Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study by Jing Yang, Jing Zhang, Xinyu Wan, Jiaoyang Cai, Jiaoyang Cai, Tianyi Wang, Xiaomin Yang, Wenjie Li, Lixia Ding, Lili Song, Yan Miao, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li

“…Furthermore, there was no difference in the recovery of B cells and the expansion of CAR-T cell copies.Conclusion and discussionIn conclusion, under the guidance of current CRS prevention and control measures, the rational use of corticosteroids does not affect the clinical efficacy and overall survival of CAR-T cell therapy in patients with B-ALL and also does not affect the persistence of CAR-T cells in vivo, but the dosage threshold needs further clinical or experimental verification.…”
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Establishing a peer advisory board in a mental health ethics research group – challenges, benefits, facilitators and lessons learned by Mirjam Faissner, Mirjam Faissner, Esther Braun, Esther Braun, Simone Agnes Efkemann, Anne-Sophie Gaillard, Iris Haferkemper, Christin Hempeler, Imke Heuer, Ursula Lux, Sarah Potthoff, Sarah Potthoff, Matthé Scholten, Sylvia Spiegel, Christina Stefaniak, Madeleine Thesing, Anna Werning, Jakov Gather, Jakov Gather

“…While participatory methods are regarded as beneficial in many areas of psychiatric research, they are still rarely considered in the field of mental health ethics. …”
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Cost-effectiveness of the CV-polypill strategy versus standard care for secondary cardiovascular prevention in Spain: an analysis based on the SECURE trialResearch in context by Thomas Gaziano, José María Castellano, Amy Dymond, Alissa Looby, Stuart Mealing, Ruth Owen, Stuart Pocock, José Ramón González-Juanatey, Alberto Cordero, Antonio Fernández-Ortiz, Aleš Linhart, François Schiele, Wolfram Doehner, Luisa Ojeda Fernández, Valentín Fuster

“…This analysis aimed to estimate the cost-effectiveness of the CV-Polypill from the Spanish healthcare perspective using SECURE trial data. Methods: A decision analytic Markov modelling approach was conducted to compare the CV-Polypill with standard care over a lifetime time horizon. …”
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Robustness of Machine Learning Predictions for Determining Whether Deep Inspiration Breath-Hold Is Required in Breast Cancer Radiation Therapy by Wlla E. Al-Hammad, Masahiro Kuroda, Ghaida Al Jamal, Mamiko Fujikura, Ryo Kamizaki, Kazuhiro Kuroda, Suzuka Yoshida, Yoshihide Nakamura, Masataka Oita, Yoshinori Tanabe, Kohei Sugimoto, Irfan Sugianto, Majd Barham, Nouha Tekiki, Miki Hisatomi, Junichi Asaumi

“…Although previous studies have explored the potential of machine learning (ML) to predict which patients might benefit from DIBH, none have rigorously assessed ML model performance across various MHD thresholds and parameter settings. This study aims to evaluate the robustness of ML models in predicting the need for DIBH across different clinical scenarios. …”
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Improvement of alexithymia in patients treated in mental health services for personality disorders: a longitudinal, observational study by Hanna Sayar, Theresa Wilberg, Theresa Wilberg, Ingeborg Ulltveit-Moe Eikenæs, Andreas Ekberg, Andreas Ekberg, Kai Leitemo, Katharina Teresa Enehaug Morken, Katharina Teresa Enehaug Morken, Eileen Oftedal, Eileen Oftedal, Siri Omvik, Dag Anders Ulvestad, Dag Anders Ulvestad, Geir Pedersen, Elfrida Hartveit Kvarstein, Elfrida Hartveit Kvarstein

“…This study aimed to investigate the prevalence of alexithymia among patients in specialized PD mental health services, differences according to PD severity and PD type, and the longitudinal course of alexithymia during treatment.MethodsThe study included 1,019 patients treated in specialized PD treatment units, with 70% of them with personality difficulties above the PD diagnostic threshold [borderline PD, 31%; avoidant PD, 39%; PD not otherwise specified (PD-NOS), 15%; other PDs, 15%; and more than one PD, 24%]. …”
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Stroke risk associated with cold spells occurring during the warm season by Cheng He, Susanne Breitner, Siqi Zhang, Markus Naumann, Claudia Traidl-Hoffmann, Gertrud Hammel, Annette Peters, Michael Ertl, Alexandra Schneider

“…Six cold spell definitions were created using different relative temperature thresholds (1st, 2.5th, and 5th percentiles) and durations (more than 1–2 consecutive days). …”
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Participants’ satisfaction with social security is closely associated with their acceptance of vulnerable groups: a nationwide cross-sectional study in China by Chaowei Guo, Yifan Wu, Lina Ge, Li Qi, Yi Ma, Shuang Zang

“…Threshold effect was examined by piecewise regression. …”
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Evaluation of serum ESPL1 as a biomarker for early diagnosis of HBV-related hepatocellular carcinoma by Lu-Huai Feng, Lu Wei, Bobin Hu, Hengkai Liang, Qingmei Li, Qianbing Yin, Tumei Su, Long Huang, Hongqian Liang, Jianning Jiang, Jianning Jiang, Minghua Su, Minghua Su

“…ObjectiveTo evaluate the reliability of serum human phosphorylated exospindle polar-like proteinase 1 (ESPL1) as a serum biomarker for early diagnosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HBV-HCC).MethodsThis retrospective study was conducted on 266 patients with chronic hepatitis B (CHB), liver cirrhosis (LC), and HBV-related HCC. …”
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Comparative study of hematological parameters among smokers and nonsmokers in Basra city, Iraq by Safa Mohammed Hussein, Huda Hasan Aziz, Wurood Hameed Abed, Kadhim Fadhil Kadhim

“…The objective of this investigation is to evaluate the influence of cigarette smoking on hematological parameters among male students enrolled at Basrah University in Iraq. Methods: The study comprised a total of seventy male participants, divided into two groups: smokers (n = 35) and nonsmokers (n = 35). …”
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Demographic, Premorbid, and Clinical Characteristics of Schizophrenia Spectrum Patients with High and Low Polygenic Liability to the Disorder by Margarita Alfimova, Marina Gabaeva, Tatyana Lezheiko, Victoria Plakunova, Yulia Chaika, Vera Golimbet

“…The discovery of phenotypes indexing genetic differences advances research into the schizophrenia etiology but has proven to be challenging. …”
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Analysis of Clinical Symptoms and Risk Factors Related to Functional Prognosis in Patients With Cardiogenic Stroke by Pen-Ju Liu, PhD, Shui-Ping Liu, MD, Peng Yuan, MD

“…This study aimed to identify clinical characteristics influencing short-term functional prognosis in patients with cardiogenic stroke. Methods: The study prospectively enrolled 212 patients with cardiogenic stroke, collecting their clinical data and laboratory results. …”
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How do people feel about sleep diaries? Factors influencing sleep diaries completion with and without daily exposure to light. by Boris Gass, Grégory Pierné, Elisabeth Ruppert, Ulker Kilic-Huck, Laurence Hugueny, Patrice Bourgin, Juliette Chambe

“…Our objectives were to compare the proportion of informative usual sleep diaries (USD) and light/sleep diaries (LSD) and to evaluate factors influencing the quality of filling them.<h4>Methods</h4>A monocentric, prospective, controlled interventional study was conducted. …”
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Modern Perspectives on the Role of L-Type Calcium Channel Blocker for Hearing Preservation in Sensorineural Hearing Loss: A Systematic Review of Recent Randomized Clinical Trials by Amelia Puspita, Dayinta Grahitanindya

“…In animal studies, L-type CCBs demonstrated reduced hearing threshold shifts and hair cell preservation under noise and ototoxic stress. …”
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Comparing the Effectiveness of Emotion Regulation and Logotherapy on the Quality of Life in Adolescents with Anxiety Disorders by Marzieh Sadat Seyed Ghandi, Hayedeh Saberi, Malek Mirhashmi

“…Data analysis was executed utilizing SPSS version 22 software at a significance threshold of 0.05, employing mixed covariance analysis. …”
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The Influence of Sweet Taste Perception on Dietary Intake in Relation to Dental Caries and BMI in Saudi Arabian Schoolchildren by Heba Ashi, Guglielmo Campus, Heléne Bertéus Forslund, Waleed Hafiz, Neveen Ahmed, Peter Lingström

“…In addition, the relationship between dietary habits and both caries and BMI was studied. Methods. A cross-sectional observational study comprising 225 schoolchildren aged 13–15 years from Jeddah, Saudi Arabia, was conducted. …”
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Association between Thyroid Dysfunction and Intensive Care Unit-Acquired Weakness: A Case-Control Study by Tarek Samir Shabana, Sherif George Anis, DiaaElDein Mahmoud Ibrahim

“…Thyroid disorders may decrease the threshold for developing myopathy. Nonthyroidal illness syndrome (NTIS) is a common form of thyroid dysfunction in critically ill patients who are prone to the development of intensive care unit-acquired weakness (ICUAW). …”
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Explainable Sinkhole Susceptibility Mapping Using Machine-Learning-Based SHAP: Quantifying and Comparing the Effects of Contributing Factors in Konya, Türkiye by Süleyman Sefa Bilgilioğlu, Cemil Gezgin, Muzaffer Can Iban, Hacer Bilgilioğlu, Halil Ibrahim Gündüz, Şükrü Arslan

“…However, the lack of explainability inherent in these methods remains a critical issue for decision-makers. …”
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Evaluation of Olfactory and Gustatory Function of HIV Infected Women by Ayotunde James Fasunla, Adekunle Daniel, Ukamaka Nwankwo, Kehinde Mobolanle Kuti, Onyekwere George Nwaorgu, Olusina Olusegun Akinyinka

“…To evaluate the olfactory and gustatory function of HIV infected women in Ibadan, Nigeria. Methods. A case control study of women comprising 83 HIV infected women and 79 HIV uninfected women. …”
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Assessment of the prognosis of the outcome of severe community-acquired pneumonia caused by <i>Klebsiella pneumoniae</i> by V. I. Sakharov, P. I. Mironov, A. A. Tсandekov, V. A. Rudnov

“…There were no statistically significant differences between the surviving and deceased patients in terms of the level of biomarkers studied. …”
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Systemic immunity-inflammation index and body mass index: A cross-sectional study. by Wei Guo, Chongheng Zhang, Fang Cao, Xinxin Sun, Jian Li, Wenfeng Zhang

“…This study aims to clarify the correlation between SII and BMI.<h4>Methods</h4>The current study investigated the association between SII and BMI using data from the National Health and Nutrition Examination Survey (NHANES). …”
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