Metabolic reprogramming induced by fructose promotes therapy´s failure in liver cancer cells in vitro and in vivo. by Lisette Chávez-Rodríguez, Oscar A. Escobedo Calvario, Johann Matschke, Verena Jendrossek, Felipe Masso, Araceli Páez Arenas, María C. Gutiérrez-Ruíz, Luis E. Gomez-Quiroz

“…Introduction and Objectives: Metabolic reprogramming is a hallmark of cancer cells. Fructose metabolism is decreased in liver cancer cells to counteract the oxidative environment induced by fructose. …”
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Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming by Rongqi Guo PhD, Rui Wang PhD, Weisong Zhang PhD, Yangyang Li PhD, Yihao Wang PhD, Hao Wang PhD, Xia Li PhD, Jianxiang Song PhD

“…Conclusions Understanding the mechanisms underlying macrophage polarisation and reprogramming offers promising avenues for developing therapies to counteract tumour progression. …”
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Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy by Rongrong Zhao, Ying Hou, Boyan Li, Ziwen Pan, Jiawei Qiu, Qingtong Wang, Yanhua Qi, Zhe Han, Hongyu Zhao, Hong Liu, Weijia Zhou, Gang Li, Hao Xue

“…Crucially, the platform concurrently induces immunogenic death in tumour cells and reprograms protumoral macrophages to antitumor phenotypes. …”
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Oral oncolytic magnetotactic bacteria elicit anti-colorectal tumor immunity and reprogram microbiota metabolism by Aodi Jiang, Baoyi Li, Menghang Zu, Li Chen, Chan Zhao, Jiesheng Tian, Rui L. Reis, Subhas C. Kundu, Bo Xiao, Xiaoxiao Shi

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Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds by Yipeng Pang, Fructueux Modeste Amona, Xiaohan Chen, Yuxin You, Ziqi Sha, Zilu Liu, Jiamin Li, Yi Liu, Xingtang Fang, Xi Chen

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Comprehensive Multiomic Analysis Reveals Metabolic Reprogramming Underlying Human Fontan‐Associated Liver Disease by Rasheed Sule, Po Hu, Clarissa Shoffler, Christopher Petucci, Benjamin J. Wilkins, Jack Rychik, Liming Pei

“…Almost all patients with Fontan operation develop liver fibrosis at a young age, known as Fontan‐associated liver disease (FALD). …”
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Enhancing selective itaconic acid synthesis in Yarrowia lipolytica through targeted metabolite transport reprogramming by Cosetta Ciliberti, Zbigniew Lazar, Kacper Szymański, Evgeniya Yuzbasheva, Tigran Yuzbashev, Ivan Laptev, Luigi Palmieri, Isabella Pisano, Gennaro Agrimi

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Exposure to polyethylene terephthalate microplastics induces reprogramming of flavonoids metabolism and gene regulatory networks in Capsicum annuum by Rongchao Yang, Yilan Cui, Long Cheng, Mangu Hu, Mingzhu Guan, Youyang Fu, Yueqin Zhang

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REPROGRAMMING OF SPLENIC MONONUCLEAR PHAGOCYTE PHENOTYPE DURING MODELING OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITISIN WISTAR RATS

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Reprogramming the tumor-immune landscape via nanomaterial-induced immunogenic cell death: a mini review by Xiangwei Meng, Xiangwei Meng, Chunqing Che, Yingjie Yi, Xiaoyang Qu

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Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages by Chengju Luo, Chenqi Huang, Yuqi Zhu, Yuxin Zhou, Yansheng Qiao, Chenxiao Shi, Yuan Gao, Yongjian Guo, Libin Wei

“…The dysregulations of Rho GTPases/ROCK are related with various diseases, including fibrosis. Nevertheless, the development of drugs for pulmonary fibrosis treatment has predominantly concentrated on ROCK inhibitors. …”
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Epigenetic regulation of reprogramming and pluripotency: insights from histone modifications and their implications for cancer stem cell therapies by Woori Bae, Eun A. Ra, Eun A. Ra, Myon Hee Lee

“…Recent studies underscore the importance of epigenetic regulators in both the reprogramming process and the regulation of cancer stem cells (CSCs), which are pivotal in tumor initiation and the development of treatment resistance. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…While benign in most people, EBV is responsible for infectious mononucleosis, up to 2% of human cancers, and is a trigger for the development of multiple sclerosis. Following latency establishment in B cells, EBV reactivates and is shed in saliva to enable infection of new hosts. …”
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Acute kidney injury through a metabolic lens: pathological reprogramming mechanisms and clinical translation potential by Jingli Gao, Liuyifei Huang, Yuzhan Zhang, Lei Wei, Zhixiang Yu, Yan Xing, Jinguo Yuan, Xiaoxuan Ning, Shiren Sun

“…Acute kidney injury (AKI) represents a clinical syndrome with a bleak short-term prognosis, posing a high risk for the development of chronic kidney diseases and end-stage kidney disease. …”
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A Self-Assembled Metabolic Regulator Reprograms Macrophages to Combat Cytokine Storm and Boost Sepsis Immunotherapy by Junyan Zhuang, Yongrui Hai, Xintong Lu, Borui Sun, Renming Fan, Bingjie Zhang, Wenhui Wang, Bingxue Han, Li Luo, Le Yang, Chun Zhang, Minggao Zhao, Gaofei Wei

“…In sepsis models, LDO effectively attenuates CCL2-driven cytokine storms, alleviates acute lung injury, and significantly enhances survival via metabolic reprogramming. This study offers a cytokine-regulatory strategy rooted in immunometabolism, providing a foundation for the translational development of immune metabolite-based sepsis therapies.…”
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THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation by Zhe Guo, Sijia Zhong, Jinpeng Bai, Xiuyuan Lang, Minmin Cao, Yang Hu, Xiaoyan Qin, Yingyu Sun

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Reprogramming of liver metabolism during West Nile virus infection unveils novel aspects of disease pathophysiology by Patricia Mingo-Casas, Ana-Belén Blázquez, Josefina Casas, Ana Esteban, Estela Escribano-Romero, Pedro J. Sánchez-Cordón, Nereida Jiménez de Oya, Juan-Carlos Saiz, Miguel A. Martín-Acebes

“…Moreover, histopathological findings supported the development of steatosis in one-third of WNV-infected animals. …”
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Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro by Anna Podleśny-Drabiniok, Carmen Romero-Molina, Tulsi Patel, Wen Yi See, Yiyuan Liu, Edoardo Marcora, Alison M. Goate

“…These findings provide insights into cytokine-mediated reprogramming of macrophages toward disease-relevant states, highlighting their role in neurodegenerative diseases and potential for therapeutic development.…”
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Metabolic Reprogramming of Gastric Cancer Revealed by a Liquid Chromatography–Mass Spectrometry-Based Metabolomics Study by Lina Zhou, Benzhe Su, Zexing Shan, Zhenbo Gao, Xingyu Guo, Weiwei Wang, Xiaolin Wang, Wenli Sun, Shuai Yuan, Shulan Sun, Jianjun Zhang, Guowang Xu, Xiaohui Lin

“…Understanding the metabolic reprogramming associated with GC is crucial for the prevention and treatment of this disease. …”
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The interplay of cellular senescence and reprogramming shapes the biological landscape of aging and cancer revealing novel therapeutic avenues by Fuan Ding, Ying Yu, Jiangqi Zhao, Shibo Wei, Yan Zhang, Jung Ho Han, Zhuo Li, Hong-Bo Jiang, Dongryeol Ryu, Minkyoung Cho, Sung-Jin Bae, Wonyoung Park, Wonyoung Park, Ki-Tae Ha, Ki-Tae Ha, Bo Gao

“…Understanding the interplay between senescence and reprogramming is crucial for developing innovative therapies. …”
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