Pharmacoeconomic analysis of antithrombotic therapy in patients with acute coronary syndrome and patients with atrial fibrillation who underwent percutaneous coronary intervention by V. А. Ryagina, К. I. Matrenin, D. G. Shchurov, Т. S. Teptsova

“…The result for ticagrelor in combination with ASA compared to clopidogrel in combination with ASA was 605,199 rubles, which was significantly lower than the willingness-to-pay threshold (2,235,201 rubles). Assessment of the impact of the therapy regimen including ticagrelor in combination with ASA on the target indicators of the State Health Care Program of the RF “Development of Healthcare” and the Federal Project “Cardiovascular Diseases Control” showed that the use of this therapy regimen will reduce mortality from myocardial infarction (MI) and cardiovascular causes by 2.45 cases per 100 thousand population provided that 100% of patients with MI and unstable angina in the RF are transferred from clopidogrel + ASA scheme to ticagrelor + ASA. …”
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A comprehensive investigation of the relationship between dietary fatty acid intake and preserved ratio impaired spirometry: multimethodology based on NHANES by Chenyuan Deng, Yu Jiang, Yuechun Lin, Hengrui Liang, Wei Wang, Jianxing He, Ying Huang

“…However, no prior research has investigated the associations of FAs and their subclasses with PRISm, particularly the combined effects of different types of FAs. Methods Data analysis was conducted on 8,836 individuals drawn from the NHANES dataset spanning the years 2007 to 2012. …”
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The S-shaped association between dietary caffeine intake and severe headache or migraine: a cross-sectional study based on NHANES by Zhiqiang Liao, Zhiqiang Liao, Aiqing Lin, Aiqing Lin, Junjian Zeng, Junjian Zeng, Yu Zou, Yu Zou, YiXun Chen, YiXun Chen, Zhonghua Liu, Zhonghua Liu, Zhidong Zhou, Zhidong Zhou

“…A smoothed two-piece logistic regression model was applied to identify threshold associations between dietary caffeine intake and severe headache or migraine. …”
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Prognostic and predictive value of tumor infiltration proportion within lymph nodes in N1 colorectal cancer by Rujie Chen, Jun Zhu, Jun Zhu, Dong Xu, Xiaoyan Fan, Yihuan Qiao, Xunliang Jiang, Jun Hao, Yongtao Du, Xihao Chen, Guo Yuan, Jipeng Li, Jipeng Li

“…Decision curve analysis (DCA) was performed to compare the net benefit of the nomogram at different threshold probabilities. Additionally, net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to evaluate the nomogram’s clinical utility.ResultsHigh TIPLN levels were significantly associated with poorer overall survival (OS). …”
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Population dynamics and fishery biology of the yellow-edged lyretail grouper Variola louti (Forsskål, 1775) along the eastern coast of the Red Sea by Sirajudheen Thayyil Kadengal, Zahra Okba, Goutham Bharathi Muthu Palani, Santhosh Charles, Adel M. S. Adam, Nesrine Boulila, Eyüp Mümtaz Tıraşın, Eyüp Mümtaz Tıraşın, Mark Dimech

“…Median FL at first maturity was 24.98 cm, with no significant sex differences. Mean natural mortality (M), derived from three different methods, was 0.243 year−1. …”
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Source apportionment and health risks of nitrate pollution in shallow groundwater in the agricultural Northern Xiaoxing' an Mountains region of China by Jilin Zheng, Xiaoyu Guo, Yanlong Cai, Junshuai Liu, Dake Wang, Xiaoqi Gao, Bowen Tan

“…This study investigated the sources, spatial distribution, and health risks of nitrate pollution using hydrochemical analysis, multivariate statistical methods, and health risk assessment. APCS-MLR (Absolute Principal Component Scores-Multiple Linear Regression) was employed to quantify pollution sources, while Monte Carlo simulation was utilized to assess health risks among different population groups. …”
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Prevalence of Onchocerca lupi in shelter dogs from an endemic region of the Southwestern USA by Maureen A. Kelly, Erin Clarke, Hassan Hakimi, Christine M. Budke, Guilherme G. Verocai

“…The objectives of this study were to: I) optimize a novel qPCR assay that detects O. lupi and II) to assess the prevalence of O. lupi in shelter dogs from Albuquerque, NM, USA. Methods This probe-based qPCR was optimized with a detection threshold of 0.33 pg for DNA of an adult female O. lupi. …”
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The snow must go on: how German cross-country skiers maintained training and performance in the face of COVID-19 lockdowns by H. Kock, H. Kock, A. Schürer, C. A. Staunton, C. A. Staunton, Helen G. Hanstock

“…TID was categorized using a 5-zone scale with Zones 1–2 representative of intensities below the first lactate threshold (LT1), zone 3 between LT1 and LT2, and zones 4–5 above LT2. …”
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Early Prediction of Abdominal Aortic Aneurysm Rupture Risk Using Numerical Biomechanical Analysis by Kristina Grassl, Thomas C. Gasser, Florian K. Enzmann, Alexandra Gratl, Josef Klocker, David Wippel, David C. Walcher, Elke R. Gizewski, Sabine H. Wipper

“…<b>Objective</b>: We aimed to predict patient-specific rupture risks and growth behaviors in abdominal aortic aneurysm (AAA) patients using biomechanical evaluation with finite element analysis to establish an additional AAA repair threshold besides diameter and sex. <b>Methods</b>: A total of 1219 patients treated between 2005 and 2024 (conservative and repaired AAAs) were screened for a pseudo-prospective single-center study. …”
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Experimental murine non-alcoholic steatohepatitis is associated with behavioural, cognitive, and peripheral neuronal dysfunction by V. A. Prikhodko, D. A. Orlyakhina, V. D. Petrova, V. E. Karev, D. Yu. Ivkin, S. M. Napalkova, S. V. Okovityi

“…The objective of this work was to characterize the short- and long-term psychoneurological and peripheral neuronal deficits that complicate different stages of NAFLD/NASH in mice.Materials and methods. 68 adult male C57Bl/6 mice were randomized into Control or NASH groups. …”
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Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…BackgroundTo explore the genetic characteristics of the Mycobacterium abscessus complex (MABC) population in China, given its rising clinical importance among nontuberculous mycobacteria.MethodsWe conducted population genetic analyses on 360 MABC genomes from China, focusing on core genome multilocus sequence typing (cgMLST), pan-genome characterization, population genetics, and antimicrobial resistance gene profiling.ResultsOur analysis identified 273 M. abscessus subsp. abscessus (MabA) and 87 M. abscessus subsp. massiliense (MabM) isolates, uncovering 68 sequence types (STs), with ST5 being the most common. cgMLST classified 33.3% of isolates into six dominant circulating clones (DCCs) and 49.4% into 59 genomic clusters at a threshold of 25 different alleles, including 18 international clusters linking Chinese isolates with seven other countries. …”
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Development and validation of a nomogram model for prolonged length of stay in spinal fusion patients: a retrospective analysis by Linghong Wu, Xiaozhong Peng, Yao Lu, Cuiping Fu, Liujun She, Guangwei Zhu, Xianglong Zhuo, Wei Hu, Xiangtao Xie

“…Abstract Objective To develop a nomogram model for the prediction of the risk of prolonged length of hospital stay (LOS) in spinal fusion patients. Methods A retrospective cohort study was carried out on 6272 patients who had undergone spinal fusion surgery. …”
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The Effect of Acute Lumbopelvic Muscular Fatigue on Neuromechanical Contraction Characteristics and Nociception by William J. Hanney, Christopher Lee, Julieanne Cuevas-Hernandez, Jing Lin, Morey J. Kolber, Abigail W. Anderson

“…Pre-intervention TMG and pressure pain threshold (PPT) measurements were taken, followed by the intervention and post-intervention measurements. …”
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Analysis of genomic ancestry and characterization of a new variant in MPS type VII by Andreza Juliana Moreira da Costa, Isabel Cristina Neves de Souza, Raimunda Helena Feio, Laurent Ketlen Leão Viana, Mislene Cisz, Célio Luiz Rafaelli, Franciele Barbosa Trapp, Maira Graeff Burin, Kristiane Michelin-Tirelli, Ana Carolina Brusius-Facchin, Alice Brinckmann Oliveira Netto, André Salim Khayat, Ney Pereira Carneiro dos Santos, Roberto Giugliani, Luiz Carlos Santana-da-Silva

“…Relative to the comparison among threshold cycles, 2/20 samples presented significantly different CT values for the patient with MPS VII when the numbers of amplification cycles were compared. …”
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Stability of a Discrete-Time Pathogen Infection Model with Adaptive Immune Response by M. A. Alshaikh, A. M. Elaiw

“…We discretize the continuous-time model by using the nonstandard finite difference (NSFD) method. We establish that NSFD preserves the nonnegativity and boundedness of the solutions of the model. …”
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Changes and significance of urinary liver type fatty acid binding protein level in patients with AKI by QIAN Jian, XU Peng, ZHANG Jun

“…Objective To investigate the changes and significance of urinary liver type fatty acid binding protein(L-FABP) level in patients with acute kidney injury(AKI).Methods Eighty-three cases of severe hospitalized patients from October 2013 to December 2015 in our hospital were selected,and divided into AKI group and non-AKI group according to whether there existed AKI on admission.The differences in biochemical indexes and urinary L-FABP levels between AKI group and non-AKI group were compared.The correlation between urinary L-FABP levels and biochemical indicators and ROC curve for urinary L-FABP level predicting AKI were analyzed.Results The serum urea nitrogen,serum creatinine,NAG and Cys C in patients with AKI of first examination after admission were higher than in non-AKI patients,and the difference was statistically significant(P<0.05).The glomerular filtration rate in patients with AKI was significantly lower than in non-AKI patients(P<0.05).The urinary L-FABP levels began to rise in the AKI patients on the 12 h after admission,and those in the non-AKI patients remained at a relatively stable level.The urinary L-FABP levels in patients with AKI were higher than those in non-AKI patients on 12,24 and 48 h after admission,and the difference was statistically significant(P<0.05).Urinary L-FABP levels in AKI patients on 12 h after admission were positively correlated with serum urea nitrogen,serum creatinine,NAG and Cys C of first examination after admission,and negatively correlated with glomerular filtration rate.ROC curve analysis revealed that the diagnostic threshold was 49.46,the sensitivity was 60.0%,the specificity was 95.83%,the Youden index was 0.558,and the area under the ROC curve was 80.89%.Qmclusions The urinary L-FABP level in patients with AKI was abnormally elevated,and it can be used as an important clinical index to predict the occurrence of AKI.…”
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Reliability and Sensitivity of Enode/Vmaxpro Sensor for Muscle Power Assessment by Milan Marković, Lazar Toskić, Veroljub Stanković, Radenko Arsenijević, Nikola Aksović, Bojan Bjelica, Saša Bubanj, Tatiana Dobrescu

“…Descriptive statistics, reliability analyses, and difference analyses were conducted to evaluate repeatability and sensitivity levels. …”
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Are Individuals With Type 2 Diabetes Metabolically Inflexible? A Systematic Review and Meta‐Analysis by Maria Hansen, Kristine Kjær Lange, Martin Bjørn Stausholm, Flemming Dela

“…Overall, metabolic flexibility appears more influenced by overweight status than T2D per se, challenging the notion of a distinct metabolic inflexibility threshold for T2D.…”
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Comparative evaluation of color stability in polished and glazed CAD/CAM ceramics subjected to coffee thermal cycling: an in vitro study by Reza Nahidi, Azita Mazaheri, Shaghayegh Golalipour, Negin Youshaei, Sotude Khorshidi

“…ANOVA was used to analyze differences between groups. Post-hoc comparisons were conducted using the Tukey test, with a significance threshold of p < 0.05. …”
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SEVERAL ASPECTS OF DILTIAZEM AND ORGANIC NITRATES USAGE IN VARIOUS SEVERITY STABLE ANGINA PATIENTS by E. K. Butina, E. V. Bochkareva, N. A. Pozdnyakova

“…Effectiveness of the regular drug intake was controlled by repeated exercise tolerance tests (ETT) by treadmill with the value of threshold effort time (ThT). Total duration of treatment was 4 weeks.Results. …”
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