Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial by Xiong M, Liu Y, Liang Y, Wang H, Zhang L, Zhang Z, Fang M

“…The AUCVAS scores were similar between the OFA (7.3 ± 1.4) and OSA (6.9 ± 1.3) groups (P = 0.201), the difference in AUCVAS between the two groups was 0.384 (95% CI: − 0.296, 1.064), which was significantly below the preset noninferiority threshold of 1.0, demonstrating the noninferiority of OFA. …”
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Prognostic value of temporalis muscle thickness as a marker of sarcopenia in intracerebral hemorrhage by Waldemar Gubarev, Jan Klinke, Ulrike Voßmann, Daniel Cantré, Bijan Zendeh Zartoshti, Artem Rafaelian, Milos Arsenovic, Daniel Dubinski, Sae-Yeon Won, Florian Gessler, Thomas Freiman, Alexander Storch, Matthias Wittstock

“…Dichotomization into sarcopenic and non-sarcopenic patients was carried out using standard threshold values.ResultsFinally, 322 patients were analyzed [median (IQR) age: 77 (66–83) years; 57.5% male]. …”
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Clinical significance of the determination of antibodies to the NR2 subunit of glutamate N-methyl-D-aspartate receptors (aNMDAR) in patients with systemic lupus erythematosus and a... by T. A. Lisitsyna, A. B. Borisova, T. M. Reshetnyak, D. Yu. Veltishchev, M. E. Diatroptov, A. S. Avdeeva, K. S. Nurbaeva, A. A. Abramkin, E. L. Nasonov

“…The concentration of aNMDAR in patients with neurological manifestations of SLE and APS did not exceed the threshold value, but was significantly higher than in healthy donors (4.32±2.0 versus 2.96±1.44 ng/ml, respectively; p=0.042). …”
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Beyond efficacy parity: a novel cost-equilibrium framework for value assessment of competing third-line therapies in metastatic colorectal cancer by Shunlong Ou, Bingjie Wang, Jing Luo, Qian Jiang

“…This real-world study evaluates clinical outcomes, safety, and cost differentials to model value-equilibrium pricing.MethodsA retrospective cohort analysis included 25 mCRC patients (regorafenib: n = 5; fruquintinib: n = 20) treated at Sichuan Cancer Hospital (2021–2022) with follow-up through June 2023. …”
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Experts' consensus over key components of online learning environments in medical education: a modified e-Delphi study by Noor-i-Kiran Naeem, Siti Nurma Hanim Hadie, Irwan Mahazir Ismail, Zil-e-Fatima Naeem, Ahmad Hassan Khan, Muhamad Saiful Bahri Yusoff

“…Friedman test showed no significant differences in rankings (p >0.05), confirming consensus. …”
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HIGH-SENSITIVITY C-REACTIVE PROTEIN IN THE FIRST TRIMESTER OF PREGNANCY IN OBESE PATIENTS WITH GESTATIONAL DIABETES by Belomestnov Sergey Razumovich, Сhumarnaya Tatyana Vladislavovna, Sevostyanova Olga Yurievna, Ksenofontov Aleksey Mikhaylovich, Isakova Tatyana Mikhaylovna, Prazdnichkova Ekaterina Dmitrievna

“…Objective: To determine the prognostic value of high-sensitivity C-reactive protein (hsCRP) levels in the first trimester for the risk of gestational diabetes mellitus (GDM) in obese pregnant women. Methods: A prospective observational descriptive cohort study included 105 obese women with a body mass index (BMI) ranging from 25.0 to 29.99 kg/m² in the first trimester. …”
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Features of haemophilus influenzae type b vaccine in patients waitlisted for lung transplantation by V. B. Polishchuk, M. P. Kostinov, A. A. Pyzhov, O. O. Magarshak, N. E. Yastrebova, N. A. Karchevskaya, E. A. Тarabrin, T. E. Kallagov, A. E. Vlasenko

“…Objective: to evaluate the immunological efficacy of haemophilus influenzae type b (Hib) vaccine in patients with severe bronchopulmonary condition waitlisted for lung transplantation. Materials and methods. 16 patients (age 22–61 years) with severe bronchopulmonary diseases were vaccinated once against Hib infection. …”
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Clinical characteristics of lean and non-lean non-alcoholic fatty liver disease: a cross-sectional study by Mengyan Xu, Rui Gong, Jiao Xie, Sanping Xu, Shi Wang

“…Methods The current study collected NAFLD patients from the physical examination population. …”
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Factors contributing to bracing success in juvenile idiopathic scoliosis and current limitations: a systematic review and meta-analysis by Kai Him Ambrose Chan, Kai Chun Augustine Chan, Elijah Maliwat, Jason Pui Yin Cheung, Prudence Wing Hang Cheung

“…This review aims to explore factors determining bracing success in JIS and to identify limitations in current literature. Methods: A literature search was conducted according to the PRISMA 2020 guidelines. …”
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Neural Responsiveness to Electrical Stimulation in Children With Common Cavity Deformity by Xiuhua Chao, Jinye Li, Jianfen Luo, Xianqi Liu, Zhaomin Fan, Haibo Wang, Lei Xu

“…Results Children with CCD exhibited significantly higher ECAP thresholds and lower amplitudes than those with normal cochlea. …”
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Molecular genetic predictors of progression of triple negative breast cancer by I. S. Panchenko, V. V. Rodionov, V. V. Kometova, S. V. Panchenko, M. G. Sharafutdinov, I. A. Lavrentieva

“…In TNBC, genes determine whether patients belong to clusters that differ in prognosis. There are not enough studies that consider genes as risk factors for progression. …”
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Agreement between CES-D and CIDI-SF scales of depression among older adults: a cross-sectional comparative study based on the longitudinal aging study in India, 2017-19 by T. Muhammad, Soomi Lee, Manish Kumar, T. V. Sekher, Mathew Varghese

“…Assuming the CIDI-SF scale as the “gold standard”, with rising threshold values, sensitivity of the CES-D scale decreased while specificity increased. …”
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Influence of hyperinsulinemic – hypoglycemic clamp on induced platelet aggregation, activity of physiological anticoagulants and von Willebrand factor in patients with type I diabe... by Iwona R. Jarek-Martynowa, Mikhail Y. Martynov, Karina G. Sarkisova, Ekaterina O. Koksharova, Ekaterina E. Mishina, Albina N. Yasamanova, Marina V. Shestakova

“…Antithrombin-III activity decreased significantly at the euglycaemic and hypoglycaemic stages, compared with the hyperglycaemic period, but still remained significantly elevated above the upper threshold. Protein C and vWf activity did not change significantly. …”
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Nomogram combining dual-energy computed tomography features and radiomics for differentiating parotid warthin tumor from pleomorphic adenoma: a retrospective study by Zhiwei Gong, Jianying Li, Yilin Han, Shiyu Chen, Lijun Wang

“…This study aimed to evaluate a nomogram combining dual-energy computed tomography (DECT) quantitative parameters and radiomics to enhance diagnostic precision.MethodsThis retrospective study included 120 patients with pathologically confirmed PA or WT, randomly divided into training and test sets (7:3). …”
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Gender-specific dual effects of physical activity on depression and mortality: a nine-year cohort study in Chinese adults aged 45 and above by Dan Shan, Dan Shan, Meina Yang, Meina Yang, Kunyan Zhou, Kunyan Zhou

“…In this study, we aimed to investigate the role of PA on new-onset depression and ACM in Chinese adults aged 45 year and older, with particular emphasis on gender differences.MethodsThis was a longitudinal cohort study that took place over a nine-year period and featured 2,264 participants drawn from the China Health and Retirement Longitudinal Study (CHARLS). …”
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Anterior Tooth Inclination Between Skeletal Class II and III Malocclusions After Surgical Orthodontic Treatment by Hiromi Tomaru, Chie Tachiki, Yu Nakamura, Dai Ariizumi, Satoru Matsunaga, Keisuke Sugahara, Akira Watanabe, Akira Katakura, Yasushi Nishii

“…Multiple regression analysis was used to establish prediction models for anterior tooth inclination. The threshold for statistical significance was set at <i>p</i> < 0.05. …”
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The Effects of Reverse Nordic Exercise Training on Measures of Physical Fitness in Youth Karate Athletes by Raja Bouguezzi, Senda Sammoud, Yassine Negra, Younés Hachana, Helmi Chaabene

“…As such, this study aimed to evaluate the effects of an 8-week eccentric training program utilizing the reverse Nordic exercise (RNE) integrated into karate training compared with regular karate training only on measures of physical fitness in youth karate athletes. <b>Methods:</b> Twenty-seven youth karatekas were recruited and allocated to either RNE group (n = 13; age = 15.35 ± 1.66 years; 7 males and 6 females) or an active control group ([CG]; n = 14; 7 males and 7 females; age = 15.30 ± 1.06 years). …”
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Impact of the Coronavirus Disease 2019 Pandemic on the Management and Outcomes of ST-Segment Elevation Myocardial Infarction Patients: A Retrospective Cohort Study by Cheng-Han Yang, Yu-Jen Lin, Shi-Ying Gao, Wei-Chen Chen, Chung-Hsien Chaou

“…<i>Results:</i> No significant difference in in-hospital mortality was observed between pre-pandemic (5.85%) and pandemic (7.03%) groups (<i>p</i> = 0.45). …”
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Development of monoclonal antibodies against SARS-CoV-2 nucleocapsid protein for COVID-19 antigen detection by Maurine Mumo Mutua, Bernard N. Kanoi, Steven Ger Nyanjom, Sebastian Musundi, Mark Makau, Shingo Inoue, Samoel Ashimosi Khamadi, Jesse Gitaka, Ernest Apondi Wandera

“…The mAbs were also assessed for their performance using RT-PCR confirmed positive samples with varying cycle threshold (CT) values and their specificity screened using virus isolates of other respiratory viruses. …”
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Synergizing Multi-Temporal Remote Sensing and Systemic Resilience for Rainstorm–Flood Risk Zoning in the Northern Qinling Foothills: A Geospatial Modeling Approach by Dong Liu, Jiaqi Zhang, Xin Wang, Jianbing Peng, Rui Wang, Xiaoyan Huang, Denghui Li, Long Shao, Zixuan Hao

“…Key advancements over existing methods include the multi-temporal SMRI and the introduction of a nonlinear threshold response function to quantify “safe-fail” adaptation capacities. …”
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