The potential price and access implications of the cost-utility and budget impact methodologies applied by NICE in England and ICER in the US for a novel gene therapy in Parkinson’... by Jesper Jørgensen, Spiros Servos, Panos Kefalas

“…Background: NICE in England, and ICER in the US both use cost-utility analyses (CUA) and budget impact analyses (BIA) to assess value for money and affordability, however the thresholds used differ greatly. Objective: To perform a cross-country comparison of the results of the CUA and BIA and detail the implications for reimbursed price and volumes, for a novel gene therapy for Parkinson’s disease (PD). …”
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Multi-State Dependent Impulsive Control for Pest Management by Huidong Cheng, Fang Wang, Tongqian Zhang

“…According to the integrated pest management strategies, we propose a model for pest control which adopts different control methods at different thresholds. …”
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Forest fire detection based on temporal and spatial correction of background brightness temperature using GF-4 PMI data by P. Cheng, H. Sui, J. Wang, L. Hua, J. Liu, Q. Zhou, Y. Zeng

“…However, existing fire detection methods for GF-4 data, which use fixed initial thresholds and insufficiently account for the influence of fires on background brightness temperatures, often result in high rates of false positives and missed detections. …”
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Usefulness of computed tomography-guided puncture biopsy coupled with rapid on-site evaluation for diagnosis of pulmonary lesions: a systematic review and meta‑analysis by Zhongbao Zhang, Rui Liu, JunLin Li, Kai Zhang, Yuan Li, Xiaoqin Zhang, Sanjay Rastogi

“…Further analysis of 3 studies that established control groups showed that the ROSE group had by 12% (95% CI, 0.08–0.16; I2 = 0) higher sampling adequacy and diagnostic accuracy than the non-ROSE group, while there was no significant difference in the rate of complications. Conclusions: For assessment of pulmonary lesions, CT-guided puncture biopsy combined with ROSE has high sensitivity, specificity, and diagnostic accuracy, and is a practical operational method that merits wide clinical application.…”
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Antibacterial and Cytotoxicity characteristics of experimental epoxy -based endodontic sealer loaded with silver gold nanoparticles: in vitro study by Nermine Hassan, Mona Riad, Shereen Hafez Ibrahim, Khaled Mahmoud, Bassam Ahmed Abulnoor, Reham Hassan

“…The chosen significance threshold was P <0.05. Results Antibacterial results revealed that there was no difference in the diameter of the inhibition zones measured in all groups at 24 h. …”
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The Role of High-Tech Jobs in Regional Development by A. A. Ugryumova, M. V. Savelyeva

“…Simultaneously, these processes in the conditions of different territories need an individual approach. …”
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Toward Smart Condition Monitoring of Rotatory Machines: An Optimized Probabilistic Signal Reconstruction Methodology for Fault Prediction With Multisource Uncertainties by Xiaomo Jiang, Weijian Tang, Haixin Zhao, Xueyu Cheng

“…Finally, the validity, feasibility and generalization of the proposed methodology are illustrated by applying two cases of different rotating machines: centrifugal compressor and gas turbine.…”
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Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test? by Fernando Chimela Chume, Mayana Hernandez Kieling, Priscila Aparecida Correa Freitas, Gabriela Cavagnolli, Joíza Lins Camargo

“…However, GA detects different subjects from those detected by HbA1c and OGTT.…”
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Is sustained virological response a marker of treatment efficacy in patients with chronic hepatitis C viral infection with no response or relapse to previous antiviral intervention... by Kurinchi S Gurusamy, Edward Wilson, Ronald L Koretz, Victoria B Allen, Brian R Davidson, Andrew K Burroughs, Christian Gluud

“…<h4>Conclusions</h4>SVR may be a good prognostic marker but does not seem to be a valid surrogate marker for assessing HCV treatment efficacy of interferon retreatment. The SVR threshold at which retreatment increases life expectancy may be different for different drugs depending upon the adverse event profile and treatment efficacy. …”
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Rapid and accurate classification of mung bean seeds based on HPMobileNet by Shaozhong Song, Shaozhong Song, Shaozhong Song, Zhenyang Chen, Helong Yu, Helong Yu, Mingxuan Xue, Mingxuan Xue, Junling Liu

“…In this study, based on the deep learning model MobileNetV2, a DMS block is proposed for mung bean seeds, and by introducing the ECA block and Mish activation function, a high-precision network model, i.e., HPMobileNet, is proposed, which is explored to be applied in the field of image recognition for the fast and accurate classification of different varieties of mung bean seeds. In this study, eight different varieties of mung bean seeds were collected and a total of 34,890 images were obtained by threshold segmentation and image enhancement techniques. …”
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Change in address in electronic health records as an early marker of homelessness. by Janet Song, Yu Deng, Yuyang Yang, Lacey Gleason, Abel Kho

“…We aim to establish recorded address changes as a screening variable for housing instability and homelessness and to attempt to define the threshold of high churn.<h4>Methods</h4>Our study is a single-center cross-sectional study of EHR data (2018-2024) conducted at a US academic center with eleven sites across Chicago. …”
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Diagnostics of Olfactory Impairment Using the Novel Olfactory Test Panoramic Smell Test by Tolstikhin, Y.V., Gavrilova, N.Y., Soprun, L.A., Chernyshova, O.A., Taalaibek-kyzy, Y.

“…The Kruskal-­Wallis test, Friedman test and Spearman correlation coefficient were used for statistical analysis. Results. Threshold testing: median score = 6.0 (IQR 6.0–6.0), with no significant differences across concentrations. …”
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Main differential endometrial microbiota associated with recurrent implantation failure: a case control study by Hong Gao, Hong Gao, Jing Xiao, Bingyan Liang, Xiaolan Wang, Huanhuan Li, Genlin Li, Baoyu Wu

“…To identify the main differential endometrial microbiota associated with RIF and to establish threshold values for their relative abundance.MethodsThis case-control study was conducted in the Departments of Obstetrics, Gynecology, and Reproductive Medicine at two large hospitals. …”
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Economic evaluation in collaborative hospital drug evaluation reports by Ana Ortega, María Dolores Fraga, Roberto Marín-Gil, Eduardo Lopez-Briz, Francesc Puigventós, George Dranitsaris

“…Main difficulties: low quality evidence in the target population, no comparative studies with a relevant comparator, non-final outcomes evaluated, no quality of life data, no fixed drug price available, dosing uncertainty, and different prices for the same drug. Conclusions: proposed improvements: incorporating different forms of aid for non-drug costs, survival estimation and adapting published economic evaluations; establishing criteria for drug price selection, decision-making in conditions of uncertainty and poor quality evidence, dose calculation and cost-effectiveness thresholds depending on different situations.…”
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The temperature variation of the maximum oxygen uptake and time to exhaustion in the spinning factory workers by Gholamreza Sharifi, Alireza Babaei, Farideh Keykhosravi

“…Therefore there were significant difference between heart rate average, maximum rate of oxygen consumption and amount of work done in two different temperatures in Strand step test (p<0/05), Also in Kankany test, significant difference observed between average of heart rate and the amount of work done at the two temperatures (p <0/05), but there was no significant difference between the maximum oxygen consumption at two temperatures. …”
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Physiological growth of ocular axial length among Chinese children and teenagers: A 6-year cohort study. by Yanxian Chen, Xiaohu Ding, Ruilin Xiong, Jian Zhang, Fan Song, Ziwei Zhao, Mengying Lai, Yangfa Zeng, Mingguang He

“…This observation suggests that when formulating effective myopia control strategies, consideration should be given to different calculation methods when applying physiological AL growth as a starting point or target.…”
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Parvovirus B19 infections serological diagnostics in rheumatic diseases by L P Ananjeva, O A Koneva, S I Soldatova, S O Salugina, M. M. Urumova, D. E. Karateev, O. N. Egorova, E. Yu. Panasuk, N. V. Bunchuk

“…High levels of antibodies (4-10 times higher positivity threshold) were revealed in 13 pts with different RD with short duration of joint syndrome (6,3±7,6 months) and fever at presentation. …”
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Magnetic nanostickers for active control of interface-enhanced selective bioadhesion by Changshun Hou, Junjia Guo, Bonan Sun, Kai Fung Chan, Xin Song, Li Zhang

“…Abstract Natural biological tissues exhibit different mechanical and surface properties. These disparate features make their connections with engineering materials quite difficult due to the lack of universal methods for tuning the interfacial bonding over a wide range. …”
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Development of a questionnaire for problematic social networking sites use: Ensuring content validity through Delphi methodology. by Seungju Lim, Ji-Hyuk Park

“…Items that did not meet the threshold criteria were revised or removed based on expert feedback.…”
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A Revision of Historical Earthquakes in the Ionian Sea, Greece: Island of Lefkada by Gerassimos A. Papadopoulos, Ioanna Triantafyllou

“…Magnitudes estimated in previous catalogues in general are larger with respect to our magnitude determinations, possibly due to different calculation methods. The descriptive part of the catalogue includes descriptions of the earthquakes’ impact on buildings and of environmental effects, e.g., landslides and local tsunamis. …”
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