Systolic blood pressure at age 40 and 30-year stroke risk in men and women by Trygve Berge, Arnljot Tveit, Marius Myrstad, Inger Ariansen, Magnus Nakrem Lyngbakken, Håkon Ihle-Hansen, Thea Vigen, Helge Røsjø, Bente Thommessen, Ole Morten Rønning, Marte Meyer Walle-Hansen, Hege Ihle-Hansen, Guri Hagberg

“…Background American and European guidelines define hypertension differently and are sex agnostic. Our aim was to assess the impact of different hypertension thresholds at the age of 40 on 30-year stroke risk and to examine sex differences.Methods We included 2608 stroke-free individuals from the Akershus Cardiac Examination 1950 Study, a Norwegian regional study conducted in 2012–2015 of the 1950 birth cohort, who had previously participated in the Age 40 Program, a nationwide health examination study conducted in 1990–1993. …”
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Falls prevention interventions for community-dwelling older adults: systematic review and meta-analysis of benefits, harms, and patient values and preferences by Jennifer Pillay, Lindsay A. Gaudet, Sabrina Saba, Ben Vandermeer, Ashiqur Rahman Ashiq, Aireen Wingert, Lisa Hartling

“…For intervention-related adverse effects, we pooled proportions except for vitamin D for which we considered data in the control groups and undertook random-effects pairwise meta-analysis using a relative risk (any adverse effects) or risk difference (serious adverse effects). For outcome valuation, we pooled disutilities (representing the impact of a negative event, e.g. fall, on one’s usual quality of life, with 0 = no impact and 1 = death and ~ 0.05 indicating important disutility) from the EQ-5D utility measurement using the inverse variance method and a random-effects model and explored heterogeneity. …”
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ddPCR Enhances early diagnosis, treatment, prognosis, and pathogen verification in elderly BSI by Jiayi Peng, Huili Bai, Ying Li, Huating Luo, Jiajun Li, Haifeng Dai, Hongmei Wang, Tao Meng, Jia Zhang, Zhijian Wang, Xuanxin Chen, Wei Cheng, Yan Peng, Wenxiang Huang

“…Droplet digital polymerase chain reaction (ddPCR), a novel pathogen detection method with superior sensitivity and rapid results, demonstrates significant diagnostic and prognostic for BSI. …”
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Nonlinear Dynamical Model and Analysis of Emotional Propagation Based on Caputo Derivative by Liang Hong, Lipu Zhang

“…The fractional-order term quantifies power-law memory decay in affective states, while the nonlinear component regulates connection strength through emotional difference thresholds. Mathematical analysis establishes the existence and uniqueness of solutions with continuous dependence on initial conditions and proves the local asymptotic stability of network equilibria (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msubsup><mi>W</mi><mrow><mi>i</mi><mi>j</mi></mrow><mo>*</mo></msubsup><mo>=</mo><mstyle scriptlevel="0" displaystyle="true"><mfrac><mn>1</mn><mi>δ</mi></mfrac></mstyle><msup><mrow><mi>sec</mi><mi mathvariant="normal">h</mi></mrow><mn>2</mn></msup><mrow><mo>(</mo><mo>∥</mo></mrow><msub><mi mathvariant="normal">E</mi><mi>i</mi></msub><mo>−</mo><msub><mi mathvariant="normal">E</mi><mi>j</mi></msub><mrow><mo>∥</mo><mo>)</mo></mrow></mrow></semantics></math></inline-formula>, e.g., <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msup><mi>W</mi><mo>*</mo></msup><mo>≈</mo><mn>1.40</mn></mrow></semantics></math></inline-formula> under typical parameters <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>η</mi><mo>=</mo><mn>0.5</mn></mrow></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>δ</mi><mo>=</mo><mn>0.3</mn></mrow></semantics></math></inline-formula>). …”
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Comparisons of acupuncture therapies combining conventional treatment in the management of vascular cognitive impairment: a systematic review and network meta-analysis by Yuan-Ling Liao, Pei-Shan Hsu, Chang-Ti Lee, Chang-Ti Lee, Li-Jen Su, Li-Jen Su, Yi-Ying Shen, Adam Tsou, Chou-Chin Lan, Chou-Chin Lan, I-Shiang Tzeng, Guan-Ting Liu, Po-Chun Hsieh, Po-Chun Hsieh

“…This study aimed to investigate the effects of different types of acupuncture therapies and conventional treatments on cognitive status and ADL in VCI patients to provide evidence-based clinical recommendations.MethodsWe searched seven electronic databases for randomized controlled trials comparing acupuncture therapies [including manual acupuncture (MA), scalp acupuncture (SA), electroacupuncture (EA), and auricular acupuncture (AA)] with conventional treatment [pharmacotherapy (P), cognitive rehabilitation (CR)] or standard care (SC) in patients with VCI. …”
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The Association of Axonal Damage Biomarkers and Osteopontin at Diagnosis Could Be Useful in Newly Diagnosed MS Patients by Eleonora Virgilio, Chiara Puricelli, Nausicaa Clemente, Valentina Ciampana, Ylenia Imperatore, Simona Perga, Sveva Stangalini, Elena Boggio, Alice Appiani, Casimiro Luca Gigliotti, Umberto Dianzani, Cristoforo Comi, Domizia Vecchio

“…We calculated and internally validated biomarker (in particular serum NFL) thresholds that significantly identified patients with higher disability. …”
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Diagnostic value of the saliva immunoglobulin free light chains concentrations measured in primary Sjцgren's syndrome by E. S. Kuvardin, I. V. Kholopova, E. A. Belyakova, I. N. Grigoryeva, A. V. Masing, O. Yu. Tkachenko, I. A. Bekhtereva, A. L. Maslyansky, Yu. A. Krivolapov, S. V. Lapin

“…Identification of diagnostic thresholds for the concentration of FLC in saliva for the diagnosis of pSS was carried out using the ROC analysis method. …”
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Characterizing sarcopenia and sarcopenic obesity in patients aged 65 years and over, at risk of mobility disability: a multicenter observational trial (SARA-OBS) by Roger A. Fielding, Yves Rolland, Olivier Bruyere, Moise Desvarieux, Lorenzo M. Donini, Raffaele Antonelli Incalzi, Maurizio Muscaritoli, Achille Tchalla, Marc Bonnefoy, Mariangela Rondanelli, Rob Van Maanen, Jean Mariani, Carole Margalef, Susanna Del Signore, Cendrine Tourette, Waly Dioh, Stanislas Veillet

“…The prevalence of sarcopenia is poorly known given the different parameters and thresholds in proposed definitions. …”
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Comparing Random Survival Forests and Cox Regression for Nonresponders to Neoadjuvant Chemotherapy Among Patients With Breast Cancer: Multicenter Retrospective Cohort Study by Yudi Jin, Min Zhao, Tong Su, Yanjia Fan, Zubin Ouyang, Fajin Lv

“…Notably, the RSF maintained improved net benefits across decision thresholds in decision curve analysis (DCA); similar results were observed in external studies. …”
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Perfusion‐Based Relative Cerebral Blood Volume Is Associated With Functional Dependence in Large‐Vessel Occlusion Ischemic Stroke by Dhairya A. Lakhani, Aneri B. Balar, Manisha Koneru, Sijin Wen, Burak Berksu Ozkara, Justin Caplan, Adam A. Dmytriw, Richard Wang, Hanzhang Lu, Meisam Hoseinyazdi, Mehreen Nabi, Ishan Mazumdar, Andrew Cho, Kevin Chen, Sadra Sepehri, Nathan Hyson, Risheng Xu, Victor Urrutia, Licia P. Luna, Argye Hillis, Jeremy J. Heit, Greg W. Albers, Ansaar T. Rai, Tobias Faizy, Max Wintermark, Kambiz Nael, Vivek S. Yedavalli

“…Hence, in this study we aim to assess the performance of different rCBV lesion volume thresholds (rCBV <42%, rCBV <38%, and rCBV <34%) with 90‐day modified Rankin Scale score including patients with large core (Alberta Stroke Program Early Computed Tomography Score <5) and strictly including only patients with anterior circulation large‐vessel occlusion. …”
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Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder by Yilu Zhao, Zhao Fu, Eric J. Barnett, Ning Wang, Kangfuxi Zhang, Xuping Gao, Xiangyu Zheng, Junbin Tian, Hui Zhang, XueTong Ding, Shaoxian Li, Shuyu Li, Qingjiu Cao, Suhua Chang, Yufeng Wang, Stephen V. Faraone, Li Yang

“…Then, DL models were constructed to predict percentage changes in symptom scores using genetic variants selected based on four different genome-wide P thresholds (E-02, E-03, E-04, E-05) as inputs. …”
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High-throughput screening of monoclonal antibodies against carbapenemases using a multiplex protein microarray platform by Sascha D. Braun, Sascha D. Braun, Martin Reinicke, Martin Reinicke, Celia Diezel, Celia Diezel, Elke Müller, Elke Müller, Katrin Frankenfeld, Thomas Schumacher, Hugo Arends, Stefan Monecke, Stefan Monecke, Ralf Ehricht, Ralf Ehricht, Ralf Ehricht

“…Signal intensities were quantified, and diagnostic performance was assessed across four thresholds.ResultsA cut-off &gt; 0.2 yielded the best balance, with approximately 61% balanced accuracy and ≥99% specificity. …”
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Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study&amp;mdash;Rational and Design by Li W, Lei J, Li B, Tang X, Peng Y, Huang K, Yang T

“…By setting a narrower range of lung function thresholds to define pre- and mild-COPD, this study will effectively observe the early disease progression of COPD patients in a shorter period of time. …”
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Association of Blood Donor-derived Cell-free DNA Levels With Banff Scores and Histopathological Lesions in Kidney Allograft Biopsies: Results From an Observational Study by Aylin Akifova, MD, Klemens Budde, MD, Mira Choi, MD, Kerstin Amann, MD, Maike Buettner-Herold, MD, Michael Oellerich, MD, Julia Beck, PhD, Kirsten Bornemann-Kolatzki, PhD, Ekkehard Schütz, PhD, Friederike Bachmann, MD, Fabian Halleck, MD, Eva V. Schrezenmeier, MD, Evelyn Seelow, MD, Bianca Zukunft, MD, Charlotte Hammett, MD, Nathan A. Pohl, Benedetta Mordà, MD, Jan Kowald, MD, Nils Lachmann, Diana Stauch, Bilgin Osmanodja, MD

“…To evaluate the association between dd-cfDNA and different histological patterns, we correlated absolute and relative dd-cfDNA (thresholds of 50 copies/mL and 0.5%, respectively) with the Banff 2022 lesion scores and the assigned diagnoses. …”
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Identification and Cross-Platform Validation of Sparse Molecular Classifiers for Antibody-Mediated and T-Cell–Mediated Rejection After Kidney Transplantation by Jasper Callemeyn, Josué Manik Nava-Sedeño, Dany Anglicheau, Jack Beadle, Jan Hinrich Bräsen, Marian C. Clahsen-van Groningen, Iacopo Cristoferi, Henriette de Loor, Andreas Deutsch, Marie Essig, Wilfried Gwinner, Philip F. Halloran, Dennis A. Hesselink, Priyanka Koshy, Dirk Kuypers, Evelyne Lerut, Pierre Marquet, Robert C. Minnee, Candice Roufosse, Ben Sprangers, Amaryllis H. Van Craenenbroeck, Haralampos Hatzikirou, Maarten Naesens

“…Herein, we aimed to develop and validate sparse molecular classifiers for ABMR and TCMR using allograft tissue. Methods: In a discovery cohort of 224 kidney transplant biopsies, lasso regression was applied on microarray gene expression data to derive a molecular classifier for ABMR and TCMR, respectively. …”
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Clinical Characteristics and Spermatogenesis in Patients with Congenital Hypogonadotropic Hypogonadism Caused by FGFR1 Mutations by Shuying Li, Yaling Zhao, Min Nie, Wanlu Ma, Xi Wang, Wen Ji, Yufan Yang, Ming Hao, Bingqing Yu, Yinjie Gao, Jiangfeng Mao, Xueyan Wu

“…The sperm concentration in the mutation-negative group was more easily achieved for different thresholds compared with that in the FGFR1 mutation group, but no significant difference was observed (p>0.05) between the two groups. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…At 12 months, there were no significant differences between groups with respect to EQ-5D-5L utility, EQ-5D-5L visual analogue scale or CAT scores. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…There were also no statistical differences in STI testing, STI diagnoses, or reported CAI between the groups. …”
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Interpretation of Change in Novel Digital Measures: A Statistical Review and Tutorial by Andrew Trigg, Bohdana Ratitch, Frank Kruesmann, Madhurima Majumder, Andrejus Parfionovas, Ulrike Krahn

“…We then review methods to estimate such thresholds, including anchor-based approaches. …”
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Interpersonal counselling for adolescent depression delivered by youth mental health workers without core professional training: the ICALM feasibility RCT by Jon Wilson, Viktoria Cestaro, Eirini Charami-Roupa, Timothy Clarke, Aoife Dunne, Brioney Gee, Sharon Jarrett, Thando Katangwe-Chigamba, Andrew Laphan, Susie McIvor, Richard Meiser-Stedman, Jamie Murdoch, Thomas Rhodes, Carys Seeley, Lee Shepstone, David Turner, Paul Wilkinson

“…Background As milder cases of adolescent depression do not meet treatment thresholds for specialist mental health services, young people often receive support from non-qualified professionals in third-sector/voluntary agencies. …”
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