Variation in KOOS JR improvement across total knee implant designs: a cohort study from Michigan Arthroplasty Registry Collaborative Quality Initiative by Eric R Cornish, Huiyong Zheng, David C Markel, Brian R Hallstrom, Richard E Hughes

“…A clinically relevance ratio (CRR) of those achieving the threshold of 23 points to the overall group was calculated for each implant. …”
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Proteome Alterations in Osteoarthritic Knee Cartilage: Comparative Analysis of Macroscopically Involved and Uninvolved Regions by Soundarrajan Dhanasekaran, Divya Arunachalam, Sharon M Nayagam, Chitra Thangavel, Shanmuganathan Rajasekaran

“…Materials and methods: Cartilage samples were collected from macroscopically involved and uninvolved regions (<i>n</i> = 12 per region). …”
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THE ANALYSIS OF CLINICAL, FUNCTIONAL, LABORATORY AND GENETIC PARAMETERS VALUES ON THE CONDITION OF PATIENTS AFTER MYOCARDIAL INFARCTION, AND PROGNOSIS OF INTRAMYOCARDIAL AUTOLOGIC... by V. I. Konenkov, O. V. Poveshchenko, V. F. Prokofiev, A. V. Shevchenko, I. N. Kim, N. A. Bondarenko, A. M. Karaskov, E. V. Pokushalov, A. B. Romanov

“…To reveal or rule out an interconnection of the specifics of structure of clinical, functional, laboratory and genetic parameters of patients, who had myocardial infarction, with the effectiveness of intramyocardial autologic cell therapy (IACT).Material and methods. The study involved 71 patients, 87% of men, with ischemic heart disease and III-IV functional class (NYHA) heart failure at the age 37-76 y.o. …”
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Cost utility analysis of acute rehabilitation approaches in the management of traumatic anterior shoulder dislocation by Henry Nwankwo, James Mason, Martin Underwood, Helen Parsons, Aminul Haque, David Torgerson, Chetan Modi, Rebecca S. Kearney

“…Aims: We aimed to conduct a cost-utility analysis comparing one session of advice, supporting materials, and option to self-refer to physiotherapy with the same advice and materials, plus an additional programme of physiotherapy for people with a first-time, traumatic anterior shoulder dislocation. Methods: We conducted an economic evaluation within a randomized controlled trial from the UK NHS and personal social services (PSS) perspective. …”
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Biochemical Markers of Cardiotoxicity of High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation in Patients with Malignant Lymphoproliferative Disorders by VO Sarzhevskii, DS Kolesnikova, VYa Mel’nichenko

“…The sensitivity threshold of the troponin T test was 0.1 ng/mL and troponin I 0.001 ng/mL (highly sensitive troponin). …”
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Durability of Supplemental Nucleus Pulposus Allograft in Patients with Lumbar Discogenic Pain by Costandi S, Beall DP, Davis TT, Amirdelfan K, Naidu RK, DePalma MJ, Yoon ES, Fleming JW, Block JE, Mekhail N

“…Minimal clinically important difference (MCID) and substantial clinical benefit (SCB) were set at ≥ 30% and ≥ 50% over baseline, respectively. …”
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Ovarian endometriosis negatively impacts pregnancy outcomes in young infertile women undergoing IVF/ICSI treatment by Ruihui Lu, Wenxiong Jiao, Xin Li, Cheng Zeng, Jing Shang, Qing Xue

“…ROC curve analysis determined an optimal AMH threshold of 1.835 ng/ml for predicting cLBR, with a sensitivity of 50.6% and specificity of 82.2%. …”
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Sports Massage and Blood Flow Restriction Combined with Cold Therapy Accelerate Muscle Recovery After Fatigue in Mixed Martial Arts Athletes: A Randomized Controlled Trial by Robert Trybulski, Robert Roczniok, Gracjan Olaniszyn, Yaroslav Svyshch, Andryi Vovkanych, Michał Wilk

“…Objectives: The purpose of this study is to quantitatively evaluate the combined effects of sports massage, blood flow restriction (BFR), and cold therapy on quadriceps recovery in mixed martial arts (MMA) athletes following eccentric exercise, focusing on muscle biomechanical properties, pain, and strength. Methods: This randomized, single-blind clinical trial involved 36 men and women MMA-trained participants, divided into three groups: massage (n = 12) received massage, BFR/cool (n = 12) received combined BFR and cooling, and control (n = 12) received passive rest as a control. …”
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A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: A double-blind, randomized controlled trial. by Robert H J Bandsma, Wieger Voskuijl, Emmanuel Chimwezi, Greg Fegan, André Briend, Johnstone Thitiri, Moses Ngari, Laura Mwalekwa, Victor Bandika, Rehema Ali, Fauzat Hamid, Betty Owor, Neema Mturi, Isabel Potani, Benjamin Allubha, Anneke C Muller Kobold, Rosalie H Bartels, Christian J Versloot, Marjon Feenstra, Deborah A van den Brink, Patrick F van Rheenen, Marko Kerac, Celine Bourdon, James A Berkley

“…We tested the hypothesis that a lactose-free, low-carbohydrate F75 milk would serve to limit these risks, thereby reducing the number of days in the stabilization phase.<h4>Methods and findings</h4>In a multicenter double-blind trial, hospitalized severely malnourished children were randomized to receive standard formula (F75) or isocaloric modified F75 (mF75) without lactose and with reduced carbohydrate. …”
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Cardio-metabolic risk factors and insulin resistance by O.Ye. Sklyarova, T.A. Maksymets, O.O. Kapustynskyi, I.A. Yuzych, O.S. Kapustynska, Ye.Ya. Sklyarov

“…According to research data, it is important to examine the significance of the homeostasis model of insulin resistance (HOMA-IR) in the Ukrainian population, particularly among individuals with cardio-metabolic risk factors that lead to the development of atherosclerotic, non-atherosclerotic cardiovascular diseases and metabolic complications. Materials and methods. One hundred and ninety-nine individuals were examined: 152 patients with stage I–II arterial hypertension (AH) and 47 individuals without any previously diagnosed diseases. …”
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A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP by Yuling Zha, Chengshuai Liu, Yuping Zhou, Miao Kong, Jinlei Liu, Lu Jing, Hailati Gulimila

“…Abstract Objective This study aimed to construct a nomogram to identify risk factors for malnutrition in patients with chronic heart failure (CHF) and to explore the correlation between Ghrelin (GHRL), Myostatin (MSTN), C-reactive protein (CRP) and High-sensitivity C-reactive protein (Hs-CRP) to further elucidate the potential pathophysiological mechanisms linking malnutrition/sarcopenia and inflammation. Methods A total of 128 patients with congestive heart failure (CHF) admitted to the Cardiology Department of Guang’anmen Hospital, China Academy of Chinese Medical Sciences, between February 2022 and February 2023, were included in the study. …”
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Associations of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with diabetes and prediabetes among adults with hypertension: a cross-section... by Qing Meng, Qing Meng, Shengqiang Fan, Shengqiang Fan, Li Zhang, Bin Shen, Chaoping Zou, Dezhou Sun, Xianghui Liu, Jian Zhang, Shugang Xu

“…This study aimed to elucidate the potential correlation between NHHR and the risk of diabetes and prediabetes among adults with hypertension.MethodsIn this cross-sectional survey, we screened National Health and Nutrition Examination Survey (NHANES)-collected data during 2009-2018, identifying a qualifying population of 10,250 individuals. …”
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Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Methods This study analyzed saliva DNA methylation patterns in 30 children (15 born to GDM mothers and 15 to non-GDM mothers) from the EPIDG cohort. …”
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Absolute risk-based versus individualized benefit approaches for determining statin eligibility in primary prevention of cardiovascular diseases in Chinese populations: A modeling... by Qiuping Liu, Chao Gong, Tianjing Zhou, Minglu Zhang, Xiaofei Liu, Xun Tang, Pei Gao

“…This study compares the absolute risk-based approach with an individualized benefit approach, based on the Causal-Benefit model considering predicted lipid-lowering effects, for statin eligibility in Chinese populations.<h4>Methods and findings</h4>We analyzed nationally representative data from the China Health and Retirement Longitudinal Study, including adults aged 40-80 years, free of diabetes and CVD history, with LDL-C levels between 1.8 mmol/L and 4.9 mmol/L, and no prior statin use. …”
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Environmental pollution and human fertility: investigating the relationship between PM2.5 exposure and assisted reproductive technology outcomes by Fei Li, Xiaoyan Duan, Mingming Li, Yumei Gao, Yuejuan Kang, WenJun Zheng, XueYan Guo, Ying Chen

“…Abstract Objective To investigate the impact of seasonal variations in particulate matter with an aerodynamic diameter of 2.5 µm or less (PM2.5) exposure on assisted reproductive technology (ART) outcomes. Methods This retrospective study, conducted at the First People’s Hospital of Shangqiu, analyzed data from 13,476 patients who underwent ART procedures between February 2018 and December 2022. …”
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Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM) by Ziying Su, Lei Cao, Hailong Chen, Peng Zhang, Chunwei Wu, Jing Lu, Ze He

“…Furthermore, it evaluates the mediating effect of obesity indicators on this association. Methods This study included 9,947 individuals from NHANES and applied appropriate weighting techniques. …”
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N-terminal propeptide of type III procollagen for predicting diastolic dysfunction in patients with myocardial infarction and preserved ejection fraction by A. V. Osokina, V. N. Karetnikova, O. M. Polikutina, A. V. Ivanova, O. E. Avramenko, O, V. Gruzdeva, O. L. Barbarash

“…To study changes in the level of fibrotic scarring marker — the N-terminal propeptide type III procollagen (PIIINP) and structural and functional parameters with the assessment of diastolic function in patients a year after ST segment elevation myocardial infarction (STEMI) and preserved left ventricle (LV) contractility.Material and methods. At first, the study included 120 (100%) STEMI patients. …”
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Building a risk prediction model for anastomotic leakage postoperative low rectal cancer based on Lasso-Logistic regression by Zhenhao Quan, Lin Lin, Renwei Huang, Kaiyu Sun, Feipeng Xu

“…Abstract Objective To build a nomogram model for predicting the risk of anastomotic leakage (AL) postoperative low rectal cancer based on Lasso-Logistic regression. Methods A total of 482 patients with rectal cancer who underwent low rectal cancer surgery in our hospital from June 2017 to May 2023 were selected as the training set, and 127 patients with rectal cancer who underwent low rectal cancer surgery in our hospital from June 2023 to April 2025 were selected as the validation set. …”
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Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people. by Joshua Elliott, Matthew Whitaker, Barbara Bodinier, Oliver Eales, Steven Riley, Helen Ward, Graham Cooke, Ara Darzi, Marc Chadeau-Hyam, Paul Elliott

“…<h4>Methods and findings</h4>We obtained throat and nose swabs with valid SARS-CoV-2 PCR test results from 1,147,370 volunteers aged 5 years and above (6,450 positive cases) in the REal-time Assessment of Community Transmission-1 (REACT-1) study. …”
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Skin/Muscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice by Juan Yang, Fei Yuan, Gang Ye, Yong-Jie Wang, Cheng Wu, Jinghua Wang, Xiang-Yao Li, Zhiying Feng

“…The paw withdrawal threshold (PWT) to mechanical stimuli and the paw withdrawal latency to heat stimuli were measured before and after SMIR. …”
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