per capita and opportunity cost. …”
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The value of a combined model based on ultra-radiomics and multi-modal ultrasound in the benign-malignant differentiation of C-TIRADS 4A thyroid nodules: a prospective multicenter... by Shuai Cui, Qifan Liu, Hailong Wang, Husha Li, Wei Li, Chenlong Li, Leilei Bi, Yang Mu, Wenjing Guo, Jundong Yao, Zhoulong Zhang

“…DeLong’s test showed that the combined model performed best in the training set, and in the test set, the combined model outperformed the multimodal ultrasound model but showed no significant difference compared to the radiomics model. DCA indicated that the combined model achieved higher net benefits within a specific threshold probability range (0.15-0.90).ConclusionThe combined model exhibits robust diagnostic capability in distinguishing benign from malignant thyroid nodules classified as C-TIRADS 4A.…”
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Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia by Dereje Mengesha Berta, Negesse Cherie, Berhanu Woldu, Aregawi Yalew, Elias Chane, Amare Mekuaninnit, Mebratu Tamir, Zufan Yiheyis, Abiy Ayele Angelo, Zewudu Mulatie, Adamu Kassie, Bisrat Birke Teketelew

“…Blood biomarkers score area under curve >.7 was selected as the best discriminative marker. The accepted threshold for statistical significance was set at P < 0.05. …”
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Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…The VO2 at anaerobic threshold (AT VO2) was also lower in the T2DM group than in the non-T2DM group, with a MD of −1.11 ml/kg/min (95% CI −2.04 to −0.18, P &lt; 0.05). …”
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Mental health treatment and its impact on survival outcomes in patients with comorbid mental health and cardiovascular diseases: a retrospective cohort study by Tirsit Ketsela Zeleke, Fasil Bayafers Tamene, Gebremariam Wulie Geremew, Tekletsadik Tekleslassie Alemayehu, Minichil Chanie Worku, Samuel Agegnew Wondm, Aschalew Mulatu Tefera, Ayelign Eshete Fitgu, Wubetu Yihunie Belay, Abraham Teym, Rahel Belete Abebe, Bantayehu Addis Tegegne

“…Adjusted hazard ratios with corresponding 95% confidence intervals were reported, and statistical significance was determined at a P-value threshold of < 0.05. Kaplan-Meier survival curves were used to illustrate differences in time to hospital readmission and emergency department visits between treated and untreated patients. …”
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Impact of three sequential orthogeriatric care models on time to surgery after hip fracture: a retrospective study by Sabine Drevet, Jérôme Tonetti, Pierre Bouzat, Mehdi Boudissa, Jules Greze, Olga Fajfrova, Laure Allan-Pattoglia, Frederic Olive, Magali Bouisse, Bastien Boussat, Catherine Bioteau, Gaetan Gavazzi

“…The length of stay did not differ between models. At discharge, 81.4% of patients from ICMA could walk at least 3 m. …”
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Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk by Rafał Watrowski, Eva Schuster, Stefan Polterauer, Toon Van Gorp, Gerda Hofstetter, Michael B. Fischer, Sven Mahner, Robert Zeillinger, Eva Obermayr

“…Subgroup analyses were stratified by menopausal status (age threshold 51 years), disease stage, and histological subtype. …”
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Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study by Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

“…We validated the NLR threshold of 5 from multiple previous studies in the data of this study, and patients with NLR > 5 also did not show a significant tendency towards the primary resistance group. …”
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Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial by Chen Z, Liu YY, Hu Q, Wang JS, Cao RY, Yu ST, Lu F, Zhong ML, Liang WD, Wang L

“…On postoperative days 1 and 3, the 3D-CAM scale was used to assess whether POD occurred in both groups of patients.Results: No statistically significant difference was observed in the general condition of the patients in the two groups. …”
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Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. by Kevin Ten Haaf, Martin C Tammemägi, Susan J Bondy, Carlijn M van der Aalst, Sumei Gu, S Elizabeth McGregor, Garth Nicholas, Harry J de Koning, Lawrence F Paszat

“…In general, scenarios that applied stringent smoking eligibility criteria (i.e., requiring higher levels of accumulated smoking exposure) were more cost-effective than scenarios with less stringent smoking eligibility criteria, with modest differences in life-years gained. Annual screening between ages 55-75 for persons who smoked ≥40 pack-years and who currently smoke or quit ≤10 y ago yielded an incremental cost-effectiveness ratio of $41,136 Canadian dollars ($33,825 in May 1, 2015, United States dollars) per life-year gained (compared to annual screening between ages 60-75 for persons who smoked ≥40 pack-years and who currently smoke or quit ≤10 y ago), which was considered optimal at a cost-effectiveness threshold of $50,000 Canadian dollars ($41,114 May 1, 2015, US dollars). …”
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Sustained effectiveness and cost-effectiveness of Counselling for Alcohol Problems, a brief psychological treatment for harmful drinking in men, delivered by lay counsellors in pri... by Abhijit Nadkarni, Helen A Weiss, Benedict Weobong, David McDaid, Daisy R Singla, A-La Park, Bhargav Bhat, Basavaraj Katti, Jim McCambridge, Pratima Murthy, Michael King, G Terence Wilson, Betty Kirkwood, Christopher G Fairburn, Richard Velleman, Vikram Patel

“…Economic analyses indicated that CAP plus EUC was dominant over EUC alone, with lower costs and better outcomes; uncertainty analysis showed a 99% chance of CAP being cost-effective per remission achieved from a health system perspective, using a willingness to pay threshold equivalent to 1 month's wages for an unskilled manual worker in Goa. …”
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Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population by Wenjian Lin, Zixin Liang, Junxuan Fang, Yu Liu, Lei Lei, Jiawen Lin, Bin Xia, Zhihua Zheng, Jingqiu Yuan, Chun Tang

“…<b>Result:</b> At the locus-wide significance threshold, we identified 18 gut microbiome features associated with CKD onset in the China Kadoorie Biobank (CKB). …”
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Insights into Sinus-Lift Bone Grafting Materials: What’s Changed? by Anida-Maria Băbțan, Claudia N. Feurdean, Anca Ionel, Willi A. Uriciuc, Radu Chifor, Chambon Antoine Bernard Jaques, Bianca A. Boșca, Aranka Ilea

“…AB had a better bone regeneration ratio compared to many of the other interventions, but only two passed the threshold of significance: A1B and B-TCP + AB. Conclusions: A grafting material’s superiority is determined by its new bone formation ratio, connective tissue integration, residual graft content, and bone resorptionratio. …”
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Mechanism of Inflammation Regulation of α7nAChR in Spleen and Spinal Dorsal Horn of Mice with Paclitaxel-induced Neuropathic Pain by Electroacupuncture on Zusanli Acupoint by PANG Lina, LAN Yanyan, WANG Zhifu, CHEN Xiaomei, YU Xiangmei

“…The changes of mechanical paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) of mice at day 0, 7 and 14 were measured by Von Frey painometer and a plantar algesia meter, respectively. …”
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Characteristics of Cerebral Cortical Structural Alterations in Female Patients with Systemic Lupus Erythematosus Without Major Neuropsychiatric Manifestations Accompanied by Anxiet... by Zhicheng Liu, Yifan Yang, Shuang Liu, Guofang Zhang, Ru Bai, Shu Li, Ruotong Zhao, Yuqi Cheng, Jian Xu

“…We also further examined the correlation between these morphological alterations and clinical characteristics. Methods: Employing advanced structural MRI (sMRI) techniques, we implemented a dual analytical approach combining voxel-based morphometry (VBM) and surface-based morphometry (SBM) to assess structural differences across three cohorts comprising 59 SLE patients with anxiety and/or depression (SLE-AD), 35 SLE patients with no anxiety and/or depression (SLE-NAD), and 48 age-matched healthy controls (HCs). …”
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Diabetes-related distress and psychological burden in patients with type 1 and type 2 diabetes – the role of child maltreatment, personality functioning, and epistemic trust: findi... by Sandra Zara, Imogen Carla Ullrich, Anna Maria Leveling, Friederike Gisela Genoveva Saretzki, Jana Schmitz, Michael Eckhard, Johannes Kruse, Johannes Kruse, Johannes Kruse, Hanna Kampling, Hanna Kampling

“…Epistemic mistrust and credulity were significantly higher (mistrust: t(111)=3.677, p&lt;.001, d=.692; credulity: t(111)=5.000, p&lt;.001, d=.941), with medium and large effect sizes. No differences regarding epistemic trust were found (t(111)=.409, p=.683, d=.077), with the effect size below the threshold for small effects. …”
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