A Model Based Cost-Effectiveness Analysis of Routine Genotyping for CYP2D6 among Older, Depressed Inpatients Starting Nortriptyline Pharmacotherapy. by Elizabeth J J Berm, Judith J Gout-Zwart, Jos Luttjeboer, Bob Wilffert, Maarten J Postma

“…<h4>Objective</h4>Genotyping for CYP2D6 has the potential to predict differences in metabolism of nortriptyline. This information could optimize pharmacotherapy. …”
Get full text

Comparative Cost-Effectiveness of Two Artificial Liver Therapies in Early-Stage Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Retrospective Cohort Study by Chen J, Luo Q, Wang L, Zheng L, Zhang Y, Liu Y, Peng L, Xu W

“…Univariate and probabilistic sensitivity analyses (Bootstrap method) were used to assess parameter uncertainty.Results: Over the 90-day follow-up period, the DPMAS+LPE group had numerically higher survival rates compared to the PE group, but this difference was not statistically significant (91.04% vs 83.07%, Logrank: P=0.094). …”
Get full text

Progression of the first stage of spontaneous labour: A prospective cohort study in two sub-Saharan African countries. by Olufemi T Oladapo, Joao Paulo Souza, Bukola Fawole, Kidza Mugerwa, Gleici Perdoná, Domingos Alves, Hayala Souza, Rodrigo Reis, Livia Oliveira-Ciabati, Alexandre Maiorano, Adesina Akintan, Francis E Alu, Lawal Oyeneyin, Amos Adebayo, Josaphat Byamugisha, Miriam Nakalembe, Hadiza A Idris, Ola Okike, Fernando Althabe, Vanora Hundley, France Donnay, Robert Pattinson, Harshadkumar C Sanghvi, Jen E Jardine, Özge Tunçalp, Joshua P Vogel, Mary Ellen Stanton, Meghan Bohren, Jun Zhang, Tina Lavender, Jerker Liljestrand, Petra Ten Hoope-Bender, Matthews Mathai, Rajiv Bahl, A Metin Gülmezoglu

“…Based on a 95th percentile threshold, nulliparous women may take up to 7 hours to progress from 4 to 5 cm and over 3 hours to progress from 5 to 6 cm. …”
Get full text

[18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging for in vivo prediction of drug resistance in pancreatic cancer by SUN Chenwei, HAI Wangxi, QU Qian, XI Yun

“…The comparison of [18F]F-FMISO and [18F]F-FLT PET differences before and after chemotherapy provides the most accurate prediction of drug resistance and survival time.…”
Get full text

Waist-to-Height Ratio &amp;ndash; Reference Values and Associations with Cardiovascular Risk Factors in a Russian Adult Population by Kholmatova K, Krettek A, Dvoryashina IV, Malyutina S, Cook S, Avdeeva E, Kudryavtsev AV

“…In women, WHtR had stronger associations with age, university education, poor financial situation, blood pressure, HDL cholesterol, and ln-transformed C-reactive protein, in men – with being married, current smoking, LDL and non-HDL cholesterol, and HbA1c.Conclusion: Three-quarters of the study population had WHtR values exceeding the conventional threshold for abdominal obesity. Men and women differed in the WHtR associations with socio-demographic and lifestyle risk factors, biomarkers of inflammation, hypertension, dyslipidemia, and diabetes. …”
Get full text

Association of Postoperative Neutrophil Lymphocyte Ratio (NLR) and Monocyte Lymphocyte Ratio (MLR) with the Presence of Osteoporosis in Japanese Patients after Hip Fracture Surgery... by Hirofumi Bekki, Takeshi Arizono, Daiki Hama, Akihiko Inokuchi, Takahiro Hamada, Ryuta Imamura

“…A YAM cutoff of 70% is an appropriate intervention threshold regarding postoperative recovery after hip fracture surgery. …”
Get full text

Comparing the effects of positional versus myofascial release of gluteus medius to manage patellofemoral pain syndrome: single blinded randomized clinical trial by Priyanka Ratan Kumar, Rabail Rani Soomro

“…Both the groups showed a significant reduction in pain, improvement in function, pressure pain threshold, strength, and quality of life (p<0.05). …”
Get full text

Association of Helicobacter pylori infection and white blood cell count: a cross-sectional study by Yang Yang, Xue Wu, Qiang Wang, Yahong Wang, Haiying Wang, Yanli Zhu, Rui Jiao, Xiaojuan Ma, Xiaoqing Guo, Shaofei Zhang

“…Additionally, a piecewise linear regression was used to examine the threshold effect of the DPM on WBC count.Results 403 subjects were diagnosed with H. pylori infection. …”
Get full text

Outbreaks of COVID-19 in a tuberculosis treatment sanatorium on the Thailand-Myanmar border: a retrospective cohort analysis [version 2; peer review: 1 approved, 2 approved with re... by Wanitda Watthanaworawit, Gornpan Gornsawun, François Nosten, Makoto Saito, Lei Lei Swe, Win Pa Pa Tun, Sophie Lesseps, Aung Than, Banyar Maung Maung, Napaporn Kaewphanderm, Htet Ko Ko Aung, Aung Pyae Phyo, Naw Janurian

“…Before COVID-19 infection, 67.1% (106/158) of patients had received at least one dose of COVID-19 vaccine. The median cycle threshold value at diagnosis was not different between TB (18.5, IQR 16.1-32.3) and non-TB patients (18.8, 15.1-30.0). …”
Get full text

Sliding window based rare partial periodic pattern mining algorithms over temporal data streams by K. Jyothi Upadhya, Ronan Lobo, Mini Shail Chhabra, Aman Paleja, B. Dinesh Rao, Geetha M., Prachi Sisodia, Bolusani Akshita Reddy

“…The findings showed that when a dense dataset Accidents is considered, for different threshold variations R3P-StreamSWBitVectorMiner outperformed R3PStreamSW-Growth by about 93%. …”
Get full text

Effect of shear rate on early Shewanella oneidensis adhesion dynamics monitored by deep learning by Lucie Klopffer, Nicolas Louvet, Simon Becker, Jérémy Fix, Cédric Pradalier, Laurence Mathieu

“…Secondly, at the individual scale, by implementing an automated image processing method based on deep learning to track each individual pioneer bacterium on the wall. …”
Get full text

Investigation on the influence of structural surface characteristics on stress wave propagation behavior by Pengxu Jing, Pengxu Jing, Wenbo Zheng, Haiying Wang, Yang Wang, Haitao Yang

“…In this paper, using the one-dimensional Hopkinson bar model as an example, a numerical method is employed to analyze the propagation behavior of stress waves through structural planes with different characteristics. …”
Get full text

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification by Rachel J. Harding, Yuanyun Xie, Nicholas S. Caron, Hailey Findlay-Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R. Hayden, Blair R. Leavitt, Douglas R. Langbehn, Amber L. Southwell

“…Abstract Huntington disease (HD) is a progressive and devastating neurodegenerative disease caused by expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene above a critical threshold of ~ 35 repeats resulting in expression of mutant HTT (mHTT). …”
Get full text

Optimization of microprobe analysis of cementitious materials incorporating glass powder under electron beam to avoid alkali migration by Wena de Nazaré do Rosário Martel, Josée Duchesne, Benoît Fournier

“…Literature-reported densities often surpass this threshold. At those conditions, the implementation of a sub-counting method effectively reduces the Na loss to 3%. …”
Get full text

Value of [¹⁸F]FDG PET/CT for predicting epidermal growth factor receptor gene mutation status in patients with newly diagnosed non-small cell lung cancer: a retrospectiv... by A. V. Leontev, A. I. Khalimon, M. M. Khodzhibekova, A V. Lokhova, T. N. Lazutina, G. F. Khamadeeva, D. Yu. Khodakova, I. V. Pylova, A. D. Kaprin

“…The anatomical volume derived from the second method was used to manually adjust the isocontour threshold for PET image ensuring that tumor MTV is equal to its anatomical volume. …”
Get full text

Identification of metastable lattice distortion free charge density wave at photoinduced interface via TRARPES by Shaofeng Duan, Binshuo Zhang, Zihao Wang, Shichong Wang, Lingxiao Gu, Haoran Liu, Jiongyu Huang, Jianzhe Liu, Dong Qian, Yanfeng Guo, Wentao Zhang

“…Abstract The interplay between different degrees of freedom governs the emergence of correlated electronic states in quantum materials, with charge density waves (CDW) often coexisting with other exotic phases. …”
Get full text

Design of an Electronic Nose System with Automatic End-Tidal Breath Gas Collection for Enhanced Breath Detection Performance by Dongfu Xu, Pu Liu, Xiangming Meng, Yizhou Chen, Lei Du, Yan Zhang, Lixin Qiao, Wei Zhang, Jiale Kuang, Jingjing Liu

“…Regarding this issue, this study proposes a novel electronic nose system and employs a threshold control method based on exhaled gas flow characteristics to design a gas collection module. …”
Get full text

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA by Lavanya Manjunath, Gisselle Santiago, Pedro Ortega, Ambrocio Sanchez, Sunwoo Oh, Alexander Garcia, Junyi Li, Dana Duong, Elodie Bournique, Alexis Bouin, Bert L. Semler, Dheva Setiaputra, Rémi Buisson

“…We find that PACT-deficient cells hyperactivate PKR in response to different RNA viruses, raising the question of why cells need to limit PKR activity. …”
Get full text

CO₂-Based Encapsulation of Rutin-Rich Extracts from Black Elderberry Waste Using Advanced PGSS Process by Zorana Mutavski, Senka Vidović, Rita Ambrus, Katarina Šavikin, João Baixinho, Naiara Fernández, Nataša Nastić

“…For the first time, rutin-rich extracts from black elderberry waste (BEW) were encapsulated using the particles from gas-saturated solutions (PGSS) method to improve the preservation of rutin. The extracts used in this study were obtained using five different extraction techniques under optimal conditions, as follows: conventional solid–liquid extraction (SLE) and four non-conventional techniques—ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), enhanced solvent extraction (ESE), and supercritical CO₂ pretreatment—followed by ESE (SFE-CO₂ + ESE). …”
Get full text

Analysis of the Influence of Bearing Plate Position on the Uplift Bearing Capacity of Low-Header CEP Single-Pile Foundations by Yongmei Qian, Deshun Qi, Yu Mou, Xihui Wang, Ziyu Wang, Lin Sun, Zhongwei Ma

“…This study investigates the impact of the bearing plate position on the uplift bearing capacity of low-header concrete expanded pile (CEP) foundations using the ANSYS finite element simulation method. Nine models of low-header CEP single piles with varying bearing plate positions are constructed. …”
Get full text