Development and validation of a non-invasive prediction model for identifying high-risk children with metabolic dysfunction-associated fatty liver disease by Yuan Xiaowu, Dong Jian, Wen Yizhu, Ma Ting, Tong Jin, Wei Juan, Wang Sirui, Wang Jinli, He Yuchen, Zhao Huan, Cheng Yuhang, Li Jun

“…ObjectiveThis study aims to investigate the prevalence and risk factors of Metabolic dysfunction-associated fatty liver disease (MAFLD) in pediatric populations and establish a novel health index scoring system derived from key risk parameters for early identification of high-risk children with MAFLD.MethodIn this cross-sectional study, a systematic random sampling method was employed to recruit children (6–18 years) with MAFLD. …”
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Reliability of nociceptive monitors vs. standard practice during general anesthesia: a prospective observational study by Daniel Widarsson Norbeck, Sophie Lindgren, Axel Wolf, Pether Jildenstål

“…However, using HR as a surrogate for nociception with a threshold of a 10% increase from baseline, the difference was significant only at skin incision. …”
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Biotin interference in routine clinical immunoassays by Kuo-Chun Chiu, Jia-Rong Jhan, Hsiao-Ni Yan, Yu-Chen Liao, Wen-Hui Lu, Kuan-Yi Lee, Li-Yuan Cheng, Chung-Kang Yeh, Ya-Fen Lee, Chiung-Hui Kuo, Kuei-Pin Chung, Tzu-I Chien

“…However, this depletion method was unnecessary with the newer reagents due to their increased biotin tolerance. …”
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Effects of glycyrrhizinic acid on neuromotor function in leptin-resistant mice by T. M. Matuzok, V. A. Prikhodko, S. M. Napalkova, O. V. Buyuklinskaya, S. V. Okovityi

“…To study the effects of course administration (1 month) of glycyrrhizinic acid (GA) (20 mg/kg/d) on neuromotor function in female leptin-resistant diabetic db/db mice of different ages using stimulation electroneuromyography (ENMG).Materials and methods. …”
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DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreat... by Tina Draškovič, Branislava Ranković, Nina Zidar, Nina Hauptman

“…Methods Our study included a cohort of 149 formalin-fixed, paraffin-embedded tissue samples, including 19 CRLMs, 10 PCLMs, 15 HCCs, 15 CCAs, 15 colorectal adenocarcinomas (CRCs), 15 pancreatic ductal adenocarcinomas (PDACs) and their paired normal tissue samples. …”
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Cost-effectiveness of universal genetic screening for familial hypercholesterolemia in young adults aged 18–40 years in China by Rui Meng, Fenghao Shi, Baoming Zhang, Chao Li, Jinyan Wang, Lingqin Song, Lei Zhang, Mingwang Shen

“…This study aims to evaluate the cost-effectiveness of universal genetic screening of young adults aged 18–40 years compared to universal cholesterol screening or current passive screening strategies (opportunistic cholesterol screening and genetic cascade testing) for FH in China. Methods A decision-analytic Markov model was constructed to simulate the lifetime (until 100 years old or 99% of patients died) coronary heart disease (CHD) events, discounted costs, gains in quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) of different screening strategies. …”
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Predicting IDH and 1p/19q molecular status of gliomas with multi-b values DWI by Shanshan Zhao, Peipei Wang, Eryuan Gao, Mengzhu Wang, Guang Yang, Shouhui Niu, Mengjiao Pan, Kai Zhao, Jingliang Cheng, Xiaoyue Ma

“…This study compares the clinical utility of mono-exponential, IVIM, SEM, and CTRW models for predicting IDH and 1p/19q molecular status in adult diffuse gliomas.Materials and methodsData of adult diffuse glioma patients from January 2021 to August 2023 were collected. …”
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Performance of OncoE6TM Cervical Test in detecting cervical precancer lesions in HIV-positive women attending an HIV clinic in Bujumbura, Burundi: a cross-sectional study by Zacharie Ndizeye, Sonia Menon, Jean-Pierre Van Geertruyden, Catherine Sauvaget, Y Jacquemyn, John-Paul Bogers, Ina Benoy, Davy Vanden Broeck

“…OncoE6 sensitivity varied from poor to low with increasing disease severity (42.1%, 95% CI 19.9% to 64.3% at CIN2+ threshold; and 58.3%, 95% CI 30.4% to 86.2% at CIN3+ threshold). …”
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Association between lactate-to-albumin ratio and mortality in hepatic failure: a retrospective cohort study by Huan Wu, Long Wu, Li Luo, Hai-yang Li, Bao-fang Zhang

“…Therefore, this study aims to investigate the correlation between LAR and all-cause mortality in patients suffering from liver failure. Methods We retrospectively analyzed data from patients with liver failure who were admitted to the intensive care unit (ICU) between 2008 and 2019, which were gathered from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. …”
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Reallocating 24-hour movement behaviors and its impact on mental health in preschool children: a compositional data and dose-response analysis by Tian Wang, Junyu Wang, Xuelin Lu, Xuhui Chen, Lanzhi Chen, Yixin Liang, DongQing Yang, Yanmei Shi, Rui Li, Yong Yang, Beibei Luo, Jie Zhuang

“…Methods In this cross-sectional study, 828 Chinese preschool children aged 3 to 6 years were assessed. …”
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Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury by Bin Zou, Juan Du, Qiwen Xuan, Yajing Wang, Zixiao Wang, Wen Zhang, Lianghua Wang, Wei Gu

“…We then performed scraping therapy on the rats that had been randomly chosen and compared treatment effects at different time points. In vitro data including skin temperature and tactile allodynia threshold were collected and histological sections were analyzed. mRNA sequencing was applied to distinguish the genes or signaling pathways that had been altered due to scraping therapy, and the results were further verified through reverse transcription polymerase chain reaction and Western blot analysis. …”
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Dietary patterns among Afghan adults and their associations with overweight and obesity: a cross-sectional study in Kandahar, Afghanistan by Mohammad Sediq Sahrai, Laure Dossus, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Abdul Wahed Wasiq, Marc J. Gunter, Inge Huybrechts

“…Methods A cross-sectional study was conducted in Kandahar, Afghanistan, where data on sociodemographic characteristics, anthropometric measurements and diet were collected. …”
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Shape-Dependent Dynamic Label Assignment for Oriented Remote Sensing Object Detection by Xue Zhang, Yanxia Wu, Guoyin Zhang, Ye Yuan, Guangliang Cheng, Yulei Wu

“…It introduces a new metric for evaluating sample box quality by considering angular differences relative to ground truth (GT) boxes and adjusts the sample scoring threshold according to the aspect ratio of each GT box. …”
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SARS-CoV-2 severity prediction in young adults using artificial intelligence by K. V. Kas’janenko, K. V. Kozlov, K. V. Zhdanov, I. I. Lapikov, V. V. Belikov

“…Aim: to build a predictive model for severe COVID-19 prediction in young adults using deep learning methods.   Materials and methods: data from 906 medical records of patients aged 18 to 44 years with laboratory-confirmed SARS-CoV-2 infection during 2020–2021 period was analyzed. …”
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Exploring the potential of remote sensing to detect marine plastic debris in the South African Ocean region by J. Pretorius, S. Haupt, B. Sibolla, B. Sibolla

“…It is therefore important to develop methods for the detection of marine plastics for more informed and targeted clean-up or prevention operations for the oceans. …”
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Features of anorectal function after radiation therapy in patients with rectal cancer by O. I. Kit, O. G. Bondarenko, Yu. A. Gevorkyan, N. V. Soldatkina, M. A. Gusareva, N. G. Kosheleva, A. A. Solntseva, D. S. Petrov, D. A. Savchenko

“…To study the function of the sphincter in patients with rectal cancer after chemoradiotherapy using the method of high-resolution anorectal manometry.Patients and methods. …”
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Optimal Cutoff Value of 1-Hour Postload Glucose to Identify Insulin Resistance in Women with Polycystic Ovary Syndrome by Sungwook Chun, Sihoon Lee

“…Categorization of patients based on the 1-h PG threshold showed significant differences for all laboratory variables related to insulin sensitivity/resistance, other than fasting insulin. …”
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Implementation of the 2022 AAP guidelines for neonatal hyperbilirubinemia could reduce the need for phototherapy in Italy by Carlo Dani, Monica Fusco, Marco Andreini, Giuseppe Pepe, Simone Pratesi

“…Total serum bilirubin (TSB) at the start of phototherapy, which was decided based on the guidelines of the Italian Society of Neonatology, was compared with the TSB thresholds recommended by AAP 2022 guidelines. Results Seven hundred and thirteen (82%) infants had TSB at the start of phototherapy lower than AAP 2022 threshold (16.2 ± 3.0 vs. 17.7 ± 3.4 mg/dL; P < 0.001) with a mean difference of 1.8 (0.7–2.6) mg/dL. …”
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Rat retinal function attenuation with IOP elevation is impacted by both blood pressure and intracranial pressure by Sera N. Ganearachchi, Anna K. van Koeverden, Christine T. O. Nguyen, Zheng He, Vickie H. Y. Wong, Bang V. Bui, Da Zhao

“…IntroductionTo consider how blood pressure and intracranial pressure modify the way that retinal function responds to intraocular pressure elevation in rats.MethodsSix groups of adult Long–Evans rats (n = 7–11 eyes/group, total animals 25) were anesthetized and underwent acute pressure modification. …”
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The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials. by Matteo Fecchio, Andrea Pigorini, Angela Comanducci, Simone Sarasso, Silvia Casarotto, Isabella Premoli, Chiara-Camilla Derchi, Alice Mazza, Simone Russo, Federico Resta, Fabio Ferrarelli, Maurizio Mariotti, Ulf Ziemann, Marcello Massimini, Mario Rosanova

“…TEPs computed from high-MEP and low-MEP trials were then compared using the same methods applied in experiment 1. In line with previous studies, TMS of M1 produced larger TEPs compared to other cortical stimulations. …”
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