Encouraging arm use in stroke survivors: the impact of smart reminders during a home-based intervention by Laura Mayrhuber, Sebastian D. Andres, Mathilde L. Legrand, Andreas R. Luft, Franziska Ryser, Roger Gassert, Janne M. Veerbeek, Jannie van Duinen, Anne Schwarz, Karmen Franinovic, Christoph Rickert, Erik Schkommodau, Jeremia P. O. Held, Chris Awai Easthope, Olivier Lambercy

“…While the results regarding the increased arm use at home are promising, patient-reported outcomes remained below clinically meaningful thresholds and showed no group differences. Further, it is essential to acknowledge feasibility issues such as adherence to wearing the trackers during the intervention and missing sensor data. …”
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Patient-Reported Outcomes From LIBRETTO-431: First-Line Selpercatinib Versus Chemotherapy With Pembrolizumab in RET Fusion-Positive NSCLC by Caicun Zhou, MD, PhD, Silvia Novello, MD, PhD, Pilar Garrido, MD, PhD, Christophe Dooms, MD, PhD, Jorge Alatorre-Alexander, MD, Niels Reinmuth, MD, Gill Worthy, PhD, Kim Cocks, PhD, Justin Williams, PhD, Hongmei Han, MS, MApSt, Minji K. Uh, PhD, Nalin Payakachat, PhD, Adrienne M. Gilligan, PhD, Koichi Goto, MD, PhD

“…TTCD was defined as the time from randomization to first deterioration in score that met prespecified thresholds, confirmed at next assessment. Patient-reported tolerability was reported as the proportion of patients with side effect bother over time. …”
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Intracameral prostaglandin implant vs Timolol in open-angle glaucoma or ocular hypertension: a systematic review and meta-analysis by Nikhil Sharma, MahalaquaNazli Khatib, AshokKumar Balaraman, Roopashree R, Mandeep Kaur, Manish Srivastava, Amit Barwal, G․V․Siva Prasad, Pranchal Rajput, Rukshar Syed, Gajendra Sharma, Sunil Kumar, MahendraPratap Singh, Ganesh Bushi, Nagavalli Chilakam, Sakshi Pandey, Manvinder Brar, Rachana Mehta, Sanjit Sah, AbhayM Gaidhane, Muhammed Shabil, Abdullah Ahmed, Hashem Abu Serhan

“…Primary outcomes were mean difference (MD) in IOP reduction and adverse events. …”
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Balancing intervention and complications: management of otitis media with effusion in children with cleft palate by Burçay Tellioğlu, Erim Pamuk, Muhammed Çağrı Külekci, Oğuz Kuşcu, Mehtap Yıldırım, Gökberk Çavuşoğlu, Murat Kara, Fatma Figen Özgür

“…Preoperative hearing thresholds, cleft severity (Veau classification), and VT related complications were analyzed statistically. …”
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Protocol for an adaptive platform trial of intended service user-derived interventions to equitably reduce non-attendance in eye screening programmes in Botswana, India, Kenya and... by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, James R Carpenter, Sailesh Mishra, Shalinder Sabherwal, Luke Allen, Sarah Karanja, Ari Ho-Foster, Nigel Bolster, Malebogo Tlhajoane, Bakgaki Ratshaa

“…Lower thresholds may be used for RCTs testing interventions with very low risks and costs. …”
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Reduced auditory perception and brain response with quiet TMS coil by David L.K. Murphy, Lari M. Koponen, Eleanor Wood, Yiru Li, Noreen Bukhari-Parlakturk, Stefan M. Goetz, Angel V. Peterchev

“…The resting motor thresholds (RMTs) for qTMS-DCC and MagVenture Cool-B65 were measured. …”
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Impact of Propranolol and Psychologically Informed Intervention on Pain Sensitivity: Secondary Analysis from the Biopsychosocial Influence on Shoulder Pain Preclinical Randomized T... by Bishop MD, Simon CB, Huo Y, Wallace MR, Borsa PA, Fillingim RB, Staud R, Wu SS, George SZ

“…Pain sensitivity outcomes (pressure pain thresholds (PPT), suprathreshold heat rating, temporal summation, and conditioned pain modulation efficiency) were compared using a mixed effect model to examine difference among groups, adjusted for age, sex and race.Results: No main effects for group assignment were noted (p > 0.05 for all), when considered as 4 groups or 2 collapsed groups (ie propranolol vs placebo or personalized psychologic vs general education). …”
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Type I Interferon Modulates the Function of Ly6C High-Expressing Naïve CD8⁺ T Cells to Promote an Antitumor Response by Hsin-Fang Tu, Julia Tao, Ming-Hung Hu, Darrell Fan, Ya-Chea Tsai, Tzyy-Choou Wu, Chien-Fu Hung

“…This study investigates the functional impact of Ly6C expression on CD8⁺ T cells and explores albumin-conjugated IFNβ (Alb-IFNβ) as a strategy to modulate Ly6C expression and improve cancer vaccine efficacy. <b>Methods:</b> We analyzed the functional differences between Ly6C high-expressing (Ly6C^hi) and Ly6C low-expressing (Ly6C^lo) naïve CD8⁺ T cells in tumor suppression. …”
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Abnormal metal ion levels following spinal instrumentation surgery by Ping Liu, Guoqiang Wang, Bing Zhou, Yijun Kang

“…Therefore, a comprehensive meta-analysis is necessary to assess the levels of metal ions in patients after spinal surgery. Methods We performed a systematic review and meta-analysis to evaluate metal ion levels after spinal surgery. …”
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Association between intake of less-healthy foods defined by the United Kingdom's nutrient profile model and cardiovascular disease: A population-based cohort study. by Oliver T Mytton, Nita G Forouhi, Peter Scarborough, Marleen Lentjes, Robert Luben, Mike Rayner, Kay Tee Khaw, Nicholas J Wareham, Pablo Monsivais

“…Items were classified as less-healthy using Ofcom regulation thresholds. We used Cox proportional hazards regression to test for an association between consumption of less-healthy food and incident CVD. …”
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Cerebrovascular Autoregulation-Based Optimal Mean Arterial Pressure During Prostate Surgery &amp;ndash; A Secondary Analysis of a Prospective Cohort Study by Mewes C, Wei P, Yang Y, Kainz E, Kahl U, Beck S, Graefen M, Zöllner C, Fischer M

“…The mean duration of intraoperative CVA measurement was 178 min.Conclusion: This study demonstrates a wide range of individual intraoperative MAPopt values and underscores that CVA-based MAPopt during non-cardiac surgery may differ from commonly accepted intraoperative MAP thresholds in clinical practice (ie 65 mmHg).Keywords: cerebral autoregulation, optimal mean arterial pressure, limits of cerebral autoregulation, non-cardiac surgery, personalized arterial pressure management…”
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Analysis of self‐monitoring of blood glucose metrics in gestational diabetes mellitus and their association with infants born large for gestational age: A historical observational... by Nael Shaat, Omar Akel, Karl Kristensen, Anton Nilsson, Kerstin Berntorp, Anastasia Katsarou

“…Receiver operating characteristic (ROC) curves were used to evaluate glucose levels for LGA prediction. Differences in means were tested using analysis of variance. …”
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Breastfeeding, HIV exposure, childhood obesity, and prehypertension: A South African cohort study. by Brian Houle, Tamsen J Rochat, Marie-Louise Newell, Alan Stein, Ruth M Bland

“…We dichotomized 3 outcome measures using pre-established thresholds for clinical interpretability: (1) overfat: ≥85th percentile of body fat; (2) overweight: >1 SD BMI z score; and (3) prehypertension: ≥90th percentile for systolic BP (SBP) or diastolic BP (DBP). …”
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The role of scapular morphological structure in degenerative rotator cuff injury: a digital reconstruction radiograph study by Wen-bin Zhang, Fei-Long Lu, Yu-Lin Ma, Xiao-Ming Du, Hao Song, Zhao-Xi Yang, Yi-Mei Hu

“…Results (1) Inter-observer reliability was excellent for all the parameters (intra-class correlation coefficient (ICC) > 0.8). (2) CSA and AGA were significantly greater in the rotator cuff injury group (P CSA = 0.003;P AGA < 0.001), whereas GIA was significantly lower (P < 0.001); no difference was detected in AT (P > 0.05). (3) Binary logistic regression analysis revealed that GIA, CSA, and AGA were risk factors for rotator cuff injury (P CSA =0.008; P AGA = 0.001; P GIA = 0.001). (4) ROC analysis yielded area under the curve (AUC) values of 0.755 (GIA), 0.700 (CSA), and 0.796 (AGA), with cutoff thresholds of 83.98°, 30.67°, and 42.04°, respectively. (5) Strong correlations were observed between the CSA and AGA (r = 0.939), whereas the GIA was inversely correlated with both the CSA (r = -0.423) and the AGA (r = -0.471). …”
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Improving chest pain risk assessment: validation of HEART, TIMI, GRACE, EDACS-ADP, and HET for MACE prediction in the emergency department by Mehdi Nasr Isfahani, Hamidreza Mohseni, Elahe Nasri Nasrabadi, Nizal Sarrafzadegan

“…Performance variations were attributed to differences in population demographics, and study design. …”
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Effects of 8-weeks of supplementation with a plant protein blend + creatine monohydrate on changes in maximal strength in resistance-trained males and females by Anthony M. Hagele, Kevin F. Holley, Alex C. Schrautemeier, James L. Tice, Joshua Iannotti, Joesi M. Krieger, Connor J. Gaige, Wyatt B. McLaughlin, Ralf Jäger, Chad M. Kerksick

“…This study sought to compare the changes in maximal strength and repetitions completed among resistance-trained males and females consuming a plant-based protein blend containing creatine.Methods Sixty resistance-trained males (n = 31; 26 years, 81.5 ± 8.8 kg, 179.2 ± 7.8 cm) and females (n = 29; 23 years, 66.3 ± 9.4 kg, 161.0 ± 12.4 cm) participated in the 8-week double-blind, placebo-controlled, randomized study. …”
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Robotic-assisted surgery and kinematic alignment in total knee arthroplasty (RASKAL study): a protocol of a national registry-nested, multicentre, 2×2 factorial randomised trial as... by Ian A Harris, Samuel J MacDessi, Aziz Bhimani, Darren B Chen, Ian Harris, Michelle Lorimer, David Parker, Tamara Hooper, Richard Boyle, Jonathan Mulford, Daniel Franks, Gregory C Wernecke, Durga Bastiras, Emma Heath, Anthony Leong, Brett Fristch, David Penn, George Kirsh, John Limbers, Julian Yu, Maurice Guzman, Peter McEwen

“…OMERACT-OARSI criteria and Patient Acceptable Symptom State outcome score thresholds for the KOOS-12 and Oxford Knee Score will be used in secondary analyses. …”
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Melanocortin-1 receptor expression as a predictive factor for postoperative outcomes in melanoma patients: a retrospective study by Tian Xiang, Tian Xiang, Haiying Li, Xiaowei Wang, Danke Su

“…Background and objectiveThis study aims to explore the relationship between melanocortin-1 receptor (MC1R) expression levels and clinical pathological parameters of melanoma, as well as its potential as a prognostic biomarker.MethodsThis retrospective study included 99 melanoma patients in our hospital from June 2017 to July 2023. …”
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Peripartum fetal Doppler sonography and perinatal outcome: a systematic review and meta-analysis by Bram Packet, Ann-Sophie Page, Jan Bosteels, Jute Richter

“…Summary Odds Ratios (ORs) and Mean Differences (MDs) are reported with 95% confidence intervals. …”
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Prediction of litchi flower induction in South China region based on the CMIP6 climate model by HOU Wei, ZHANG Liuhong, ZHANG Lei, LUAN Lan, ZHANG Mingjie, WANG Xiuzhen, ZHANG Hui

“…To identify the key climatic factors affecting litchi flower formation, we calculated chilling accumulation for low temperature thresholds of 10 ℃, 12 ℃, 15 ℃, 18 ℃, and 20 ℃, as well as heat accumulation for high temperature thresholds of 25 ℃, 28 ℃, and 30 ℃. …”
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