CRISPR/dCas-mediated counter-silencing: reprogramming dCas proteins into antagonists of xenogeneic silencers by Johanna Wiechert, Biel Badia Roigé, Doris Dohmen-Olma, Hindra, Xiafei Zhang, Roberto G. Stella, Marie A. Elliot, Julia Frunzke

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Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy by Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei

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LncRNA mediated metabolic reprogramming: the chief culprits of solid tumor malignant progression: an update review by Kun Fang, Huizhe Xu, Shuai Yuan, Xiaoxi Li, Xiaoyu Chen, Xiushi Fan, Xiaoxin Gao, Lu Zhang, Shulan Sun, Xudong Zhu

“…Abstract Metabolism reprogramming (MR) is one of the top ten hallmarks of malignant tumors. …”
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LEC2 induces somatic cell reprogramming through epigenetic activation of plant cell totipotency regulators by Jing Peng, Qi Zhang, Li Ping Tang, Biao Jie Xu, Thomas Laux, Xian Sheng Zhang, Ying Hua Su

“…Abstract Many plant species can develop embryos from somatic cells without fertilization. …”
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Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas by Hoi Man Iao, Chih‐Ying Chen, Ya‐Hui Lin, Wan‐Chi Pan, Chun‐Yi Liang, Hsiu‐Ching Liu, Lo‐Jei Ching, Pei‐Yu Weng, Min‐Ren Chiang, Ru‐Siou Hsu, Tsu‐Chin Chou, I‐Chi Lee, Lun‐De Liao, Li‐An Chu, Shih‐Hwa Chiou, Shang‐Hsiu Hu

“…This in situ catalytic SOCO with noncontact AMF presents an “electromagnetic messenger”‐based therapeutics for reprogramming the neuro‐regeneration and brain function recovery in TBI.…”
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Enteral immunization with live bacteria reprograms innate immune cells and protects neonatal foals from pneumonia by Bibiana Petri da Silveira, Susanne K. Kahn, Rebecca M. Legere, Jocelyne M. Bray, Hannah M. Cole-Pfeiffer, Michael C. Golding, Noah D. Cohen, Angela I. Bordin

“…Abstract Using a horse foal model, we show that enteral immunization of newborn foals with Rhodococcus equi overcomes neonatal vaccination challenges by reprogramming innate immune responses, inducing R. equi-specific adaptive humoral and cell-mediated immune responses and protecting foals against experimental pneumonia challenge. …”
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Nanozyme-driven self-assembled rhein gels for osteoarthritis therapy: Alleviating chondrocyte inflammation by reprogramming macrophages by Jian Jiang, Chao Song, Xuefeng Hou, Kangjie Xu, Zhongkai Ji, Lei Fan, Juqun Xi, Ailang Zhang

“…Current therapeutic strategies are hindered by systemic adverse effects and insufficient intra-articular drug bioavailability, underscoring the demand for enhanced delivery mechanisms. In this study, we developed a CeO2 nanozyme-driven gel system synergistically integrated with the herbal monomer rhein (RH). …”
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Mechanisms of Cisplatin-Induced Acute Kidney Injury: The Role of NRF2 in Mitochondrial Dysfunction and Metabolic Reprogramming by Jihan Liu, Yiming Wang, Panshuang Qiao, Yi Ying, Simei Lin, Feng Lu, Cai Gao, Min Li, Baoxue Yang, Hong Zhou

“…NRF2 may serve as a potential target for developing therapeutic strategies to prevent cisplatin nephrotoxicity.…”
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Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion by Mien-Chie Hung, Jun Yao, Chia-Hung Chen, Chih-Yen Tu, Zhiguo Liu, Qihui Chen, Liyan Gu, Dongli Linghu, Jiaming Song, Chengjie Liu, Boning Liu, Riyao Yang, Swathi Priya Manickam, Navaneethan Sundhar, Delong Liu, Hsiao-Fan Chen, Shasha Shi, Shunjie Xiong, Linlin Sun

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The role of acetylation and deacetylation in cancer metabolism by Cuicui Wang, Xiaoxin Ma

“…In this review, we focus on discussing how acetylation and deacetylation regulate cancer metabolism, thereby highlighting the central role of these post‐translational modifications in metabolic reprogramming, and hoping to provide strong support for the development of novel cancer treatment strategies. …”
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Pharmacologically inducing regenerative cardiac cells by small molecule drugs by Wei Zhou, Kezhang He, Chiyin Wang, Pengqi Wang, Dan Wang, Bowen Wang, Han Geng, Hong Lian, Tianhua Ma, Yu Nie, Sheng Ding

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One arrow two eagles: Multifunctional nano-system for macrophage reprogramming and osteoclastogenesis inhibition against inflammatory osteolysis by Tong Sha, Ze Wang, Jinwei Li, Yahong Wu, Jinbiao Qiang, Zhenming Yang, Yue Hu, Kaijuan Zheng, Shuyu Zhang, Haizhu Sun, Andrew K. Whittaker, Bai Yang, Hongchen Sun, Quan Lin, Ce Shi

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Napabucasin-loaded PLGA nanoparticles trigger anti-HCC immune responses by metabolic reprogramming of tumor-associated macrophages by Zhenwei Song, Hongfei Chen, Xueyao Wang, Zhiyue Zhang, Hui Li, Huajun Zhao, Yang Liu, Qiuju Han, Jian Zhang

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Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth by Xia Peng, Siqi Yu, Lin Xu, Qinghua Wang, Lin Yang, Yi Su, Zhirou Xiong, Mengjie Shao, Meiyu Geng, Ao Zhang, Lei Zhang, Jing Ai, Chunyong Ding

“…Tumor-associated macrophages (TAMs) are pivotal for tumor development and progression. Reprogramming the M2-like pro-tumoral behavior of TAMs towards the M1-like anti-tumor phenotype to unleash their potential against tumors has become one of the most promising anti-tumor immunotherapy strategies. …”
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A human antibody specific for SIRPα reprograms macrophages and promotes antibody mediated anti-cancer activity. by Keifer G Kurtz, Irina Lebedeva, Stephanie A Pierre, David Andrew, Yu-Rou Liao, Daisy Ambriz, Olivia Vergnolle, Leyi Shen, Elizabeth Nyakatura, Manuel Baca, David A Scheinberg

“…Furthermore, we show F05 reprograms immunosuppressive macrophages toward a phagocytic profile in vitro. …”
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From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways by Anna M. Wójcik, Kamila Krypczyk, Weronika M. Buchcik, Małgorzata D. Gaj

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Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies by Boran Pang, Hao Wu

“…Metabolic reprogramming in CRC is characterized by a shift from oxidative phosphorylation to glycolysis, termed the Warburg effect. …”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…ObjectiveMitochondrial metabolic reprogramming in macrophages is crucial in the development and progression of inflammation. …”
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Liposome-encapsulated AICAR hydrogel regulates macrophage metabolic reprogramming via SIK1 activation to alleviate osteoarthritis by Yong Fu, Jiahui Hou, Qinmeng Yang, Yanpeng Lin, Nie Rui, Jun Wang, Hangtian Wu, Bin Yu

“…The anti-inflammatory effects of its agonist, AICAR, were validated, underscoring its role in reprogramming macrophage glucose and lipid metabolism. …”
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Dynamic Changes in Occupancy of Histone Variant H2A.Z during Induced Somatic Cell Reprogramming by Fulu Dong, Zhenwei Song, Jiali Yu, Baole Zhang, BaoChun Jiang, Ying Shen, Youde Lu, Chunlei Song, Peiqing Cong, Honglin Liu

“…The development of induced pluripotent stem cells (iPSCs) has enabled study of the mechanisms underlying cellular reprogramming. …”
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