Application of the American Heart Association/American College of Cardiology/Heart Failure Society of America Heart Failure Staging Guidelines in Adults With Chronic Kidney Disease by Anna M. Zemke, Leila R. Zelnick, Joachim H. Ix, Alan S. Go, Edward D. Siew, Nisha Bansal

“…The applicability of this staging system in chronic kidney disease is not well established. Methods This is a prospective cohort study of 2415 participants from CRIC (Chronic Renal Insufficiency Cohort). …”
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Extreme heat and pediatric health in a warming world: a space-time stratified case-crossover investigation in Ontario, Canada by Hallah Kassem, Eric Lavigne, Kate Weinberger, Michael Brauer

“…This study evaluated pediatric emergency healthcare utilizations associated with EHEs in Ontario. Methods Applying a space-time stratified case-crossover design, associations between EHEs (same-day or lagged exposure to 2 consecutive days of daily maximum temperatures above percentile thresholds) and 15 causes of pediatric emergency healthcare use in Ontario, Canada from 2005 to 2015 were analysed using conditional quasi-Poisson regression. …”
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Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cognitive impairment in patients with acute mild ischemic... by Huiting Wang, Jingru Wang, Depeng Feng, Lin Wang, Jingjing Zhang

“…By collecting data from patients with acute minor ischemic stroke in hospital, we will analyze the relationship between NHHR and cognitive function in these patients. Methods This study enrolled 817 acute ischemic stroke (AIS) patients (NIHSS ≤ 5), Cognitive function was assessed using Mini-Mental State Examination (MMSE) within 2 weeks, with cognitive impairment defined by education-stratified thresholds. …”
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The role of adenosine monophosphate-activated protein kinase and serum amyloid A proteins in the early diagnosis of neonatal sepsis by P.A. Orujova, N.H. Sultanova

“…The ROC analysis indicated that AMPK and SAA levels below specific thresholds were significant for excluding sepsis. …”
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The Effectiveness of Virtual Reality–Based Mindfulness Interventions for Managing Stress, Anxiety, and Depression: Protocol for a Systematic Review and Meta-Analysis of Randomized... by Ravi Shankar, Anjali Bundele, Amartya Mukhopadhyay

“…Meta-analysis will use random effects models with inverse variance weighting, calculating standardized mean differences with 95% CIs. Preplanned subgroup analyses will examine intervention duration (<2 wk, 2-8 wk, and >8 wk), VR technology type (head-mounted displays vs cave environments), population characteristics (clinical vs nonclinical samples), and mindfulness technique type, with heterogeneity quantification using prespecified I2 thresholds. …”
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Correlation and predictive value of oxygenation and oxygen saturation indices in extremely preterm infants: a prospective study by Ibrahim Alanazi, Saleh S. Algarni, Saleh S. Algarni, Saad Alshreedah, Naif Alotaibi, Mohammed Sufyani, Sami S. Alanazi, Abeer H. Alharthi, Abadi Ghazwani, Omar M. Almutairi, Maryam Alkaabi, Abdulaziz Homedi, Ibrahim Ali, Mohammed Khawaji, Saif Alsaif, Kamal Ali, Kamal Ali, Kamal Ali

“…Further research is needed to refine these diagnostic thresholds to enhance neonatal care outcomes.…”
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Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial). by Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Hywel C Williams, Taraneh Dean, Nigel P Burrows, Ian Pollock, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eleanor J Mitchell, Fiona Cowdell, Sara J Brown, Alan A Montgomery, UK Dermatology Clinical Trials Network’s CLOTHES Trial Team

“…This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to standard care) for the management of eczema in children with moderate to severe disease.<h4>Methods and findings</h4>This was a parallel-group, randomised, controlled, observer-blind trial. …”
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Gestational weight gain adequacy and intrapartum oxytocin and cesarean section use: Observational population‐based study in France by Melissa Amyx, Jennifer Zeitlin, Béatrice Blondel, Camille Le Ray

“…GWG was calculated as the difference between end of pregnancy and prepregnancy weight (both self‐reported) and categorized as insufficient, adequate (reference group), or excessive by prepregnancy body mass index (BMI; underweight <18.5, normal weight 18.5–24.9, overweight 25–29.9, obese ≥30 kg/m2) using the 2009 Institute of Medicine thresholds. …”
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Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample by Damien Lekkas, Amanda C. Collins, Michael V. Heinz, Tess Z Griffin, Arvind Pillai, Subigya K. Nepal, Daniel M. Mackin, Andrew T. Campbell, Nicholas C. Jacobson

“…Data consisted of thrice-daily SI severity scores measured through self-report responses to item 9 of the Patient Health Questionnaire mobile version (MPHQ-9) as well as free-form diary text. Using difference scores and probability of acute change thresholds, eleven acute SI phase trajectory types were defined to label change in SI over three consecutive EMAs. …”
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Evaluating the impact of the ‘Blow, Breathe, Cough’ health promotion intervention in resolving otitis media with effusion in children: An adaptive randomized-controlled trial proto... by Jaimee R. Rich, Michael Dymock, Elke J. Seppanen, Elena Montgomery, Tanisha Cayley, Tamara Veselinović, Greta Bernabei, Anri Lester, Amy Hannigan, Nicole Irvine, Kerryn Gidgup, Edna Ninyette, Steph Bray, Tu Trang Tran, Valerie M. Swift, Melinda Edmunds, Natalie Strobel, Daniel McAullay, Julie Marsh, Evelyn Tay, Lea-Ann S. Kirkham, Ruth B. Thornton, Robyn S.M. Choi, Lydia Timms, Emily Jackson, Jafri Kuthubutheen, Peter C. Richmond, Christopher G. Brennan-Jones

“…The primary outcome is the difference in OME resolution rates between trial arms, assessed using tympanometry (type B to A or C1 transition) and otoscopy. …”
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Sleep characteristics and hearing loss in middle-aged and older adults: The National Health and Nutrition Examination Survey 2015–2018 by Kening Jiang, Adam P. Spira, Nicholas S. Reed, Frank R. Lin, Jennifer A. Deal

“…Audiometric hearing thresholds at 0.5, 1, 2 and 4 kilohertz were averaged to calculate better-ear pure-tone average (PTA). …”
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Development of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study by Emily Senerth, Paul Whaley, Elie Akl, Brandy Beverly, Pablo Alonso-Coello, Ezza Jalil, Jayati Khattar, Nicole R. Palmer, Andrew Rooney, Holger J. Schünemann, Kristina A. Thayer, Katya Tsaioun, Rebecca L. Morgan

“…Background: Environmental and occupational health (EOH) assessments increasingly utilize systematic review methods and structured frameworks for evaluating evidence about the human health effects of exposures. …”
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Age-stratified reference ranges for adenoid hypertrophy in children: a single-center retrospective study by Enfu Tao, Wei Liang, Hongdan Gu, Junfen Zhou, Changhua Zheng, Junhui Yuan

“…Current diagnostic criteria for the adenoid-to-nasopharyngeal (A/N) ratio lack age-specific adjustments, potentially resulting in diagnostic inaccuracies.MethodsThis retrospective study assessed pediatric outpatients aged 1–12 years who underwent lateral nasopharyngeal radiography. …”
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Effect of prognostic nutritional index on laboratory parameters and survival in metastatic colorectal cancer patients treated with fruquintinib: a retrospective study by Zeng Wang, Sining Zhao, Xuan Zhang, Xinyi Mao, Guonong Yang, Meiqin Yuan, Xiaofang Zhou

“…PNI values were calculated using a specific formula. The optimal thresholds (cut-off values) for post-treatment PNI were determined through the ROC curve analysis. …”
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Enhanced prognostic value of a composite nutritional-inflammatory index (P-CONUT) for predicting mortality risk in patients initiating peritoneal dialysis. by Xing Li, Xueli Zhou, Kuo Li, Li Pu, Xueqin He, Xia Liu, Hui Zhong, Dengyan Ma

“…Kaplan-Meier survival curves compared outcomes across groups, and log-rank tests assessed differences. Univariate and multivariate cox regression analyses identified independent mortality predictors. …”
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Feasibility of applying infrared thermal imaging for home monitoring of arthritis in children by Stephen Wong, Nivrutti Bhide, Erin Balay-Dustrude, Erin Sullivan, Joshua Scheck, Ian Muse, Kevin Cain, Debosmita Biswas, Savannah C. Partridge, Yongdong Zhao

“…The sensitivity and specificity of detecting arthritis of the knee using TAWiC adjustments from previously defined thresholds were similar regardless of the setting of image acquisition (0.44 and 0.79). …”
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Comparative analysis of third-generation dual-energy CT and IVUS for in-stent restenosis detection by Mohey E. A. Eldeeb, Mohamed A. Mostafa, Tarek A. Nagiub, Mohammed H. E. Alshair, Islam E. Shehata

“…When employing an IVUS MLA of 4.0 mm2 as a reference for identifying the ISDR, no significant difference was observed between DSDECT and ICA in the identification of the ISDR. …”
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Impact of left anterior descending lesion location on midterm outcomes in patients undergoing left internal mammary artery grafting: a five-year cohort study integrating quantitati... by Ziang Sun, Yuhui Wu, Rui Jiang, Zeyu Chen, Tianyu Wang, Wenlong Yan, Sumin Yang

“…This study evaluates the impact of QFR-guided revascularization, stratified by LAD lesion location, on midterm clinical outcomes.MethodsA retrospective cohort of 481 patients undergoing left internal mammary artery (LIMA) to LAD grafting (2019–2023) was analyzed. …”
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Development and validation of predictive models for disease-free survival and overall survival in non-metastatic right-sided colon adenocarcinoma patients based on inflammatory and... by Yifan Zhang, Yun Zhou, Chengjun Wu, Cheng Ma

“…An external cohort from a secondary institution (n = 103) provided independent validation. Optimal thresholds for neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) were established via X-tile software. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…What is the cost-effectiveness of HCL for managing glucose in people who have type 1 diabetes and are having difficulty managing their condition despite prior use of at least one of the following technologies: CSII, rt-CGM, isCGM? Methods Systematic review methods followed the principles outlined in the Cochrane Handbook. …”
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