A Cost-Effectiveness Analysis of Mosunetuzumab vs Tisagenlecleucel for Treatment of Third- or Higher-Line (3L+) Relapsed or Refractory (R/R) Follicular Lymphoma (FL) in Italy by Luminari S, Pinto A, Puccini B, D’Arpino A, Omodeo Salè E, Bellone M, Pradelli L, Sabinot A

“…A matching-adjusted indirect treatment comparison (MAIC) approach was used to account for differences in trial population characteristics on the relative efficacy of mosunetuzumab to tisagenlecleucel. …”
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Evaluation of Perinatal Outcome in Women with Impaired Glucose Homeostasis During Pregnancy by Neha SAHAY, Felice FAIZAL

“…Background: Glucose tolerance testing in pregnancy identifies many women with glycaemic responses that exceed normal range but that do not meet the threshold required to diagnose Gestational Diabetes Mellitus. …”
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Trends and Disparities in Liver Transplantation in the United States: A Nationwide Analysis of Demographic, Clinical, and Socioeconomic Factors (2016–2021) by Vignesh Krishnan Nagesh, Vivek Joseph Varughese, Marina Basta, Emelyn Martinez, Shruthi Badam, Lokaesh Subramani Shobana, Abdifitah Mohamed, Alin J, Simcha Weissman, Adam Atoot

“…One-way ANOVA and Hensel’s test were used to assess variance and distribution homogeneity, with a significance threshold of <i>p</i> < 0.05. Results: A total of 9677 liver transplant admissions were analyzed. …”
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Identification and validation of NEIL2 as a prognostic biomarker and potential therapeutic target in cervical cancer by Yan Li, Jiayuan Du, Lingjia Wei, Tianmeng Tan, Liyi Bao, Jinqiu Su, He Wang

“…CC samples in the TCGA-CESC cohort were divided into high and low-expression groups according to the optimal threshold of NEIL2 expression, and survival analysis was performed. …”
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Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials by Gordon Guyatt, Arnav Agarwal, Qi Zhou, Dena Zeraatkar, Thomas Agoritsas, Reed AC Siemieniuk, Romina Brignardello-Petersen, Nazmul Islam, Per Olav Vandvik, Saifur R Chowdhury, Md Kamrul Hasan, Mahmudur Rahman Chowdhury

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Speech sound discrimination in background noise across the lifespan: a comparative study in Mongolian gerbils and humans by Carolin Jüchter, Carolin Jüchter, Chieh-Ju Chi, Rainer Beutelmann, Rainer Beutelmann, Georg Martin Klump, Georg Martin Klump

“…Many elderly listeners have difficulties with speech-in-noise perception, even if auditory thresholds in quiet are normal. The mechanisms underlying this compromised speech perception with age are still not understood. …”
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Numerical Simulation of Low-Level Wind Shear Using CFD and LSTM Technology Based on the WRF Model by Zexin DONG, Shuoyan WU, Fang YE, Lijing CHEN, Yi LI, Chenbo SUN, Feng XU, Lei LIU

“…In an effort to elevate the precision of low-level wind shear forecasting， this paper amalgamates European Centre for Medium-Range Weather Forecasts （ECMWF） fifth-generation reanalysis data （ERA5） and National Centers for Environmental Prediction Final Operational Global Analysis （FNL） reanalysis data， high-resolution Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model （ASTER GDEM） terrain data， and real-time observational data from Lanzhou Zhongchuan Airport.It employs the Weather Research and Forecasting Model （WRF）， WRF integrated with Computational Fluid Dynamics （CFD）， and Long Short-Term Memory （LSTM） neural network methods to simulate and analyze two wind shear events at Lanzhou Zhongchuan Airport on April 15-16， 2021.The findings reveal that： （1） within grids smaller than 1 kilometer utilizing Large Eddy Simulation （LES）， the WRF model demonstrates superior performance in wind speed simulation for individual stations， yet it falls short when compared to the WRF model combined with Computational Fluid Dynamics （CFD） models in simulating near-surface horizontal wind field wind speeds； （2） concerning the simulation of two low-level wind shears encountered during aircraft landing， both Weather Research and Forecasting Model - Large Eddy Simulation （WRF-LES） and Weather Research and Forecasting Model - Computational Fluid Dynamics （WRF-CFD） models are capable of simulating the first wind shear， however， the second appears to be influenced by the potentially lower wind speed data input into the models， with neither model achieving the threshold for wind speed difference， necessitating further validation in future work； （3） under low wind speed conditions （6 meters per second）， the LSTM-based single-variable wind speed prediction model maintains an average absolute error of approximately 0.59 meters per second， effectively capturing the nonlinear relationship of wind speed changes under various terrain and circulation background conditions.Despite being constrained by WRF errors and incomplete observational elements， multi-variable wind speed prediction can achieve wind speed forecasting with higher computational efficiency and generalization capabilities while ensuring that the average absolute percentage error is less than 6.60%.This paper not only verifies the differences between WRF-CFD and WRF-LES coupling schemes in wind field and low-level wind shear forecasting but also explores the feasibility and accuracy of LSTM-based wind speed prediction， aspiring to offer new perspectives and methods for enhancing wind field simulation accuracy and reducing the time required for detailed wind field simulation.…”
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An AI-Based Digital Scanner for <i>Varroa destructor</i> Detection in Beekeeping by Daniela Scutaru, Simone Bergonzoli, Corrado Costa, Simona Violino, Cecilia Costa, Sergio Albertazzi, Vittorio Capano, Marko M. Kostić, Antonio Scarfone

“…Detecting the parasite and defining the intervention thresholds for effective treatment is a difficult and time-consuming task; different detection methods exist, but they are mainly based on human eye observations, resulting in low accuracy. …”
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Comparison of SARS-CoV-2 IgG responses in hemodialysis patients and healthcare workers after COVID-19 vaccination by Hakkı Öztürk, Metin Özsoy, Ayşegül Tuna, Artuner Varlibas, Salih Cesur, Altan Aksoy, Aydın Çifci, Mehmet Emin Demir

“…However, among HD patients, IgG levels did not differ by vaccine regimen.ConclusionHD patients mounted a SARS-CoV-2 IgG antibody response comparable to that of healthy HCWs, with no participant falling below the positivity threshold. …”
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Suaeda Salsa Hyperspectral Index (SSHI) for mapping S. salsa in coastal wetlands using hyperspectral satellite imagery: case studies in northern coastal China by Mengyao Zhang, Yinghai Ke, Kun Shang, Zhaojun Zhuo, Han Liu, Peng Li, Nana Zhao, Jinghan Sha, Jinyuan Li

“…To evaluate the performance of SSHI, a simple thresholding method and a random forest (RF) model were used to map S. salsa, respectively. …”
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Human motor control during movements with high demands by Paul Kaufmann, Willi Koller, Elias Wallnöfer, Basilio Goncalves, Clara Scheer, Juliana Exel, Olivia Froschauer, Catherine Hlavac, Mathias Wiplinger, Lorenz Zweier, Arnold Baca, Hans Kainz

“…The temporal overlap between different synergies within one trial and the trial-to-trial similarity between different trials within one synergy were determined through the Pearson correlation of the activation coefficients (Figure 1A). …”
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Consistency Is Key: A Secondary Analysis of Wearable Motion Sensor Accuracy Measuring Knee Angles Across Activities of Daily Living Before and After Knee Arthroplasty by Robert C. Marchand, Kelly B. Taylor, Emily C. Kaczynski, Skye Richards, Jayson B. Hutchinson, Shayan Khodabakhsh, Ryan M. Chapman

“…Results: Pre-TKA/post-TKA errors were not different. No differences were noted across activities. …”
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A consistent ocean oxygen profile dataset with new quality control and bias assessment by V. Gouretski, L. Cheng, J. Du, X. Xing, F. Chai, F. Chai, Z. Tan

“…This procedure consists of a suite of 10 quality checks, with outlier rejection thresholds being defined based on underlying statistics of the data. …”
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Cost-effectiveness of direct oral anticoagulants in non-valvular atrial fibrillation by Inigo Gorostiza, Amaia Bilbao-Gonzalez, Javier Mar

“…The incremental cost-effectiveness ratio of DOAC compared to acenocoumarol ranged from €1,732 to €2,556/QALY, while the incremental net benefit for different willingness-to-pay thresholds was only negative for values below €3,000/QALY. …”
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Road Safety Risk Assessment Approach for Freight Vehicles Using Warning Data by Cheng Yang, Xiaoling Zhai, Xiaoqin Zhou, Tao Wang, Shiyi Chen, Xiyuan Zhang

“…Finally, cluster analysis is used to determine optimal risk classification thresholds. The method is validated using warning data and historical accident records from 47 road segments across three major roads in Nanning. …”
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Oral immunotherapy for cow’s milk allergy in children: a systematic review and meta-analysis by Yan Wang, Yan Wang, Shunli Liu, Shunli Liu, Meizhu Lu, Meizhu Lu, Jingyu Guo, Jingyu Guo, Can Lv, Can Lv, Lan Huang, Lan Huang

“…The meta-analysis indicated that oral immunotherapy significantly facilitated desensitization in patients with cow’s milk allergy in children (relative risk [RR] 2.51, 95% CI: 1.54–4.09, I²=84.4%). Tolerance threshold at oral food challenges (OFC) increased following oral immunotherapy compared with a standard mean difference (SMD) of 3.58 (2.82–4.33). …”
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Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET Trial in the Gambia. by Emma M Harding-Esch, Ansumana Sillah, Tansy Edwards, Sarah E Burr, John D Hart, Hassan Joof, Mass Laye, Pateh Makalo, Ahmed Manjang, Sandra Molina, Isatou Sarr-Sissoho, Thomas C Quinn, Tom Lietman, Martin J Holland, David Mabey, Sheila K West, Robin Bailey, Partnership for Rapid Elimination of Trachoma (PRET) study group

“…There was no evidence of any difference in TF or Ct prevalence at 36 months resulting from enhanced coverage or from one round of MDA compared to three.…”
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Diagnostic Accuracy of the Alice NightOne Single-Belt Monitor for Obstructive Sleep Apnea and Reliability of Wireless Data Transfer by Peng M, Zhang Y, Zhao R, Li J, Zhang X, Deng L, Zhao L, Zhou B, Wang X, Dong X, Han F

“…For REI on ANOhome versus AHI on PSG, the difference is − 8.0 (− 9.9, − 6.0) events/h. With threshold of REI ≥ 5 events/h for OSA diagnosis, ANOhome had 98.8% sensitivity, 90.0% specificity, 99.4% positive predictive value. …”
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The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial. by Bai Li, Miranda Pallan, Wei Jia Liu, Karla Hemming, Emma Frew, Rong Lin, Wei Liu, James Martin, Mandana Zanganeh, Kiya Hurley, Kar Keung Cheng, Peymane Adab

“…The primary outcome, assessed blind to allocation, was between-arm difference in body mass index (BMI) z score at completion of the intervention. …”
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The impact of early vs. delayed surgery on outcomes in cervical spinal cord injury without fracture or dislocation by Sirui Xiao, Hui Yan, Beixi Bao, Yuxuan Wu, Xiaokang Cheng, Chunyang Xu, Jiaguang Tang

“…Notably, the 2-year postoperative JOA score difference between groups was 2.71 points, exceeding the minimal clinically important difference (MCID) threshold. …”
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