Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy by Hiroki Matsushita, Koki Kurono, Mikie Nakabayashi, Kei Sato, Hidetaka Morita, Yuki Yoshida, Masafumi Fukumitsu, Kazunori Uemura, Toru Kawada, Masashi Ichinose, Yumie Ono, Keita Saku

“…ROC analysis identified a relative BFI threshold of 35.5% of the baseline for predicting elevated lactate levels, with 62% sensitivity and 100% specificity (AUC = 0.75). …”
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What the VAF? A guide to the interpretation of variant allele fraction, percent mosaicism, and copy number in cancer by Adam C. Smith, Hubert Tsui, Sila Usta, Jose-Mario Capo-Chichi

“…This review illustrates how the different methods of interpreting and reporting data are performed and identifies challenges in the conversion of these values to a proportion of the sample. …”
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Left atrial dysfunction relates to symptom onset in patients affected by severe degenerative mitral regurgitation by Giacomo Ingallina, Gabriele Paci, Davide Margonato, Leonardo Italia, Francesco Ancona, Stefano Stella, Federico Biondi, Annamaria Tavernese, Martina Belli, Monica Barki, Michele Morosato, Jennifer Wong, Massimo Slavich, Alessandro Castiglioni, Michele De Bonis, Francesco Maisano, Eustachio Agricola

“…A LASr value below 22% emerged as an effective threshold, identifying symptomatic patients with 86% specificity and 68% sensitivity. …”
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Effect of Intravenous Contrast on CT Body Composition Measurements in Patients with Intraductal Papillary Mucinous Neoplasm by Ranjit S. Chima, Tetiana Glushko, Margaret A. Park, Pamela Hodul, Evan W. Davis, Katelyn Martin, Aliya Qayyum, Jennifer B. Permuth, Daniel Jeong

“…Background: The effect of differing post-contrast phases on CT body composition measurements is not yet known. …”
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Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey by Hong-jin Liu, Yong Lin, Wang Li, Hai Yang, Wen-yue Kang, Pei-lei Guo, Xiao-hui Guo, Ning-ning Cheng, Jie-chao Tan, Yi-na He, Si-si Chen, Yan Mu, Xian-wen Liu, Hui Zhang, Mei-fang Chen

“…Multiple regression analysis revealed that the volume-control ventilation mode and an SpO2 intervention threshold of < 85% were independent risk factors for hypoxemia during OLV in lung and cardiovascular surgeries. …”
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Relationship Between Renal Resistive Index and Retinal Vascular Density in Individuals with Hypertension by Caterina Carollo, Maria Vadalà, Alessandra Sorce, Nicola Sinatra, Emanuele Orlando, Emanuele Cirafici, Miriam Bennici, Riccardo Polosa, Vincenza Maria Elena Bonfiglio, Giuseppe Mulè, Giulio Geraci

“…Participants were divided into two groups based on the 75th percentile threshold of the RRI distribution (0.66, 95% CI 0.64–0.68). …”
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Predictive Value of Residual SYNTAX Score II for Patients With Complex Coronary Disease and Chronic Renal Insufficiency After Percutaneous Coronary Intervention by Shuaiyong Zhang, Yumeng Lei, Jingfu Chen, Youcheng Wang, Huanting Liu, Nan Guo, Yunfei Wang, Xufen Cao, Liqiu Yan

“…Additionally, decision curve analysis showed that the rSS-II had a high net benefit for long-term outcomes over threshold probabilities, indicating its superiority in daily practice. …”
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Beta-adrenergic reactivity of erythrocyte membranes in various phenotypes of uncontrolled hypertension by M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev

“…The compared groups did not differ in sex and age composition, prevalence of T2D and basic clinical data. …”
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The effect of acute beetroot juice consumption prior to climbing on lower-body isokinetic and isometric strength, aerobic power, and muscle soreness among mountain climbers by Alireza Daneshparvar, Mohammad Hemmatinafar, Mohsen Salesi, Rasoul Rezaei, Babak Imanian, Sepideh Pirmohammadi

“…The study evaluated swelling around the thigh (Sw-T), pressure pain threshold (PPT), isokinetic and isometric strength, horizontal jump (HJ), wall-sit, handgrip strength (HGS), flexibility, and the Queen’s College Step test. …”
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Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. by Benedikt Ley, Ari Winasti Satyagraha, Hisni Rahmat, Michael E von Fricken, Nicholas M Douglas, Daniel A Pfeffer, Fe Espino, Lorenz von Seidlein, Gisela Henriques, Nwe Nwe Oo, Didier Menard, Sunil Parikh, Germana Bancone, Amalia Karahalios, Ric N Price

“…<h4>Conclusions</h4>The CSG performed well at the 30% threshold. Its high NPV suggests that the test is suitable to guide PQ treatment, and the high LR+ and low LR- render the test suitable to confirm and exclude G6PDd. …”
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Comparison between a Novel Knee Arthrometer and Simultaneous Stress Radiography for the Diagnosis of Complete and Partial Acute Anterior Cruciate Ligament Tears by Junqiao Li, Jiayao Zhang, Mingke You, Xiaolong Yang, Wenjing Ma, Qian Deng, Gang Chen, Xin Tang, Weili Fu, Yan Xiong, Qi Li, Jian Li

“…Preoperative arthrometry and simultaneous stress radiography were performed using the Ligs arthrometer at 90, 120, and 150 N to assess side‐to‐side difference (SSD) in anterior knee laxity. The optimal threshold was determined using the receiver operating characteristic (ROC) curve. …”
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Substance-Related Acute Toxicity Deaths in Canada From 2016 to 2017: Protocol for a Retrospective Chart Review Study of Coroner and Medical Examiner Files by Jenny Rotondo, Amanda VanSteelandt, Fiona Kouyoumdjian, Matthew J Bowes, Tanya Kakkar, Graham Jones, Brandi Abele, Regan Murray, Emily Schleihauf, Jessica Halverson, Jennifer Leason, Dirk Huyer, Beth Jackson, Songul Bozat-Emre, Devanshi Shah, Erin E Rees

“…Most abstractors (25/26, 96%) met the established threshold for consistency throughout abstraction without the need for remedial training. …”
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Fu’s subcutaneous needling for knee osteoarthritis: a systematic review and meta-analysis by Xiaohu Zhao, Jingxuan Liu, Dake Li, Shangkun Si, Xuanhe Tian, Deke Zhang, Ping Jiang, Ping Jiang

“…The meta-analyses of included studies used odds ratios and mean differences when appropriate, along with significance threshold α = 0.1. …”
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Cost-Effectiveness of Oral Nutritional Supplements in Malnourished or at Risk of Disease-Related Malnutrition Cancer Patients in North Macedonia by Kapedanovska Nestorovska A, Sterjev Z

“…Beyond this period, ONS remained cost-effective within the willingness-to-pay threshold. This supports reimbursement decisions for addressing malnutrition in this vulnerable patient group, helping to maximize health benefits within constrained budgets.Keywords: health economics, medical nutrition, tumor cachexia, reimbursement, cancer care program…”
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Weight Percentile Is Maintained During Spica Casting: A Retrospective Cohort Study of Patients Treated with Closed or Open Reduction for Developmental Dysplasia of the Hip by Olivia C. Tracey, BA, Kiranpreet Nagra, BA, Keza Levine, BA, Akshitha Adhiyaman, BS, Paige McBoyle, Erikson Nichols, MS MMS, Melanie Prior, MD, Ernest L. Sink, MD, David Scher, MD, Shevaun M. Doyle, MD, Emily Dodwell, MD, MPH

“…Mean weight percentiles did not differ during or after treatment (range: 55-61st percentile, P ​= ​.974). …”
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Personalized neuron-specific enolase level based on EEG pattern for prediction of poor outcome after cardiac arrest by Juliette Pelle, Estelle Pruvost-Robieux, Florence Dumas, Antonin Ginguay, Julien Charpentier, Clara Vigneron, Frédéric Pène, Jean Paul Mira, Alain Cariou, Sarah Benghanem

“…Methods A retrospective study was conducted in a tertiary CA center, using a prospective registry of 155 adult patients comatose 72 h after CA. …”
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Development of automatic organ segmentation based on positron-emission tomography analysis system using Swin UNETR in breast cancer patients in Korea by Dong Hyeok Choi, Joonil Hwang, Hai-Jeon Yoon, So Hyun Ahn

“…Comparison of maximum SUV and mean SUV values from our automated segmentation with those from traditional single‐ROI methods revealed differences of 0.19 and 0.16, respectively, demonstrating improved reliability and accuracy in whole‐organ SUV analysis. …”
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Immune checkpoint inhibitors and cancer-related cognitive decline: a propensity score matched analysis in active chemotherapy patients by Guangmin Jian, Jiling Zeng, Jun Lu, Weidong Wang, Yongluo Jiang, Tong Huang, Yu Si Niu, Zhoufang Chai, Xin Qi, Nianqi Liu, Youlong Wang, Cantong Liu, Jiacai Lin, Guanqing Zhong, Yiming Li, Pengfei Zhu, Zong-qing Zheng, Zong-qing Zheng, Fadian Ding, Fadian Ding, Fadian Ding, Fadian Ding, Xinjia Wang, Xinjia Wang, Weizhi Liu, Weizhi Liu, Ao Zhang, Yifei Ma, Yifei Ma, Yifei Ma, Yifei Ma

“…Primary endpoints were MoCA and PCI score changes and minimal clinically important difference (MCID), which was defined as threshold for meaningful impairment events. …”
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Sustained effectiveness and cost-effectiveness of the Healthy Activity Programme, a brief psychological treatment for depression delivered by lay counsellors in primary care: 12-mo... by Benedict Weobong, Helen A Weiss, David McDaid, Daisy R Singla, Steven D Hollon, Abhijit Nadkarni, A-La Park, Bhargav Bhat, Basavraj Katti, Arpita Anand, Sona Dimidjian, Ricardo Araya, Michael King, Lakshmi Vijayakumar, G Terence Wilson, Richard Velleman, Betty R Kirkwood, Christopher G Fairburn, Vikram Patel

“…HAP plus EUC also had a marginal effect on WHO Disability Assessment Schedule score at 12 months (aPR = -1.58; 95% CI -3.33, 0.17; p = 0.08); other outcomes (days unable to work, intimate partner violence toward females) did not statistically significantly differ between the two arms. Economic analyses indicated that HAP plus EUC was dominant over EUC alone, with lower costs and better outcomes; uncertainty analysis showed that from this health system perspective there was a 95% chance of HAP being cost-effective, given a willingness to pay threshold of Intl$16,060-equivalent to GDP per capita in Goa-per quality-adjusted life year gained. …”
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Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy by Philip Bonomi, Hita Moudgalya, Sandra L. Gomez, Palmi Shah, Sanjib Basu, Marta Batus, Levi B. Martinka, Ahmed Abdelkader, Iphigenia Tzameli, Sonia Cobain, Susie Collins, Edmund J. Keliher, Danna M. Breen, Roberto A. Calle, Mary Jo Fidler, Jeffrey A. Borgia

“…Standard statistical methods were used to calculate relationships between changes in weight and in body composition. …”
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