Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis by Francisco Artime-Naveda, David Hevia, Rebeca Alonso-Arias, Carmen Martínez, Isabel Quirós-González, Rafael Cernuda-Cernuda, Alejando Alvarez-Artime, Iván Menéndez-Valle, Rosa M. Sainz, Juan C. Mayo

“…CSF levels of Aβ, T-tau and P-tau were assayed, and patients were further classified according to threshold CSF levels of the three markers protein following the criteria of NIA-AA. …”
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Exploring the Relationship Between Sleep Apnea, Myocardial Infarct Size, and Coronary Collaterals in Acute Myocardial Infarction: A Multidisciplinary Study by Kundel V, Devarakonda K, Khan S, Suarez-Farinas M, Cohen O, Santos-Gallego C, Menegus MA, Kini A, Vengrenyuk Y, Okamoto N, Ueda H, Gidwani U, Kizer JR, Redline S, Kaplan R, Shah N

“…Rentrop Score quantified coronary collateralization (scores 0– 3, higher scores indicating augmented collaterals). Group differences in Rentrop grade and infarct size were compared using the Wilcoxon Rank-Sum test and Fisher’s Exact test as appropriate, with a significance threshold set at p < 0.05.Results: Among 33 adults, mean age was 54.4± 11.5 and mean BMI was 28.4± 5.9. 8 patients (24%) had no SA, and 25 (76%) had SA (mild n=10, moderate n=8, severe n=7). 66% (n=22) underwent CMR, and all patients had Rentrop scores. …”
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Revisiting hemodynamic definition: Incidence of chronic thromboembolic pulmonary hypertension following acute intermediate-high and high-risk pulmonary embolism by Bárbara Lacerda Teixeira, André Grazina, Ricardo Carvalheiro, Tiago Mendonça, Tiago Pereira da Silva, António Fiarresga, Ruben Ramos, Duarte Cacela, João Reis, Ana Galrinho, Luís Almeida Morais, Rui Cruz Ferreira

“…Background: The hemodynamic definition of pulmonary hypertension (PH) was updated, lowering the mean pulmonary arterial pressure (PAP) threshold to 20 mmHg and the pulmonary vascular resistance (PVR) to 2 Wood units. …”
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Anti-VEGF drugs compared with laser photocoagulation for the treatment of diabetic retinopathy: a systematic review and economic analysis by Mark Simmonds, Matthew Walton, Rob Hodgson, Alexis Llewellyn, Ruth Walker, Helen Fulbright, Laura Bojke, Lesley Stewart, Sofia Dias, Thomas Rush, John Lawrenson, Tunde Peto, David Steel

“…There was no evidence of a difference in effectiveness among the different anti-vascular endothelial growth factors. …”
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Cessation of smoking in people attending UK emergency departments: the COSTED RCT with economic and process evaluation by Ian Pope, Lucy V Clark, Allan Clark, Emma Ward, Pippa Belderson, Susan Stirling, Steve Parrott, Jinshuo Li, Timothy Coats, Linda Bauld, Richard Holland, Sarah Gentry, Sanjay Agrawal, Benjamin M Bloom, Adrian Boyle, Alasdair Gray, M Geraint Morris, Caitlin Notley

“…Design A two-arm pragmatic, multicentre, parallel-group, individually randomised, controlled superiority trial with an internal pilot, economic evaluation and mixed-methods process evaluation. Setting Six emergency departments across England and Scotland. …”
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CA19-9/DBil: a promising indicator to distinguish between CA19-9-elevated pancreatic head-type autoimmune pancreatitis and pancreatic head cancer by Wenfeng Xi, Wanying Liao, Tao Guo, Qingwei Jiang, Xiaoyin Bai, Xi Wu, Yunlu Feng, Shengyu Zhang, Dongsheng Wu, Qiang Wang, Aiming Yang

“…The sensitivity, specificity, and accuracy at the best threshold were all > 0.7. Model 1, although simple, was not inferior in its discriminative ability compared to complex models: the difference in discrimination between Model 1 and each of two adjusted models was not statistically significant (P > 0.05, both AUC and NRI). …”
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Testing linearity of CT System and Contrast Volume Tailoring for Optimal Hounsfield Units: A Theoretical and Experimental Study by Anahita Jafari, Fariba Zarei, Hamidreza Masjedi, Samira Moshiri, Vyas Akondi, Sabyasachi Chatterjee, Rezvan Ravanfar Haghighi

“…Materials and Methods: Aqueous solutions of Iopaque, with 300mgI/mL of iodine, were prepared for different weight/weight ( ) iodine concentrations and filled in a water-pool phantom, and the  observations were taken at different kVps for 10 different CT machines. …”
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Research on the characteristics of 18F-FDG PET/CT in mantle cell lymphoma and the discrimination between cellular morphological variants by REN Yixuan, CHEN Cheng, CAI Mingci, CHEN Jiamin, YANG Xinxin, WANG Chao, LIN Xiaozhu, CHENG Shu, JIANG Xufeng, CHEN Dongxu

“…Objective·To analyze the imaging characteristics and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) in mantle cell lymphoma (MCL) and explore its application to distinguishing between classic and aggressive variants of MCL.Methods·A retrospective analysis was conducted on the 18F-FDG PET/CT images and clinical data of 116 pathologically confirmed, newly diagnosed MCL patients. …”
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Predictive value of pulse oximetry for mortality in infants and children presenting to primary care with clinical pneumonia in rural Malawi: A data linkage study. by Tim Colbourn, Carina King, James Beard, Tambosi Phiri, Malizani Mdala, Beatiwel Zadutsa, Charles Makwenda, Anthony Costello, Norman Lufesi, Charles Mwansambo, Bejoy Nambiar, Shubhada Hooli, Neil French, Naor Bar Zeev, Shamim Ahmad Qazi, Yasir Bin Nisar, Eric D McCollum

“…All data were collected in Lilongwe and Mchinji districts, Malawi, from January 2012 to June 2014. We determined differences in mortality rates using <90% and <93% oxygen saturation (SpO2) thresholds and World Health Organization (WHO) and Malawi clinical guidelines for referral. …”
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The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women:... by Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi, Csaba Lengyel, János Zádori

“…Peripheral sensory function tests revealed significant deterioration in vibration sense and the current perception threshold of the median nerve at 2000 Hz in patients with obesity, as compared to controls. …”
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Association between the early or late onset of gestational diabetes mellitus with neonatal adverse outcomes: a retrospective cohort study by Fabiana Vieira Duarte de Souza Reis, Carlos Izaias Sartorão Filho, Luis Sobrevia, Caroline Baldini Prudencio, Bruna Bologna, Luana Favaro Iamundo, Adriely Magyori, Luiz Takano, Raissa Escandiussi Avramidis, Rafael Guilen de Oliveira, Marilza Vieira Cunha Rudge, Angélica Mércia Pascon Barbosa, Diamater Study Group

“…For early-onset GDM, a fasting glucose level of ≥ 92 mg/dL is a recognized threshold associated with an increased risk of adverse pregnancy outcomes, while < 126 mg/dL ensures the exclusion of overt diabetes. …”
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The efficacy and safety of ketorolac for postoperative pain management in lumbar spine surgery: a meta-analysis of randomized controlled trials by Jianbin Guan, Ningning Feng, Kaitan Yang, Haimiti Abudouaini, Peng Liu

“…Ketorolac significantly reduced pain compared to controls at 0–6 h, with a mean difference (MD) of − 1.42 (95% CI: − 2.03 to − 0.80; P < 0.0001), exceeding the Minimal Clinically Important Difference (MCID) of 1.2 to 2.0 points on the Visual Analog Scale (VAS), indicating clinically meaningful pain relief. …”
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Evaluation of water treadmill training, lunging and treadmill training in the rehabilitation of horses with back pain by Tobias Geiger, Liesa Lindenhahn, Julien Delarocque, Florian Geburek

“…Results Visual muscle development scores for the lumbar region (p = 0.001) and palpation sensitivity scores along the thoracic and lumbar region significantly improved at week 6, compared to baseline (p < 0.001). No differences in mechanical nociceptive thresholds were detected between water treadmill training, lunging and dry treadmill training at any time-point (p > 0.05). …”
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SAR Image Target Segmentation Guided by the Scattering Mechanism-Based Visual Foundation Model by Chaochen Zhang, Jie Chen, Zhongling Huang, Hongcheng Zeng, Zhixiang Huang, Yingsong Li, Hui Xu, Xiangkai Pu, Long Sun

“…Therefore, this paper fully integrates the SAR scattering mechanism, and proposes a SAR image target segmentation method guided by the SAR scattering mechanism-based visual foundation model. …”
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Cancer pain and quality of life structural equation model based on the biopsychosocial model by Xiaoyu Hu, Jingjing Lü, Chang Qin, Xiaoxuan Liu, Jianbiao Zhu, Yongchun Cui

“…Confirmatory factor analysis and SEM were subsequently conducted using AMOS 23.0, with parameters estimated via the maximum likelihood method. Results Two SEMs were developed to elucidate relationships between cancer pain and quality of life. …”
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Evaluation and implementation effects of soil erosion control technologies in typical ecologically vulnerable regions by WANG Shuang, ZHEN Lin, LI Wenjun, LIANG Li

“…The aim was to prevent, mitigate, and reverse soil erosion trends, while providing a reference for adaptation to local conditions, comprehensive management, rational development and utilization of resources in typical vulnerable regions, and supporting technology transfer between regions. [Methods] In this study, based on field research, questionnaire survey, key informant interviews, and content analysis of literature, we systematically reviewed soil erosion control technologies applied in 66 typical ecologically vulnerable regions worldwide, followed by the construction of a composite index from five dimensions, including potential to transfer, ease to use, readiness, effectiveness, and suitability and summarized the restoration effectiveness in different regions. …”
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Abstract 149: Metabolic Neuroimaging in the Assessment of Cardiovascular Risk: A Regional FDG‐PET Analysis by Robert C. Subtirelu, Eric M. Teichner, Yvonne Su, Thomas Werner, Abass Alavi, Poul Flemming Høilund‐Carlsen, Mona‐Elisabeth Revheim

“…An independent samples t‐test was used to assess the differences in z‐scores between controls and at‐risk subjects. …”
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Cost-effectiveness of camrelizumab plus rivoceranib for advanced hepatocellular carcinoma in the context of regional disparities in China by Zhonghua Zhao, Xiongying Jiang, Shiping Wen, Yanzhang Hao

“…The ICERs were compared against the willingness-to-pay (WTP) thresholds of different regions in China, including low-income ($16,426.80), medium-income ($34,319.01), and high-income regions ($81,036.63). …”
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External Validation of 3 Prediction Models for Mortality in Out‐of‐Hospital Cardiac Arrest Survivors: A Retrospective Multicenter Study by Chun‐Hsiang Huang, Edward Pei‐Chuan Huang, Cheng‐Yi Fan, Yi‐Chien Kuo, Chien‐Tai Huang, Ching‐Yu Chen, Chi‐Hsin Chen, Yi‐Ju Ho, Chun‐Ju Lien, Yun‐Chang Chen, Sih‐Shiang Huang, Tzu‐Hsueh Wang, Wen‐Chu Chiang, Wei‐Tien Chang, Chien‐Hua Huang, Chih‐Wei Sung

“…The positive predictive value threshold was set at 0.85 to minimize false‐positive predictions. …”
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Cervical cancer screening: Impact of collection technique on human papillomavirus detection and genotyping by Alisa P. Young, Mutiya Olorunfemi, Leigh Morrison, Scott A. Kelley, Anna Laurie, Anna McEvoy, Jill Schneiderhan, Julie Prussack, Marie Claire O'Dwyer, Pamela Rockwell, Philip Zazove, Jonathan Gabison, Jane Chargot, Kristina Gallagher, Ananda Sen, Dongru Chen, Elizabeth A. Haro, Emma A. Butcher, Martha L. Alves, Christelle El Khoury, Melinda L. Dendrinos, Nicole Brashear, Roger Smith, Richard W. Lieberman, Natalie Saunders, Elizabeth Campbell, Heather M. Walline, Diane M. Harper

“…The findings emphasize the utility of self-collection in identifying high-grade lesions and the consistency of HPV detection across different collection methods.…”
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