Urinary Metabolic Profiling During Epileptogenesis in Rat Model of Lithium–Pilocarpine-Induced Temporal Lobe Epilepsy by Fatma Merve Antmen, Emir Matpan, Ekin Dongel Dayanc, Eylem Ozge Savas, Yunus Eken, Dilan Acar, Alara Ak, Begum Ozefe, Damla Sakar, Ufuk Canozer, Sehla Nurefsan Sancak, Ozkan Ozdemir, Osman Ugur Sezerman, Ahmet Tarık Baykal, Mustafa Serteser, Guldal Suyen

“…This study investigated urinary metabolites in a rat model of TLE to identify biomarkers that track epileptogenesis progression across the acute, latent, and chronic phases and elucidate the underlying mechanisms. <b>Methods</b>: Status epilepticus (SE) was induced in rats using repeated intraperitoneal injections of lithium chloride–pilocarpine hydrochloride. …”
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The Positive Effects of Soil Organic Carbon on European Cereal Yields Level Off at 1.4% by Ana Campos‐Cáliz, Enrique Valencia, César Plaza, Gina Garland, Anna Edlinger, Chantal Herzog, Marcel G. A. van derHeijden, Samiran Banerjee, Matthias C. Rillig, Sara Hallin, Aurélien Saghaï, Fernando T. Maestre, David S. Pescador, Laurent Philippot, Ayme Spor, Sana Romdhane, Pablo García‐Palacios

“…The quadratic relationship between SOC and cereal yield was conspicuous even after controlling for large differences in climate, soil and farming practices across countries. …”
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Psychiatric disorders in patients with benign and malignant sinonasal tumors: a prospective cross-sectional study by Guang-Ye Zhan, Guang-Ye Zhan, Guang-Ye Zhan, Hui-Fang Wang, Dong-Fang Wang, Yi-Hui Wen, Yi-Hui Wen, Hua Zhong, Hua Zhong, Wei-Ping Wen, Wei-Ping Wen, Jian Li, Jian Li, Jian Li, Liang Peng, Liang Peng

“…The benign and malignant groups did not differ significantly regarding symptomatology and mental wellbeing. …”
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Burden, clinical outcomes, and characteristics of tuberculosis in migrant populations in the middle East and North African region: A systematic review and meta-analyses by Taha Maatoug, Farah Seedat, Eman Elafef, Anissa Ouahchi, Ali Mtiraoui, Stella Evangelidou, Wejdene Mansour, Ana Requena-Méndez, Dominik Zenner

“…Migrants had lower TB-related mortality (pooled OR 0.8, 95 % CI 0.7–0.9; I2 = 2.9 %), however, treatment success rates were consistently below the WHO-recommended 90 % threshold. Migrant TB patients were younger (mean age difference: 12.8 years; 95 % CI 8.8–16.0; I2 = 86.5 %) and predominantly male (sex ratio: 1:5). …”
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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…We projected long-term TB incidence, mortality and costs to 2035 and conducted a threshold analysis to identify the maximum possible epidemiological impact of a DAT intervention by assuming 100% treatment completion for patients on DAT.Findings We estimated small and uncertain epidemiological benefits of the pillbox intervention compared with the standard of care in Ethiopia, with a difference of −0.4% (95% uncertainty interval (UI) −1.1%; +2.0%) incident TB episodes and −0.7% (95% UI −2.2%; +3.6%) TB deaths. …”
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Early Palliative Care Following Aborted Cancer Surgery: Results of a Prospective Feasibility Trial by Jordan M. Cloyd, MD, Rakhsha Khatri, BA, Angela Sarna, BS, Lena Stevens, PhD, Victor Heh, PhD, Mary Dillhoff, MD, Alex Kim, MD, Timothy M. Pawlik, MD, PhD, MPH, Aslam Ejaz, MD, Sharla Wells-Di Gregorio, PhD, Erin Scott, MD, Sachin S. Kale, MD

“…Only 13 of 25 (52%) met the primary endpoint of ambulatory PC within 30 days, less than the prespecified threshold of 70%. Overall, 16 (64%) patients completed ambulatory PC consultation a mean of 29.2 ± 15.8 days after enrollment. …”
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Cost‐effectiveness analysis of a community‐based model for delivery of antiretroviral therapy to people with clinically stable HIV in Cambodia by Lo Yan Esabelle Yam, Pheak Chhoun, Ziya Tian, Michiko Nagashima‐Hayashi, Marina Zahari, Sovannary Tuot, Sovannarith Samreth, Bora Ngauv, Vichea Ouk, Kiesha Prem, Siyan Yi

“…Cost‐effectiveness thresholds (CETs) were one‐time gross domestic product (GDP) per capita and opportunity cost. …”
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The value of a combined model based on ultra-radiomics and multi-modal ultrasound in the benign-malignant differentiation of C-TIRADS 4A thyroid nodules: a prospective multicenter... by Shuai Cui, Qifan Liu, Hailong Wang, Husha Li, Wei Li, Chenlong Li, Leilei Bi, Yang Mu, Wenjing Guo, Jundong Yao, Zhoulong Zhang

“…DeLong’s test showed that the combined model performed best in the training set, and in the test set, the combined model outperformed the multimodal ultrasound model but showed no significant difference compared to the radiomics model. DCA indicated that the combined model achieved higher net benefits within a specific threshold probability range (0.15-0.90).ConclusionThe combined model exhibits robust diagnostic capability in distinguishing benign from malignant thyroid nodules classified as C-TIRADS 4A.…”
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Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia by Dereje Mengesha Berta, Negesse Cherie, Berhanu Woldu, Aregawi Yalew, Elias Chane, Amare Mekuaninnit, Mebratu Tamir, Zufan Yiheyis, Abiy Ayele Angelo, Zewudu Mulatie, Adamu Kassie, Bisrat Birke Teketelew

“…Blood biomarkers score area under curve >.7 was selected as the best discriminative marker. The accepted threshold for statistical significance was set at P < 0.05. …”
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Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…The VO2 at anaerobic threshold (AT VO2) was also lower in the T2DM group than in the non-T2DM group, with a MD of −1.11 ml/kg/min (95% CI −2.04 to −0.18, P &lt; 0.05). …”
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Automatic Condition Monitoring of Industrial Rolling-Element Bearings Using Motor’s Vibration and Current Analysis by Zhenyu Yang

“…The practical issues, such as deviations of predicted characteristic frequencies, sideband effects, time-average of spectra, and selection of fault index and thresholds, are also discussed. The experimental work shows a huge potential to use some simple methods for successful diagnosis of industrial bearing systems.…”
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Mental health treatment and its impact on survival outcomes in patients with comorbid mental health and cardiovascular diseases: a retrospective cohort study by Tirsit Ketsela Zeleke, Fasil Bayafers Tamene, Gebremariam Wulie Geremew, Tekletsadik Tekleslassie Alemayehu, Minichil Chanie Worku, Samuel Agegnew Wondm, Aschalew Mulatu Tefera, Ayelign Eshete Fitgu, Wubetu Yihunie Belay, Abraham Teym, Rahel Belete Abebe, Bantayehu Addis Tegegne

“…Adjusted hazard ratios with corresponding 95% confidence intervals were reported, and statistical significance was determined at a P-value threshold of < 0.05. Kaplan-Meier survival curves were used to illustrate differences in time to hospital readmission and emergency department visits between treated and untreated patients. …”
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Impact of three sequential orthogeriatric care models on time to surgery after hip fracture: a retrospective study by Sabine Drevet, Jérôme Tonetti, Pierre Bouzat, Mehdi Boudissa, Jules Greze, Olga Fajfrova, Laure Allan-Pattoglia, Frederic Olive, Magali Bouisse, Bastien Boussat, Catherine Bioteau, Gaetan Gavazzi

“…The length of stay did not differ between models. At discharge, 81.4% of patients from ICMA could walk at least 3 m. …”
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Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk by Rafał Watrowski, Eva Schuster, Stefan Polterauer, Toon Van Gorp, Gerda Hofstetter, Michael B. Fischer, Sven Mahner, Robert Zeillinger, Eva Obermayr

“…Subgroup analyses were stratified by menopausal status (age threshold 51 years), disease stage, and histological subtype. …”
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Inflammatory markers predict efficacy of immunotherapy in advanced non-small cell lung cancer: a preliminary exploratory study by Yingqing Zhang, Na Yan, Yan Feng, Yonglei Wu, Yuejiao Sun, Xixi Gao, Chao Gu, Xiaolong Ma, Feng Gao, Hui Zhang, Jiaqi Zhou

“…We validated the NLR threshold of 5 from multiple previous studies in the data of this study, and patients with NLR > 5 also did not show a significant tendency towards the primary resistance group. …”
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Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial by Chen Z, Liu YY, Hu Q, Wang JS, Cao RY, Yu ST, Lu F, Zhong ML, Liang WD, Wang L

“…This trial aimed to explore the effect of ciprofol on the pathogenesis of POD and whether SIRT3 had a correlation with the pathogenesis of POD.Patients and methods: One hundred fourteen elderly patients scheduled for elective hip joint surgery were included in this randomized controlled, double blind study. …”
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Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada. by Kevin Ten Haaf, Martin C Tammemägi, Susan J Bondy, Carlijn M van der Aalst, Sumei Gu, S Elizabeth McGregor, Garth Nicholas, Harry J de Koning, Lawrence F Paszat

“…In general, scenarios that applied stringent smoking eligibility criteria (i.e., requiring higher levels of accumulated smoking exposure) were more cost-effective than scenarios with less stringent smoking eligibility criteria, with modest differences in life-years gained. Annual screening between ages 55-75 for persons who smoked ≥40 pack-years and who currently smoke or quit ≤10 y ago yielded an incremental cost-effectiveness ratio of $41,136 Canadian dollars ($33,825 in May 1, 2015, United States dollars) per life-year gained (compared to annual screening between ages 60-75 for persons who smoked ≥40 pack-years and who currently smoke or quit ≤10 y ago), which was considered optimal at a cost-effectiveness threshold of $50,000 Canadian dollars ($41,114 May 1, 2015, US dollars). …”
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Sustained effectiveness and cost-effectiveness of Counselling for Alcohol Problems, a brief psychological treatment for harmful drinking in men, delivered by lay counsellors in pri... by Abhijit Nadkarni, Helen A Weiss, Benedict Weobong, David McDaid, Daisy R Singla, A-La Park, Bhargav Bhat, Basavaraj Katti, Jim McCambridge, Pratima Murthy, Michael King, G Terence Wilson, Betty Kirkwood, Christopher G Fairburn, Richard Velleman, Vikram Patel

“…Economic analyses indicated that CAP plus EUC was dominant over EUC alone, with lower costs and better outcomes; uncertainty analysis showed a 99% chance of CAP being cost-effective per remission achieved from a health system perspective, using a willingness to pay threshold equivalent to 1 month's wages for an unskilled manual worker in Goa. …”
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Association Between Gut Microbiota and Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study in a Chinese Population by Wenjian Lin, Zixin Liang, Junxuan Fang, Yu Liu, Lei Lei, Jiawen Lin, Bin Xia, Zhihua Zheng, Jingqiu Yuan, Chun Tang

“…<b>Result:</b> At the locus-wide significance threshold, we identified 18 gut microbiome features associated with CKD onset in the China Kadoorie Biobank (CKB). …”
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Insights into Sinus-Lift Bone Grafting Materials: What’s Changed? by Anida-Maria Băbțan, Claudia N. Feurdean, Anca Ionel, Willi A. Uriciuc, Radu Chifor, Chambon Antoine Bernard Jaques, Bianca A. Boșca, Aranka Ilea

“…AB had a better bone regeneration ratio compared to many of the other interventions, but only two passed the threshold of significance: A1B and B-TCP + AB. Conclusions: A grafting material’s superiority is determined by its new bone formation ratio, connective tissue integration, residual graft content, and bone resorptionratio. …”
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